Santa Cruz Vacations from $761
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The Latest Santa Cruz vacation packages
Price found within the past 48 hours. Click for updated prices.
Radisson Riviera Panama
$761
per person
Nov 23 - Nov 26
found 1 day ago
Roundtrip flight included
Miami (MIA) to Panama City (PTY)
8.8/10 Excellent! (193 reviews)
Excelente propiedad, muy limpia y hermosamente decorada. Podías salir de tu habitación directo a la playa! Todo muy cómodo y accesible para todas las edades. Volveré de nuevo.
Reviewed on Oct 16, 2026
Megapolis Hotel Panamá
San Francisco
$1,102
per person
Dec 4 - Dec 8
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
8.6/10 Excellent! (1,764 reviews)
I had to ask for clean towels and washcloths every night if my stay. The room and elevators had a very stale smell (almost like urine). The staff at checkout were horrible and unfriendly. They did not even ask about my stay.
Reviewed on Oct 18, 2026
Central Hotel Panama Casco Viejo
Casco Viejo
$1,252
per person
Dec 4 - Dec 8
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9/10 Wonderful! (1,006 reviews)
Excelente ubicación, buen trato, buenos restaurantes, buen servicio.
Reviewed on Oct 18, 2026
Santa Cruz Hotel Deals
Bocas del Mar Hotel
Road to Boca Chica Boca Chica Chiriqui
$198 nightly
$220 total
Nov 18 - Nov 19
Total with taxes and fees
9.6/10 Exceptional! (239 reviews)
"Some of the staff at the restaurant were not very happy and at times I felt like they did not want to be there . Maria was amazing kind and always smiling 😍"
Reviewed on Sep 24, 2026
Seagull Cove Resort
Calle Principal Boca Chica Chiriqui
$140 nightly
$153 total
Oct 22 - Oct 23
Total with taxes and fees
Show Pony Ranchero Resort - Boutique Beach Hotel
Jobo Las Lajas Chiriqui
$94 nightly
$103 total
Nov 17 - Nov 18
Total with taxes and fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find the Best Santa Cruz Vacation Packages
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Frequently asked questions
How to find the best Santa Cruz package deals?
Use Expedia's filter tool to find some terrific Santa Cruz package deals. When you begin your search, simply set your maximum budget and then sort the results by "Price: low to high." If you're looking to save, plan your escape for midweek, or search for Santa Cruz package deals in the off-season. Switch up your travel dates and you may score even bigger discounts. As a rule of thumb, it's usually best to lock in your vacation package as soon as possible.
When to book a vacation package to Santa Cruz?
Score incredible bargains by booking your flights early with Expedia. If spontaneity is more your thing, take advantage of our last-minute deals for an impromptu Santa Cruz vacation.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
