Santo Tomas Vacations from $525

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Your Santo Tomas Vacation

Entertainment, food, art and more … There's a whole lot to discover with a Santo Tomas vacation package. And with the ability to easily customize your city break, it's guaranteed to be one that's hard to forget. If your trip to Santo Tomas includes some sightseeing, hit up well-known attractions like Zócalo, Angel of Independence Monument and Basilica of Our Lady of Guadalupe. Expedia will help you escape your daily routine. Tailor your vacation to Santo Tomas to match your travel style, whatever that may look like.

The Latest Santo Tomas Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hotel Del Prado

Hotel Del Prado

3 out of 5
Miguel Hidalgo
Price was $877, price is now $525 per person
$525
per person
Jan 7 - Jan 11
found 1 day ago
Roundtrip non-stop flight included
New York (NYC) to Mexico City (MEX)
8.2/10 Very Good! (814 reviews)
The property is old, which I knew, but the rooms have not been renovated in a while. The room space is very good. the staff did not allowed me to check in early even when there were rooms available, the reason was because I reserved in Expedia and not directly in the hotel...

Reviewed on Sep 14, 2025

Casa de la Luz Hotel Boutique

Casa de la Luz Hotel Boutique

4 out of 5
Historic Center
Save 100% on your flight
Price was $2,334, price is now $1,270 per person
$1,270
per person
Jan 24 - Jan 30
found 1 day ago
Roundtrip non-stop flight included
Burbank (BUR) to Mexico City (MEX)
9.6/10 Exceptional! (413 reviews)
Everything was wonderful. Beautiful room, excellent service, centrally located to major attractions. We walked from the hotel to the Basilica and all the other major attractions around there. Our welcome drink awaited us upstairs in the terrace restaurant. Food was excellent. Will def return back for a longer stay!

Reviewed on Nov 3, 2025

Vuestro Hotel Boutique

Vuestro Hotel Boutique

3.5 out of 5
Reforma
Save 100% on your flight
Price was $1,435, price is now $841 per person
$841
per person
Jan 12 - Jan 19
found 1 day ago
Roundtrip flight included
Chicago (CHI) to Mexico City (MEX)
9.6/10 Exceptional! (172 reviews)
No formal greeting upon arrival. Did not offer any assistance with a map, sites around the city, etc. Ask about noise level in the room assigned, told it would be very quiet. But turned out our room was on the first floor in front of the street and right across is a bar that plays music all through the night with very noisy customers right outside the establishment. Our room had water leakage in the bathroom, told the front desk, but did not offer any change to a different room. It looks like a nice and new property but it seems that the renovation was subpar. The room next to us already has water damage on the wall next to our room; noticed that when housekeeping was cleaning the room. Also, housekeeping is hit or miss, several days, did not refill the complimentary water bottles even though they were empty. Same goes for the coffee pods and toilet paper. All and all, for that price point, I expect more from this hotel. Very disappointed.

Reviewed on Oct 18, 2025

Colima 71 Casa de Arte Hotel

Colima 71 Casa de Arte Hotel

3 out of 5
Roma Norte
Save 100% on your flight
Price was $3,226, price is now $1,949 per person
$1,949
per person
Jan 8 - Jan 15
found 14 hours ago
Roundtrip non-stop flight included
Chicago (CHI) to Mexico City (MEX)
10/10 Exceptional! (37 reviews)
Liked the hotel a lot and our room was very large

Reviewed on Oct 28, 2025

Reforma Guest House

Reforma Guest House

3.5 out of 5
Reforma
Save 100% on your flight
Price was $1,286, price is now $779 per person
$779
per person
Jan 27 - Feb 2
found 1 day ago
Roundtrip non-stop flight included
Los Angeles (LAX) to Mexico City (MEX)
9.2/10 Wonderful! (156 reviews)
Excelente atención, muy buena ubicación, muy limpio y agradable. Cumple con lo que ofrece en la descripción del lugar.

