Santo Tomas Vacations from $767
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Your Santo Tomas Vacation
Entertainment, food, art and more … There's a whole lot to discover with a Santo Tomas vacation package. And with the ability to easily customize your city break, it's guaranteed to be one that's hard to forget. If your trip to Santo Tomas includes some sightseeing, hit up well-known attractions like Zócalo, Angel of Independence Monument and Basilica of Our Lady of Guadalupe. Expedia will help you escape your daily routine. Tailor your vacation to Santo Tomas to match your travel style, whatever that may look like.
The Latest Santo Tomas Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Reforma Guest House
Reforma
Price was $1,398, price is now $767 per person
$767
per person
Jan 16 - Jan 23
found 1 day ago
Roundtrip flight included
Dallas (DFW) to Mexico City (MEX)
9.4/10 Exceptional! (187 reviews)
Super seguro y en una excelente area para caminar y muchos restaurantes muy bonitos
Reviewed on Oct 2, 2026
Roma Nueve Dos Hotel Boutique
Roma Norte
Price was $3,161, price is now $1,538 per person
$1,538
per person
Jan 16 - Jan 23
found 1 day ago
Roundtrip flight included
Dallas (DFW) to Mexico City (MEX)
9.6/10 Exceptional! (39 reviews)
Everything was wonderful. The staff was lovely, the room beautiful, and the rooftop bar had great drinks. The location is very central and walkable.
Reviewed on Oct 26, 2026
Colima 71 Casa de Arte Hotel
Roma Norte
Price was $4,304, price is now $2,338 per person
$2,338
per person
Jan 16 - Jan 23
found 1 day ago
Roundtrip flight included
Dallas (DFW) to Mexico City (MEX)
9.8/10 Exceptional! (53 reviews)
Superb.
One of the best (if not the best) boutique hotels I’ve ever stayed in.
All the space is exquisitely designed. The food is glorious but it’s the staff what makes it absolutely outstanding.
Yes you can stay in so many other different small, boutique, design-forward hotels in CDMX, but know, you’ll be missing out.
Reviewed on Sep 13, 2026
Where to stay in Santo Tomas
Find the best Santo Tomas areas and neighborhoods for the activities you enjoy most. Learn more about Santo Tomas
Roma Norte
Known for its fascinating museums and popular shops, there's plenty to explore in Roma Norte. Check out top attractions like Avenida Insurgentes and MUCA Roma, and jump on the metro at Insurgentes Station or Sevilla Station to see more of the city.
Santo Tomas Hotel Deals
Camino Real Aeropuerto Mexico
Mexico City
Fully refundable
$136 nightly
The price is $163 total per night from Dec 1 to Dec 2
$163 total
Dec 1 - Dec 2
Total with taxes and fees
8.8/10 Excellent! (14,348 reviews)
"Close to airport Great service at check in Polite people"
Reviewed on Oct 31, 2026
Camino Real Polanco Mexico
Mariano Escobedo 700, Col Anzures Mexico City CDMX
$207 nightly
The price is $247 total per night from Nov 20 to Nov 21
$247 total
Nov 20 - Nov 21
Total with taxes and fees
Studio with Terrace next to Parque Mexico | ChiCo
Ciudad de México Ciudad de México
$137 nightly
The price is $162 total per night from Nov 9 to Nov 10
$162 total
Nov 9 - Nov 10
Total with taxes and fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Things to do
Chapultepec Castle, Anthropology Museum & Forest Train
$21
per adult
92% of travellers recommend
Turibus Hop On - Hop Off Mexico City Tour
$21
per adult
72% of travellers recommend
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- Hospital de Jesus Nazareno
- National Museum of Anthropology
- Antara Polanco
- Monumento a los Ninos Heroes
- Basilica of Our Lady of Guadalupe
- Visit Villa de Guadalupe
- Chapultepec Park
- Popotla Vacations
- National Palace
- Visit Cuauhtémoc
- Museo de Arte Moderno
- Visit La Condesa
- Monument to the Revolution
- Visit Coyoacan
- Paseo de la Reforma
- Chapultepec Castle
- Visit Polanco
- Zócalo
- Auditorio Nacional
- La Raza Medical Center
- Mexico City Arena
- Alameda Central
- Avenida Presidente Masaryk
- House of Tiles
- Visit Mexico City
- Visit Santa Fe
- Visit Azcapotzalco
- Palacio de Bellas Artes
- Frida Kahlo Museum
- Jumex Museum
- Metropolitan Cathedral
- Angel of Independence Monument
- Luis Barragán House and Studio
- Mexico City Vacations
- Soumaya Museum
- Torre Latinoamericana
- Visit Miguel Hidalgo
- Where to stay in Mexico City
- Parque Zoologico de Chapultepec
- Templo Mayor Museum
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.