Santa María Vacations from $917

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $1,045 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Your Santa María Vacation

When you book a Santa María vacation package, you can kick back and enjoy your escape to the fullest. Uncover the highlights of this fascinating city knowing that all the travel planning has been looked after before you go. San Jose Beach and Plaza de Armas are a couple of the must-see sights to visit during a trip to Santa María. No matter your travel plans or the size of your budget, putting together a tailored Santa María vacation is a breeze with Expedia.

The Latest Santa María vacation packages

Price found within the past 48 hours. Click for updated prices.
Factoria Hotel

Factoria Hotel

4 out of 5
Villa Morra
Price was $997, price is now $917 per person
$917
per person
Apr 24 - Apr 28
found 20 hours ago
Roundtrip non-stop flight included
New York (NYC) to Asuncion (ASU)
9.6/10 Exceptional! (139 reviews)
We love the breakfast and the staff are always great. The facilities are really beautiful.

Reviewed on Jan 25, 2026

Nino Hotel Boutique

Nino Hotel Boutique

4 out of 5
Villa Morra
Price was $1,328, price is now $1,052 per person
$1,052
per person
Apr 15 - Apr 20
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Asuncion (ASU)
9.6/10 Exceptional! (9 reviews)
Papalo Resort Hotel

Papalo Resort Hotel

3 out of 5
Price was $1,188, price is now $971 per person
$971
per person
Apr 15 - Apr 20
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Asuncion (ASU)
6/10 (1 review)
Green Palace Hotel

Green Palace Hotel

3 out of 5
Price was $1,282, price is now $1,073 per person
$1,073
per person
Apr 15 - Apr 20
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Asuncion (ASU)
No reviews
Divina Tower

Divina Tower

3.5 out of 5
Recoleta
Price was $1,112, price is now $937 per person
$937
per person
Apr 15 - Apr 20
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Asuncion (ASU)
9.8/10 Exceptional! (24 reviews)
This place is really great. Outstanding family suite with 2 bdrm and 2 full bathrooms. Full kitchen and nice living room. Breakfast was very good. Staff was very nice and very helpful. Rooftop pool is small but really nice. Nice little bar up there too. We're coming back in 6 months and will definitely be staying here again. Tremendous value.

Reviewed on Dec 3, 2025

Don't see what you're looking for?
See all available trips from Columbus to Santa María
View all trips

The Annual Vacation Sale

Members save up to 40% on hotels and homes. Plan this year’s big trip and save.
Book now

Discover the most popular places to visit in Santa María

Costanera de la Ciudad de Encarnacion Paraguay

Enjoy an outing to Costanera de la Ciudad de Encarnacion Paraguay during your stay in Encarnacion. Wander the riverfront and beaches while you're in the area.

Costanera de la Ciudad de Encarnacion Paraguay

Carnival Sambadrome

You can find out about the history of Encarnacion when you stop by Carnival Sambadrome. Stroll along the riverfront or visit the spas while you're in the area.

Carnival Sambadrome

San Jose Beach

If a restful vacation is part of your travel plans, San Jose Beach might be the perfect place to seek out during your trip to Encarnacion. Discover the area's museums and shops.

San Jose Beach

Santa María Hotel Deals

Carnaval Hotel Casino

Carnaval Hotel Casino

3.5 out of 5
Av. Irrazabal, 750 Encarnacion
Fully refundableReserve now, pay when you stay
$65 nightly
The price is $71 total per night from Apr 5 to Apr 6
$71 total
Apr 5 - Apr 6
Total with taxes and fees
Carnaval Hotel Casino
Sun Hotel

Sun Hotel

3.5 out of 5
Encarnacion Itapúa
$83 nightly
The price is $91 total per night from Mar 13 to Mar 14
$91 total
Mar 13 - Mar 14
Total with taxes and fees
9/10 Wonderful! (113 reviews)
Excelent.

Reviewed on Jan 11, 2026

Sun Hotel
Hotel Luxsur

Hotel Luxsur

3.5 out of 5
Jorge Memmel 661 Encarnacion
Fully refundableReserve now, pay when you stay
$59 nightly
The price is $66 total per night from Mar 26 to Mar 27
$66 total
Mar 26 - Mar 27
Total with taxes and fees
8.8/10 Excellent! (167 reviews)
Amazing

Reviewed on Feb 24, 2026

Hotel Luxsur
See all 27 properties in Santa María
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Santa María Vacation Packages

Santa Marían Essential Information

Language
Spanish
Currency
Paraguayan guaranís
Local Welcome
¡Hola!
Local Goodbye
Adiós
Closest Airport
Libertador General Jose de San Martin Airport (PSS)
Top Sights
San Jose Beach and Plaza de Armas

More vacations you might like

All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Frequently asked questions

How much does a Santa María vacation package cost?
Offering great value package deals from $917 on Expedia, you'll be pleasantly surprised at how much a vacation to Santa María costs! Our packages make travel planning easier and save you more.
What are the cheapest months to go to Santa María?
You can typically find lower rates and better availability in February, March and August. Take a look at our cheap Santa María vacation packages and you could land some great off-season discounts.
How many days is enough for Santa María?
With a well-organized schedule, you can easily tick off the top Santa Marían attractions in a handful of days. But if you want to discover lesser-known spots or take day trips, think about booking your Santa María vacation for longer.
How to find the best Santa María package deals?
Use Expedia's handy filters to find some fabulous Santa María package deals. When you start your search, just set your maximum budget and then sort the results by "Price: low to high." If you want to save, plan your trip for midweek, or look for Santa María package deals in the off-peak season. Switch up your travel dates and you may land even bigger discounts. As a rule of thumb, it's usually best to lock in your vacation package well in advance.
Is it cheaper to book a Santa María vacation as a package?
An Expedia vacation package could save you hundreds of dollars when compared to booking hotels and flights separately. Better still, you can customize your Santa Marían escape to fit your exact needs. Pick your preferred flight time, select the hotel type and add a car rental. Explore our bundles to see how much you can save.
When to book a vacation package to Santa María?
If you have your Santa María vacation dates locked in, book as early as you can to snap up some terrific deals. With Expedia, you can often reserve some flights up to one year in advance. Prefer spontaneous trips? Our last-minute deals are great for setting off on a whim.
Does Expedia offer Book Now, Pay Later Santa María vacation packages?
If you're anything like us, you love traveling the world but are not a fan of the big price tag that can come with it. That's why we offer Book Now, Pay Later vacations. With the help of online lender Affirm, you can spread the total cost of your Santa María vacation across 3, 6 or 12 months. There are also no late payment fees or hidden costs, so you can snap up great vacation packages with payment plans as soon as you spot them.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.