Santa Croce Vacations from $1,233

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Your Santa Croce Vacation

Discover the best that Santa Croce offers with a Santa Croce vacation package. From its culture to every other thing that makes it special, this neighborhood will charm you from beginning to end. When it's time to take in the sights, you'll find loads of popular attractions nearby including Rialto Bridge, St. Marks Basilica and St. Marks Square. Visit one, two or more during your trip to Santa Croce. Don't just dream it — do it! Lock in your ideal Santa Croce vacation with Expedia and experience travel your way.

The Latest Santa Croce Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hotel Bisanzio

Hotel Bisanzio

Castello
$1,233
per person
Dec 11 - Dec 18
found 1 day ago
Roundtrip non-stop flight included
Dallas (DFW) to Venice (VCE)
9/10 Wonderful! (1,004 reviews)
The hotel has a great location if you’re looking for St Mark’s square proximity. Breakfast was nice. Just be aware the hotel has an annex and you may end up there. You leave the hotel, go down a short alley, through a small courtyard to their annex building. The room was ok but we would have preferred the main building. Breakfast is in the real hotel. Also, for those who care, English language tv is scarce and inconsistent.

Reviewed on Sep 23, 2026

Ca' Sagredo

Ca' Sagredo

Cannaregio
$1,548
per person
Dec 11 - Dec 18
found 1 day ago
Roundtrip non-stop flight included
Dallas (DFW) to Venice (VCE)
9.2/10 Wonderful! (534 reviews)
Old building , very pretty . Good location . Excellent breakfast

Reviewed on Oct 3, 2026

Palazzo Veneziano

Palazzo Veneziano

Dorsoduro
$1,599
per person
Dec 11 - Dec 18
found 1 day ago
Roundtrip non-stop flight included
Dallas (DFW) to Venice (VCE)
9.6/10 Exceptional! (1,206 reviews)
Palazzo Venart Luxury Hotel

Palazzo Venart Luxury Hotel

Venice City Center
$2,551
per person
Dec 12 - Dec 18
found 15 hours ago
Roundtrip non-stop flight included
Dallas (DFW) to Venice (VCE)
9.8/10 Exceptional! (191 reviews)
Hotel Ai Reali di Venezia

Hotel Ai Reali di Venezia

Castello
$1,627
per person
Nov 7 - Nov 13
found 19 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Venice (VCE)
9.6/10 Exceptional! (1,000 reviews)
We asked for room upgrade but claimed not to have. Our friends who stayed at same time had much better and bigger room. Lots to eat at breakfast but not a lot of state.

Reviewed on Oct 1, 2026

Where to stay in Santa Croce

Find the best Santa Croce areas and neighborhoods for the activities you enjoy most. Learn more about Santa Croce
A historic building with a dome and bell tower by the water.

Venice City Center

5 out of top 10 points of interest in this area

Discover an abundance of architectural monuments and great art by grandmasters in the heart of an Italian city built on water.

Find hotels in Venice City Center
A canal with gondolas, people walking on the steps, and storefronts with signs like "Giorgio Armani".

San Marco

In the heart of Venice, this densely built area boasts iconic attractions like St Mark's Square, Saint Mark's Basilica, and the Doge's Palace. Find numerous hotels, banks, and high-end shops amid the bustling tourist scene.

Find hotels in San Marco
A canal in Venice with colorful buildings and a bridge.

Cannaregio

Explore historic churches like Santa Maria di Nazareth and Santa Maria dei Miracoli, or admire stunning palazzos such as Ca' d'Oro and Ca' Vendramin Calergi. Enjoy morning markets, local shops, and quaint cafés in this residential, peaceful district.

Find hotels in Cannaregio
A canal with boats docked, historic buildings, and a clear sky.

San Polo

Smallest and most central sestiere, San Polo boasts churches in the west, palaces in the east, and iconic attractions like Rialto Bridge and Scuola Grande di San Rocco.

Find hotels in San Polo
A canal with a bridge, buildings with blue shutters, and a sign in Italian.

Dorsoduro

Boasting the highest land areas in Venice, this sestiere features the stunning Basilica of Santa Maria della Salute and the picturesque Zattere quay. Easily connect to San Marco via Ponte dell'Accademia.

