Santo Tomas Vacations from $815
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Your Santo Tomas Vacation
Entertainment, food, art and more … There's a whole lot to discover with a Santo Tomas vacation package. And with the ability to easily customize your city break, it's guaranteed to be one that's hard to forget. If your trip to Santo Tomas includes some sightseeing, hit up well-known attractions like Zócalo, Angel of Independence Monument and Basilica of Our Lady of Guadalupe. Expedia will help you escape your daily routine. Tailor your vacation to Santo Tomas to match your travel style, whatever that may look like.
The Latest Santo Tomas Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Casa Decu
La Condesa
Save 100% on your flight
Price was $1,551, price is now $815 per person
$815
per person
Jan 25 - Jan 31
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Mexico City (MEX)
9.4/10 Exceptional! (790 reviews)
Casa Decu was the perfect home base for my trip to Mexico City. The location couldn’t be better—right in the heart of La Condesa, surrounded by beautiful tree-lined streets, great restaurants, cafés, and parks. It’s the ideal spot for exploring the city on foot while still feeling tucked away in a calm, stylish neighborhood.
The rooftop patio was truly a highlight. It’s beautifully designed, peaceful, and the perfect place to start the day with breakfast or wind down in the evening. The views over Condesa are charming, and the space feels both upscale and welcoming.
What really sets Casa Decu apart is the staff. Everyone I encountered was warm, attentive, and genuinely eager to help. Whether it was offering local recommendations, arranging transportation, or assisting with small requests, they made the stay feel effortless and personal.
Casa Decu combines boutique charm, an unbeatable location, and exceptional service. I wouldn’t hesitate to stay here again and highly recommend it to anyone visiting Mexico City.
Reviewed on Dec 3, 2025
Hotel Avandaro Golf And Spa
Avandaro
Save 100% on your flight
Price was $2,724, price is now $1,397 per person
$1,397
per person
Jan 9 - Jan 15
found 4 hours ago
Roundtrip non-stop flight included
New York (NYC) to Toluca (TLC)
8.6/10 Excellent! (1,000 reviews)
Nuggets breakfast was amazing
Reviewed on Oct 12, 2025
Casa de la Luz Hotel Boutique
Historic Center
Save 100% on your flight
Price was $1,784, price is now $920 per person
$920
per person
Jan 8 - Jan 12
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Mexico City (MEX)
9.6/10 Exceptional! (428 reviews)
Room was amazing! The hotel staff was so gracious.
Reviewed on Nov 30, 2025
Gran Hotel Ciudad de Mexico Zocalo View
Historic Center
Save 100% on your flight
Price was $2,552, price is now $1,422 per person
$1,422
per person
Feb 15 - Feb 21
found 1 day ago
Roundtrip non-stop flight included
Burbank (BUR) to Mexico City (MEX)
9.6/10 Exceptional! (1,075 reviews)
Best thing was the view in and out! Great experience
Reviewed on Dec 3, 2025
HOTEL LUCA
Roma Norte
Save 100% on your flight
Price was $2,029, price is now $1,145 per person
$1,145
per person
Feb 15 - Feb 21
found 1 day ago
Roundtrip non-stop flight included
Burbank (BUR) to Mexico City (MEX)
9.2/10 Wonderful! (301 reviews)
Great location, spotless large room; outstanding cleaning staff, great breakfast on roof patio with fantastic staff.
Reviewed on Dec 3, 2025
Where to stay in Santo Tomas
Find the best Santo Tomas areas and neighborhoods for the activities you enjoy most. Learn more about Santo Tomas
Roma Norte
Known for its fascinating museums and popular shops, there's plenty to explore in Roma Norte. Check out top attractions like Avenida Insurgentes and MUCA Roma, and jump on the metro at Insurgentes Station or Sevilla Station to see more of the city.
Santo Tomas Hotel Deals
Camino Real Aeropuerto Mexico
Mexico City
Fully refundable
$132 nightly
The price is $158 total per night from Dec 29 to Dec 30
$158 total
Dec 29 - Dec 30
Total with taxes and fees
8.6/10 Excellent! (11,799 reviews)
I liked everything
Reviewed on Dec 4, 2025
Barceló México Reforma
Paseo De La Reforma 1 Mexico City
Fully refundableReserve now, pay when you stay
$123 nightly
The price is $146 total per night from Jan 5 to Jan 6
$146 total
Jan 5 - Jan 6, 2026
Total with taxes and fees
9.2/10 Wonderful! (5,055 reviews)
What I like the most about this property is that the staff was friendly, knowledgeable, caring, respectful, prompt and respectful.
Reviewed on Nov 29, 2025
Galeria Plaza Reforma
Mexico City CDMX
Fully refundableReserve now, pay when you stay
$156 nightly
The price is $186 total per night from Dec 15 to Dec 16
$186 total
Dec 15 - Dec 16
Total with taxes and fees
9.2/10 Wonderful! (3,171 reviews)
El Hotel está muy bien ubicado! El personal muy amable. Solo necesitan mejorar con la limpieza un poco.
Reviewed on Nov 30, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Santo Tomas
Paseo de la Reforma
Like the Champs Elysées in Paris, this famous wide avenue provides a distinctive elegance to the historic plan of this huge global city.
Angel of Independence Monument
Gaze upon this tall and majestic structure that symbolizes for the whole nation’s citizens the country’s long struggle for independence.
Basilica of Our Lady of Guadalupe
Mexico’s patron saint, the Virgin of Guadalupe, is believed to have appeared on the site of this church, making it an important pilgrimage site for many Catholics.
Things to do
Frida Kahlo Museum Skip-the-line Tickets with Digital Guide
$45
per adult
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.