Santa Isabel Vacations from $407

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Your Santa Isabel Vacation

Our vacation packages to Santa Isabel give you endless opportunities to immerse yourself in new sights, sounds and sensations. And with all the details taken care of, you'll be free to enjoy your city adventure to the fullest. Make your trip to Santa Isabel even more fun and exciting by including some sightseeing. Plaza Comercial La Cachanilla, City Forest and Zoo and Juventud 2000 Sport Center are among the big attractions worth exploring. A few quick clicks is all it takes to put together the perfect Santa Isabel vacation on Expedia.

The Latest Santa Isabel vacation packages

Price found within the past 48 hours. Click for updated prices.
Hotel Lucerna Mexicali

Hotel Lucerna Mexicali

4 out of 5
per person
Sep 26 - Sep 29
found 1 day ago
Roundtrip flight included
Dallas (DFW) to Mexicali (MXL)
9.2/10 Wonderful! (1,258 reviews)
Check in only had 1 person working the counter

Reviewed on Jul 6, 2025

Hotel Araiza Mexicali

Hotel Araiza Mexicali

4 out of 5
per person
Sep 26 - Sep 29
found 1 day ago
Roundtrip flight included
Dallas (DFW) to Mexicali (MXL)
8.6/10 Excellent! (1,473 reviews)
Very convenient to go anywhere and shopping centers walk by, super clean and safe

Reviewed on Jul 14, 2025

Extended Suites Mexicali Cataviña

Extended Suites Mexicali Cataviña

3 out of 5
per person
Aug 28 - Sep 1
found 13 hours ago
Roundtrip non-stop flight included
Orlando (MCO) to Mexicali (MXL)
8/10 Very Good! (2,011 reviews)
Estuvo muy bien para un viaje rapido

Reviewed on Jul 14, 2025

Hotel El Cortez by TFE Travel

Hotel El Cortez by TFE Travel

3 out of 5
per person
Aug 28 - Sep 1
found 13 hours ago
Roundtrip non-stop flight included
Orlando (MCO) to Mexicali (MXL)
7.8/10 Good! (65 reviews)
The hotel is right on the beach, so it doesn’t get much better than that. Rooms could use updating but the AC works great, which is most important. The guy at the front desk hates his job.

Reviewed on Jun 18, 2025

Hotel Mision Santa Maria

Hotel Mision Santa Maria

2.5 out of 5
per person
Aug 28 - Sep 1
found 13 hours ago
Roundtrip non-stop flight included
Orlando (MCO) to Mexicali (MXL)
9.2/10 Wonderful! (492 reviews)
Tesla Level 2 free charging at the hotel made this trip possible for us!!!

Reviewed on Jul 11, 2025

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Discover the most popular places to visit in Santa Isabel

Mexicali Border Port I

After visiting Mexicali Border Port I, make a plan to see the other sights and activities in Mexicali. While in this family-friendly area, you can savor the top-notch restaurants.

Mexicali Border Port I

Eagles Nest Stadium

4.5/5(9 reviews)

Catch an event at Eagles Nest Stadium during your trip to Mexicali. While you're here, you can savor the top-notch restaurants.

Eagles Nest Stadium

Plaza La Gran Via

4.5/5(14 reviews)

You can enjoy retail therapy at Plaza La Gran Via during your trip to Mexicali. While in this family-friendly area, you can savor the top-notch restaurants.

Plaza La Gran Via

Santa Isabel Hotel Deals

Hotel Araiza Mexicali
Hotel Araiza Mexicali
4 out of 5
Blvd. Benito Juarez 2220, Fracc Jardines Del Valle, Mexicali, BC
Fully refundable
$102 nightly
The price is $115 total per night from Jul 30 to Jul 31
$115 total
Jul 30 - Jul 31
Total includes taxes and fees
8.4/10 Very Good! (1,480 reviews)
"Nos toco cuartos renovados muy limpios el staff muy amable"

Reviewed on Jul 11, 2025

Hotel Araiza Mexicali
Real Inn Mexicali
Real Inn Mexicali
4 out of 5
Avenida de Los Heroes 201, Centro Civico, Mexicali, BC
Fully refundableReserve now, pay when you stay
$78 nightly
The price is $88 total per night from Jul 20 to Jul 21
$88 total
Jul 20 - Jul 21
Total includes taxes and fees
8/10 Very Good! (1,404 reviews)
"I like it …the room is spacious"

Reviewed on Jul 14, 2025

Real Inn Mexicali
Hotel Lucerna Mexicali
Hotel Lucerna Mexicali
4 out of 5
Boulevard Benito Juarez 2151, Mexicali, BC
Fully refundableReserve now, pay when you stay
$87 nightly
The price is $98 total per night from Jul 20 to Jul 21
$98 total
Jul 20 - Jul 21
Total includes taxes and fees
9/10 Wonderful! (1,264 reviews)
"N/A"

Reviewed on Jul 8, 2025

Hotel Lucerna Mexicali
See all 72 properties in Santa Isabel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Santa Isabel Vacation Packages

Santa Isabel Essential Information

Language
Spanish
Currency
Mexican pesos
Local Welcome
¡Hola!
Local Goodbye
Adiós
Closest Airport
General Rodolfo Sanchez Taboada Intl. Airport (MXL)
Population
29,300
Top Sights
City Forest and Zoo, Sol Childrens Museum and Aguilas de Mexicali Stadium

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Frequently asked questions

How much does a Santa Isabel vacation package cost?
You'll find cheap prices from $407 on Expedia for your Santa Isabel getaway. However, factors like the season, length of stay and your choice of hotel will influence how much your vacation to Santa Isabel costs.
What are the cheapest months to go to Santa Isabel?
If you're hoping to snag a cheap Santa Isabel vacation package, consider visiting in January, June and December. You'll usually find lower rates on accommodations and flights during these quieter months --- perfect for a budget-friendly break.
How many days is enough for Santa Isabel?
Generally, a handful of days is enough to see the main sights during your Santa Isabel vacation. However, if you prefer to have some time to relax or go on day trips, think about extending your itinerary.
How to find the best Santa Isabel package deals?
Start your search for a Santa Isabel package deal by entering your preferred travel dates and destination under our "Packages" tab. Then apply a few filters, like "Guest rating" and "Property type," to tailor the results to your exact needs. You can also sort by "Package discount" and discover offers that come with irresistible savings. If you don't find the perfect Santa Isabel package deal straight away, simply tweak your dates and search again. Bear in mind that deals are only available for a limited time, so book early and get your Santa Isabel escape underway.
Is it cheaper to book a Santa Isabel vacation as a package?
Expedia vacation packages are designed to make your money go further. Bundle your flight, car rental and hotel into one great-value price and you could save hundreds of dollars. You'll generally land a better deal than booking each component individually. And you'll still have the flexibility to create a personalized Santa Isabel vacation by choosing your favorite accommodation type, airline and car class.
When to book a vacation package to Santa Isabel?
If you have your Santa Isabel vacation dates confirmed, book as soon as you can to grab some incredible deals. With Expedia, you can generally reserve some flights up to a year in advance. Prefer spontaneous adventures? Our last-minute deals are perfect for traveling on a whim.
Does Expedia offer Book Now, Pay Later Santa Isabel vacation packages?
Your Santa Isabel trip is meant to be a relaxing escape from your busy life, not a source of money worries. So to allow you extra flexibility, we've joined up with online lender Affirm to bring you our Book Now, Pay Later vacations. Choose one of our vacation packages with payment plans and split up the total cost over 3, 6 or 12 months. Plus, there aren't any late payment fees or hidden costs to worry about.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.