Title: Top 10 Hotels in Santana from $52 - Competitive Prices | Expedia.com [Vacation Rentals in Santana](https://expedia.com/Santana-Vacation-Rentals.d553248635974903086.Travel-Guide-VacationRentals)[Car Rentals in Santana](https://expedia.com/Car-Rentals-In-Santana.d553248635974903086.Car-Rental-Guide)[Santana Vacation Packages](https://expedia.com/Santana.d553248635974903086.Destination-Travel-Guides) ![Isn’t this a nice place to have a breakfast!](https://images.trvl-media.com/place/3486/bf4844fd-f36f-47b2-97bc-8390385f8488.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Fabrice Récalt ![](https://images.trvl-media.com/place/3486/bf4844fd-f36f-47b2-97bc-8390385f8488.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Upfront pricing Our total price for your stay includes taxes and fees - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save 10% or more on over 100,000 hotels worldwide with Member Prices [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in Santana Pool [](https://www.expedia.com/Hotel-Search?destination=Santana%2C+Cantagalo%2C+S%C3%A3o+Tom%C3%A9+and+Pr%C3%ADncipe®ionId=553248635974903086&latLong=0.2532%2C6.741371&adults=2&startDate=2026-04-04&d1=2026-04-04&endDate=2026-04-06&d2=2026-04-06&amenities=POOL) Pet friendly [](https://www.expedia.com/Hotel-Search?destination=Santana%2C+Cantagalo%2C+S%C3%A3o+Tom%C3%A9+and+Pr%C3%ADncipe®ionId=553248635974903086&latLong=0.2532%2C6.741371&adults=2&startDate=2026-04-04&d1=2026-04-04&endDate=2026-04-06&d2=2026-04-06&amenities=PETS) ## Check prices for these dates Tonight [Mar 21 - Mar 22](https://www.expedia.com/Hotel-Search?regionId=553248635974903086&startDate=2026-03-21&endDate=2026-03-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Mar 22 - Mar 23](https://www.expedia.com/Hotel-Search?regionId=553248635974903086&startDate=2026-03-22&endDate=2026-03-23&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Mar 27 - Mar 29](https://www.expedia.com/Hotel-Search?regionId=553248635974903086&startDate=2026-03-27&endDate=2026-03-29&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Apr 3 - Apr 5](https://www.expedia.com/Hotel-Search?regionId=553248635974903086&startDate=2026-04-03&endDate=2026-04-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Santana hotels ![Bungalow | Desk, blackout drapes, soundproofing, iron/ironing board](https://images.trvl-media.com/lodging/40000000/39490000/39486200/39486195/afa4170d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bungalow | Desk, blackout drapes, soundproofing, iron/ironing board](https://images.trvl-media.com/lodging/40000000/39490000/39486200/39486195/b8ac8133.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/40000000/39490000/39486200/39486195/a9f64453.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/40000000/39490000/39486200/39486195/3753b3ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Guest House Quinta Natural [](https://www.expedia.com/Sao-Tome-Island-Hotels-Guest-House-Quinta-Natural.h39486195.Hotel-Information) Trindade 10/10 Exceptional (1 review) [](https://www.expedia.com/Sao-Tome-Island-Hotels-Guest-House-Quinta-Natural.h39486195.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/7000000/6770000/6762300/6762264/dcc8cb9a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/7000000/6770000/6762300/6762264/d9028277.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/7000000/6770000/6762300/6762264/741e11cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily local cuisine breakfast](https://images.trvl-media.com/lodging/7000000/6770000/6762300/6762264/6100ac64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Omali São Tomé – Principe Collection [](https://www.expedia.com/Sao-Tome-Island-Hotels-Omali-Sao-Tome.h6762264.Hotel-Information) São Tomé 9.4/10 Exceptional (63 reviews) "Staff was very friendly. Food was excellent. Room was clean and well kept." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) christopher $211 nightly $245 total Mar 26 - Mar 27 Total with taxes and fees [](https://www.expedia.com/Sao-Tome-Island-Hotels-Omali-Sao-Tome.h6762264.