Santo Tomas Vacations from $971
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to $2,000 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
The Latest Santo Tomas vacation packages
Price found within the past 48 hours. Click for updated prices.
Megapolis Hotel Panamá
San Francisco
$971
per person
Nov 10 - Nov 16
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
8.4/10 Very Good! (1,671 reviews)
El agua caliente no funcionaba me cambiaron de habitación y no funcionaba el control del
TV y no hubo quien lo arreglara
Reviewed on Aug 28, 2026
Central Hotel Panama Casco Viejo
Casco Viejo
$1,261
per person
Nov 10 - Nov 16
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
9.2/10 Wonderful! (1,005 reviews)
Don’t expect to sleep
Upon checkin I was out in my “Jr Suite”. It was just a room. But worse, I tried to soon and heard a rhythmic banging that was impossible to sleep through. It was so bad that I decided to see what it was. My room was DIRECTLY UNDER the gym, in a centuries old building?! If anyone is on the treadmill- you’re screwed! Anyone dropping weights, anything. Walls were paper thin. Outside of that… the place was beautiful, and fantastic location!
Reviewed on Aug 29, 2026
Don't see what you're looking for?
See all available trips from Columbus to Santo Tomas
View all tripsSanto Tomas Hotel Deals
Hotel Ciudad De David
Calle D Norte, Avenida 2da Este David Chiriqui
Fully refundableReserve now, pay when you stay
$90 nightly
$99 total
Aug 30 - Aug 31
Total with taxes and fees
9.4/10 Exceptional! (1,001 reviews)
"I’d stay here again."
Reviewed on Aug 20, 2026
Aranjuez Hotel & Suites
Avenida Red Gray David Sur Chiriqui
Fully refundableReserve now, pay when you stay
$52 nightly
$58 total
Sep 19 - Sep 20
Total with taxes and fees
9.2/10 Wonderful! (852 reviews)
"NO"
Reviewed on Aug 24, 2026
Hampton by Hilton David
Calle F Sur David Provincia d David Sur
Fully refundableReserve now, pay when you stay
$89 nightly
$97 total
Sep 5 - Sep 6
Total with taxes and fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Find the Best Santo Tomas Vacation Packages
More vacations you might like
Frequently asked questions
How to find the best Santo Tomas package deals?
Use Expedia's filter tool to help you find some tempting Santo Tomas package deals. When you start your search, just set your maximum budget and then sort the results by "Price: low to high." If you want to save, plan your escape for midweek, or look for Santo Tomas package deals in the off-peak season. Switch up your travel dates and you may score even better discounts. As a rule of thumb, it's usually best to lock in your vacation package as early as possible.
When to book a vacation package to Santo Tomas?
Score incredible bargains by booking your flights in advance with Expedia. If spontaneity is more your style, snap up one of our last-minute deals for a spur-of-the-moment Santo Tomas trip.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
