Title: Visit Santa Cruz Mixtepec: 2026 Travel Guide for Santa Cruz Mixtepec, Oaxaca | Expedia.com [Hotels in Santa Cruz Mixtepec](https://expedia.com/Santa-Cruz-Mixtepec-Hotels.d553248635640628853.Travel-Guide-Hotels)[Vacation Rentals in Santa Cruz Mixtepec](https://expedia.com/Santa-Cruz-Mixtepec-Vacation-Rentals.d553248635640628853.Travel-Guide-VacationRentals)[Flights to Santa Cruz Mixtepec](https://expedia.com/Cheap-Flights-To-Santa-Cruz-Mixtepec.d553248635640628853.Travel-Guide-Flights)[Car Rentals in Santa Cruz Mixtepec](https://expedia.com/Car-Rentals-In-Santa-Cruz-Mixtepec.d553248635640628853.Car-Rental-Guide)[Santa Cruz Mixtepec Vacation Packages](https://expedia.com/Santa-Cruz-Mixtepec.d553248635640628853.Destination-Travel-Guides) # Santa Cruz Mixtepec ## Travel Guide ## Visit Santa Cruz Mixtepec ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.com/deals?rfrr=DX_SPRING_PROMO_553248635640628853) - Santa Cruz Mixtepec Hotel Deals - Vacation Rentals in Santa Cruz Mixtepec ![Maria Ines Hotel Suite](https://images.trvl-media.com/lodging/20000000/19120000/19114500/19114426/d5d7f7f0_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Maria Ines Hotel Suite Av. Simbolos Patrios KM 4.5 - Lote 1 Oaxaca Oaxaca $71 nightly $85 total Mar 12 - Mar 13 Total with taxes and fees Stay at this hotel in Oaxaca. Enjoy free WiFi, free parking, and room service. Our guests praise the helpful staff in our reviews. Popular attractions Zócalo ... 9.4/10 Exceptional! (415 reviews) The room was good Reviewed on Feb 24, 2026 [](https://expedia.com/Hotel-Search?startDate=3%2F12%2F2026&endDate=3%2F13%2F2026&selected=19114426&PinnedHotelID=19114426&HadPinnedHotel=true®ionId=553248635640628853) ![OYO Hotel Rey David, Oaxaca](https://images.trvl-media.com/lodging/47000000/46340000/46331800/46331727/fc660c33_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### OYO Hotel Rey David, Oaxaca 16 de Septiembre 248 Ocotlán de Morelos OAX $20 nightly $23 total Mar 2 - Mar 3 Total with taxes and fees Stay at this hotel in Ocotlán de Morelos. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attraction Workshop of Jacobo and Maria Angeles is ... [](https://expedia.com/Hotel-Search?startDate=3%2F2%2F2026&endDate=3%2F3%2F2026&selected=46331727&PinnedHotelID=46331727&HadPinnedHotel=true®ionId=553248635640628853) ![Hotel Guivá Aeropuerto](https://images.trvl-media.com/lodging/37000000/36700000/36699000/36698970/d4f10f9d_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hotel Guivá Aeropuerto Av. Símbolos Patrios 917 Oaxaca OAX $76 nightly $90 total Mar 2 - Mar 3 Total with taxes and fees Book a stay at this business-friendly hotel in Oaxaca. Enjoy free WiFi, free parking, and a rooftop terrace. Popular attractions Zócalo and San Juan de Dios ... 7.4/10 Good! (32 reviews) Staff was friendly and helpful. Check on and out was easy and quick. Room was clean. Reviewed on Nov 5, 2025 [](https://expedia.com/Hotel-Search?startDate=3%2F2%2F2026&endDate=3%2F3%2F2026&selected=36698970&PinnedHotelID=36698970&HadPinnedHotel=true®ionId=553248635640628853) [See all 35 properties in Santa Cruz Mixtepec](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=3%2F2%2F2026&endDate=3%2F3%2F2026®ionId=553248635640628853) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![Espectacular y Moderno Apartamento, con Jacuzzi!!! ](https://images.trvl-media.com/lodging/109000000/108730000/108720600/108720591/c01c41d6_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Espectacular y Moderno Apartamento, con Jacuzzi!!! Santa Cruz Xoxocotlán OAX Stay at this apartment in Oaxaca. Enjoy laundry facilities and air conditioning. Popular attractions Zócalo and Calle Alcalá are located nearby. [](https://expedia.com/Oaxaca-Hotels-Espectacular-Y-Moderno-Apartamento.h108720591.Hotel-Information) !["Comfortable and cozy house south of the city, ideal for couples or families."](https://images.trvl-media.com/lodging/115000000/114450000/114440500/114440467/0ce91fe3_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### "Comfortable and cozy house south of the city, ideal for couples or families." Santa Cruz Xoxocotlán Oax. Stay at this vacation home in Oaxaca. Enjoy an in-room coffeemaker. Popular attractions Zócalo and Temazcal Spa Maya are located nearby. [](https://expedia.com/Oaxaca-Hotels-Vrbo-Property.h114440467.Hotel-Information) ![Private cabin in Oaxaca with bathtub, barbecue and fire pit.](https://images.trvl-media.com/lodging/120000000/119700000/119691700/119691685/3c0be33a_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Private cabin in Oaxaca with bathtub, barbecue and fire pit. Villa de Zaachila OAX Stay at this cabin in Villa de Zaachila. Popular attractions Dona Rosa Studio and Convento de Cuilapam are located nearby. [](https://expedia.com/Villa-De-Zaachila-Hotels-Private-Cabin-In-Oaxaca-With-Bathtub.h119691685.Hotel-Information) [See all properties in Santa Cruz Mixtepec](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience®ionId=553248635640628853&sort=VACATION_RENTAL) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Check Santa Cruz Mixtepec hotel availability [Tonight ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635640628853&startDate=2026-03-01&endDate=2026-03-02)[Mar 1 - Mar 2](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635640628853&startDate=2026-03-01&endDate=2026-03-02) [Tomorrow night ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635640628853&startDate=2026-03-02&endDate=2026-03-03)[Mar 2 - Mar 3](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635640628853&startDate=2026-03-02&endDate=2026-03-03) [Next weekend ](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635640628853&startDate=3%2F6%2F2026&endDate=3%2F8%2F2026)[Mar 6 - Mar 8](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635640628853&startDate=3%2F6%2F2026&endDate=3%2F8%2F2026) ## Cities near Santa Cruz Mixtepec ![Panorama Hierve el Agua, Oaxaca, Mexico](https://images.trvl-media.com/place/553248635640641342/6f05157c-27c5-417a-9851-3444f5b9fd1d.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Zimatlán de Álvarez - Cities near Santa Cruz Mixtepec - Places of interest [Zimatlán de Álvarez](https://expedia.com/Zimatlan-De-Alvarez.dx553248635640641342) - [Monte Albán ](https://expedia.com/Monte-Alban-Santa-Cruz-Xoxocotlan.d6113656.Vacation-Attraction) - [Convento de Cuilapam ](https://expedia.com/Convento-De-Cuilapam-Cuilapam-de-Guerrero.d6299881.Vacation-Attraction) - [Dona Rosa Studio ](https://expedia.com/Dona-Rosa-Studio-San-Bartolo-Coyotepec.d553248621561955627.Vacation-Attraction) - [Workshop of Jacobo and Maria Angeles ](https://expedia.com/Workshop-Of-Jacobo-And-Maria-Angeles-San-Martin-Tilcajete.d553248621532629911.Vacation-Attraction) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save even more - get up to 20% on select hotels when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. 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