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/11000000/10350000/10348400/10348352/d968c0c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk](https://images.trvl-media.com/lodging/11000000/10350000/10348400/10348352/d348c5fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Economy Triple Room | Desk](https://images.trvl-media.com/lodging/11000000/10350000/10348400/10348352/90e86a6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk](https://images.trvl-media.com/lodging/11000000/10350000/10348400/10348352/538d97d4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Mucumbli Hotel [](https://www.expedia.com/Sao-Tome-Island-Hotels-Mucumbli-Hotel.h10348352.Hotel-Information) Neves 9.4/10 Exceptional (26 reviews) "A bit rustier than i expected. Beds were SUPER sq " ![Norway](https://a.travel-assets.com/egds/marks/flags/no.svg) Morten $133 nightly $155 total Apr 1 - Apr 2 Total with taxes and fees [](https://www.expedia.com/Sao-Tome-Island-Hotels-Mucumbli-Hotel.h10348352.Hotel-Information) ![Pool](https://images.trvl-media.com/lodging/3000000/2160000/2150500/2150447/4b0f9c44.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Minibar, in-room safe, free WiFi](https://images.trvl-media.com/lodging/3000000/2160000/2150500/2150447/bab15252.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pool views, open daily](https://images.trvl-media.com/lodging/3000000/2160000/2150500/2150447/b432c63a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; Regional cuisine, pool views ](https://images.trvl-media.com/lodging/3000000/2160000/2150500/2150447/28b20cc6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Pestana São Tomé [](https://www.expedia.com/Sao-Tome-Island-Hotels-Pestana-Sao-Tome.h2150447.Hotel-Information) Vila Maria 8.2/10 Very Good (79 reviews) "Wonderful stay, great staff, easy, relaxing delightful." ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) alexander $198 nightly $228 total Mar 22 - Mar 23 Total with taxes and fees [](https://www.expedia.com/Sao-Tome-Island-Hotels-Pestana-Sao-Tome.h2150447.Hotel-Information) ![Basic Double or Twin Room, Pool View | In-room dining](https://images.trvl-media.com/lodging/110000000/109260000/109259000/109258960/47d5c80e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/110000000/109260000/109259000/109258960/0bd9a157.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/110000000/109260000/109259000/109258960/5fe608c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/110000000/109260000/109259000/109258960/13076316.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Kenito [](https://www.expedia.com/Sao-Tome-Hotels-Hotel-Kenito.h109258960.Hotel-Information) São Tomé 10/10 Exceptional (3 reviews) "Exceptional" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Nii Tetteh $90 nightly $104 total Mar 27 - Mar 28 Total with taxes and fees [](https://www.expedia.com/Sao-Tome-Hotels-Hotel-Kenito.h109258960.Hotel-Information) ![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/27000000/26600000/26593200/26593135/90eb3603.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Shower, free toiletries, towels](https://images.trvl-media.com/lodging/27000000/26600000/26593200/26593135/184b1734.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/27000000/26600000/26593200/26593135/89c59b7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business center](https://images.trvl-media.com/lodging/27000000/26600000/26593200/26593135/54c71534.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Praia Accommodation [](https://www.expedia.com/Sao-Tome-Island-Hotels-Praia-Accommodation.h26593135.Hotel-Information) São Tomé 7.4/10 Good (19 reviews) "Great place to stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Daniel $126 nightly $145 total Mar 23 - Mar 24 Total with taxes and fees [](https://www.expedia.com/Sao-Tome-Island-Hotels-Praia-Accommodation.h26593135.Hotel-Information) ![Buffet](https://images.trvl-media.com/lodging/23000000/22450000/22443300/22443247/92cde547.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/23000000/22450000/22443300/22443247/de137179.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family Room | Minibar, in-room safe, desk, free WiFi](https://images.trvl-media.com/lodging/23000000/22450000/22443300/22443247/2b0a4725.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/23000000/22450000/22443300/22443247/cdbf65a7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### SH Boutique Hotel [](https://www.expedia.com/Sao-Tome-Island-Hotels-SH-Boutique-Hotel.h22443247.Hotel-Information) São Tomé 8.6/10 Excellent (10 reviews) "Staff were very accommodating " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Simon Peter [](https://www.expedia.com/Sao-Tome-Island-Hotels-SH-Boutique-Hotel.h22443247.Hotel-Information) ![Outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/19000000/18910000/18900300/18900207/4766b5b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Beach](https://images.trvl-media.com/lodging/19000000/18910000/18900300/18900207/74d1540a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Minibar, in-room safe, desk, free WiFi](https://images.trvl-media.com/lodging/19000000/18910000/18900300/18900207/468f15c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Flat-screen TV](https://images.trvl-media.com/lodging/19000000/18910000/18900300/18900207/73338a21.