Reviewed on Jul 30, 2025

Where to stay in Santo Tomas

Find the best Santo Tomas areas and neighborhoods for the activities you enjoy most. Learn more about Santo Tomas
Polanco featuring a church or cathedral, a park and heritage architecture

Polanco

4.5/5(491 area reviews)

Luxury shopping along Presidente Masaryk Avenue and upscale restaurants await, while nearby Chapultepec Park houses the National Museum of Anthropology and other cultural institutions. Enjoy a stroll in Parque Lincoln or explore Polanquito's vibrant dining scene.

Find hotels in Polanco

Santo Tomas Hotel Deals

Camino Real Aeropuerto Mexico

Camino Real Aeropuerto Mexico

4 out of 5
Mexico City
Fully refundable
$127 nightly
The price is $152 total per night from Dec 7 to Dec 8
$152 total
Dec 7 - Dec 8
Total with taxes and fees
8.6/10 Excellent! (11,614 reviews)
It was a very late arrival/check-in. Reception was very professional, personable and efficient. I don’t think it took more than 4 minutes from entering the hotel to arriving to my room. The room was a nice surprise… a big upgrade from what I had booked. I’m a regular client at this hotel as it’s ...

Reviewed on Nov 4, 2025

Camino Real Aeropuerto Mexico
Fiesta Americana Reforma

Fiesta Americana Reforma

4 out of 5
Paseo De La Reforma 80, Col. Juarez, Mexico City, CDMX
Fully refundableReserve now, pay when you stay
$123 nightly
The price is $149 total per night from Dec 6 to Dec 7
$149 total
Dec 6 - Dec 7
Total with taxes and fees
9.2/10 Wonderful! (3,908 reviews)
Perfect place to stay stuff super nice and friendly

Reviewed on Nov 4, 2025

Fiesta Americana Reforma
Galeria Plaza Reforma

Galeria Plaza Reforma

4 out of 5
Mexico City
Fully refundableReserve now, pay when you stay
$116 nightly
The price is $138 total per night from Dec 7 to Dec 8
$138 total
Dec 7 - Dec 8
Total with taxes and fees
9.2/10 Wonderful! (3,138 reviews)
Beautiful hotel to stay on the city

Reviewed on Nov 3, 2025

Galeria Plaza Reforma
See all 5,956 properties in Santo Tomas
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Discover the most popular places to visit in Santo Tomas

Reforma which includes a high rise building, a park and a city

Paseo de la Reforma

4.5/5(945 reviews)

Like the Champs Elysées in Paris, this famous wide avenue provides a distinctive elegance to the historic plan of this huge global city.

Paseo de la Reforma
Zócalo featuring heritage architecture, a city and night scenes

Zócalo

4.5/5(2,390 reviews)

This is the heart of Mexico City with wide-ranging architecture, cultural events and a lively arts scene.

Zócalo
Basilica of Our Lady of Guadalupe showing a square or plaza, religious aspects and a church or cathedral

Basilica of Our Lady of Guadalupe

4.5/5(1,720 reviews)

Mexico’s patron saint, the Virgin of Guadalupe, is believed to have appeared on the site of this church, making it an important pilgrimage site for many Catholics.

Basilica of Our Lady of Guadalupe

Things to do

Ticket to Chapultepec Castle

Chapultepec Castle Ticket

$10
per adult
90% of travellers recommend
Chapultepec Castle Ticket
Historic Downtown Walking Tour

Historic Downtown Walking Tour

$33
per adult
98% of travellers recommend
Historic Downtown Walking Tour
Ebike Tour, Boat and Cable car -Land, Sea & Air Small Group

360o Barcelona eBike with Montjuic Cable Car & Boat Ride - Small Group

$140
per adult
92% of travellers recommend
360o Barcelona eBike with Montjuic Cable Car & Boat Ride - Small Group
See all activities in Mexico City

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.