Sant'Antonio Vacations from $1,089

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $2,000 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Plan, book, and manage your trip all in one place

Your SantAntonio Vacation

Reserve a SantAntonio vacation package and prepare to experience all this lively city has to offer. Consider staying in the neighborhood of Vecchiano, which is great for bars and pubs, walking and nature. Fill your spare time with visits to Cathedral of Pisa, Knights Square and Pisa Baptistry, some of the things you should see during your trip to SantAntonio. A couple of clicks is all it takes to put together the perfect SantAntonio vacation on Expedia.

The Latest Sant'Antonio vacation packages

Price found within the past 48 hours. Click for updated prices.
Eurostars Florence Boutique

Eurostars Florence Boutique

Historic Centre of Florence
$1,089
per person
Dec 6 - Dec 13
just found
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Florence (FLR)
8.6/10 Excellent! (503 reviews)
The bed was comfortable but low to the floor. The shower was very slippery and could have used a shower mat. The breakfast was great. The staff were very nice and helpful.

Reviewed on Oct 10, 2026

Hotel Villa Betania

Hotel Villa Betania

Oltrarno
$1,130
per person
Dec 6 - Dec 13
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Florence (FLR)
9/10 Wonderful! (732 reviews)
Aurum Uffizi

Aurum Uffizi

Historic Centre of Florence
$1,961
per person
Dec 29 - Jan 3
found 24 hours ago
Roundtrip non-stop flight included
Atlanta (ATL) to Florence (FLR)
7.6/10 Good! (1,003 reviews)
The staff was excellent, especially Joshua. The room was cleaned daily. Breakfast was ok.

Reviewed on Oct 20, 2026

Hotel Atlantic Palace

Hotel Atlantic Palace

Historic Centre of Florence
$1,310
per person
Dec 31 - Jan 4
found 1 day ago
Roundtrip non-stop flight included
New York (NYC) to Florence (FLR)
8.8/10 Excellent! (75 reviews)
The Moon Boutique Hotel & Spa

The Moon Boutique Hotel & Spa

Historic Centre of Florence
$1,275
per person
Jan 2 - Jan 7
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Florence (FLR)
9.6/10 Exceptional! (605 reviews)
Great place!

Reviewed on Oct 19, 2026

Don't see what you're looking for?
See all available trips from Columbus to Sant'Antonio
View all trips

Stay near popular Sant'Antonio attractions

A river with buildings along its banks, a prominent church with a spire, and a mountain in the background.

Church of Santa Maria della Spina

9.4/10 (6 reviews)
In a city of remarkable architecture, this Gothic church on the River Arno is considered to be one of Pisa’s most impressive structures despite its small size.
See properties
A historic building with a sign reading "DOM ETSCHRISTINA VETM DICATUM" and a colorful banner for "WANDY WARHOL".

Palazzo Blu

8.8/10 (26 reviews)
Explore this time capsule of classic Pisan life and learn about the achievements of this fascinating town’s most creative sons and daughters.
See properties
A historic building with arched walkways, palm trees, and a flag on top.

Giardino Scotto

9.4/10 (3 reviews)
Explore the great outdoors at Giardino Scotto, a lovely green space in Sant'Antonio. Stroll along the riverfront in this culturally rich area, or check out its lively bars.
See properties

Arsenale Cinema

Enjoy a show at Arsenale Cinema, a storied theater in Sant'Antonio. Stroll along the riverfront in this culturally rich area, or check out its lively bars.
See properties

Piazza Vittorio Emanuele II

You can learn about the history of Sant'Antonio with a stop at Piazza Vittorio Emanuele II. Stroll along the riverfront in this culturally rich area, or check out its lively bars.
See properties

Saint Cristina Church

Saint Cristina Church is just one of the places to see in Sant'Antonio, so why not enjoy the other things to explore during your travels? Check out the stunning cathedral and lively bars in this culturally rich area.
See properties

Santo Sepolcro

Learn about the local history of Sant'Antonio with a stop at Santo Sepolcro. Check out the stunning cathedral and lively bars in this culturally rich area.
See properties

Museo della Grafica

10.0/10 (1 review)
You can study the exhibits at Museo della Grafica, a museum with a story of its own, during your trip to Sant'Antonio. Stroll along the riverfront or visit the stunning cathedral in this culturally rich area.
See properties

What to do in Sant'Antonio

Lucca: Puccini Festival Opera Recitals and Concerts

Lucca: Puccini Festival Opera Recitals and Concerts

$34
per adult
92% of travellers recommend
Lucca: Puccini Festival Opera Recitals and Concerts
Pisa: Leaning Tower and Cathedral Skip-the-Line Tickets

Pisa: Leaning Tower & Cathedral Tickets with Timed Entry

$34
per adult
96% of travellers recommend
Pisa: Leaning Tower & Cathedral Tickets with Timed Entry
From Livorno: Shore Excursion to Florence and Pisa

From Livorno: Shore Excursion to Florence and Pisa

$41
per adult
84% of travellers recommend
From Livorno: Shore Excursion to Florence and Pisa
See all activities in Sant'Antonio

Sant'Antonio Hotel Deals

Hotel Bologna

Hotel Bologna

Via Mazzini 57 Pisa PI
Fully refundableReserve now, pay when you stay
$82 nightly
$97 total
Nov 17 - Nov 18
Total with taxes and fees
8.8/10 Excellent! (1,005 reviews)
"Staff was very helpful during our stay. We had to leave at 5am and they had made us a nice breakfast to go. Room was nice and we were in a great location."

