Santa María Vacations from $481

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The Latest Santa María vacation packages

Price found within the past 48 hours. Click for updated prices.
El Gran Gomero

El Gran Gomero

2 out of 5
Price was $488, price is now $481 per person
$481
per person
Mar 18 - Mar 22
found 1 day ago
Roundtrip non-stop flight included
São Paulo (GRU) to Posadas (PSS)
No reviews
Howard Johnson Plaza La Ribera

Howard Johnson Plaza La Ribera

3.5 out of 5
Price was $627, price is now $568 per person
$568
per person
Mar 18 - Mar 22
found 1 day ago
Roundtrip non-stop flight included
São Paulo (GRU) to Posadas (PSS)
9.2/10 Wonderful! (112 reviews)
The staff were exceptional. Jessica was extremely kind, and always had ice prepared for us after noticing that we had requested it twice. She was such a kind face at the front of the hotel and made our experience wonderful

Reviewed on Feb 3, 2026

ALWA Suites

ALWA Suites

3 out of 5
Price was $510, price is now $486 per person
$486
per person
Mar 18 - Mar 22
found 1 day ago
Roundtrip non-stop flight included
São Paulo (GRU) to Posadas (PSS)
6.8/10 (16 reviews)
Niyat Urban Hotel

Niyat Urban Hotel

2.5 out of 5
Price was $522, price is now $522 per person
$522
per person
Mar 18 - Mar 22
found 1 day ago
Roundtrip non-stop flight included
São Paulo (GRU) to Posadas (PSS)
7.2/10 Good! (10 reviews)
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Santa María Hotel Deals

Gran Melia Iguazú

Gran Melia Iguazú

5 out of 5
Parque Nacional Iguazu Puerto Iguazú Misiones
Fully refundableReserve now, pay when you stay
$964 nightly
The price is $970 total per night from Feb 27 to Feb 28
$970 total
Feb 27 - Feb 28
9.2/10 Wonderful! (1,003 reviews)
This is an excellent hotel inside the national park. The staff is very friendly and provide top tier service. They also upgraded our room to water fall view room which has a stunning view of the fall. The experience is superior!

Reviewed on Jan 25, 2026

Gran Melia Iguazú
Hotel Saint George

Hotel Saint George

4 out of 5
Avenida Cordoba 148 Puerto Iguazú Misiones
Fully refundableReserve now, pay when you stay
$121 nightly
The price is $125 total per night from Feb 5 to Feb 6
$125 total
Feb 5 - Feb 6
8.8/10 Excellent! (1,002 reviews)
The romm was great. Spacious, clean and beautifully appointed

Reviewed on Jan 28, 2026

Hotel Saint George
Mercure Iguazu Hotel Iru

Mercure Iguazu Hotel Iru

4.5 out of 5
Selva Iryapu S N - Predio 600 Has Puerto Iguazú Misiones
$159 nightly
The price is $163 total per night from Mar 1 to Mar 2
$163 total
Mar 1 - Mar 2
9/10 Wonderful! (573 reviews)
Staff was great, hotel was wonderful and food was very good

Reviewed on Jan 27, 2026

Mercure Iguazu Hotel Iru
See all 372 properties in Misiones Province
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Santa María Vacation Packages

Santa Marían Essential Information

Language
Spanish
Currency
Argentine pesos
Local Welcome
¡Hola!
Local Goodbye
Adiós
Population
1,700

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Frequently asked questions

How much does a Santa María vacation package cost?
You'll find cheap prices from $481 on Expedia for your Santa María break. However, factors like your choice of hotel, the season and length of stay will determine how much your vacation to Santa María costs.
What are the cheapest months to go to Santa María?
You're likely to find lower prices and better availability in December, January and February. Browse our cheap Santa María vacation packages and you could get some great off-season deals.
How many days is enough for Santa María?
With a well-organized itinerary, you can easily tick off the main Santa María sights in a handful of days. But if you'd like to explore off the beaten track or go on day tours, consider booking your Santa María vacation for longer.
How to find the best Santa María package deals?
Landing a cheap Santa María package deal is easy with Expedia. Once you've entered your destination and trip dates under our "Packages" tab, set your budget range, apply some filters and browse what's available. You can tweak your search by "Amenities," "Property type," "Guest rating" and more. Order the results by "Price: low to high" to discover the most pocket-friendly Santa María package deals. Want a simple trick to score the biggest savings? Be flexible with your departure dates and consider going away on a weekday, when prices are often lower.
Is it cheaper to book a Santa María vacation as a package?
Expedia vacation packages are designed to give you more bang for your buck. Bundle your flight, hotel and car rental into one great-value price and you could save hundreds of dollars. You'll generally snag a better deal than booking each component separately. And you'll still have the freedom to create a tailored Santa María vacation by choosing your favorite airline, accommodation type and car class.
When to book a vacation package to Santa María?
If you have your Santa María vacation dates confirmed, book as early as you can to grab some unbeatable deals. With Expedia, you can generally reserve some flights up to one year in advance. Prefer spur-of-the-moment trips? Our last-minute deals are perfect for jetting off on a whim.
Does Expedia offer Book Now, Pay Later Santa María vacation packages?
Set off on your perfect escape to Santa María with Expedia's Book Now, Pay Later vacations. There's no need to save like crazy or wait until your next paycheck — we've joined forces with online lender Affirm to give you flexibility with your finances. Our vacation packages with payment plans let you spread the total cost over 3, 6 or 12 months. With no hidden charges or late payment fees, it's easy to budget for your trip and snap up bargains before they sell out.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.