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Praia [](https://www.expedia.com/Sao-Tome-Island-Hotels-Hotel-Praia.h18900207.Hotel-Information) São Tomé 7.4/10 Good (18 reviews) "Solid, basic hotel. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jonathan $146 nightly $172 total Mar 24 - Mar 25 Total with taxes and fees [](https://www.expedia.com/Sao-Tome-Island-Hotels-Hotel-Praia.h18900207.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/32000000/31070000/31068700/31068683/3a896a59.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Design Triple Room | Minibar, soundproofing, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/32000000/31070000/31068700/31068683/b9167af0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/32000000/31070000/31068700/31068683/a14f497e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Living room](https://images.trvl-media.com/lodging/32000000/31070000/31068700/31068683/f180a525.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Porcelana Hotel [](https://www.expedia.com/Sao-Tome-Island-Hotels-Porcelana-Hotel.h31068683.Hotel-Information) Vila Maria 9.6/10 Exceptional (9 reviews) "The place is great, water flows very well and you can get warm for your shower real quick. The hotel manager Leu was helpful and addressed any concerns I had. Again Sipson Tours was great with helping me navigate my accommodation. There is breakfast included and my best part is the fruit options which always part of the meal. The downside is that there is really no variety in the breakfast meal. However, overall I enjoyed my stay. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Linda [](https://www.expedia.com/Sao-Tome-Island-Hotels-Porcelana-Hotel.h31068683.Hotel-Information) ![Coffee shop](https://images.trvl-media.com/lodging/38000000/37700000/37697100/37697027/5e2988d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/38000000/37700000/37697100/37697027/c312f98a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Staircase](https://images.trvl-media.com/lodging/38000000/37700000/37697100/37697027/88c0f958.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Staircase](https://images.trvl-media.com/lodging/38000000/37700000/37697100/37697027/fc496aaa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Central [](https://www.expedia.com/Sao-Tome-Island-Hotels-Hotel-Central.h37697027.Hotel-Information) São Tomé 8.2/10 Very Good (25 reviews) "Great value. Great location. Ok breakfast. Overall good value for money" ![Norway](https://a.travel-assets.com/egds/marks/flags/no.svg) Elisabeth [](https://www.expedia.com/Sao-Tome-Island-Hotels-Hotel-Central.h37697027.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/28000000/27100000/27093800/27093780/e065a121.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Economy Room, Corner | Hypo-allergenic bedding, individually decorated, individually furnished](https://images.trvl-media.com/lodging/28000000/27100000/27093800/27093780/fc229a53.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/28000000/27100000/27093800/27093780/a9318aac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Living area](https://images.trvl-media.com/lodging/28000000/27100000/27093800/27093780/27ea3314.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Casa de Ferias [](https://www.expedia.com/Sao-Tome-Island-Hotels-Casa-De-Ferias.h27093780.Hotel-Information) São Tomé 8.8/10 Excellent (6 reviews) "I had a very good time here, got a lot of service and information from the family and in fact almost felt like a family member." ![Sweden](https://a.travel-assets.com/egds/marks/flags/se.svg) Lars Roland $66 nightly $76 total Mar 22 - Mar 23 Total with taxes and fees [](https://www.expedia.com/Sao-Tome-Island-Hotels-Casa-De-Ferias.h27093780.Hotel-Information) ![Aerial view](https://images.trvl-media.com/lodging/42000000/41650000/41640400/41640341/87364023.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, bed sheets](https://images.trvl-media.com/lodging/42000000/41650000/41640400/41640341/5eb72f72.