Santa María Vacations from $556

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Your Santa María Vacation

When you book a Santa María vacation package, you can kick back and enjoy your escape to the fullest. Uncover the highlights of this fascinating city knowing that all the travel planning has been looked after before you go. San Jose Beach and Plaza de Armas are a couple of the must-see sights to visit during a trip to Santa María. No matter your travel plans or the size of your budget, putting together a tailored Santa María vacation is a breeze with Expedia.

The Latest Santa María vacation packages

Price found within the past 48 hours. Click for updated prices.
Divina Tower

Divina Tower

3.5 out of 5
Recoleta
Price was $638, price is now $556 per person
$556
per person
Mar 6 - Mar 9
found 6 hours ago
Roundtrip non-stop flight included
Montevideo (MVD) to Asuncion (ASU)
9.8/10 Exceptional! (15 reviews)
This place is really great. Outstanding family suite with 2 bdrm and 2 full bathrooms. Full kitchen and nice living room. Breakfast was very good. Staff was very nice and very helpful. Rooftop pool is small but really nice. Nice little bar up there too. We're coming back in 6 months and will definitely be staying here again. Tremendous value.

Reviewed on Dec 3, 2025

Five Hotel & Residences

Five Hotel & Residences

4 out of 5
Villa Morra
Price was $705, price is now $599 per person
$599
per person
Mar 6 - Mar 9
found 6 hours ago
Roundtrip non-stop flight included
Montevideo (MVD) to Asuncion (ASU)
9.2/10 Wonderful! (314 reviews)
Breakfast is gr8 and lot of options

Reviewed on Dec 11, 2025

La Casona Hotel Boutique

La Casona Hotel Boutique

4 out of 5
Recoleta
Price was $666, price is now $591 per person
$591
per person
Mar 6 - Mar 9
found 6 hours ago
Roundtrip non-stop flight included
Montevideo (MVD) to Asuncion (ASU)
9.4/10 Exceptional! (26 reviews)
Very wellcoming place.

Reviewed on Dec 1, 2025

La Mision Hotel Boutique

La Mision Hotel Boutique

4 out of 5
Recoleta
Price was $863, price is now $771 per person
$771
per person
Mar 6 - Mar 9
found 6 hours ago
Roundtrip non-stop flight included
Montevideo (MVD) to Asuncion (ASU)
9.8/10 Exceptional! (317 reviews)
The staff was exceptional!

Reviewed on Jan 2, 2026

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Discover the most popular places to visit in Santa María

Costanera de la Ciudad de Encarnacion Paraguay

Enjoy an outing to Costanera de la Ciudad de Encarnacion Paraguay during your stay in Encarnacion. Wander the riverfront and beaches while you're in the area.

Costanera de la Ciudad de Encarnacion Paraguay

Carnival Sambadrome

You can find out about the history of Encarnacion when you stop by Carnival Sambadrome. Stroll along the riverfront or visit the spas while you're in the area.

Carnival Sambadrome

San Jose Beach

If a restful vacation is part of your travel plans, San Jose Beach might be the perfect place to seek out during your trip to Encarnacion. Discover the area's museums and shops.

San Jose Beach

Santa María Hotel Deals

Carnaval Hotel Casino

Carnaval Hotel Casino

3.5 out of 5
Av. Irrazabal, 750 Encarnacion
$77 nightly
The price is $84 total per night from Jan 12 to Jan 13
$84 total
Jan 12 - Jan 13
Total with taxes and fees
9.2/10 Wonderful! (169 reviews)
All was great , nice hotel , excellent staff, perfect location

Reviewed on Nov 11, 2025

Carnaval Hotel Casino
Awa Resort Hotel

Awa Resort Hotel

4 out of 5
Ruta 1 Km 367, Calles Tajy y Naranjal Encarnacion
Fully refundableReserve now, pay when you stay
$133 nightly
The price is $147 total per night from Jan 11 to Jan 12
$147 total
Jan 11 - Jan 12
Total with taxes and fees
9/10 Wonderful! (119 reviews)
Awesome stay !!

Reviewed on Aug 31, 2025

Awa Resort Hotel
Hotel Luxsur

Hotel Luxsur

3.5 out of 5
Jorge Memmel 661 Encarnacion
Fully refundableReserve now, pay when you stay
$77 nightly
The price is $86 total per night from Jan 15 to Jan 16
$86 total
Jan 15 - Jan 16
Total with taxes and fees
8.8/10 Excellent! (158 reviews)
The breakfast was good. rooms were clean

Reviewed on Feb 6, 2025

Hotel Luxsur
See all 29 properties in Santa María
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Santa María Vacation Packages

Santa Marían Essential Information

Language
Spanish
Currency
Paraguayan guaranís
Local Welcome
¡Hola!
Local Goodbye
Adiós
Closest Airport
Libertador General Jose de San Martin Airport (PSS)
Top Sights
San Jose Beach and Plaza de Armas

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Frequently asked questions

How much does a Santa María vacation package cost?
Offering great value package deals from $556 on Expedia, you'll be pleasantly surprised at how much a vacation to Santa María costs! Our packages make travel planning easier and save you more.
What are the cheapest months to go to Santa María?
You can typically find lower rates and better availability in February, March and August. Take a look at our cheap Santa María vacation packages and you could land some great off-season discounts.
How many days is enough for Santa María?
With a well-organized schedule, you can easily tick off the top Santa Marían attractions in a handful of days. But if you want to discover lesser-known spots or take day trips, think about booking your Santa María vacation for longer.
How to find the best Santa María package deals?
Use Expedia's handy filters to find some fabulous Santa María package deals. When you start your search, just set your maximum budget and then sort the results by "Price: low to high." If you want to save, plan your trip for midweek, or look for Santa María package deals in the off-peak season. Switch up your travel dates and you may land even bigger discounts. As a rule of thumb, it's usually best to lock in your vacation package well in advance.
Is it cheaper to book a Santa María vacation as a package?
An Expedia vacation package could save you hundreds of dollars when compared to booking hotels and flights separately. Better still, you can customize your Santa Marían escape to fit your exact needs. Pick your preferred flight time, select the hotel type and add a car rental. Explore our bundles to see how much you can save.
When to book a vacation package to Santa María?
If you have your Santa María vacation dates locked in, book as early as you can to snap up some terrific deals. With Expedia, you can often reserve some flights up to one year in advance. Prefer spontaneous trips? Our last-minute deals are great for setting off on a whim.
Does Expedia offer Book Now, Pay Later Santa María vacation packages?
If you're anything like us, you love traveling the world but are not a fan of the big price tag that can come with it. That's why we offer Book Now, Pay Later vacations. With the help of online lender Affirm, you can spread the total cost of your Santa María vacation across 3, 6 or 12 months. There are also no late payment fees or hidden costs, so you can snap up great vacation packages with payment plans as soon as you spot them.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.