Santissima Annunziata Vacations from $687

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Your Santissima Annunziata Vacation

Organizing your next travel adventure just got simpler with a vacation package to Santissima Annunziata. Enjoy all this neighborhood has to offer while making incredible memories you'll remember for years. Kick start your trip to Santissima Annunziata with a visit to nearby attractions such as Cathedral of Santa Maria del Fiore, Ponte Vecchio and Uffizi Gallery. Expedia is here to help put your travel plans into action. Book your ultimate Santissima Annunziata vacation now.

The Latest Santissima Annunziata Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Villa Tolomei Hotel & Resort

Villa Tolomei Hotel & Resort

5 out of 5
Oltrarno
Price was $923, price is now $687 per person
$687
per person
Dec 6 - Dec 10
found 19 hours ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Florence (FLR)
8.8/10 Excellent! (397 reviews)
Great place to stay near Florence, it’s quite and relaxing. The pool is great.

Reviewed on Jul 31, 2025

The Moon Boutique Hotel & Spa

The Moon Boutique Hotel & Spa

4 out of 5
Historic Centre of Florence
Price was $1,445, price is now $1,016 per person
$1,016
per person
Jan 19 - Jan 24
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Florence (FLR)
9.6/10 Exceptional! (485 reviews)
the hotel is located a little far from historic area of the town. but if you are a go walking person, it is 15 minutes walk. the hotel itself is very good. fresh and nice design, very nice buffet breakfast and kind stuff.

Reviewed on Oct 21, 2025

Aurum Uffizi

Aurum Uffizi

4 out of 5
Historic Centre of Florence
Price was $1,251, price is now $884 per person
$884
per person
Jan 19 - Jan 24
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Florence (FLR)
7.8/10 Good! (1,015 reviews)
Very friendly and supportive staff

Reviewed on Oct 29, 2025

Hotel Villani

Hotel Villani

2 out of 5
Historic Centre of Florence
Price was $1,032, price is now $791 per person
$791
per person
Jan 8 - Jan 14
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Florence (FLR)
8.6/10 Excellent! (403 reviews)
Breakfast catered for a wide variety of guests needs. The staff were always there to help and support with any additional requests. Very well presented

Reviewed on Oct 23, 2025

Hotel Duomo Firenze

Hotel Duomo Firenze

3 out of 5
Historic Centre of Florence
Price was $1,173, price is now $902 per person
$902
per person
Jan 11 - Jan 14
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Florence (FLR)
9/10 Wonderful! (1,006 reviews)
Great location with a great staff

Reviewed on Oct 29, 2025

Where to stay in Santissima Annunziata

Find the best Santissima Annunziata areas and neighborhoods for the activities you enjoy most. Learn more about Santissima Annunziata
Arcetri showing a bridge and a river or creek

Historic Centre of Florence

10 out of top 10 points of interest in this area

Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.

Find hotels in Historic Centre of Florence

Santissima Annunziata Hotel Deals

Four Seasons Hotel Firenze

Four Seasons Hotel Firenze

5 out of 5
Borgo Pinti, 99, Florence, FI
Fully refundableReserve now, pay when you stay
$932 nightly
The price is $1,044 total per night from Nov 11 to Nov 12
$1,044 total
Nov 11 - Nov 12
Total with taxes and fees
9.6/10 Exceptional! (283 reviews)
Beautiful property and exceptional service. Will definitely go back.

Reviewed on Oct 2, 2025

Four Seasons Hotel Firenze
Relais la Corte di Cloris

Relais la Corte di Cloris

Via Masaccio 234, Florence, FI
Fully refundableReserve now, pay when you stay
$67 nightly
The price is $87 total per night from Nov 2 to Nov 3
$87 total
Nov 2 - Nov 3
Total with taxes and fees
9/10 Wonderful! (327 reviews)
Very friendly check in. The bed was comfortable and the view was nice.

Reviewed on Aug 8, 2025

Relais la Corte di Cloris
Hotel Astro Mediceo

Hotel Astro Mediceo

3 out of 5
Via Frà Bartolommeo 54/56, Florence, FI
8.6/10 Excellent! (347 reviews)
This hotel was amazing. I am traveling solo and location was perfect. Breakfast was delicious and the Staff was so helpful. Specially Antonella. Looking forward to back.

Reviewed on Oct 16, 2025

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Hotel Astro Mediceo
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Discover the most popular places to visit in Santissima Annunziata

Accademia Gallery which includes street scenes as well as a large group of people

Gallery of the Academy of Florence

Michelangelo’s David statue is the impressive star of the show at one of Florence’s most popular and well-attended art museums.

Gallery of the Academy of Florence
Statue of David

Statue of David

You can learn about the history of Florence with a stop at Statue of David. Experience the fascinating museums and acclaimed art scene in this vibrant area.

Statue of David
The streets of Florence are dominated by the massive Duomo dome. It is peeking from the end of each street you walk in #firenze

Santissima Annunziata Square

Find out about the history of Florence when you spend time at Santissima Annunziata Square. Experience the acclaimed art scene and fascinating museums in this vibrant area.

Santissima Annunziata Square

Things to do

Skip-the-Line Duomo: Priority-Access 30-Minute Guided Tour

Skip-the-Line Florence Duomo: Priority-Access Express Guided Tour

$24
per adult
78% of travellers recommend
Skip-the-Line Florence Duomo: Priority-Access Express Guided Tour
The Best tour in Florence: Renaissance and Medici Tales

The Best Tour in Florence: Renaissance and Medici Tales

$3
per adult
96% of travellers recommend
The Best Tour in Florence: Renaissance and Medici Tales
Florence half day combo tour with David, Uffizi & Duomo

Florence Half Day Tour with Uffizi, Michelangelo’s David & Accademia

$50
per adult
90% of travellers recommend
Florence Half Day Tour with Uffizi, Michelangelo’s David & Accademia
See all activities in Florence
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.