Santiago Sur Vacations from $666

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The Latest Santiago Sur vacation packages

Price found within the past 48 hours. Click for updated prices.
Hotel Panamonte

Hotel Panamonte

3.5 out of 5
Price was $924, price is now $666 per person
$666
per person
Oct 11 - Oct 15
found 1 day ago
Roundtrip flight included
Port of Spain (POS) to Panama City (PTY)
9.4/10 Exceptional! (111 reviews)
The staff provided a great service

Reviewed on Aug 29, 2025

Central Hotel Bocas del Toro

Central Hotel Bocas del Toro

3 out of 5
Save 100% on your flight
Price was $2,440, price is now $1,425 per person
$1,425
per person
Nov 5 - Nov 9
found 4 hours ago
Roundtrip flight included
New York (NYC) to Panama City (PTY)
No reviews
Casa Fofo Family House

Casa Fofo Family House

3 out of 5
Price was $1,511, price is now $1,002 per person
$1,002
per person
Nov 8 - Nov 12
found 1 day ago
Roundtrip flight included
New York (NYC) to Panama City (PTY)
No reviews
La Coralina Island House

La Coralina Island House

3.5 out of 5
Price was $1,771, price is now $1,205 per person
$1,205
per person
Nov 5 - Nov 9
found 4 hours ago
Roundtrip flight included
New York (NYC) to Panama City (PTY)
9.4/10 Exceptional! (84 reviews)
Wow! This resort is absolutely amazing! Bekar went above and beyond for us! He even brought in a TV to the lobby so we could watch the NHL playoff game! Food is 10/10 as well. We will definitely go back!

Reviewed on May 18, 2025

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Price was $1,487, price is now $1,034 per person
$1,034
per person
Nov 5 - Nov 9
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9/10 Wonderful! (974 reviews)
clean and functional with excellent staff

Reviewed on Aug 23, 2025

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Santiago Sur Hotel Deals

Cabañas Palma Real

Cabañas Palma Real

3 out of 5
Las Colomas, Santiago Sur via principal, 68035902, Santiago Sur, Provincia de Veraguas
$68 nightly
The price is $75 total per night from Aug 30 to Aug 31
$75 total
Aug 30 - Aug 31
Total with taxes and fees
Cabañas Palma Real
Hotel Gran David

Hotel Gran David

3.5 out of 5
Vía Interamericana, Santiago, Veraguas
Fully refundableReserve now, pay when you stay
Get rates
Hotel Gran David
Hotel Mykonos Panama

Hotel Mykonos Panama

3.5 out of 5
Panamerican Highway, in front of Ruben Cantu Airport, Nuevo Santiago, Veraguas
Fully refundableReserve now, pay when you stay
$81 nightly
The price is $91 total per night from Sep 7 to Sep 8
$91 total
Sep 7 - Sep 8
Total with taxes and fees
Hotel Mykonos Panama
See all 53 properties in Santiago Sur
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Frequently asked questions

How to find the best Santiago Sur package deals?
Landing a cheap Santiago Sur package deal is easy with Expedia. After you've entered your preferred dates and destination under our "Packages" tab, set your maximum budget, apply a couple of filters and browse what's available. You can tweak your search by "Property class," "Number of bedrooms," "Traveler experience" and more. Sort the results by "Price: low to high" to view the most affordable Santiago Sur package deals. Want a simple trick to score the biggest savings? Have some flexibility with your departure dates and consider traveling on a weekday, when prices are usually lower.
When to book a vacation package to Santiago Sur?
If you have your Santiago Sur vacation dates finalized, book as soon as you can to bag some fantastic deals. With Expedia, you can often reserve some flights up to one year ahead of time. Prefer spur-of-the-moment trips? Our last-minute deals are ideal for quick escapes.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.