Santa Isabel Vacations from $382

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Your Santa Isabel Vacation

Our vacation packages to Santa Isabel give you endless opportunities to immerse yourself in new sights, sounds and sensations. And with all the details taken care of, you'll be free to enjoy your city adventure to the fullest. Make your trip to Santa Isabel even more fun and exciting by including some sightseeing. Plaza Comercial La Cachanilla, City Forest and Zoo and Juventud 2000 Sport Center are among the big attractions worth exploring. A few quick clicks is all it takes to put together the perfect Santa Isabel vacation on Expedia.

The Latest Santa Isabel vacation packages

Price found within the past 48 hours. Click for updated prices.
California Comfort and Suites

California Comfort and Suites

3 out of 5
Price was $402, price is now $382 per person
$382
per person
Nov 13 - Nov 16
found 1 day ago
Roundtrip flight included
Dallas (DFW) to Mexicali (MXL)
8.6/10 Excellent! (1,002 reviews)
I did. See one cockroach at the facility but overall clean and staff very friendly. The coffee shop and restaurant on the property are very good

Reviewed on Sep 2, 2025

Hotel Araiza Mexicali

Hotel Araiza Mexicali

4 out of 5
Price was $534, price is now $459 per person
$459
per person
Nov 13 - Nov 16
found 1 day ago
Roundtrip flight included
Dallas (DFW) to Mexicali (MXL)
8.6/10 Excellent! (1,545 reviews)
It is safely and have easy access to restaurants and bars around. It is a family place. Clean rooms. It is located on one of the main boulevards.

Reviewed on Sep 3, 2025

Hotel Lucerna Mexicali

Hotel Lucerna Mexicali

4 out of 5
Price was $510, price is now $453 per person
$453
per person
Nov 13 - Nov 16
found 1 day ago
Roundtrip flight included
Dallas (DFW) to Mexicali (MXL)
9.2/10 Wonderful! (1,327 reviews)
I like everything about this place and all the staff is welcoming I feel safe, it’s very clean and I love their pool, also the restaurant and the piano bar

Reviewed on Aug 30, 2025

Don't see what you're looking for?
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Discover the most popular places to visit in Santa Isabel

Mexicali Border Port I

After visiting Mexicali Border Port I, make a plan to see the other sights and activities in Mexicali. While in this family-friendly area, you can savor the top-notch restaurants.

Mexicali Border Port I

Eagles Nest Stadium

4.5/5(9 reviews)

Catch an event at Eagles Nest Stadium during your trip to Mexicali. While you're here, you can savor the top-notch restaurants.

Eagles Nest Stadium

Plaza La Gran Via

4.5/5(14 reviews)

You can enjoy retail therapy at Plaza La Gran Via during your trip to Mexicali. While in this family-friendly area, you can savor the top-notch restaurants.

Plaza La Gran Via

Santa Isabel Hotel Deals

Hotel Lucerna Mexicali

Hotel Lucerna Mexicali

4 out of 5
Boulevard Benito Juarez 2151, Mexicali, BC
Fully refundableReserve now, pay when you stay
$100 nightly
The price is $113 total per night from Sep 21 to Sep 22
$113 total
Sep 21 - Sep 22
Total with taxes and fees
Hotel Lucerna Mexicali
Hotel Araiza Mexicali

Hotel Araiza Mexicali

4 out of 5
Blvd. Benito Juarez 2220, Fracc Jardines Del Valle, Mexicali, BC
Fully refundable
$106 nightly
The price is $119 total per night from Sep 18 to Sep 19
$119 total
Sep 18 - Sep 19
Total with taxes and fees
Hotel Araiza Mexicali
Real Inn Mexicali

Real Inn Mexicali

4 out of 5
Avenida de Los Heroes 201, Centro Civico, Mexicali, BC
Fully refundableReserve now, pay when you stay
$70 nightly
The price is $80 total per night from Sep 21 to Sep 22
$80 total
Sep 21 - Sep 22
Total with taxes and fees
Real Inn Mexicali
See all 71 properties in Santa Isabel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Frequently asked questions

How much does a Santa Isabel vacation package cost?
You'll find cheap prices from $382 on Expedia for your Santa Isabel getaway. However, factors like the season, length of stay and your choice of hotel will influence how much your vacation to Santa Isabel costs.
What are the cheapest months to go to Santa Isabel?
If you're hoping to snag a cheap Santa Isabel vacation package, consider visiting in January, June and December. You'll usually find lower rates on accommodations and flights during these quieter months — perfect for a budget-friendly break.
How many days is enough for Santa Isabel?
Generally, a handful of days is enough to see the main sights during your Santa Isabel vacation. However, if you prefer to have some time to relax or go on day trips, think about extending your itinerary.
How to find the best Santa Isabel package deals?
Start your search for a Santa Isabel package deal by entering your preferred travel dates and destination under our "Packages" tab. Then apply a few filters, like "Guest rating" and "Property type," to tailor the results to your exact needs. You can also sort by "Package discount" and discover offers that come with irresistible savings. If you don't find the perfect Santa Isabel package deal straight away, simply tweak your dates and search again. Bear in mind that deals are only available for a limited time, so book early and get your Santa Isabel escape underway.
Is it cheaper to book a Santa Isabel vacation as a package?
Expedia vacation packages are designed to make your money go further. Bundle your flight, car rental and hotel into one great-value price and you could save hundreds of dollars. You'll generally land a better deal than booking each component individually. And you'll still have the flexibility to create a personalized Santa Isabel vacation by choosing your favorite accommodation type, airline and car class.
When to book a vacation package to Santa Isabel?
If you have your Santa Isabel vacation dates confirmed, book as soon as you can to grab some incredible deals. With Expedia, you can generally reserve some flights up to a year in advance. Prefer spontaneous adventures? Our last-minute deals are perfect for traveling on a whim.
Does Expedia offer Book Now, Pay Later Santa Isabel vacation packages?
Your Santa Isabel trip is meant to be a relaxing escape from your busy life, not a source of money worries. So to allow you extra flexibility, we've joined up with online lender Affirm to bring you our Book Now, Pay Later vacations. Choose one of our vacation packages with payment plans and split up the total cost over 3, 6 or 12 months. Plus, there aren't any late payment fees or hidden costs to worry about.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.