
St. Charles Vacations from $526
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Your St. Charles Vacation
When you book a St. Charles vacation package, it's easy to enjoy your getaway to the fullest. Uncover the highlights of this vibrant city knowing that all the travel planning has been organized in advance. Any trip to St. Charles has to include a little sightseeing. Whitewater State Park is a good place to start your exploring. Whoever you're escaping with and whatever you want to spend, your dream St. Charles vacation is just a few clicks away with Expedia.
The Latest St. Charles vacation packages
Price found within the past 48 hours. Click for updated prices.


Hotel Indigo Rochester – Mayo Clinic Area by IHG
Downtown Rochester
Price was $687, price is now $578 per person
$578
per person
Oct 5 - Oct 8
found 11 hours ago
Roundtrip non-stop flight included
Denver (DEN) to Rochester (RST)
8.8/10 Excellent! (813 reviews)
Pros- 5 min walk from main Mayo Buildings
Excellent food at restaurant
Mostly quiet, service vehicles noisy at night
Cons- restaurant very expensive - 40 bucks for burgher and beer
Breakfast 20 bucks
Housecleaning unreliable, doesn’t always come
Reviewed on Aug 23, 2025

The Towers At Kahler Grand Hotel
Downtown Rochester
Price was $1,150, price is now $970 per person
$970
per person
Oct 5 - Oct 8
found 11 hours ago
Roundtrip non-stop flight included
Denver (DEN) to Rochester (RST)
9.4/10 Exceptional! (87 reviews)
Great place to stay if going to Mayo. You don’t have to go outside to get to the buildings at Mayo with the subway level. Food is good for 2 meals a day. There’s room service & deliveries from Instacart if needed for groceries or outside food/beverage source. Personalized concierge service is good. Our stay was 10 days - they accommodated our extended stay flawlessly. My only complaint is the room temperature everywhere; it can be stuffy moving place to place. Take a fan to cool off in your room.
Reviewed on Jun 18, 2025

Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys
Kutzky Park
Price was $640, price is now $552 per person
$552
per person
Oct 5 - Oct 8
found 11 hours ago
Roundtrip non-stop flight included
Denver (DEN) to Rochester (RST)
9.2/10 Wonderful! (444 reviews)
We had a trailer and the night staff was extremely helpful in providing us on-site parking.
Reviewed on Aug 24, 2025

Comfort Inn & Suites West - Medical Center
Price was $634, price is now $552 per person
$552
per person
Oct 5 - Oct 8
found 11 hours ago
Roundtrip non-stop flight included
Denver (DEN) to Rochester (RST)
9/10 Wonderful! (480 reviews)
The front desk gal during check-in was excellent. She was friendly, courteous, and efficient. I stay here for my annual appointment at Mayo for many reasons, but really appreciate a friendly smile when I arrive.
Reviewed on Aug 25, 2025
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White Valley Motel
449 W. 6th Street, St. Charles, MN
Fully refundableReserve now, pay when you stay
$72 nightly
The price is $77 total per night from Aug 27 to Aug 28
$77 total
Aug 27 - Aug 28
Total with taxes and fees
5.8/10 (113 reviews)
"Place is clean but old. Staff got great personality and nice"
Reviewed on Jun 22, 2025

Kahler Grand Hotel
20 2nd Ave Sw, Rochester, MN
Fully refundableReserve now, pay when you stay
$152 nightly
The price is $175 total per night from Aug 28 to Aug 29
$175 total
Aug 28 - Aug 29
Total with taxes and fees
8.2/10 Very Good! (1,532 reviews)
"Bery good but parking ito unload still a problem. Basic room has only desk chair and desk does not have light/-hard to work in room. But still the best location"
Reviewed on Aug 23, 2025

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
4353 Canal Pl SE, Rochester, MN
Fully refundableReserve now, pay when you stay
$72 nightly
The price is $83 total per night from Aug 31 to Sep 1
$83 total
Aug 31 - Sep 1
Total with taxes and fees
7.2/10 Good! (1,002 reviews)
Okay stay
"Hotel was clean. Sink drain not working. Fire alarm for faulty sensor sent everyone outdoors at 2330 hrs. Mgmt was apologetic."
Reviewed on Aug 21, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.