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/42000000/41650000/41640400/41640341/ed9ed478.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Aerial view](https://images.trvl-media.com/lodging/42000000/41650000/41640400/41640341/580879b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### N Guembú Nature Resort [](https://www.expedia.com/Sao-Tome-Island-Hotels-N-Guembu-Nature-Resort.h41640341.Hotel-Information) Malanza 7.4/10 Good (9 reviews) "Very nice area and very friendly staff, who organized a trip to the island Ilhéu das Rolas with the Equator Monument. The beach on the left is fine for a swim. Good beds. Very good internet. " ![Denmark](https://a.travel-assets.com/egds/marks/flags/dk.svg) Dorte $91 nightly $104 total Mar 23 - Mar 24 Total with taxes and fees [](https://www.expedia.com/Sao-Tome-Island-Hotels-N-Guembu-Nature-Resort.h41640341.Hotel-Information) ![On the beach](https://images.trvl-media.com/lodging/23000000/22710000/22709500/22709437/c133a29b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Balcony](https://images.trvl-media.com/lodging/23000000/22710000/22709500/22709437/6b6a3057.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Double Room | Minibar, individually decorated, free WiFi](https://images.trvl-media.com/lodging/23000000/22710000/22709500/22709437/61594a9b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/23000000/22710000/22709500/22709437/19a68080.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Residêncial Tamarindos [](https://www.expedia.com/Sao-Tome-Island-Hotels-Residencial-Tamarindos.h22709437.Hotel-Information) Guadalupe 8.6/10 Excellent (14 reviews) "Couldn’t have had better hosts Perfect location for great hikes and waterfalls Many thanks to Marlena and Betty who made our visit memorable x" ![United Kingdom](https://a.travel-assets.com/egds/marks/flags/uk.svg) Maria $45 nightly $52 total Mar 22 - Mar 23 Total with taxes and fees [](https://www.expedia.com/Sao-Tome-Island-Hotels-Residencial-Tamarindos.h22709437.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/6000000/5720000/5710500/5710443/a4e1f9fb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pool](https://images.trvl-media.com/lodging/6000000/5720000/5710500/5710443/1932dcf2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/6000000/5720000/5710500/5710443/e6ae62f6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Junior Suite | View from room](https://images.trvl-media.com/lodging/6000000/5720000/5710500/5710443/1097ed78.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Pestana Miramar São Tomé [](https://www.expedia.com/Sao-Tome-Island-Hotels-Pestana-Miramar-Sao-Tome.h5710443.Hotel-Information) São Tomé 7.2/10 Good (46 reviews) "Very helpful and accommodating staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) sandra $144 nightly $165 total Mar 25 - Mar 26 Total with taxes and fees [](https://www.expedia.com/Sao-Tome-Island-Hotels-Pestana-Miramar-Sao-Tome.h5710443.Hotel-Information) ![Standard Cabin | Laptop workspace, bed sheets](https://images.trvl-media.com/lodging/105000000/104080000/104073700/104073683/03f83718.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/105000000/104080000/104073700/104073683/9357faa5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Traditional Cabin, Beach View | Laptop workspace, bed sheets](https://images.trvl-media.com/lodging/105000000/104080000/104073700/104073683/4155521b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Traditional Cabin, Beach View | Laptop workspace, bed sheets](https://images.trvl-media.com/lodging/105000000/104080000/104073700/104073683/746e5f79.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### CAMPISMO PRAIA GRANDE [](https://www.expedia.com/Sao-Tome-Island-Hotels-CAMPISMO-PRAIA-GRANDE.h104073683.Hotel-Information) Malanza 9.0/10 Wonderful (6 reviews) "A little piece of paradise on an amazing beach. " ![United Kingdom](https://a.travel-assets.com/egds/marks/flags/uk.svg) John $52 nightly $61 total Mar 29 - Mar 30 Total with taxes and fees [](https://www.expedia.com/Sao-Tome-Island-Hotels-CAMPISMO-PRAIA-GRANDE.h104073683.Hotel-Information) ![On the beach](https://images.trvl-media.com/lodging/11000000/10400000/10392300/10392236/30a802d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Buffet](https://images.trvl-media.com/lodging/11000000/10400000/10392300/10392236/b06fcbca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, free cribs/infant beds](https://images.trvl-media.com/lodging/11000000/10400000/10392300/10392236/5142afa5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Double Room | Desk, free cribs/infant beds](https://images.trvl-media.com/lodging/11000000/10400000/10392300/10392236/bdd83e01.