St. Charles Vacations from $563

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Your St. Charles Vacation

When you book a St. Charles vacation package, it's easy to enjoy your getaway to the fullest. Uncover the highlights of this vibrant city knowing that all the travel planning has been organized in advance. Any trip to St. Charles has to include a little sightseeing. Whitewater State Park is a good place to start your exploring. Whoever you're escaping with and whatever you want to spend, your dream St. Charles vacation is just a few clicks away with Expedia.

The Latest St. Charles vacation packages

Price found within the past 48 hours. Click for updated prices.
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

3 out of 5
Historic Southwest
Price was $656, price is now $563 per person
$563
per person
Oct 6 - Oct 10
found 1 day ago
Roundtrip non-stop flight included
Memphis (MEM) to Rochester (RST)
8.6/10 Excellent! (1,008 reviews)
We coukd not ask for a better combination of very reasonably priced accommodation, free parking, and great dinner spot (attached to the hotel). We have stayed here at least a half dozen times in the last five years. It's a pleasant 6 block walk to the Mayo Clinic, and the hotel also offers a shuttle. The food co-op is a couple blocks away, too, which is very handy.

Reviewed on Jul 16, 2026

The Towers At Kahler Grand Hotel

The Towers At Kahler Grand Hotel

4 out of 5
Downtown Rochester
Price was $1,319, price is now $1,052 per person
$1,052
per person
Oct 6 - Oct 10
found 1 day ago
Roundtrip non-stop flight included
Memphis (MEM) to Rochester (RST)
9.6/10 Exceptional! (115 reviews)
Everyone was very helpful throughout our stay. Our Tower Suite was wonderful and amenities were great.

Reviewed on Jun 29, 2026

Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

3 out of 5
Kutzky Park
Price was $702, price is now $591 per person
$591
per person
Oct 6 - Oct 10
found 1 day ago
Roundtrip non-stop flight included
Memphis (MEM) to Rochester (RST)
9.2/10 Wonderful! (521 reviews)
The building was clean and kept up well. I really enjoyed the location and having a shuttle to the hospital. The only downfall I saw was the amount you pay per night to park, $20, seems a little steep and there was not enough parking with the construction and painting blocking off spots.

Reviewed on Jul 12, 2026

The Berkman

The Berkman

3 out of 5
Folwell
Price was $860, price is now $735 per person
$735
per person
Oct 6 - Oct 10
found 1 day ago
Roundtrip non-stop flight included
Memphis (MEM) to Rochester (RST)
9.6/10 Exceptional! (421 reviews)
Wonderful property with a few caveats. The amenities are great, and the location is ideal for St Mary’s. The apartment is large and parking safe and easy. That said, the bed is very hard and pillows aren’t great. The vents also hit directly on your face in the bed, so that was hard to get used to. I would stay again but only if I brought my own pillows and blankets

Reviewed on Jul 2, 2026

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

3 out of 5
Kutzky Park
Price was $655, price is now $570 per person
$570
per person
Oct 6 - Oct 10
found 1 day ago
Roundtrip non-stop flight included
Memphis (MEM) to Rochester (RST)
8.6/10 Excellent! (1,001 reviews)
Hotel staff was amazing and professional. Room was spotless.

Reviewed on Jul 14, 2026

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St. Charles Hotel Deals

Kahler Grand Hotel

Kahler Grand Hotel

3 out of 5
20 2nd Ave Sw Rochester MN
Fully refundableReserve now, pay when you stay
$128 nightly
The price is $147 total per night from Jul 29 to Jul 30
$147 total
Jul 29 - Jul 30
Total with taxes and fees
8.4/10 Very Good! (2,210 reviews)
"Bathroom very cramped. Lighting in bath poor."

Reviewed on Jul 17, 2026

Kahler Grand Hotel
Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

3.5 out of 5
9 3rd Ave Nw Rochester MN
Fully refundableReserve now, pay when you stay
$135 nightly
The price is $156 total per night from Jul 26 to Jul 27
$156 total
Jul 26 - Jul 27
Total with taxes and fees
8/10 Very Good! (1,616 reviews)
"The breakfast was very good with a lot of options. The parking is convenient, although the immediate roads are under construction so you have to deal with lane closures and detours, but at least you can still utilize their parking lot. The thing I was mostly disappointed with was the dirty carpet ..."

Reviewed on Jul 16, 2026

Kahler Inn and Suites - Mayo Clinic Area
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

2.5 out of 5
1517 16th St Sw Rochester MN
Fully refundableReserve now, pay when you stay
$94 nightly
The price is $108 total per night from Jul 30 to Jul 31
$108 total
Jul 30 - Jul 31
Total with taxes and fees
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
See all 487 properties in St. Charles
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best St. Charles Vacation Packages

St. Charles Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Rochester Intl. Airport (RST)
Population
3,700
Max Temp Winter
25ºF
Max Temp Summer
75ºF

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Frequently asked questions

How much does a St. Charles vacation package cost?
You can grab a vacation package to this destination from $563 on Expedia. But how much your vacation to St. Charles costs will depend on factors like the season, length of stay and hotel choice.
What are the cheapest months to go to St. Charles?
January, February and November are great times to search for cheap St. Charles vacation packages. Traveling in less busy months means you can usually find reduced prices on hotels and flights.
How many days is enough for St. Charles?
Generally, a handful of days is enough to check out the main attractions during your St. Charles vacation. However, if you want to have more time to relax or go on day tours, consider extending your itinerary.
How to find the best St. Charles package deals?
Use Expedia's filter tool to find some terrific St. Charles package deals. When you start your search, just set your maximum budget and then sort the results by "Price: low to high." If you're looking to save, plan your trip for midweek, or browse for St. Charles package deals in the low season. Switch up your travel dates and you may score even better discounts. As a rule of thumb, it's typically best to book your vacation package as soon as possible.
Is it cheaper to book a St. Charles vacation as a package?
An Expedia vacation package could land you considerable savings when compared to booking hotels and flights separately. Better still, you can customize your St. Charles escape to match your exact needs. Pick your preferred flight time, select the hotel type and add a rental car. Explore our bundles to see how much you can save.
When to book a vacation package to St. Charles?
If you've got your St. Charles travel dates finalized, book early to grab some outstanding deals. With Expedia, you can generally reserve some flights up to one year ahead of time. Prefer spontaneous adventures? Our last-minute deals are ideal for setting off on a whim.
Does Expedia offer Book Now, Pay Later St. Charles vacation packages?
Your St. Charles getaway should be a relaxing escape from your busy life, not a reason for money-related stress. So to allow you a little more flexibility, we've partnered with online lender Affirm to bring you our Book Now, Pay Later vacations. Pick one of our vacation packages with payment plans and break down the cost over 3, 6 or 12 months. Plus, there aren't any hidden costs or late payment fees to worry about.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.