Find hotels in Dorsoduro

Santa Croce Hotel Deals

Hotel Antiche Figure

Hotel Antiche Figure

Santa Croce 687 Venice VE
Fully refundableReserve now, pay when you stay
$225 nightly
$255 total
Nov 3 - Nov 4
Total with taxes and fees
9.8/10 Exceptional! (1,000 reviews)
"Very convenient location and beautiful hotel. The trip to Murano and Burano was very memorable. Plus we took a private sunset tour by boat, highly recommend!"

Reviewed on Sep 29, 2026

Hotel Antiche Figure
Hotel Canal Grande

Hotel Canal Grande

Santa Croce 932 Venice VE
Fully refundableReserve now, pay when you stay
$176 nightly
$204 total
Nov 3 - Nov 4
Total with taxes and fees
9.6/10 Exceptional! (1,002 reviews)
"Perfect in every aspect- extremely helpful staff that booked all of our dinner reservations for us, provided a complimentary trip to Murano to see glass blowing, and was always available for any questions. We booked the junior suite which was a corner unit with canal views and incredible authentic ..."

Reviewed on Oct 3, 2026

Hotel Canal Grande
Santa Chiara Hotel

Santa Chiara Hotel

Santa Croce 548 Venice VE
$304 nightly
$345 total
Oct 25 - Oct 26
Total with taxes and fees
9.4/10 Exceptional! (408 reviews)
"My room overlooked the canal. It is a beautiful hotel and the staff was superb!! I found them to be very helpful. I was afraid there would be a language bearer or that Americans would be treated rudely like I experienced in France, this was not the case at all. I learned simply greetings which did ..."

Reviewed on Oct 3, 2026

Santa Chiara Hotel
See all 6,665 properties in Santa Croce
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Santa Croce attractions

A bridge over a canal with buildings and a green dome in the background.

Piazzale Roma

8.6/10 (9,106 reviews)
You can learn about the local history of Venice during your trip to a top site like Piazzale Roma. Stroll along the marina or visit the stunning cathedral in the area.
See properties
A historic building with arched windows and a domed structure in the background.

Fondaco dei Turchi

9.4/10 (10 reviews)
You can browse the exhibits at Fondaco dei Turchi, a museum with a storied past, during your trip to Venice. Stroll along the marina or visit the churches in the area.
See properties
A historic building with a row of arches and a series of pointed towers.

Venetian Museum of Natural History

9.0/10 (2 reviews)
You can study the exhibits at Venetian Museum of Natural History, a museum with a storied past, during your trip to Venice. Stroll along the area's marina or experience its acclaimed art scene.
See properties
A calm water body reflecting buildings, including a modern white structure and a yellow building.

Fondazione Prada

You can browse the exhibits at Fondazione Prada, a museum with a storied past, during your trip to Venice. Visit the area's stunning cathedral or amble around its marina.
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A narrow canal in Venice, Italy, flanked by historic buildings with arched windows and balconies.

Ca'Pesaro

6.0/10 (1 review)
You can browse the exhibits at Ca'Pesaro, a museum with a storied past, during your trip to Venice. Stroll along the marina or visit the stunning cathedral in the area.
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San Stae

8.0/10 (1 review)
Find out about the history of Venice when you take a trip to San Stae. Stroll along the area's marina or experience its acclaimed art scene.
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Ca' Pesaro Galleria Internazionale d'Arte Moderna

6.0/10 (1 review)
You can browse the exhibits at Ca' Pesaro Galleria Internazionale d'Arte Moderna, a museum with a story of its own, during your travels to Venice. Discover the area's fascinating museums and stunning cathedral.
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Papadopoli Gardens

Papadopoli Gardens is just one of the places to see in Venice, so why not enjoy the other things to explore during your travels? Visit the area's churches or amble around its marina.
See properties

Things to do

Venice in a Day with St. Mark's Basilica, Doge's Palace, & Gondola Ride

Venice in a Day:Gondola Ride, Doge's Palace, St Mark's Basilica & City Tour

$187
per adult
94% of travellers recommend
Venice in a Day:Gondola Ride, Doge's Palace, St Mark's Basilica & City Tour
Sidewalk flanked by colorful buildings in Burano

Murano & Burano Tour

$58
per adult
90% of travellers recommend
Murano & Burano Tour
Taste of Venice: Local Tapas Tastings & Wine Tour

Venice Small Group Food Tour: Venetian Tapas, Wine, Spritz & Gondola Ride

$114
per adult
96% of travellers recommend
Venice Small Group Food Tour: Venetian Tapas, Wine, Spritz & Gondola Ride
See all activities in Venice
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.