Santa Cruz Vacations from $547

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Your Santa Cruz Vacation

Say bye-bye to the worries of planning and hello to a Santa Cruz vacation package. With your travel details organized before you go, you can focus on discovering the best of this city, starting with Tlalnepantla Centro, which is great for bars and pubs, shopping and dining. If taking in the sights is a priority during your trip to Santa Cruz, make sure you find your way to well-known attractions like Xochitla Ecological Park and Temple of San Francisco Javier. Whoever you're taking time off with and whatever the size of your budget, your dream Santa Cruz vacation is just a few clicks away with Expedia.

The Latest Santa Cruz vacation packages

Price found within the past 48 hours. Click for updated prices.
Hotel & Suites PF

Hotel & Suites PF

3.5 out of 5
Reforma
Save 100% on your flight
Price was $1,011, price is now $547 per person
$547
per person
Feb 26 - Mar 5
found 22 hours ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Mexico City (MEX)
8.6/10 Excellent! (2,116 reviews)
Clean room, friendly staff

Reviewed on Dec 8, 2025

Gran Hotel Ciudad de Mexico Zocalo View

Gran Hotel Ciudad de Mexico Zocalo View

4.5 out of 5
Historic Center
Price was $2,341, price is now $1,172 per person
$1,172
per person
Feb 26 - Mar 5
found 22 hours ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Mexico City (MEX)
9.6/10 Exceptional! (1,075 reviews)
We enjoyed our stay. Best service

Reviewed on Dec 8, 2025

Historico Central Hotel

Historico Central Hotel

4 out of 5
Historic Center
Save 100% on your flight
Price was $1,682, price is now $884 per person
$884
per person
Feb 26 - Mar 5
found 22 hours ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Mexico City (MEX)
9.8/10 Exceptional! (2,379 reviews)
The staff where amazing. The room was clean and the amenities where wonderful.

Reviewed on Dec 14, 2025

The Mark Hotel

The Mark Hotel

3 out of 5
Miguel Hidalgo
Save 100% on your flight
Price was $1,191, price is now $653 per person
$653
per person
Feb 26 - Mar 5
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Mexico City (MEX)
8/10 Very Good! (13 reviews)
Great breakfast and beautiful rooms and property

Reviewed on Oct 24, 2025

Canada Central & Rooftop

Canada Central & Rooftop

4 out of 5
Historic Center
Save 100% on your flight
Price was $1,251, price is now $698 per person
$698
per person
Feb 26 - Mar 5
found 22 hours ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Mexico City (MEX)
8.6/10 Excellent! (1,001 reviews)
Room is clean. Staff are very helpful and nice. Food was good and plus providing free food beyond breakfast.

Reviewed on Dec 7, 2025

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Discover the most popular places to visit in Santa Cruz

Xochitla which includes a garden

Xochitla Ecological Park

3/5(2 reviews)

Take part in fun-filled activities suitable for all ages, explore a botanical garden and enjoy picnics on grassy lawns at this large ecological park.

Xochitla Ecological Park
Tula de Allende

National Museum of the Viceroyalty

Marvel at the dazzling exhibitions of well-preserved colonial art on display inside one of Mexico’s finest examples of Baroque architecture.

National Museum of the Viceroyalty

Hacienda La Concepcion

You can take time to visit Hacienda La Concepcion during your travels to Tepotzotlán. Amble around the area's parks or experience its museums.

Hacienda La Concepcion

Santa Cruz Hotel Deals

Hyatt Regency Mexico City

Hyatt Regency Mexico City

5 out of 5
Campos Eliseos No. 204 Polanco Mexico City
Fully refundableReserve now, pay when you stay
$234 nightly
The price is $279 total per night from Jan 1 to Jan 2
$279 total
Jan 1 - Jan 2, 2026
Total with taxes and fees
9.4/10 Exceptional! (1,327 reviews)
Everything was perfect

Reviewed on Dec 14, 2025

Hyatt Regency Mexico City
InterContinental Presidente Mexico City by IHG

InterContinental Presidente Mexico City by IHG

4 out of 5
Campos Eliseos 218 Mexico City
Fully refundableReserve now, pay when you stay
$247 nightly
The price is $295 total per night from Jan 9 to Jan 10
$295 total
Jan 9 - Jan 10, 2026
Total with taxes and fees
9.2/10 Wonderful! (2,087 reviews)
Great location!! The staff is excelente!!

Reviewed on Dec 1, 2025

InterContinental Presidente Mexico City by IHG
Downtown Treasure Place

Downtown Treasure Place

2.5 out of 5
85 Marte Guerrero Mexico City CDMX
Fully refundableReserve now, pay when you stay
$44 nightly
The price is $53 total per night from Dec 16 to Dec 17
$53 total
Dec 16 - Dec 17
Total with taxes and fees
8.6/10 Excellent! (730 reviews)
The staff was very kind, easy access, very good place to stay…

Reviewed on Nov 8, 2025

Downtown Treasure Place
See all 1,853 properties in Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Santa Cruz Vacation Packages

Santa Cruz Essential Information

Language
Spanish
Currency
Mexican pesos
Local Welcome
¡Hola!
Local Goodbye
Adiós
Closest Airport
Mexico City Intl. Airport (MEX)
Population
2,000
Top Sights
Xochitla Ecological Park and Temple of San Francisco Javier

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Frequently asked questions

How much does a Santa Cruz vacation package cost?
Offering excellent value package deals from $547 on Expedia, you'll be pleasantly surprised at how much a vacation to Santa Cruz costs! Our packages make travel planning easier and save you more.
What are the cheapest months to go to Santa Cruz?
If you're looking to snag a cheap Santa Cruz vacation package, consider planning a trip in June, October and December. You'll usually find better rates on accommodations and flights during these quieter months — perfect for a budget-friendly getaway.
How many days is enough for Santa Cruz?
With a well-organized travel plan, you can easily tick off the main Santa Cruz sights in a handful of days. But if you'd like to explore off the beaten track or take day trips, consider booking your Santa Cruz vacation for longer.
How to find the best Santa Cruz package deals?
Bagging a cheap Santa Cruz package deal is a breeze with Expedia. Once you've entered your destination and travel dates under our "Packages" tab, set your budget, add some filters and browse what's available. You can personalize your search by "Amenities," "Property type," "Popular locations" and more. Sort the results by "Price: low to high" to discover the most wallet-friendly Santa Cruz package deals. Want a simple trick to score even more savings? Have some flexibility with your departure dates and consider going away on a weekday, when prices are often lower.
Is it cheaper to book a Santa Cruz vacation as a package?
Expedia vacation packages are designed to help you keep more cash in your pocket. Bundle your car rental, hotel and flight into one great-value price and enjoy significant savings. You'll usually land a better deal than booking each component individually. And you'll still enjoy the freedom to create a customized Santa Cruz vacation by choosing your preferred accommodation type, airline and car class.
When to book a vacation package to Santa Cruz?
If you're planning a spontaneous Santa Cruz trip, browse our last-minute deals that can be booked up to a week before you go. Don't want to leave things to the last minute? You can land incredible deals on your flights and hotels by booking ahead.
Does Expedia offer Book Now, Pay Later Santa Cruz vacation packages?
Jet off on your perfect escape to Santa Cruz with our Book Now, Pay Later vacations. There's no need to save up or wait for the next payday — we've partnered with online lender Affirm to give you financial flexibility. Our vacation packages with payment plans let you spread the total cost across 3, 6 or 12 months. With no late payment fees or hidden charges, you can easily stay on budget and snap up bargains before they disappear.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.