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Praia Inhame Eco-Lodge [](https://www.expedia.com/Sao-Tome-Island-Hotels-Praia-Inhame-Eco-Lodge.h10392236.Hotel-Information) Malanza 8.8/10 Excellent (26 reviews) "Bungalow is a bit outdated but good enough. Location is great and the food even better. Big thumbs up for the chefs! Best hotel food in STP for us. " ![Netherlands](https://a.travel-assets.com/egds/marks/flags/nl.svg) Rob $84 nightly $97 total Apr 14 - Apr 15 Total with taxes and fees [](https://www.expedia.com/Sao-Tome-Island-Hotels-Praia-Inhame-Eco-Lodge.h10392236.Hotel-Information) ![Iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/121000000/120460000/120451900/120451805/8c12cec9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/121000000/120460000/120451900/120451805/dfafa2c8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/121000000/120460000/120451900/120451805/ee79bee6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/121000000/120460000/120451900/120451805/02be10f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Alojamento Santos Silva [](https://www.expedia.com/Sao-Tome-Hotels-Alojamento-Santos-Silva.h120451805.Hotel-Information) São Tomé $310 nightly $358 total Mar 29 - Mar 30 Total with taxes and fees [](https://www.expedia.com/Sao-Tome-Hotels-Alojamento-Santos-Silva.h120451805.Hotel-Information) ![Basic Apartment | Living area | Flat-screen TV](https://images.trvl-media.com/lodging/126000000/125770000/125763300/125763221/8fe55824.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Basic Apartment | Blackout drapes, soundproofing, free WiFi](https://images.trvl-media.com/lodging/126000000/125770000/125763300/125763221/895dc7c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Basic Apartment | Living area | Flat-screen TV](https://images.trvl-media.com/lodging/126000000/125770000/125763300/125763221/36adc5ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Nour Apartments [](https://www.expedia.com/Sao-Tome-Hotels-Nour-Apartments.h125763221.Hotel-Information) São Tomé $53 nightly $62 total Mar 29 - Mar 30 Total with taxes and fees [](https://www.expedia.com/Sao-Tome-Hotels-Nour-Apartments.h125763221.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.com/Hotel-Search?startDate=2026-04-04&endDate=2026-04-05®ionId=553248635974903086&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSantana-Hotels.d553248635974903086.Travel-Guide-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSantana-Hotels.d553248635974903086.Travel-Guide-Hotels) ## Learn more about Santana Venture to Estadio Nacional 12 de Julho and São Sebastião Museum—just two of the sights around Santana. [See all hotels in Santana](https://www.expedia.com/Hotel-Search?startDate=2026-04-04&endDate=2026-04-05&adults=2®ionId=553248635974903086) ![Isn’t this a nice place to have a breakfast!](https://images.trvl-media.com/place/3486/bf4844fd-f36f-47b2-97bc-8390385f8488.jpg?impolicy=fcrop&w=900&h=506&p=1&q=high) Photo by Fabrice Récalt ## Top Santana Hotel Reviews ![Omali São Tomé – Principe Collection](https://images.trvl-media.com/lodging/7000000/6770000/6762300/6762264/dcc8cb9a_y.jpg) ### Omali São Tomé – Principe Collection 10/10 Excellent "Lovely hotel, staff and location. Very close to airport as well Recommend highly" [](https://expedia.com/Sao-Tome-Island-Hotels-Omali-Sao-Tome.h6762264.Hotel-Information) ![Porcelana Hotel](https://images.trvl-media.com/lodging/32000000/31070000/31068700/31068683/3a896a59_y.jpg) ### Porcelana Hotel 10/10 Excellent "Great value for price. Nice staff. Excellent breakfast." [](https://expedia.com/Sao-Tome-Island-Hotels-Porcelana-Hotel.h31068683.Hotel-Information) ![Pestana São Tomé](https://images.trvl-media.com/lodging/3000000/2160000/2150500/2150447/4b0f9c44_y.jpg) ### Pestana São Tomé 10/10 Excellent "Wonderful stay, great staff, easy, relaxing delightful." [](https://expedia.com/Sao-Tome-Island-Hotels-Pestana-Sao-Tome.h2150447.Hotel-Information) ![Hotel Kenito](https://images.trvl-media.com/lodging/110000000/109260000/109259000/109258960/47d5c80e_y.jpg) ### Hotel Kenito 10/10 Excellent "Exceptional" [](https://expedia.com/Sao-Tome-Hotels-Hotel-Kenito.h109258960.Hotel-Information) ## More cheap stays in Santana ![Nour Apartments](https://images.trvl-media.com/lodging/126000000/125770000/125763300/125763221/8fe55824_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Nour