Title: Santissima Annunziata Vacation Packages 2026 from $1,171 | Expedia.com

[Santissima Annunziata Travel Guide](https://expedia.com/Florence-Santissima-Annunziata.dx6084890)[Hotels in Santissima Annunziata](https://expedia.com/Santissima-Annunziata-Florence-Hotels.0-n6084890-0.Travel-Guide-Filter-Hotels)[Flights to Florence](https://expedia.com/Cheap-Flights-To-Florence.d1222.Travel-Guide-Flights)[Things to do in Florence](https://expedia.com/Things-To-Do-In-Florence.d1222.Travel-Guide-Activities)[Car Rentals in Santissima Annunziata](https://expedia.com/Car-Rentals-In-Santissima-Annunziata.d6084890.Car-Rental-Guide)

![](https://images.trvl-media.com/place/179893/52657877-1033-47c5-8f22-0a8b6b0d8389.jpg?impolicy=fcrop&w=1200&h=300&q=medium)

# Santissima Annunziata Vacations from $1,171

## Book a Hotel + Flight or Car together to unlock savings

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## Your Santissima Annunziata Vacation

Organizing your next travel adventure just got simpler with a vacation package to Santissima Annunziata. Enjoy all this neighborhood has to offer while making incredible memories you'll remember for years. Kick start your trip to Santissima Annunziata with a visit to nearby attractions such as [Cathedral of Santa Maria del Fiore](https://www.expedia.com/Cathedral-Of-Santa-Maria-Del-Fiore-Duomo.d501046.Vacation-Attraction), [Ponte Vecchio](https://www.expedia.com/Ponte-Vecchio-Oltrarno.d6075434.Vacation-Attraction) and [Uffizi Gallery](https://www.expedia.com/Uffizi-Gallery-Duomo.d6075462.Vacation-Attraction). Expedia is here to help put your travel plans into action. Book your ultimate Santissima Annunziata vacation now.

## The Latest Santissima Annunziata Vacation Packages

Price found within the past 48 hours. Click for updated prices.

![Aurum Uffizi](https://images.trvl-media.com/lodging/3000000/2550000/2541700/2541615/4fb74083_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Aurum Uffizi

Historic Centre of Florence

$1,171

per person

May 20 - May 25

found 1 day ago

Roundtrip non-stop flight included

Boston (BOS) to Florence (FLR)

7.6/10 Good! (1,000 reviews)

Smaller room then expected and shower did flood the floor so not the best of showers. Bed very comfortable Nice friendly & helpful staff and perfect location to explore the city.

Reviewed on Feb 22, 2026

![Eurostars Florence Boutique](https://images.trvl-media.com/lodging/2000000/1170000/1167000/1166901/88283612_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Eurostars Florence Boutique

Historic Centre of Florence

Save 100% on your flight

$1,269

per person

Apr 22 - Apr 28

found 1 day ago

Roundtrip non-stop flight included

Boston (BOS) to Florence (FLR)

8.6/10 Excellent! (483 reviews)

The room was clean and the staff very accommodating. The breakfast was quite sufficient and had a good variety. The location is great. It's a short walk from the square, shopping and from restaurants.

Reviewed on Dec 13, 2025

![Aurum Firenze](https://images.trvl-media.com/lodging/29000000/28970000/28962000/28961941/26fd50f1_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Aurum Firenze

Historic Centre of Florence

$1,190

per person

May 20 - May 25

found 1 day ago

Roundtrip non-stop flight included

Boston (BOS) to Florence (FLR)

7.6/10 Good! (1,002 reviews)

It was near the train and next to awesome places. The view if you get a balcony is so cute and peaceful

Reviewed on Feb 28, 2026

![Relais Uffizi, Tailor made Hotel](https://images.trvl-media.com/lodging/3000000/2550000/2542800/2542717/3e59e5ae_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Relais Uffizi, Tailor made Hotel

Historic Centre of Florence

Save 100% on your flight

$2,334

per person

May 20 - May 25

found 1 day ago

Roundtrip non-stop flight included

Boston (BOS) to Florence (FLR)

9.4/10 Exceptional! (120 reviews)

The room was stunning, it was large, the bed was comfy and the design was unique. Staff were very friendly and helpful.

