A forested landscape with a winding road and distant hills under a partly cloudy sky.

Spessart-Main-Odenwald Vacations from $1,586

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Your Spessart-Main-Odenwald Vacation

Reserve a Spessart-Main-Odenwald vacation package and wander wherever your adventurous soul takes you. This destination has so much to offer, including its views, markets, festivals, and much more. Start your trip to Spessart-Main-Odenwald with a few nights in Frankfurt visiting popular attractions like Deutsche Bank Park and Frankfurt Christmas Market. Aschaffenburg is another city that lures travelers from far and wide. Mespelbrunn Castle and Schoenbusch Park are two of the top places to see here. If you're ready to stop dreaming and start traveling, Expedia will help turn your Spessart-Main-Odenwald vacation into a reality.

The Latest Spessart-Main-Odenwald Vacation Packages

Price found within the past 48 hours. Click for updated prices.

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Jan 27 - Feb 2
Hotel Attaché by ANS + Flight
Gallus

5 nights
8.0/10 - Very good (647 reviews)
"This guy assist me is not good asking me the money"
Reviewed September 25, 2026

Roundtrip • Phoenix (PHX) - Frankfurt (FRA)

PHX - FRA • 1 stop FRA - PHX • 1 stop
~~$1,983~~
$1,586
per traveler
found 12 hours ago
Jan 28 - Feb 2
Villa Westend Hotel an der Messe + Flight
Westend-Süd

4 nights
8.2/10 - Very good (205 reviews)
"I was very happy to find this boutique hotel within shouting distance of the Messe. For many years I stayed at the Marriott but wanted a change. It is a charming, quiet and comfortable hotel. The staff are particularly good natured and helpful. I hope no one reads this review so the rates don’t go up too much for next year. Be aware though it’s not fancy or upscale so if that is what you are after it may not be the right fit for you."
Reviewed October 9, 2026

Roundtrip • Phoenix (PHX) - Frankfurt (FRA)

PHX - FRA • 1 stop FRA - PHX • 1 stop
~~$2,911~~
$2,122
per traveler
found 11 hours ago
Jan 27 - Feb 2
Hotel Scala Frankfurt City + Flight
Innenstadt

5 nights
7.8/10 - Good (666 reviews)
"The staff, location, and amenities that we expected were all good. The food was just okay. Besides that, the quality of the room was very bad. Not enough hangers for two people on a four day work trip, no air conditioning, a fan to cool down that was incredibly noisy, and a shower where there was no proper place to hang the shower head. We had to keep the window open all night. The room rate we paid was not at all worth the quality of the room. I am sure the hotel raised their standard rates..."
Reviewed September 11, 2026

Roundtrip • Phoenix (PHX) - Frankfurt (FRA)

PHX - FRA • 1 stop FRA - PHX • 1 stop
~~$2,064~~
$1,727
per traveler
found 12 hours ago
Dec 15 - Dec 22
Sofitel Frankfurt Opera + Flight
Innenstadt

6 nights
9.4/10 - Exceptional (606 reviews)

Roundtrip • Atlanta (ATL) - Frankfurt (FRA)

ATL - FRA • Nonstop FRA - ATL • Nonstop
~~$2,805~~
$2,355
per traveler
found 4 hours ago
Jan 28 - Feb 2
Skyline Hotel + Flight
Gallus

4 nights
8.4/10 - Very good (150 reviews)

Roundtrip • Phoenix (PHX) - Frankfurt (FRA)

PHX - FRA • 1 stop FRA - PHX • 1 stop
~~$2,385~~
$2,003
per traveler
found 11 hours ago

Discover the most popular places to visit in Spessart-Main-Odenwald

A Christmas market with illuminated stalls and a large decorated tree.

Frankfurt Christmas Market

Rating: 9.0/10 (579 reviews)

You can find the perfect gifts to bring home at Frankfurt Christmas Market during your stay in Frankfurt. Experience the fascinating museums or attend a sporting event in this walkable area.

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A bustling European square with traditional half-timbered buildings, a prominent church tower, and outdoor cafes.

Römerberg

Rating: 9.0/10 (2,478 reviews)

Admire the medieval architecture and experience the charm of a magical Christmas market at this pretty square, which marks the center of the Old Town.

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A modern building with a sign reading "messe Frankfurt" and a large glass facade.

Frankfurt Trade Fair

Rating: 8.4/10 (1,424 reviews)

Learn about the events happening at Frankfurt Trade Fair during your trip to Frankfurt. Check out the shops and top-notch restaurants in this family-friendly area.

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A large, modern stadium with a curved roof and multiple levels of seating.

Deutsche Bank Park

Rating: 8.4/10 (1,271 reviews)

Experience the excitement of a sporting event or concert at this iconic stadium, which has hosted World Cup and Confederations Cup games.

