Santa María Vacations

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $2,000 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Plan, book, and manage your trip all in one place

Santa María Hotel Deals

Gran Melia Iguazú

Gran Melia Iguazú

5 out of 5
Parque Nacional Iguazu Puerto Iguazú Misiones
Fully refundableReserve now, pay when you stay
$595 nightly
The price is $603 total per night from May 30 to May 31
$603 total
May 30 - May 31
9.4/10 Exceptional! (1,002 reviews)
The whole experience was perfect. The first things you see when entering the hotel are the waterfalls - such an amazing view. The staff was truly lovely as well. Being able to get up in the morning to be the first in the park was such a pleasure. Highly recommend this hotel.

Reviewed on May 10, 2026

Gran Melia Iguazú
Hotel Saint George

Hotel Saint George

4 out of 5
Avenida Cordoba 148 Puerto Iguazú Misiones
$102 nightly
The price is $109 total per night from Jun 1 to Jun 2
$109 total
Jun 1 - Jun 2
9/10 Wonderful! (1,013 reviews)
Todo muy bien

Reviewed on May 12, 2026

Hotel Saint George
Loi Suites Iguazú Hotel

Loi Suites Iguazú Hotel

5 out of 5
Selva Iriapu Sin Numero Puerto Iguazú Misiones
Fully refundableReserve now, pay when you stay
$335 nightly
The price is $344 total per night from May 31 to Jun 1
$344 total
May 31 - Jun 1
9.2/10 Wonderful! (1,000 reviews)
Breakfast was very good, the staff was excellent, I would stay again.

Reviewed on May 1, 2026

Loi Suites Iguazú Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Santa María Vacation Packages

Santa Marían Essential Information

Language
Spanish
Currency
Argentine pesos
Local Welcome
¡Hola!
Local Goodbye
Adiós
Population
1,700

More vacations you might like

Frequently asked questions

How much does a Santa María vacation package cost?
You'll find cheap prices on Expedia for your Santa María break. However, factors like your choice of hotel, the season and length of stay will determine how much your vacation to Santa María costs.
What are the cheapest months to go to Santa María?
You're likely to find lower prices and better availability in December, January and February. Browse our cheap Santa María vacation packages and you could get some great off-season deals.
How many days is enough for Santa María?
With a well-organized itinerary, you can easily tick off the main Santa María sights in a handful of days. But if you'd like to explore off the beaten track or go on day tours, consider booking your Santa María vacation for longer.
How to find the best Santa María package deals?
Landing a cheap Santa María package deal is easy with Expedia. Once you've entered your destination and trip dates under our "Packages" tab, set your budget range, apply some filters and browse what's available. You can tweak your search by "Amenities," "Property type," "Guest rating" and more. Order the results by "Price: low to high" to discover the most pocket-friendly Santa María package deals. Want a simple trick to score the biggest savings? Be flexible with your departure dates and consider going away on a weekday, when prices are often lower.
Is it cheaper to book a Santa María vacation as a package?
Expedia vacation packages are designed to give you more bang for your buck. Bundle your flight, hotel and car rental into one great-value price and you could save hundreds of dollars. You'll generally snag a better deal than booking each component separately. And you'll still have the freedom to create a tailored Santa María vacation by choosing your favorite airline, accommodation type and car class.
When to book a vacation package to Santa María?
If you have your Santa María vacation dates confirmed, book as early as you can to grab some unbeatable deals. With Expedia, you can generally reserve some flights up to one year in advance. Prefer spur-of-the-moment trips? Our last-minute deals are perfect for jetting off on a whim.
Does Expedia offer Book Now, Pay Later Santa María vacation packages?
Set off on your perfect escape to Santa María with Expedia's Book Now, Pay Later vacations. There's no need to save like crazy or wait until your next paycheck — we've joined forces with online lender Affirm to give you flexibility with your finances. Our vacation packages with payment plans let you spread the total cost over 3, 6 or 12 months. With no hidden charges or late payment fees, it's easy to budget for your trip and snap up bargains before they sell out.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.