Santa Croce Vacations from $554

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $1,045 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Your Santa Croce Vacation

Discover the best that Santa Croce offers with a Santa Croce vacation package. From its culture to every other thing that makes it special, this neighborhood will charm you from beginning to end. When it's time to take in the sights, you'll find loads of popular attractions nearby including Rialto Bridge, St. Marks Basilica and St. Marks Square. Visit one, two or more during your trip to Santa Croce. Don't just dream it — do it! Lock in your ideal Santa Croce vacation with Expedia and experience travel your way.

The Latest Santa Croce Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Eurostars Residenza Cannaregio Hotel

Eurostars Residenza Cannaregio Hotel

4 out of 5
Cannaregio
Price was $819, price is now $554 per person
$554
per person
Jan 15 - Jan 20
found 1 day ago
Roundtrip flight included
Boston (BOS) to Venice (VCE)
8.6/10 Excellent! (1,004 reviews)
Clean rooms, great service, professional staff

Reviewed on Nov 21, 2025

Cà Bonfadini Historic Experience

Cà Bonfadini Historic Experience

5 out of 5
Cannaregio
Save 100% on your flight
Price was $2,904, price is now $1,868 per person
$1,868
per person
Dec 31 - Jan 5
found 8 hours ago
Roundtrip non-stop flight included
Boston (BOS) to Venice (VCE)
9.8/10 Exceptional! (206 reviews)
Staff fantastic,all of them Room excellent Shower excellent Restaurant should be a Michelin starred eatery If you need a European adaptor They are available Breakfast wonderful Location terrific

Reviewed on Nov 5, 2025

Hotel Gabrielli - Starhotels Collezione

Hotel Gabrielli - Starhotels Collezione

5 out of 5
Castello
Save 100% on your flight
Price was $3,534, price is now $2,359 per person
$2,359
per person
Feb 15 - Feb 19
found 1 day ago
Roundtrip flight included
Boston (BOS) to Venice (VCE)
10/10 Exceptional! (14 reviews)
Superb location and all facilities excellent. Roof terrace a fantastic asset

Reviewed on Oct 21, 2025

Hotel San Moisè

Hotel San Moisè

3 out of 5
Venice City Center
Price was $1,468, price is now $999 per person
$999
per person
Feb 15 - Feb 19
found 1 day ago
Roundtrip flight included
Boston (BOS) to Venice (VCE)
7.8/10 Good! (725 reviews)
Excellent experience overall. The property was clean, well-managed, and easy to access

Reviewed on Oct 23, 2025

Hotel Bisanzio

Hotel Bisanzio

4 out of 5
Castello
Price was $895, price is now $610 per person
$610
per person
Jan 15 - Jan 20
found 1 day ago
Roundtrip flight included
Boston (BOS) to Venice (VCE)
9/10 Wonderful! (1,001 reviews)
Great location. Nice room and terrace. Zero complaints. Would return 100%

Reviewed on Nov 28, 2025

Black Friday Sale

Limited-time deals: Save up to 50% on select hotels.
Book now

Where to stay in Santa Croce

Find the best Santa Croce areas and neighborhoods for the activities you enjoy most. Learn more about Santa Croce
Dorsoduro featuring heritage architecture and a coastal town

Venice City Center

5 out of top 10 points of interest in this area

Discover an abundance of architectural monuments and great art by grandmasters in the heart of an Italian city built on water.

Find hotels in Venice City Center

Santa Croce Hotel Deals

Hotel Carlton on the Grand Canal

Hotel Carlton on the Grand Canal

4 out of 5
Sestiere Di Santa Croce 578 Venice VE
Fully refundableReserve now, pay when you stay
$91 nightly
The price is $110 total per night from Dec 2 to Dec 3
$110 total
Dec 2 - Dec 3
Total with taxes and fees
8.2/10 Very Good! (1,005 reviews)
Location on the grand canal across from the train station where the water ‘bus’ stops are, so easy to get around. First night in a single, just a twin bed but a new bathroom and the best shower I have had. Second night, different reservation, larger room with a good shower. Both were clean and comfortable. ...

Reviewed on Nov 25, 2025

Hotel Carlton on the Grand Canal
Hotel Antiche Figure

Hotel Antiche Figure

3 out of 5
Santa Croce 687 Venice VE
$131 nightly
The price is $152 total per night from Dec 15 to Dec 16
$152 total
Dec 15 - Dec 16
Total with taxes and fees
9.6/10 Exceptional! (1,008 reviews)
The hotel was wonderful We really enjoyed staying there

Reviewed on Nov 25, 2025

Hotel Antiche Figure
Hotel Al Duca Di Venezia

Hotel Al Duca Di Venezia

3 out of 5
Fontego dei Turchi 1739 Santa Croce Venice VE
Fully refundableReserve now, pay when you stay
$109 nightly
The price is $128 total per night from Dec 8 to Dec 9
$128 total
Dec 8 - Dec 9
Total with taxes and fees
9.2/10 Wonderful! (994 reviews)
Staff were very friendly and welcoming.

Reviewed on Nov 7, 2025

Hotel Al Duca Di Venezia
See all 5,746 properties in Santa Croce
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in Santa Croce

Ca'Pesaro

Ca'Pesaro

You can browse the exhibits at Ca'Pesaro, a museum with a storied past, during your trip to Venice. Stroll along the marina or visit the stunning cathedral in the area.

Ca'Pesaro
Fondaco dei Turchi

Fondaco dei Turchi

5/5(4 reviews)

You can browse the exhibits at Fondaco dei Turchi, a museum with a storied past, during your trip to Venice. Stroll along the marina or visit the stunning cathedral in the area.

Fondaco dei Turchi
Fondazione Prada

Fondazione Prada

You can browse the exhibits at Fondazione Prada, a museum with a storied past, during your trip to Venice. Visit the area's churches or amble around its marina.

Fondazione Prada

Things to do

Single gondola paddles down waterway in Venice

Classic 30 minutes Gondola Ride

$45
per traveler
Classic 30 minutes Gondola Ride
Half Day Murano and Burano Island Tour by Private Boat

Half Day Murano and Burano Island Tour by Private Boat

$28
per adult
88% of travellers recommend
Half Day Murano and Burano Island Tour by Private Boat
I Musici Veneziani - 4 Seasons

I Musici Veneziani Concert: Vivaldi Four Seasons

$41
per adult
88% of travellers recommend
I Musici Veneziani Concert: Vivaldi Four Seasons
See all activities in Venice
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.