St. Charles Vacations from $526

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Your St. Charles Vacation

When you book a St. Charles vacation package, it's easy to enjoy your getaway to the fullest. Uncover the highlights of this vibrant city knowing that all the travel planning has been organized in advance. Any trip to St. Charles has to include a little sightseeing. Whitewater State Park is a good place to start your exploring. Whoever you're escaping with and whatever you want to spend, your dream St. Charles vacation is just a few clicks away with Expedia.

The Latest St. Charles vacation packages

Price found within the past 48 hours. Click for updated prices.
Aspen Select

Aspen Select

3.5 out of 5
Price was $629, price is now $526 per person
$526
per person
Oct 5 - Oct 8
found 11 hours ago
Roundtrip non-stop flight included
Denver (DEN) to Rochester (RST)
8.4/10 Very Good! (1,001 reviews)
Everything was great

Reviewed on Aug 23, 2025

Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG

3.5 out of 5
Downtown Rochester
Price was $687, price is now $578 per person
$578
per person
Oct 5 - Oct 8
found 11 hours ago
Roundtrip non-stop flight included
Denver (DEN) to Rochester (RST)
8.8/10 Excellent! (813 reviews)
Pros- 5 min walk from main Mayo Buildings Excellent food at restaurant Mostly quiet, service vehicles noisy at night Cons- restaurant very expensive - 40 bucks for burgher and beer Breakfast 20 bucks Housecleaning unreliable, doesn’t always come

Reviewed on Aug 23, 2025

The Towers At Kahler Grand Hotel

The Towers At Kahler Grand Hotel

4 out of 5
Downtown Rochester
Price was $1,150, price is now $970 per person
$970
per person
Oct 5 - Oct 8
found 11 hours ago
Roundtrip non-stop flight included
Denver (DEN) to Rochester (RST)
9.4/10 Exceptional! (87 reviews)
Great place to stay if going to Mayo. You don’t have to go outside to get to the buildings at Mayo with the subway level. Food is good for 2 meals a day. There’s room service & deliveries from Instacart if needed for groceries or outside food/beverage source. Personalized concierge service is good. Our stay was 10 days - they accommodated our extended stay flawlessly. My only complaint is the room temperature everywhere; it can be stuffy moving place to place. Take a fan to cool off in your room.

Reviewed on Jun 18, 2025

Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

3 out of 5
Kutzky Park
Price was $640, price is now $552 per person
$552
per person
Oct 5 - Oct 8
found 11 hours ago
Roundtrip non-stop flight included
Denver (DEN) to Rochester (RST)
9.2/10 Wonderful! (444 reviews)
We had a trailer and the night staff was extremely helpful in providing us on-site parking.

Reviewed on Aug 24, 2025

Comfort Inn & Suites West - Medical Center

Comfort Inn & Suites West - Medical Center

3 out of 5
Price was $634, price is now $552 per person
$552
per person
Oct 5 - Oct 8
found 11 hours ago
Roundtrip non-stop flight included
Denver (DEN) to Rochester (RST)
9/10 Wonderful! (480 reviews)
The front desk gal during check-in was excellent. She was friendly, courteous, and efficient. I stay here for my annual appointment at Mayo for many reasons, but really appreciate a friendly smile when I arrive.

Reviewed on Aug 25, 2025

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St. Charles Hotel Deals

White Valley Motel

White Valley Motel

2.5 out of 5
449 W. 6th Street, St. Charles, MN
Fully refundableReserve now, pay when you stay
$72 nightly
The price is $77 total per night from Aug 27 to Aug 28
$77 total
Aug 27 - Aug 28
Total with taxes and fees
5.8/10 (113 reviews)
"Place is clean but old. Staff got great personality and nice"

Reviewed on Jun 22, 2025

White Valley Motel
Kahler Grand Hotel

Kahler Grand Hotel

3 out of 5
20 2nd Ave Sw, Rochester, MN
Fully refundableReserve now, pay when you stay
$152 nightly
The price is $175 total per night from Aug 28 to Aug 29
$175 total
Aug 28 - Aug 29
Total with taxes and fees
8.2/10 Very Good! (1,532 reviews)
"Bery good but parking ito unload still a problem. Basic room has only desk chair and desk does not have light/-hard to work in room. But still the best location"

Reviewed on Aug 23, 2025

Kahler Grand Hotel
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

3 out of 5
4353 Canal Pl SE, Rochester, MN
Fully refundableReserve now, pay when you stay
$72 nightly
The price is $83 total per night from Aug 31 to Sep 1
$83 total
Aug 31 - Sep 1
Total with taxes and fees
7.2/10 Good! (1,002 reviews)
Okay stay
"Hotel was clean. Sink drain not working. Fire alarm for faulty sensor sent everyone outdoors at 2330 hrs. Mgmt was apologetic."

Reviewed on Aug 21, 2025

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
See all 492 properties in St. Charles
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Frequently asked questions

How much does a St. Charles vacation package cost?
You can grab a vacation package to this destination from $526 on Expedia. But how much your vacation to St. Charles costs will depend on factors like the season, length of stay and hotel choice.
What are the cheapest months to go to St. Charles?
January, February and November are great times to search for cheap St. Charles vacation packages. Traveling in less busy months means you can usually find reduced prices on hotels and flights.
How many days is enough for St. Charles?
Generally, a handful of days is enough to check out the main attractions during your St. Charles vacation. However, if you want to have more time to relax or go on day tours, consider extending your itinerary.
How to find the best St. Charles package deals?
Use Expedia's filter tool to find some terrific St. Charles package deals. When you start your search, just set your maximum budget and then sort the results by "Price: low to high." If you're looking to save, plan your trip for midweek, or browse for St. Charles package deals in the low season. Switch up your travel dates and you may score even better discounts. As a rule of thumb, it's typically best to book your vacation package as soon as possible.
Is it cheaper to book a St. Charles vacation as a package?
An Expedia vacation package could land you considerable savings when compared to booking hotels and flights separately. Better still, you can customize your St. Charles escape to match your exact needs. Pick your preferred flight time, select the hotel type and add a rental car. Explore our bundles to see how much you can save.
When to book a vacation package to St. Charles?
If you've got your St. Charles travel dates finalized, book early to grab some outstanding deals. With Expedia, you can generally reserve some flights up to one year ahead of time. Prefer spontaneous adventures? Our last-minute deals are ideal for setting off on a whim.
Does Expedia offer Book Now, Pay Later St. Charles vacation packages?
Your St. Charles getaway should be a relaxing escape from your busy life, not a reason for money-related stress. So to allow you a little more flexibility, we've partnered with online lender Affirm to bring you our Book Now, Pay Later vacations. Pick one of our vacation packages with payment plans and break down the cost over 3, 6 or 12 months. Plus, there aren't any hidden costs or late payment fees to worry about.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.