Reviewed on Feb 26, 2026

![Hotel La Scaletta Al Ponte Vecchio](https://images.trvl-media.com/lodging/2000000/1610000/1604300/1604285/d1c916cb_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Hotel La Scaletta Al Ponte Vecchio

Historic Centre of Florence

Save 100% on your flight

$1,892

per person

May 20 - May 25

found 1 day ago

Roundtrip non-stop flight included

Boston (BOS) to Florence (FLR)

8.8/10 Excellent! (965 reviews)

The staff at breakfast prepare plain scrambled eggs for our 7 month old son and were very sweet! This our second time staying here and we absolutely love the hotel. Location, views, comfort. 10/10!

Reviewed on Feb 28, 2026

## Where to stay in Santissima Annunziata

Find the best Santissima Annunziata areas and neighborhoods for the activities you enjoy most. [Learn more about Santissima Annunziata](https://expedia.com/Florence-Santissima-Annunziata.dx6084890)

![Arcetri showing a bridge and a river or creek](https://images.trvl-media.com/place/6075434/96ba5e7b-ca43-4d9f-9921-bde07164fcbc.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### Historic Centre of Florence

10 out of top 10 points of interest in this area

 Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias. 

[Find hotel + flight trips in Historic Centre of Florence](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Historic%20Centre%20of%20Florence&DestID=6141938&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

![Duomo featuring heritage architecture and street scenes as well as a small group of people](https://images.trvl-media.com/place/6141938/4816fa4b-dceb-4db3-bc3d-7fd0a5eb8789.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### Duomo

5/5(2,214 area reviews)

 Framed by a magnificent cathedral and charming streets lined with churches and restaurants, this neighborhood rests at the very heart of Florence. 

[Find hotel + flight trips in Duomo](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Duomo&DestID=6084346&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

![Ponte Vecchio showing a bridge and a river or creek](https://images.trvl-media.com/place/6075434/7c194037-41c2-40fb-a601-3da01105de7b.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### San Giovanni

 If you're spending some time in San Giovanni, Cathedral of Santa Maria del Fiore and Piazza della Repubblica are top sights worth seeing. 

[Find hotel + flight trips in San Giovanni](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=San%20Giovanni&DestID=553248635976383065&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

![Santa Maria Novella which includes heritage architecture, a church or cathedral and street scenes](https://images.trvl-media.com/place/6084343/def994ac-70f7-40cd-89a8-ec519f783ac9.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### Santa Maria Novella

4.5/5(1,057 area reviews)

 Spend some time in an attractive neighborhood close to the city center that encompasses ancient buildings and churches and a large park of outstanding beauty. 

[Find hotel + flight trips in Santa Maria Novella](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Santa%20Maria%20Novella&DestID=6084343&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

![Piazza Santa Croce showing a city and street scenes](https://images.trvl-media.com/place/6248194/236c34a1-6c95-481e-b9b8-957b594360cd.jpg?impolicy=fcrop&w=350&h=192&q=medium)

### Santa Croce

4.5/5(211 area reviews)

 One of the historic districts of Florence has a network of medieval streets lined with opulent churches, leather stores, markets and atmospheric restaurants. 

