Santa Cruz Vacations from $315

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Your Santa Cruz Vacation

Say bye-bye to the worries of planning and hello to a Santa Cruz vacation package. With your travel details organized before you go, you can focus on discovering the best of this city, starting with Tlalnepantla Centro, which is great for bars and pubs, shopping and dining. If taking in the sights is a priority during your trip to Santa Cruz, make sure you find your way to well-known attractions like Xochitla Ecological Park and Temple of San Francisco Javier. Whoever you're taking time off with and whatever the size of your budget, your dream Santa Cruz vacation is just a few clicks away with Expedia.

The Latest Santa Cruz vacation packages

Price found within the past 48 hours. Click for updated prices.
Hotel Park Villa

Hotel Park Villa

3 out of 5
Miguel Hidalgo
Save 100% on your flight
Price was $495, price is now $315 per person
$315
per person
Oct 7 - Oct 12
found 1 day ago
Roundtrip flight included
Tijuana (TIJ) to Mexico City (MEX)
8.4/10 Very Good! (604 reviews)
El servicio desde que llegas asta que sales tienes la excelente disposición de Cesar y su personal muchas gracias regreso pronto

Reviewed on May 19, 2025

Zocalo Central & Rooftop Mexico City

Zocalo Central & Rooftop Mexico City

4 out of 5
Historic Center
Price was $950, price is now $604 per person
$604
per person
Nov 13 - Nov 16
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Mexico City (MEX)
9.8/10 Exceptional! (2,451 reviews)
Very well kept, beautiful property. Loved the room, the roof top restaurant with a great view of the downtown area of Mexico city

Reviewed on Aug 31, 2025

Collection O Casa Anzures Thematic, Mexico City

Collection O Casa Anzures Thematic, Mexico City

3 out of 5
Miguel Hidalgo
Price was $1,251, price is now $808 per person
$808
per person
Oct 23 - Oct 28
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Mexico City (MEX)
8.8/10 Excellent! (115 reviews)
A creative and unique space.

Reviewed on Jul 21, 2025

Hotel Amomoxtli

Hotel Amomoxtli

4 out of 5
Santo Domingo
Save 100% on your flight
Price was $1,929, price is now $1,266 per person
$1,266
per person
Nov 19 - Nov 23
found 1 day ago
Roundtrip non-stop flight included
New York (JFK) to Mexico City (MEX)
9.4/10 Exceptional! (605 reviews)
Wonderful spot and service. Spectacular view of the mountains.

Reviewed on Aug 26, 2025

Hacienda Peña Pobre

Hacienda Peña Pobre

4 out of 5
Tlalpan
Save 100% on your flight
Price was $1,435, price is now $956 per person
$956
per person
Oct 16 - Oct 23
found 1 hour ago
Roundtrip non-stop flight included
New York (JFK) to Mexico City (MEX)
9.6/10 Exceptional! (625 reviews)
Everything was excellent

Reviewed on Aug 17, 2025

Don't see what you're looking for?
See all available trips from Columbus to Santa Cruz
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Discover the most popular places to visit in Santa Cruz

Xochitla which includes a garden

Xochitla Ecological Park

Take part in fun-filled activities suitable for all ages, explore a botanical garden and enjoy picnics on grassy lawns at this large ecological park.

Xochitla Ecological Park
Tula de Allende

National Museum of the Viceroyalty

Marvel at the dazzling exhibitions of well-preserved colonial art on display inside one of Mexico’s finest examples of Baroque architecture.

National Museum of the Viceroyalty

Hacienda La Concepcion

You can take time to visit Hacienda La Concepcion during your travels to Tepotzotlán. Amble around the area's parks or experience its museums.

Hacienda La Concepcion

What to do in Santa Cruz

ATV Adventure

Private Jeep & ATV Tour to Jade Cavern in Cozumel: All-Inclusive

$130
per adult
Private Jeep & ATV Tour to Jade Cavern in Cozumel: All-Inclusive
See all activities in Santa Cruz

Santa Cruz Hotel Deals

InterContinental Presidente Mexico City by IHG

InterContinental Presidente Mexico City by IHG

4 out of 5
Campos Eliseos 218, Mexico City
Fully refundableReserve now, pay when you stay
$265 nightly
The price is $317 total per night from Sep 7 to Sep 8
$317 total
Sep 7 - Sep 8
Total with taxes and fees
9.2/10 Wonderful! (1,887 reviews)
"Excellent. Amazing views"

Reviewed on Aug 21, 2025

InterContinental Presidente Mexico City by IHG
Hyatt Regency Mexico City

Hyatt Regency Mexico City

5 out of 5
Campos Eliseos No. 204 Polanco, Chapultepec, Mexico City
Fully refundableReserve now, pay when you stay
$218 nightly
The price is $261 total per night from Sep 14 to Sep 15
$261 total
Sep 14 - Sep 15
Total with taxes and fees
9.2/10 Wonderful! (1,183 reviews)
"Recommend it!"

Reviewed on Aug 25, 2025

Hyatt Regency Mexico City
Casa Olea

Casa Olea

2 out of 5
C. de Francisco Díaz Covarrubias, 76, Mexico City, CDMX
Fully refundableReserve now, pay when you stay
$59 nightly
The price is $70 total per night from Sep 2 to Sep 3
$70 total
Sep 2 - Sep 3
Total with taxes and fees
Casa Olea
See all 1,817 properties in Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Frequently asked questions

How much does a Santa Cruz vacation package cost?
Offering excellent value package deals from $315 on Expedia, you'll be pleasantly surprised at how much a vacation to Santa Cruz costs! Our packages make travel planning easier and save you more.
What are the cheapest months to go to Santa Cruz?
If you're looking to snag a cheap Santa Cruz vacation package, consider planning a trip in June, October and December. You'll usually find better rates on accommodations and flights during these quieter months — perfect for a budget-friendly getaway.
How many days is enough for Santa Cruz?
With a well-organized travel plan, you can easily tick off the main Santa Cruz sights in a handful of days. But if you'd like to explore off the beaten track or take day trips, consider booking your Santa Cruz vacation for longer.
How to find the best Santa Cruz package deals?
Bagging a cheap Santa Cruz package deal is a breeze with Expedia. Once you've entered your destination and travel dates under our "Packages" tab, set your budget, add some filters and browse what's available. You can personalize your search by "Amenities," "Property type," "Popular locations" and more. Sort the results by "Price: low to high" to discover the most wallet-friendly Santa Cruz package deals. Want a simple trick to score even more savings? Have some flexibility with your departure dates and consider going away on a weekday, when prices are often lower.
Is it cheaper to book a Santa Cruz vacation as a package?
Expedia vacation packages are designed to help you keep more cash in your pocket. Bundle your car rental, hotel and flight into one great-value price and enjoy significant savings. You'll usually land a better deal than booking each component individually. And you'll still enjoy the freedom to create a customized Santa Cruz vacation by choosing your preferred accommodation type, airline and car class.
When to book a vacation package to Santa Cruz?
If you're planning a spontaneous Santa Cruz trip, browse our last-minute deals that can be booked up to a week before you go. Don't want to leave things to the last minute? You can land incredible deals on your flights and hotels by booking ahead.
Does Expedia offer Book Now, Pay Later Santa Cruz vacation packages?
Jet off on your perfect escape to Santa Cruz with our Book Now, Pay Later vacations. There's no need to save up or wait for the next payday — we've partnered with online lender Affirm to give you financial flexibility. Our vacation packages with payment plans let you spread the total cost across 3, 6 or 12 months. With no late payment fees or hidden charges, you can easily stay on budget and snap up bargains before they disappear.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.