Santa Isabel Vacations from $629

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Your Santa Isabel Vacation

Our vacation packages to Santa Isabel give you endless opportunities to immerse yourself in new sights, sounds and sensations. And with all the details taken care of, you'll be free to enjoy your city adventure to the fullest. Make your trip to Santa Isabel even more fun and exciting by including some sightseeing. Plaza Comercial La Cachanilla, City Forest and Zoo and Juventud 2000 Sport Center are among the big attractions worth exploring. A few quick clicks is all it takes to put together the perfect Santa Isabel vacation on Expedia.

The Latest Santa Isabel vacation packages

Price found within the past 48 hours. Click for updated prices.
Hotel Siesta Real

Hotel Siesta Real

$629
per person
Oct 15 - Oct 19
found 5 hours ago
Roundtrip non-stop flight included
Denver (DEN) to Mexicali (MXL)
8.4/10 Very Good! (1,003 reviews)
Hotel Colonial Mexicali

Hotel Colonial Mexicali

Civic Center
$670
per person
Oct 15 - Oct 19
found 5 hours ago
Roundtrip non-stop flight included
Denver (DEN) to Mexicali (MXL)
8/10 Very Good! (1,002 reviews)
Hotel El Cortez by TFE Travel

Hotel El Cortez by TFE Travel

$734
per person
Oct 15 - Oct 19
found 1 day ago
Roundtrip non-stop flight included
Denver (DEN) to Mexicali (MXL)
8/10 Very Good! (102 reviews)
Great

Reviewed on Aug 11, 2026

Hotel Lucerna Mexicali

Hotel Lucerna Mexicali

$709
per person
Oct 15 - Oct 19
found 13 hours ago
Roundtrip non-stop flight included
Denver (DEN) to Mexicali (MXL)
9.2/10 Wonderful! (1,739 reviews)
Fiesta Inn Mexicali

Fiesta Inn Mexicali

Civic Center
$639
per person
Oct 15 - Oct 19
found 5 hours ago
Roundtrip non-stop flight included
Denver (DEN) to Mexicali (MXL)
8.6/10 Excellent! (1,008 reviews)
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Santa Isabel Hotel Deals

Hotel Araiza Mexicali

Hotel Araiza Mexicali

Blvd. Benito Juarez 2220 Mexicali BC
Fully refundableReserve now, pay when you stay
$100 nightly
$115 total
Aug 31 - Sep 1
Total with taxes and fees
Hotel Araiza Mexicali
Hotel Lucerna Mexicali

Hotel Lucerna Mexicali

Boulevard Benito Juarez 2151 Mexicali BC
Fully refundableReserve now, pay when you stay
$115 nightly
$130 total
Sep 6 - Sep 7
Total with taxes and fees
Hotel Lucerna Mexicali
Calafia Hotel

Calafia Hotel

1495 Justo Sierra, Fracc. Los Pinos Mexicali BC
$75 nightly
$85 total
Aug 19 - Aug 20
Total with taxes and fees
Calafia Hotel
See all 73 properties in Santa Isabel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Santa Isabel Vacation Packages

Santa Isabel Essential Information

Language
Spanish
Currency
Mexican pesos
Local Welcome
¡Hola!
Local Goodbye
Adiós
Closest Airport
General Rodolfo Sanchez Taboada Intl. Airport (MXL)
Population
29,300
Top Sights
City Forest and Zoo, Sol Childrens Museum and Aguilas de Mexicali Stadium

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Frequently asked questions

How much does a Santa Isabel vacation package cost?
You'll find cheap prices from $629 on Expedia for your Santa Isabel getaway. However, factors like the season, length of stay and your choice of hotel will influence how much your vacation to Santa Isabel costs.
What are the cheapest months to go to Santa Isabel?
If you're hoping to snag a cheap Santa Isabel vacation package, consider visiting in January, June and December. You'll usually find lower rates on accommodations and flights during these quieter months — perfect for a budget-friendly break.
How many days is enough for Santa Isabel?
Generally, a handful of days is enough to see the main sights during your Santa Isabel vacation. However, if you prefer to have some time to relax or go on day trips, think about extending your itinerary.
How to find the best Santa Isabel package deals?
Start your search for a Santa Isabel package deal by entering your preferred travel dates and destination under our "Packages" tab. Then apply a few filters, like "Guest rating" and "Property type," to tailor the results to your exact needs. You can also sort by "Package discount" and discover offers that come with irresistible savings. If you don't find the perfect Santa Isabel package deal straight away, simply tweak your dates and search again. Bear in mind that deals are only available for a limited time, so book early and get your Santa Isabel escape underway.
Is it cheaper to book a Santa Isabel vacation as a package?
Expedia vacation packages are designed to make your money go further. Bundle your flight, car rental and hotel into one great-value price and you could save hundreds of dollars. You'll generally land a better deal than booking each component individually. And you'll still have the flexibility to create a personalized Santa Isabel vacation by choosing your favorite accommodation type, airline and car class.
When to book a vacation package to Santa Isabel?
If you have your Santa Isabel vacation dates confirmed, book as soon as you can to grab some incredible deals. With Expedia, you can generally reserve some flights up to a year in advance. Prefer spontaneous adventures? Our last-minute deals are perfect for traveling on a whim.
Does Expedia offer Book Now, Pay Later Santa Isabel vacation packages?
Your Santa Isabel trip is meant to be a relaxing escape from your busy life, not a source of money worries. So to allow you extra flexibility, we've joined up with online lender Affirm to bring you our Book Now, Pay Later vacations. Choose one of our vacation packages with payment plans and split up the total cost over 3, 6 or 12 months. Plus, there aren't any late payment fees or hidden costs to worry about.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.