Santa María Vacations

Book a Hotel + Flight or Car together to unlock savings

Santa María Hotel Deals

Hotel Saint George

Hotel Saint George

4 out of 5
Avenida Cordoba 148, Puerto Iguazú, Misiones
Fully refundableReserve now, pay when you stay
$88 nightly
The price is $88 total per night from Sep 7 to Sep 8
$88 total
Sep 7 - Sep 8
8.6/10 Excellent! (1,000 reviews)
Modern and clean
"Good location and hotel is well maintained, modern and clean. Pool is lovely and there is a nice pool bar too. Breakfast is average. Unfortunately unable to review about the spa as there was no staff present and they proceeded to put the phone down on me when attempting to book on 2 occasions."

Reviewed on Aug 22, 2025

Hotel Saint George
Gran Melia Iguazú

Gran Melia Iguazú

5 out of 5
Parque Nacional Iguazu, Puerto Iguazú, Misiones
Fully refundableReserve now, pay when you stay
$580 nightly
The price is $580 total per night from Sep 1 to Sep 2
$580 total
Sep 1 - Sep 2
Gran Melia Iguazú
Mercure Iguazu Hotel Iru

Mercure Iguazu Hotel Iru

4.5 out of 5
Selva Iryapu S N - Predio 600 Has, Puerto Iguazú, Misiones
Fully refundableReserve now, pay when you stay
$156 nightly
The price is $156 total per night from Sep 4 to Sep 5
$156 total
Sep 4 - Sep 5
9/10 Wonderful! (509 reviews)
"Top-shelf room and property that exudes class but be warned - the hotel is not within walking distance of downtown except in dire need. Going anywhere will necessitate hiring a driver. Pool and jacuzzi were cold and unusable during my stay."

Reviewed on Jul 12, 2025

Mercure Iguazu Hotel Iru
See all 375 properties in Misiones Province
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Frequently asked questions

How much does a Santa María vacation package cost?
You'll find cheap prices on Expedia for your Santa María break. However, factors like your choice of hotel, the season and length of stay will determine how much your vacation to Santa María costs.
What are the cheapest months to go to Santa María?
You're likely to find lower prices and better availability in December, January and February. Browse our cheap Santa María vacation packages and you could get some great off-season deals.
How many days is enough for Santa María?
With a well-organized itinerary, you can easily tick off the main Santa María sights in a handful of days. But if you'd like to explore off the beaten track or go on day tours, consider booking your Santa María vacation for longer.
How to find the best Santa María package deals?
Landing a cheap Santa María package deal is easy with Expedia. Once you've entered your destination and trip dates under our "Packages" tab, set your budget range, apply some filters and browse what's available. You can tweak your search by "Amenities," "Property type," "Guest rating" and more. Order the results by "Price: low to high" to discover the most pocket-friendly Santa María package deals. Want a simple trick to score the biggest savings? Be flexible with your departure dates and consider going away on a weekday, when prices are often lower.
Is it cheaper to book a Santa María vacation as a package?
Expedia vacation packages are designed to give you more bang for your buck. Bundle your flight, hotel and car rental into one great-value price and you could save hundreds of dollars. You'll generally snag a better deal than booking each component separately. And you'll still have the freedom to create a tailored Santa María vacation by choosing your favorite airline, accommodation type and car class.
When to book a vacation package to Santa María?
If you have your Santa María vacation dates confirmed, book as early as you can to grab some unbeatable deals. With Expedia, you can generally reserve some flights up to one year in advance. Prefer spur-of-the-moment trips? Our last-minute deals are perfect for jetting off on a whim.
Does Expedia offer Book Now, Pay Later Santa María vacation packages?
Set off on your perfect escape to Santa María with Expedia's Book Now, Pay Later vacations. There's no need to save like crazy or wait until your next paycheck — we've joined forces with online lender Affirm to give you flexibility with your finances. Our vacation packages with payment plans let you spread the total cost over 3, 6 or 12 months. With no hidden charges or late payment fees, it's easy to budget for your trip and snap up bargains before they sell out.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.