[Find hotel + flight trips in Santa Croce](https://expedia.com/go/package/search/FlightHotel/?FromAirport=Downtown%20Columbus,%20Columbus,%20Ohio,%20United%20States%20of%20America&Destination=Santa%20Croce&DestID=6084344&DaysInFuture=30&StayLength=7&rfrr=TG.LP.Dest.PKG.Neighborhoods)

## Santissima Annunziata Hotel Deals

![Forte16 View & Spa](https://images.trvl-media.com/lodging/9000000/8080000/8071800/8071708/a7fcea2f_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Forte16 View & Spa

Viale Antonio Gramsci 16 Florence FI

Fully refundableReserve now, pay when you stay

$116 nightly

$142 total

Mar 9 - Mar 10

Total with taxes and fees

9.6/10 Exceptional! (920 reviews)

Great staff

Reviewed on Feb 27, 2026

[](https://expedia.com/Hotel-Search?startDate=3%2F9%2F2026&endDate=3%2F10%2F2026&selected=8071708&PinnedHotelID=8071708&HadPinnedHotel=true&regionId=6084890)

![Four Seasons Hotel Firenze](https://images.trvl-media.com/lodging/2000000/1840000/1838800/1838796/e43ee04b_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Four Seasons Hotel Firenze

Borgo Pinti, 99 Florence FI

Fully refundableReserve now, pay when you stay

$865 nightly

$971 total

Mar 10 - Mar 11

Total with taxes and fees

9.8/10 Exceptional! (297 reviews)

Very beautiful hotel and gardens with gracious staff.

Reviewed on Feb 9, 2026

[](https://expedia.com/Hotel-Search?startDate=3%2F10%2F2026&endDate=3%2F11%2F2026&selected=1838796&PinnedHotelID=1838796&HadPinnedHotel=true&regionId=6084890)

![Hotel Astro Mediceo](https://images.trvl-media.com/lodging/11000000/10370000/10361100/10361025/a75744f5_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Hotel Astro Mediceo

Via Frà Bartolommeo 54/56 Florence FI

Fully refundableReserve now, pay when you stay

[Get rates](https://expedia.com/Hotel-Search?startDate=3%2F17%2F2026&endDate=3%2F18%2F2026&selected=10361025&PinnedHotelID=10361025&HadPinnedHotel=true&regionId=6084890)

[](https://expedia.com/Hotel-Search?startDate=3%2F17%2F2026&endDate=3%2F18%2F2026&selected=10361025&PinnedHotelID=10361025&HadPinnedHotel=true&regionId=6084890)

[See all 485 properties in Santissima Annunziata](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=3%2F4%2F2026&endDate=3%2F5%2F2026&regionId=6084890)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

All Inclusive Vacations

[](https://expedia.com/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Beach Vacations

[](https://expedia.com/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Kid Friendly Vacations

[](https://expedia.com/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Kid_Friendly%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Golf Vacations

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![](https://forever.travel-assets.com/flex/flexmanager/images/2022/07/15/US_Luxury_VR_Miami.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Luxury Vacations

[](https://expedia.com/lp/theme-vacations/luxury-vacations?rfrr=editorial.Luxury_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/29/romantic.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Romantic Vacations

[](https://expedia.com/lp/theme-vacations/romantic-vacations?rfrr=editorial.Romantic_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/31952_v1_atfraraski22_insta_4.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Ski Vacations

[](https://expedia.com/lp/theme-vacations/ski-vacations?rfrr=editorial.Ski_Vacations.click)

![Gay Friendly Vacations](https://forever.travel-assets.com/flex/flexmanager/images/2023/06/15/LGBTQIA_Holiday_Package.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

LGBTQ Friendly Vacations

[](https://expedia.com/lp/theme-holidays/gay-friendly-holidays?rfrr=editorial.LGBTQ_Friendly%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2017/07/05/170615_Adventure_1320_2.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Adventure Vacations

[](https://expedia.com/lp/theme-vacations/adventure-vacations?rfrr=editorial.Adventure_Vacations.click)

![Vacations in Month](https://forever.travel-assets.com/flex/flexmanager/images/2023/05/10/mesog-34434-card-venice.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Where to go when

[](https://expedia.com/lp/b/where-to-go-when?rfrr=editorial.Where_to%20go%20when.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/21/honeymoon_hawaii.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Honeymoon Vacations

[](https://expedia.com/lp/theme-vacations/honeymoon-vacations?rfrr=editorial.Honeymoon_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/Mountain-vacations.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Mountain Vacations

