Santo Tomas Vacations from $617

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Your Santo Tomas Vacation

Entertainment, food, art and more … There's a whole lot to discover with a Santo Tomas vacation package. And with the ability to easily customize your city break, it's guaranteed to be one that's hard to forget. If your trip to Santo Tomas includes some sightseeing, hit up well-known attractions like Zócalo, Angel of Independence Monument and Basilica of Our Lady of Guadalupe. Expedia will help you escape your daily routine. Tailor your vacation to Santo Tomas to match your travel style, whatever that may look like.

The Latest Santo Tomas Vacation Packages

Price found within the past 48 hours. Click for updated prices.

Hotel & Suites PF

Reforma

Save 100% on your flight

$617

per person

Oct 23 - Oct 30

found 1 day ago

Roundtrip flight included

Dallas (DFW) to Mexico City (MEX)

8.6/10 Excellent! (2,380 reviews)

Todo excelente, ubicación, servicios, todo me encantó de este hotel

Reviewed on Aug 21, 2026

Hacienda Peña Pobre

Tlalpan

$649

per person

Oct 13 - Oct 20

found 1 day ago

Roundtrip flight included

Dallas (DFW) to Mexico City (MEX)

9.6/10 Exceptional! (824 reviews)

The hacienda and staff were exceptional and made my stay in Mexico City extra special. The staff were extremely kind and welcoming (thank you!). The property was charming with a lovely, comfortable and clean room. The garden/sitting area outside was a calm place to relax, read and do a little work. There was a shopping area nearby, but for me the park/natural area near the hacienda was a relaxing place to walk during my stay. This is a particularly nice place to stay for anyone visiting UNAM main campus.

Reviewed on Aug 21, 2026

Hotel Misión Grand Valle De Bravo

$717

per person

Nov 8 - Nov 14

found 1 day ago

Roundtrip flight included

Tijuana (TIJ) to Mexico City (MEX)

8.6/10 Excellent! (1,006 reviews)

Love the hotel. The scenery is beautiful, the river and the waterfalls. Food delicious.

Reviewed on Aug 7, 2026

El Santuario Resort & Spa

$709

per person

Nov 8 - Nov 14

found 1 day ago

Roundtrip flight included

Tijuana (TIJ) to Mexico City (MEX)

8.4/10 Very Good! (978 reviews)

Fantastic lake view

Reviewed on Aug 12, 2026

Marquis Sky Suites

Reforma

$872

per person

Nov 4 - Nov 8

found 1 day ago

Roundtrip non-stop flight included

Los Angeles (LAX) to Mexico City (MEX)

9.2/10 Wonderful! (52 reviews)

The hotel was well located I. The centre of Mexico making it easy to use as a base for local excursions. There was a cliche to start as we had asked for a vegan breakfast and it was limiting - we asked for avocados as there was no real choice and the staff were looking to charge us. I was unimpressed. The 2 nd day the manager had shared it was okay and would provide us with gluten free bread and avocado which was great The spa was lovely and gym had more than enough equipment. Was a great hotel.

Reviewed on Jul 27, 2026

Where to stay in Santo Tomas

Find the best Santo Tomas areas and neighborhoods for the activities you enjoy most. Learn more about Santo Tomas

An aerial view of a city with a central circular plaza, surrounded by buildings and trees.

Roma Norte

Known for its fascinating museums and popular shops, there's plenty to explore in Roma Norte. Check out top attractions like Avenida Insurgentes and MUCA Roma, and jump on the metro at Insurgentes Station or Sevilla Station to see more of the city.

A large stone church with a central dome and arched entrance.

Polanco

Luxury shopping along Presidente Masaryk Avenue and upscale restaurants await, while nearby Chapultepec Park houses the National Museum of Anthropology and other cultural institutions. Enjoy a stroll in Parque Lincoln or explore Polanquito's vibrant dining scene.

A yellow building with a sign reading "El Jolgorio."

La Condesa

Fashionable and popular with young professionals, Condesa boasts international restaurants, bars, and nightclubs. Stroll along tree-lined avenues, admire Art Deco architecture, and visit landmarks like Edificio San Martín and Basurto Building.

A historic church with intricate architecture and a bell tower.

Historic Center

2 out of top 10 points of interest in this area

Historic center with 1,550 significant buildings, the neighborhood offers museums like MUNAL and Palacio de Bellas Artes. Enjoy upscale eateries, fashionable stores, and pedestrianized streets for easy exploration.

A city street at dusk with illuminated buildings, palm trees, and vehicles with light trails.

Reforma

1 out of top 10 points of interest in this area

Consider a visit to Angel of Independence Monument and take some time to enjoy the important monuments during your time in Reforma. If you want to see more of the city, jump on the metro at Insurgentes Station or Cuauhtemoc Station.

Santo Tomas Hotel Deals

Camino Real Aeropuerto Mexico

Mexico City

Fully refundable

$139 nightly

$167 total

Sep 14 - Sep 15

Total with taxes and fees

8.8/10 Excellent! (13,856 reviews)

"Bueno"

Reviewed on Aug 23, 2026

Fiesta Americana Reforma

Paseo De La Reforma 80 Mexico City CDMX

Fully refundableReserve now, pay when you stay

$92 nightly

$110 total

Sep 13 - Sep 14

Total with taxes and fees

Hotel Zócalo Central

Cinco de Mayo 61 Mexico City

Fully refundableReserve now, pay when you stay

$123 nightly

$152 total

Sep 7 - Sep 8

Total with taxes and fees

9.8/10 Exceptional! (2,875 reviews)

"Excellent service"

Reviewed on Aug 23, 2026

See all 5,736 properties in Santo Tomas

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.