Downtown, SC
Seneca
Visit Downtown
Stay near popular Downtown attractions
Downtown Hotel Deals
Days Inn by Wyndham Anderson
1007 George Smith Mill Rd Anderson SC
Fully refundableReserve now, pay when you stay
$59 nightly
The price is $65 total per night from Oct 26 to Oct 27
$65 total
Oct 26 - Oct 27
Total with taxes and fees
Book a stay at this business-friendly motel in Anderson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Best Western Plus Clemson Hotel & Conference Center
1310 Tiger Blvd Clemson SC
$105 nightly
The price is $117 total per night from Nov 16 to Nov 17
$117 total
Nov 16 - Nov 17
Total with taxes and fees
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the helpful staff and the ...
8/10 Very Good! (1,004 reviews)
"Enjoyed our stay . Thank you!"
Reviewed on Oct 17, 2026
Clemson University's James F. Martin Inn
240 Madren Center Drive Clemson SC
$149 nightly
The price is $165 total per night from Oct 18 to Oct 19
$165 total
Oct 18 - Oct 19
Total with taxes and fees
Book a stay at this golf hotel in Clemson. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the clean rooms in our ...
9.4/10 Exceptional! (1,000 reviews)
"The property was in excellent condition. Clean and well maintained. On par with Hilton Garden suites."
Reviewed on Oct 14, 2026
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
299 Outpost Rd Seneca SC
$133 nightly
The price is $146 total per night from Nov 16 to Nov 17
$146 total
Nov 16 - Nov 17
Total with taxes and fees
Stay at this cabin in Seneca. Enjoy free parking, patios, and climate control. Popular attractions Friendship Recreation Area and Cross Creek Plantation Golf ...
9.8/10 Exceptional! (113 reviews)
"Been multiple times now. Only issue was there was no lantern this go around so I had to go purchase one but other than that. It was lovely. Love the postcard!"
Reviewed on Oct 15, 2026
Lakeside Lodge Clemson
13500 Clemson Blvd Seneca SC
$123 nightly
The price is $135 total per night from Oct 18 to Oct 19
$135 total
Oct 18 - Oct 19
Total with taxes and fees
Stay at this hotel in Seneca. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff and the clean rooms in our reviews. Popular ...
Comfort Inn & Suites Clemson - University Area
1305 Tiger Blvd Clemson SC
$105 nightly
The price is $117 total per night from Nov 15 to Nov 16
$117 total
Nov 15 - Nov 16
Total with taxes and fees
Book a stay at this business-friendly hotel in Clemson. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
8.4/10 Very Good! (1,002 reviews)
"We will stay here again if we go to Clemson. Room was excellent...staff was excellent and the breakfast room and food was excellent!"
Reviewed on Oct 14, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Downtown
Find the best Downtown areas and neighborhoods for the activities you enjoy most.
Serenity Bay
Though Serenity Bay might not have many top sights, you can venture to the surrounding area to see attractions like Keowee Key Golf Course and Lake Keowee.
Pine Ridge Point
While Pine Ridge Point isn't home to many top sights, South Beach and Lake Keowee are some notable places to visit nearby.
Indian Oaks
While there might not be top attractions in Indian Oaks, you can explore the larger area and discover places like Oconee County Library Seneca Branch and Keowee Reservoir.
Keowee Plantation
When in Keowee Plantation, you can plan a visit to Oconee County Library Seneca Branch and Keowee Reservoir, some noteworthy sights in the nearby area.
