Santo Tomas Vacations from $374

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Your Santo Tomas Vacation

Entertainment, food, art and more … There's a whole lot to discover with a Santo Tomas vacation package. And with the ability to easily customize your city break, it's guaranteed to be one that's hard to forget. If your trip to Santo Tomas includes some sightseeing, hit up well-known attractions like Zócalo, Angel of Independence Monument and Basilica of Our Lady of Guadalupe. Expedia will help you escape your daily routine. Tailor your vacation to Santo Tomas to match your travel style, whatever that may look like.

The Latest Santo Tomas Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hotel Ilebal Cuernavaca Centro - un lugar con encanto

Hotel Ilebal Cuernavaca Centro - un lugar con encanto

3 out of 5
Save 100% on your flight
Price was $638, price is now $374 per person
$374
per person
Feb 28 - Mar 7
found 1 day ago
Roundtrip flight included
Tijuana (TIJ) to Mexico City (MEX)
8.4/10 Very Good! (497 reviews)
It is a very nice place, but it really needs maintenance. The pool has a lot of tiles missing, there is no food service of any type, not even ice after 300pm. There is a lot of noise coming from the pool machines from the hotel above them.

Reviewed on Dec 1, 2025

Hacienda Peña Pobre

Hacienda Peña Pobre

4 out of 5
Tlalpan
Save 100% on your flight
Price was $1,846, price is now $951 per person
$951
per person
Feb 19 - Feb 26
found 1 day ago
Roundtrip non-stop flight included
New York (JFK) to Mexico City (MEX)
9.6/10 Exceptional! (665 reviews)
Beautiful small hotel

Reviewed on Dec 1, 2025

Casa de la Luz Hotel Boutique

Casa de la Luz Hotel Boutique

4 out of 5
Historic Center
Save 100% on your flight
Price was $1,422, price is now $816 per person
$816
per person
Mar 19 - Mar 22
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Mexico City (MEX)
9.6/10 Exceptional! (428 reviews)
What a beautiful boutique hotel in an Unbelievable location. A 600 year old historic building only 2 blocks from the Zocolo. Renovated perfectly with old school charm and modern amenities. The on site restaurant is fabulous. We ate there twice on a four night stay. Simply put this place is a cannot miss if you can find availability, few rooms. Worth every minute.

Reviewed on Jan 15, 2026

Andaz Condesa Mexico City, By Hyatt

Andaz Condesa Mexico City, By Hyatt

5 out of 5
La Condesa
Save 100% on your flight
Price was $1,960, price is now $1,143 per person
$1,143
per person
Apr 12 - Apr 18
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Mexico City (MEX)
9/10 Wonderful! (294 reviews)
Great location and general facilities. The area was quiet despite being in the middle of everything. The room was small but well laid out and equipped. There was black mold around the sink. The room was over the bar so music which was not overly loud but could be heard all evening. The noise from other rooms was a bit loud both overhead, beside and the hallway.

Reviewed on Jan 14, 2026

Alteza Polanco

Alteza Polanco

4 out of 5
Polanco
Save 100% on your flight
Price was $1,756, price is now $1,035 per person
$1,035
per person
Apr 12 - Apr 18
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Mexico City (MEX)
8.6/10 Excellent! (625 reviews)
Habitaciones limpias y en perfecto estado

Reviewed on Jan 2, 2026

Where to stay in Santo Tomas

Find the best Santo Tomas areas and neighborhoods for the activities you enjoy most. Learn more about Santo Tomas
A bus parked at the plaza. I hear the art work on it is continuously evolving and in the past it has been filled with cotton candy.

Roma Norte

Known for its fascinating museums and popular shops, there's plenty to explore in Roma Norte. Check out top attractions like MUCA Roma and Centro Cultural El Punto, and jump on the metro at Insurgentes Station or Sevilla Station to see more of the city.

Find hotels in Roma Norte

Santo Tomas Hotel Deals

Fiesta Americana Reforma

Fiesta Americana Reforma

4 out of 5
Paseo De La Reforma 80 Mexico City CDMX
Fully refundableReserve now, pay when you stay
$115 nightly
The price is $137 total per night from Feb 8 to Feb 9
$137 total
Feb 8 - Feb 9
Total with taxes and fees
9.2/10 Wonderful! (4,220 reviews)
Very pleased with hotel

Reviewed on Jan 14, 2026

Fiesta Americana Reforma
Hyatt Regency Mexico City

Hyatt Regency Mexico City

5 out of 5
Campos Eliseos No. 204 Polanco Mexico City
Fully refundableReserve now, pay when you stay
$261 nightly
The price is $312 total per night from Feb 1 to Feb 2
$312 total
Feb 1 - Feb 2
Total with taxes and fees
9.4/10 Exceptional! (1,375 reviews)
I have paid 100$ per a day for better room

Reviewed on Jan 16, 2026

Hyatt Regency Mexico City
Camino Real Aeropuerto Mexico

Camino Real Aeropuerto Mexico

4 out of 5
Mexico City
Fully refundable
$127 nightly
The price is $152 total per night from Feb 5 to Feb 6
$152 total
Feb 5 - Feb 6
Total with taxes and fees
8.6/10 Excellent! (12,035 reviews)
Much nicer room. Food was good at the bar. Staff were much more engaged

Reviewed on Jan 19, 2026

Camino Real Aeropuerto Mexico
See all 6,376 properties in Santo Tomas
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
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Beach Vacations
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Discover the most popular places to visit in Santo Tomas

Reforma which includes a high rise building, a park and a city

Paseo de la Reforma

Like the Champs Elysées in Paris, this famous wide avenue provides a distinctive elegance to the historic plan of this huge global city.

Paseo de la Reforma
Basilica of Our Lady of Guadalupe showing a square or plaza, religious aspects and a church or cathedral

Basilica of Our Lady of Guadalupe

Mexico’s patron saint, the Virgin of Guadalupe, is believed to have appeared on the site of this church, making it an important pilgrimage site for many Catholics.

Basilica of Our Lady of Guadalupe
Zócalo featuring heritage architecture, a city and night scenes

Zócalo

This is the heart of Mexico City with wide-ranging architecture, cultural events and a lively arts scene.

Zócalo

Things to do

Ticket to Chapultepec Castle

Chapultepec Castle Ticket

$29
per adult
92% of travellers recommend
Chapultepec Castle Ticket
Frida Kahlo & Anahuacalli Museum ticket

Frida Kahlo Museum Skip-the-line Tickets with Digital Guide

$45
per adult
84% of travellers recommend
Frida Kahlo Museum Skip-the-line Tickets with Digital Guide
See all activities in Mexico City

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