Reviewed on Oct 21, 2026

Hotel Bologna
Grand Hotel Duomo

Grand Hotel Duomo

Via Santa Maria 94 Pisa PI
Fully refundableReserve now, pay when you stay
$106 nightly
$117 total
Nov 4 - Nov 5
Total with taxes and fees
Grand Hotel Duomo
Hotel Galilei

Hotel Galilei

Via Darsena 1 Pisa PI
Fully refundableReserve now, pay when you stay
$101 nightly
$118 total
Nov 21 - Nov 22
Total with taxes and fees
Hotel Galilei
See all 6,370 properties in Sant'Antonio
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Sant'Antonio Vacation Packages

SantAntonio Essential Information

Language
Italian
Currency
Euros
Local Welcome
Ciao
Local Goodbye
Ciao
Closest Airport
Galileo Galilei Airport (PSA)
Max Temp Winter
50ºF
Max Temp Summer
80ºF
Top Sights
Cathedral of Pisa, Calambrone Beach and Palazzo Blu

More vacations you might like

Frequently asked questions

How much does a Sant'Antonio vacation package cost?
Offering great value package deals from $1,089 on Expedia, you'll be pleasantly surprised at how much a vacation to Sant'Antonio costs! Expedia's packages mean less travel planning for you and greater savings.
What are the cheapest months to go to Sant'Antonio?
October, November and December are the best times to look for cheap Sant'Antonio vacation packages. Choosing to travel in quieter months means you can typically find better prices on hotels and flights.
How many days is enough for Sant'Antonio?
Usually, a handful of days is enough to check out the major attractions during your Sant'Antonio vacation. But if you prefer to have some time to relax or take day trips, think about extending your itinerary.
Is it worth booking a vacation package to Sant'Antonio?
From leading attractions such as Arsenale Cinema and San Martino Church to its terrific culture, a Sant'Antonio vacation delivers big on experiences. With so much to do and see, it's time to find out for yourself why Sant'Antonio is such a good vacation destination.
How to find the best Sant'Antonio package deals?
Finding a cheap Sant'Antonio package deal is a breeze with Expedia. After you've entered your preferred dates and destination under our "Packages" tab, set your maximum budget, add a few filters and see what's available. You can tweak your search by "Property class," "Number of bedrooms," "Traveler experience" and more. Sort the results by "Price: low to high" to discover the most affordable Sant'Antonio package deals. Want a simple trick to get the biggest savings? Be flexible with your departure dates and consider going away on a weekday, when prices are typically lower.
Is it cheaper to book a Sant'Antonio vacation as a package?
An Expedia vacation package could score you significant savings when compared to arranging flights and hotels separately. Better still, you can tailor your Sant'Antonio escape to fit your exact needs. Choose your preferred flight time, select the hotel type and add a car rental. Browse our bundle deals and find out how much you can save.
When to book a vacation package to Sant'Antonio?
Score fantastic discounts by reserving your flights ahead of time with Expedia. If being spontaneous is more your thing, grab one of our last-minute deals for an impromptu Sant'Antonio break.
How to plan a trip to Sant'Antonio?
  1. Pick the perfect time to travel: Your schedule, preferred season and the type of weather you like can all influence your decision on when to travel to Sant'Antonio.
  2. Figure out your budget: Ensure you have enough money to cover everything from dining out and transportation to activities and flights. Your hotel will probably be the biggest expense during your trip to Sant'Antonio.
  3. Use our trip planning tool to explore Sant'Antonio: Research every part of your trip to Sant'Antonio with this comprehensive planner. Invite family or friends to collaborate on a group getaway, search for stays or things to do and make bookings.
  4. Work out your trip length: Consider how much time you want to spend exploring Sant'Antonio. Plan your itinerary so you can get to all the attractions and activities you're interested in without rushing.
  5. Combine your airfare and accommodations: After you've nailed down your travel dates and duration, book the ideal Sant'Antonio vacation package for you.
  6. Book any excursions or activities: Here's the fun part — locking in everything you want to do and see. Explore some of the best things to do in Sant'Antonio and reserve your tickets early to save time (and maybe some money too!).
Does Expedia offer Book Now, Pay Later Sant'Antonio vacation packages?
Your Sant'Antonio trip is meant to be a relaxing escape from your busy life, not a source of money-related stress. So to give you more flexibility, we've partnered with online lender Affirm to bring you our Book Now, Pay Later vacations. Choose one of our vacation packages with payment plans and break down the cost over 3, 6 or 12 months. Plus, there are no late payment fees or hidden costs to worry about.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.