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A modern glass building with a curved facade, surrounded by trees and a parking area with cars.

Congress Center Messe Frankfurt

Rating: 8.4/10 (1,118 reviews)

Join thousands of fellow participants at one of the many events held at Frankfurt’s largest conference center, and enjoy its state-of-the-art facilities and impressive architecture.

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A street with trees, benches, and outdoor seating.

MyZeil

Rating: 8.6/10 (1,771 reviews)

Browse high street retailers and boutique fashion outlets and pick up local produce at a farmer’s market as you explore Frankfurt’s premier shopping district.

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An ornate stone archway with intricate carvings and a cobblestone path leading through a lush garden.

Gateway Gardens

Rating: 8.0/10 (195 reviews)

After visiting Gateway Gardens, make a plan to see the other sights and activities in Frankfurt. Attend a sporting event or simply enjoy the lively bars while you're in the area.

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A historic building with ornate architecture and a large open square in front.

Alte Oper

Rating: 8.8/10 (1,774 reviews)

Once the city’s opera house, this building is now a concert hall that hosts some of the world’s greatest classical music ensembles.

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Spessart-Main-Odenwald Hotel Deals

B&B HOTEL Aschaffenburg-City

A modern lobby with a leather sofa, a yellow chair, a small table, and a large potted plant.

Address: ELISENSTRASSE 21, Aschaffenburg, 63739, DE
Location: 10.2 mi from Spessart-Main-Odenwald
Guest rating: 9/10 (Wonderful, 272 reviews)
Price: $82 nightly, $88 total, Dec 14 - Dec 15, Total with taxes and fees

DORMERO Hotel Aschaffenburg

A modern hotel room with a large bed, a desk, and a chair.

Address: Goldbacher Str. 29, Aschaffenburg, BY, 63739, DE
Location: 10.3 mi from Spessart-Main-Odenwald
Guest rating: 9.2/10 (Wonderful, 300 reviews)
Price: $57 nightly, $61 total, Nov 15 - Nov 16, Total with taxes and fees
Review: Lovely small friendly and clean hotel in a great location in Aschaffenburg. Would definitely stay again!

Hotel Best One

Address: Arheilger Weg 9, Roßdorf, 64380, DE
Location: 11 mi from Spessart-Main-Odenwald
Guest rating: 7.6/10 (Good, 36 reviews)
Price: $51 nightly, $55 total, Nov 14 - Nov 15, Total with taxes and fees
Review: Perfect stay

Lufthansa Group Hotel & Campus Seeheim

A pool area with lounge chairs and a view of the city.

Address: Lufthansaring 1, Seeheim-Jugenheim, 64342, DE
Location: 17 mi from Spessart-Main-Odenwald
Star rating: 4/5
Guest rating: 9.2/10 (Wonderful, 295 reviews)
Price: $138 nightly, $151 total, Dec 4 - Dec 5, Total with taxes and fees
Review: Amazing stay!!

Sunday Hotel Frankfurt Airport - Neu-Isenburg

A hotel courtyard with potted plants, outdoor seating, and a building entrance.

Address: Wernher-Von-Braun-Strasse 12, Neu-Isenburg, HE, 63263, DE
Location: 17.4 mi from Spessart-Main-Odenwald
Guest rating: 8.2/10 (Very good, 319 reviews)
Price: $60 nightly, $64 total, Nov 23 - Nov 24, Total with taxes and fees
Review: Recommend A bit far from airport but clean and cosy

Heiner Hotel Darmstadt

An outdoor dining area with tables and chairs, a white picket fence, and a building with large windows.

Address: Eschollbrucker Strasse 16, Darmstadt, HE, 64295, DE
Location: 15.6 mi from Spessart-Main-Odenwald
Guest rating: 8.6/10 (Excellent, 485 reviews)
Price: $83 nightly, $91 total, Nov 22 - Nov 23, Total with taxes and fees
Review: Excellent and very professional stuff

Welcome Hotel Darmstadt City Center

A modern hotel with a rectangular layout, multiple floors, and a flat roof.

Address: Karolinenplatz 4, Darmstadt, HE, 64289, DE
Location: 15 mi from Spessart-Main-Odenwald
Star rating: 4/5
Guest rating: 8.8/10 (Excellent, 451 reviews)
Price: $99 nightly, $108 total, Dec 13 - Dec 14, Total with taxes and fees

Platzhirsch Living Hotel

A modern restaurant with round tables and green chairs, featuring a high ceiling with hanging lights and a view of the city through large windows.

Address: Am Südpark 15, Kelsterbach, HE, 65451, DE
Location: 23.9 mi from Spessart-Main-Odenwald
Guest rating: 9.2/10 (Wonderful, 1331 reviews)
Price: $67 nightly, $76 total, Nov 29 - Nov 30, Total with taxes and fees

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.