Apartments Rua 3 de Fevereiro São Tomé $53 nightly $62 total Mar 29 - Mar 30 Total with taxes and fees [](https://expedia.com/Sao-Tome-Hotels-Nour-Apartments.h125763221.Hotel-Information) ![Praia Inhame Eco-Lodge](https://images.trvl-media.com/lodging/11000000/10400000/10392300/10392236/30a802d6_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Praia Inhame Eco-Lodge Porto Alegre 64 Malanza $84 nightly $97 total Apr 14 - Apr 15 Total with taxes and fees 8.8/10 Excellent! (26 reviews) [](https://expedia.com/Sao-Tome-Island-Hotels-Praia-Inhame-Eco-Lodge.h10392236.Hotel-Information) ![Hotel Kenito](https://images.trvl-media.com/lodging/110000000/109260000/109259000/109258960/47d5c80e_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hotel Kenito Campo de Milho São Tomé $90 nightly $104 total Mar 27 - Mar 28 Total with taxes and fees 10/10 Exceptional! (3 reviews) [](https://expedia.com/Sao-Tome-Hotels-Hotel-Kenito.h109258960.Hotel-Information) ![Sweet Guest House](https://images.trvl-media.com/lodging/13000000/12340000/12336300/12336226/6d211eb5_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Sweet Guest House Vila Dolores n. 087 São Tomé [Get rates](https://expedia.com/Hotel-Search?startDate=4%2F4%2F2026&endDate=4%2F5%2F2026&selected=12336226&PinnedHotelID=12336226&HadPinnedHotel=true®ionId=553248635974903086) [](https://expedia.com/Sao-Tome-Island-Hotels-Sweet-Guest-House.h12336226.Hotel-Information) ![Inviting 10 Bed Apartment in Sao Tome](https://images.trvl-media.com/lodging/96000000/95320000/95318700/95318611/5916db57_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Inviting 10 Bed Apartment in Sao Tome Avenida Marginal 12 de Julho São Tomé São Tomé [Get rates](https://expedia.com/Hotel-Search?startDate=4%2F4%2F2026&endDate=4%2F5%2F2026&selected=95318611&PinnedHotelID=95318611&HadPinnedHotel=true®ionId=553248635974903086) [](https://expedia.com/Sao-Tome-Island-Hotels-Inviting-10-Bed-Apartment-In-Sao-Tome.h95318611.Hotel-Information) ### Pousada Roça São João dos Angolares Cidade dos Angolares São João dos Angolares Sao Tome [Get rates](https://expedia.com/Hotel-Search?startDate=4%2F4%2F2026&endDate=4%2F5%2F2026&selected=46350098&PinnedHotelID=46350098&HadPinnedHotel=true®ionId=553248635974903086) [](https://expedia.com/Sao-Tome-Island-Hotels-Pousada-Roca-Sao-Joao-Dos-Angolares.h46350098.Hotel-Information) ## Frequently asked questions ### What is the best area to stay in Santana? > This area is characterized by its proximity to the ocean and lush tropical vegetation. Hotels here are typically set back from the main road, offering privacy and often direct beach access. It's a convenient location for exploring both Santana and the wider island, with easy access to attractions further north and south. > > > For couples seeking a romantic and private retreat, this coastal stretch is ideal. Many accommodations offer ocean views, secluded beaches, and a tranquil setting great for relaxation. The natural beauty of the surroundings provides a beautiful backdrop for a memorable escape. > > > Families will also find this area suitable due to the availability of resorts with amenities designed for all ages. These properties often feature swimming pools, spacious grounds for children to play, and easy access to calmer beach areas. ### When is the best time to go to Santana? > During these months, you'll experience less rainfall and more sunshine, making it ideal for outdoor activities like hiking and beach visits. The ocean conditions are generally calmer, which is great for swimming, snorkeling, and boat excursions around the nearby islets. > > > Travelers looking for a relaxed beach holiday will find this season particularly appealing, as the sunny days are excellent for enjoying Santana's coastal areas. ### Can I cancel my hotel reservation on Expedia? ### How can I save on a Santana hotel booking with Expedia? > \*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo. ### How much is the nightly rate at a Santana hotel? ## Explore a world of travel with Expedia - Flights - [Flights from Ribeira Afonso ](https://www.expedia.com/lp/flights/899027489549205504/flights-from-ribeira-afonso) - [Flights from Cantagalo ](https://www.expedia.com/lp/flights/899021965959114752/flights-from-cantagalo) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save even more - get up to 20% on select hotels when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app