[](https://expedia.com/lp/theme-vacations/mountain-vacations?rfrr=editorial.Mountain_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/fishing-vacations-2.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Fishing Vacations

[](https://expedia.com/lp/theme-vacations/fishing-vacations?rfrr=editorial.Fishing_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2019/05/16/Hyatt%20Zilara%20Cancun%20-%20All%20Inclusive%20-%20Adults%20Only.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Adults Only Vacations

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![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/waterpark-vacations.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Waterpark Vacations

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![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/08/Caribean_scuba_diving.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Scuba Diving Vacations

[](https://expedia.com/lp/theme-vacations/scuba-diving-vacations?rfrr=editorial.Scuba_Diving%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/08/aruba_yoga.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Yoga Vacations

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![](https://forever.travel-assets.com/flex/flexmanager/images/2023/04/04/EPS-RBC-SummerBeachVacations-AdobeStock_206356322.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Cheap Vacations

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![](https://forever.travel-assets.com/flex/flexmanager/images/2024/06/26/1175883311.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Solo Vacations

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### Discover the most popular places to visit in Santissima Annunziata

![Accademia Gallery which includes street scenes as well as a large group of people](https://images.trvl-media.com/place/501039/e4494d76-dd66-4788-b81e-a1f57271c5a8.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Gallery of the Academy of Florence

4.5/5(1,097 reviews)

Michelangelo’s David statue is the impressive star of the show at one of Florence’s most popular and well-attended art museums.

[](https://expedia.com/Gallery-Of-The-Academy-Of-Florence-Historic-Centre-of-Florence.d501039.Vacation-Attraction)

![0_BXP44952](https://images.trvl-media.com/place/553248621532501825/3e6487aa-aa39-423a-9f07-18a0493c6de6.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Statue of David

5/5(370 reviews)

You can learn about the history of Florence with a stop at Statue of David. Experience the fascinating museums and acclaimed art scene in this vibrant area. 

[](https://expedia.com/Statue-Of-David-Historic-Centre-of-Florence.d553248621532501825.Vacation-Attraction)

![Province of Florence featuring street scenes, a square or plaza and a statue or sculpture](https://images.trvl-media.com/place/179893/52657877-1033-47c5-8f22-0a8b6b0d8389.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Santissima Annunziata Square

5/5(2 reviews)

Find out about the history of Florence when you spend time at Santissima Annunziata Square. Experience the fascinating museums and acclaimed art scene in this vibrant area. 

[](https://expedia.com/Santissima-Annunziata-Square-Historic-Centre-of-Florence.d6160187.Vacation-Attraction)

### Things to do

![Skip-the-Line Duomo: Priority-Access 30-Minute Guided Tour](https://mediaim.expedia.com/localexpert/507532/cbdef260-9919-420e-a482-1d2f9b3d6ccc.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Skip-the-Line Florence Duomo: Priority-Access Express Guided Tour

$26

per adult

**80%** of travellers recommend

[](https://expedia.com/things-to-do/skip-the-line-florence-duomo-priority-access-express-guided-tour.a507532.activity-details)

![Micheal Angelo's David](https://mediaim.expedia.com/localexpert/2479829/2bebb71d-abeb-452a-9a00-2b6fddf3b233.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Skip the Line: Florence's Accademia Gallery Priority Entrance Ticket

$37

per adult

**86%** of travellers recommend

[](https://expedia.com/things-to-do/skip-the-line-florences-accademia-gallery-priority-entrance-ticket.a2479829.activity-details)

![Tuscany Experience In Pisa, Siena, San Gimignano & Chianti](https://mediaim.expedia.com/localexpert/880286/269c0081-b51e-4e1d-ac21-b19cf125da10.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Tuscany Experience In Pisa, Siena, San Gimignano & Chianti

$101

per adult

**92%** of travellers recommend

[](https://expedia.com/things-to-do/tuscany-experience-in-pisa.a880286.activity-details)

[See all activities in Florence](https://expedia.com/things-to-do/search?rid=6084890)

\* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.