St. Charles Vacations from $457

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $1,045 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Your St. Charles Vacation

When you book a St. Charles vacation package, it's easy to enjoy your getaway to the fullest. Uncover the highlights of this vibrant city knowing that all the travel planning has been organized in advance. Any trip to St. Charles has to include a little sightseeing. Whitewater State Park is a good place to start your exploring. Whoever you're escaping with and whatever you want to spend, your dream St. Charles vacation is just a few clicks away with Expedia.

The Latest St. Charles vacation packages

Price found within the past 48 hours. Click for updated prices.
Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG

3.5 out of 5
Downtown Rochester
Price was $539, price is now $457 per person
$457
per person
Jan 20 - Jan 23
found 4 hours ago
Roundtrip non-stop flight included
Houston (HOU) to Rochester (RST)
8.8/10 Excellent! (867 reviews)
room clean poor location

Reviewed on Nov 24, 2025

Aspen Select

Aspen Select

3.5 out of 5
Price was $562, price is now $464 per person
$464
per person
Jan 20 - Jan 23
found 4 hours ago
Roundtrip non-stop flight included
Houston (HOU) to Rochester (RST)
8.4/10 Very Good! (1,003 reviews)
The best stay I have had in a while. Breakfast was so/so , still would recommend ! PEACEFUL!!

Reviewed on Nov 30, 2025

Kahler Grand Hotel

Kahler Grand Hotel

3 out of 5
Downtown Rochester
Price was $610, price is now $512 per person
$512
per person
Jan 20 - Jan 23
found 4 hours ago
Roundtrip non-stop flight included
Houston (HOU) to Rochester (RST)
8.2/10 Very Good! (1,746 reviews)
You cannot beat the proximity of this hotel to Mayo Clinic - just a quick elevator ride down to the subway level so that you never have to go outside in the cold. The attached city parking ramp is also quite convenient. And the woman at the front desk was very pleasant and accommodating when we checked in. We enjoyed our room with a beautiful view of the decorated streets for Christmas other than a slow drain in the shower.

Reviewed on Dec 4, 2025

Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

3.5 out of 5
Downtown Rochester
Price was $592, price is now $501 per person
$501
per person
Jan 20 - Jan 23
found 4 hours ago
Roundtrip non-stop flight included
Houston (HOU) to Rochester (RST)
8/10 Very Good! (1,495 reviews)
Super helpful staff! Clean, comfortable room and great location for appts at the Mayo Clinic.

Reviewed on Dec 2, 2025

The Berkman

The Berkman

3 out of 5
Folwell
Price was $663, price is now $574 per person
$574
per person
Jan 20 - Jan 23
found 4 hours ago
Roundtrip non-stop flight included
Houston (HOU) to Rochester (RST)
9.6/10 Exceptional! (363 reviews)
All of the above. Room and staff were great! Never had any issues and will be coming back again and again! Thank you!

Reviewed on Nov 11, 2025

Don't see what you're looking for?
See all available trips from Columbus to St. Charles
View all trips

St. Charles Hotel Deals

White Valley Motel

White Valley Motel

2.5 out of 5
449 W. 6th Street St. Charles MN
Fully refundableReserve now, pay when you stay
$72 nightly
The price is $77 total per night from Dec 5 to Dec 6
$77 total
Dec 5 - Dec 6
Total with taxes and fees
5.6/10 (124 reviews)
Very nice owner i wil come back again thank you..

Reviewed on Nov 14, 2025

White Valley Motel
Kahler Grand Hotel

Kahler Grand Hotel

3 out of 5
20 2nd Ave Sw Rochester MN
Fully refundableReserve now, pay when you stay
$111 nightly
The price is $128 total per night from Dec 6 to Dec 7
$128 total
Dec 6 - Dec 7
Total with taxes and fees
8.2/10 Very Good! (1,784 reviews)
Nice comfortable. Renovated rooms.

Reviewed on Dec 2, 2025

Kahler Grand Hotel
Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

3.5 out of 5
9 3rd Ave Nw Rochester MN
Fully refundableReserve now, pay when you stay
$109 nightly
The price is $125 total per night from Dec 12 to Dec 13
$125 total
Dec 12 - Dec 13
Total with taxes and fees
7.8/10 Good! (1,519 reviews)
I was at Methodist Hospital and great for people that need to visit there. Convenient

Reviewed on Nov 27, 2025

Kahler Inn and Suites - Mayo Clinic Area
See all 500 properties in St. Charles
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best St. Charles Vacation Packages

St. Charles Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Rochester Intl. Airport (RST)
Population
3,700
Max Temp Winter
25ºF
Max Temp Summer
75ºF

More vacations you might like

All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Frequently asked questions

How much does a St. Charles vacation package cost?
You can grab a vacation package to this destination from $457 on Expedia. But how much your vacation to St. Charles costs will depend on factors like the season, length of stay and hotel choice.
What are the cheapest months to go to St. Charles?
January, February and November are great times to search for cheap St. Charles vacation packages. Traveling in less busy months means you can usually find reduced prices on hotels and flights.
How many days is enough for St. Charles?
Generally, a handful of days is enough to check out the main attractions during your St. Charles vacation. However, if you want to have more time to relax or go on day tours, consider extending your itinerary.
How to find the best St. Charles package deals?
Use Expedia's filter tool to find some terrific St. Charles package deals. When you start your search, just set your maximum budget and then sort the results by "Price: low to high." If you're looking to save, plan your trip for midweek, or browse for St. Charles package deals in the low season. Switch up your travel dates and you may score even better discounts. As a rule of thumb, it's typically best to book your vacation package as soon as possible.
Is it cheaper to book a St. Charles vacation as a package?
An Expedia vacation package could land you considerable savings when compared to booking hotels and flights separately. Better still, you can customize your St. Charles escape to match your exact needs. Pick your preferred flight time, select the hotel type and add a rental car. Explore our bundles to see how much you can save.
When to book a vacation package to St. Charles?
If you've got your St. Charles travel dates finalized, book early to grab some outstanding deals. With Expedia, you can generally reserve some flights up to one year ahead of time. Prefer spontaneous adventures? Our last-minute deals are ideal for setting off on a whim.
Does Expedia offer Book Now, Pay Later St. Charles vacation packages?
Your St. Charles getaway should be a relaxing escape from your busy life, not a reason for money-related stress. So to allow you a little more flexibility, we've partnered with online lender Affirm to bring you our Book Now, Pay Later vacations. Pick one of our vacation packages with payment plans and break down the cost over 3, 6 or 12 months. Plus, there aren't any hidden costs or late payment fees to worry about.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.