Santa Croce Vacations from $1,238

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Your Santa Croce Vacation

Discover the best that Santa Croce offers with a Santa Croce vacation package. From its culture to every other thing that makes it special, this neighborhood will charm you from beginning to end. When it's time to take in the sights, you'll find loads of popular attractions nearby including Rialto Bridge, St. Marks Basilica and St. Marks Square. Visit one, two or more during your trip to Santa Croce. Don't just dream it — do it! Lock in your ideal Santa Croce vacation with Expedia and experience travel your way.

The Latest Santa Croce Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hotel Bisanzio

Hotel Bisanzio

Castello
$1,238
per person
Nov 9 - Nov 13
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Venice (VCE)
9/10 Wonderful! (1,003 reviews)
The staff were very helpful in holding our luggage until check-in time. They also gave great advice on site seeing - great for us first timers. So much to do so close by - wonderful experience!

Reviewed on Sep 1, 2026

Palazzo Dei Fiori By Room Mate

Palazzo Dei Fiori By Room Mate

Venice City Center
$1,482
per person
Oct 15 - Oct 19
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Venice (VCE)
10/10 Exceptional! (86 reviews)
Hotel San Moisè

Hotel San Moisè

Venice City Center
$1,527
per person
Oct 23 - Oct 26
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Venice (VCE)
7.8/10 Good! (750 reviews)
We expected more.

Reviewed on Aug 27, 2026

Orient Express Venezia

Orient Express Venezia

Cannaregio
$2,642
per person
Nov 26 - Nov 30
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Venice (VCE)
No reviews
Eight Venezia

Eight Venezia

Castello
$1,908
per person
Nov 9 - Nov 13
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Venice (VCE)
9.8/10 Exceptional! (60 reviews)
Always a great stay and experience. Fabulous staff.

Reviewed on Nov 4, 2024

Where to stay in Santa Croce

Find the best Santa Croce areas and neighborhoods for the activities you enjoy most. Learn more about Santa Croce
A historic building with a dome and bell tower by the water.

Venice City Center

5 out of top 10 points of interest in this area

Discover an abundance of architectural monuments and great art by grandmasters in the heart of an Italian city built on water.

Find hotels in Venice City Center
A canal with gondolas, people walking on the steps, and storefronts with signs like "Giorgio Armani".

San Marco

In the heart of Venice, this densely built area boasts iconic attractions like St Mark's Square, Saint Mark's Basilica, and the Doge's Palace. Find numerous hotels, banks, and high-end shops amid the bustling tourist scene.

Find hotels in San Marco
A canal in Venice with colorful buildings and a bridge.

Cannaregio

Explore historic churches like Santa Maria di Nazareth and Santa Maria dei Miracoli, or admire stunning palazzos such as Ca' d'Oro and Ca' Vendramin Calergi. Enjoy morning markets, local shops, and quaint cafés in this residential, peaceful district.

Find hotels in Cannaregio
A canal with boats docked, historic buildings, and a clear sky.

San Polo

Smallest and most central sestiere, San Polo boasts churches in the west, palaces in the east, and iconic attractions like Rialto Bridge and Scuola Grande di San Rocco.

Find hotels in San Polo
A canal with a bridge, buildings with blue shutters, and a sign in Italian.

Dorsoduro

Boasting the highest land areas in Venice, this sestiere features the stunning Basilica of Santa Maria della Salute and the picturesque Zattere quay. Easily connect to San Marco via Ponte dell'Accademia.

Find hotels in Dorsoduro

Santa Croce Hotel Deals

Hotel Arlecchino

Hotel Arlecchino

Fondamenta Delle Burchielle Venice VE
$342 nightly
$384 total
Sep 30 - Oct 1
Total with taxes and fees
9.4/10 Exceptional! (1,006 reviews)
"Very clean room. Although we did put a do not disturb sign on while we were out & they still came in & changed bedding, towels. It was nice, but we prefer when traveling to not have our room entered by staff. Our bags were everywhere. We didn’t say anything, but it annoyed me. Our gondola ride was ..."

Reviewed on Sep 3, 2026

Hotel Arlecchino
Hotel Antiche Figure

Hotel Antiche Figure

Santa Croce 687 Venice VE
Fully refundableReserve now, pay when you stay
$349 nightly
$392 total
Sep 13 - Sep 14
Total with taxes and fees
Hotel Antiche Figure
Hotel Canal Grande

Hotel Canal Grande

Santa Croce 932 Venice VE
Fully refundableReserve now, pay when you stay
$396 nightly
$446 total
Sep 14 - Sep 15
Total with taxes and fees
9.6/10 Exceptional! (1,000 reviews)
"It was clean and comfortable, and the staff were helpful. The AC in the room was powerful."

Reviewed on Aug 31, 2026

Hotel Canal Grande
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Santa Croce attractions

A bridge over a canal with buildings and a green dome in the background.

Piazzale Roma

8.6/10 (9,106 reviews)
You can learn about the local history of Venice during your trip to a top site like Piazzale Roma. Stroll along the marina or visit the stunning cathedral in the area.
See properties
A narrow canal in Venice, Italy, flanked by historic buildings with arched windows and balconies.

Ca'Pesaro

6.0/10 (1 review)
You can browse the exhibits at Ca'Pesaro, a museum with a storied past, during your trip to Venice. Stroll along the marina or visit the stunning cathedral in the area.
See properties
A calm water body reflecting buildings, including a modern white structure and a yellow building.

Fondazione Prada

You can browse the exhibits at Fondazione Prada, a museum with a storied past, during your trip to Venice. Visit the area's churches or amble around its marina.
See properties
A canal in Venice with colorful buildings and boats.
Photo by Anand Gajelli

San Simeone Piccolo

San Simeone Piccolo is just one of the places to see in Venice, so why not enjoy the other things to explore during your travels? Visit the area's stunning cathedral or amble around its marina.
See properties
A historic building with a row of arches and a series of pointed towers.

Venetian Museum of Natural History

9.0/10 (2 reviews)
You can study the exhibits at Venetian Museum of Natural History, a museum with a storied past, during your trip to Venice. Stroll along the area's marina or experience its acclaimed art scene.
See properties

Ca' Pesaro Galleria Internazionale d'Arte Moderna

6.0/10 (1 review)
You can browse the exhibits at Ca' Pesaro Galleria Internazionale d'Arte Moderna, a museum with a story of its own, during your travels to Venice. Discover the area's fascinating museums and churches.
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San Stae

8.0/10 (1 review)
Find out about the history of Venice when you take a trip to San Stae. Stroll along the area's marina or experience its fascinating museums.
See properties

Tolentini

Learn about the local history of Venice when you take a trip to Tolentini. Visit the area's stunning cathedral or amble around its marina.
See properties

Things to do

Taste of Venice: Local Tapas Tastings & Wine Tour

Venice Small Group Food Tour: Venetian Tapas, Wine, Spritz & Gondola Ride

$92
per adult
96% of travellers recommend
Venice Small Group Food Tour: Venetian Tapas, Wine, Spritz & Gondola Ride
Sidewalk flanked by colorful buildings in Burano

Murano & Burano Tour

$41
per adult
90% of travellers recommend
Murano & Burano Tour
Sunset Cruise with Aperitivo & Lagoon Views

Sunset Cruise with Aperitivo & Lagoon Views

$34
per adult
Sunset Cruise with Aperitivo & Lagoon Views
See all activities in Venice
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.