St. Charles Vacation Rentals

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Nov 28 - Nov 30
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Mar 6 - Mar 8

Vacation Rentals in St. Charles

Cabin, 2 Bedrooms | Private kitchen | Full-size fridge, microwave, oven, stovetop
Big River Escape Riverside Cabins

Big River Escape Riverside Cabins

3.0 star property
Cochrane
9.2 out of 10, Wonderful, (38)
"The staff went above and beyond my expectations!!!!!! The camper was clean and comfortable. Great location for a get away. Would HIGHLY recommend! "
United States
Kerri
$110 nightly
The price is $117
Nov 16 - Nov 17
Total with taxes and fees
Big River Escape Riverside Cabins
Exterior
Valley Cabin

Valley Cabin

Spring Valley
9.2 out of 10, Wonderful, (7)
"Great property with plenty of outdoor activities. Had fun fishing the stream and exploring the area. Dan is a great host and I will be visiting again."
United States
JAKE I.
$118 nightly
The price is $127
Nov 16 - Nov 17
Total with taxes and fees
Valley Cabin
Terrace/patio
Treehouse Cabin in the Bluff Woodlands

Treehouse Cabin in the Bluff Woodlands

Elba
9.8 out of 10, Exceptional, (15)
"Great location with privacy. Hopefully it stays that way. Beautiful nature and whitewater state park 3 minutes away is spectacular!! Recommended!!"
United States
Karl Y.
$153 nightly
The price is $165
Nov 16 - Nov 17
Total with taxes and fees
Treehouse Cabin in the Bluff Woodlands
Exterior
Treehouse Cabin in the Bluff Woodlands North

Treehouse Cabin in the Bluff Woodlands North

Elba
9.6 out of 10, Exceptional, (9)
"Great area a place to stay. "
United States
Paul T.
$153 nightly
The price is $165
Nov 16 - Nov 17
Total with taxes and fees
Treehouse Cabin in the Bluff Woodlands North
Interior
Suite #3 - Spacious King Suite -Mississippi River

Suite #3 - Spacious King Suite -Mississippi River

Fountain City
8.8 out of 10, Excellent, (5)
"This is a historic home that is beautifully restored to its glory, and tastefully outfitted with the modern conveniences one hopes for. very comfortable. Plus it is right there along the Mississippi, with the barges and ships moving up and down. Logan's communications were excellent--clear and straightforward."
United States
Robert
$105 nightly
The price is $111
Nov 17 - Nov 18
Total with taxes and fees
Suite #3 - Spacious King Suite -Mississippi River
Cookware/dishes/utensils
Great River Road Cabin on the Mississippi Backwaters Fox Cabin

Great River Road Cabin on the Mississippi Backwaters Fox Cabin

Buffalo City
10.0 out of 10, Exceptional, (1)
"We enjoyed our stay and really enjoyed the screened in porch. Spent a lot of time sitting at the table in the screened in porch playing cards."
United States
Jenny D.
$172 nightly
The price is $181
Dec 1 - Dec 2
Total with taxes and fees
Great River Road Cabin on the Mississippi Backwaters Fox Cabin
Family Cottage, Park View | Private kitchen
Big River Escape Parkside Bungalow

Big River Escape Parkside Bungalow

3.0 star property
Winona
$218 nightly
The price is $243
Nov 17 - Nov 18
Total with taxes and fees
Big River Escape Parkside Bungalow
Exterior
Studio Suite! Free Breakfast + Shared Pool & Hot Tub. Great for Business Travelers!

Studio Suite! Free Breakfast + Shared Pool & Hot Tub. Great for Business Travelers!

Rochester
10.0 out of 10, Exceptional, (3)
"Nice property, great outdoor spaces to hang out. Nice indoor pool. Room just fine for our needs. AC a bit loud but otherwise we had a great stay and would go back."
United States
Martine B.
$140 nightly
The price is $161
Nov 28 - Nov 29
Total with taxes and fees
Studio Suite! Free Breakfast + Shared Pool & Hot Tub. Great for Business Travelers!
Microwave, oven, stovetop, dishwasher
Discounted Charming 2-bedroom house in Rochester

Discounted Charming 2-bedroom house in Rochester

East Side Pioneers
8.8 out of 10, Excellent, (10)
"Great stay for a quick stop in Rochester. Clean, quiet neighborhood."
United States
Jill S.
$176 nightly
The price is $203
Nov 18 - Nov 19
Total with taxes and fees
Discounted Charming 2-bedroom house in Rochester
Smart TV, books
Vintage Lustron Home Piece of History

Vintage Lustron Home Piece of History

Minnesota City
10.0 out of 10, Exceptional, (27)
"Our second time staying here. This time brought friends and we had a great time. Had everything we needed and were very comfortable."
United States
steve f.
$198 nightly
The price is $213
Nov 16 - Nov 17
Total with taxes and fees
Vintage Lustron Home Piece of History
Exterior
Charming 1-bedroom house in delightful Winona with WiFi, AC and PRIVATE PATIO

Charming 1-bedroom house in delightful Winona with WiFi, AC and PRIVATE PATIO

Winona
10.0 out of 10, Exceptional, (19)
"It was a wonderful stay with a nice and helpful host! Place was clean and well maintained. "
United States
enforcer1219
$170 nightly
The price is $183
Nov 17 - Nov 18
Total with taxes and fees
Charming 1-bedroom house in delightful Winona with WiFi, AC and PRIVATE PATIO
Dining
Discounted Oasis, 2 Bedroom Lower-Level Duplex 5 Minutes to Mayo Clinic!

Discounted Oasis, 2 Bedroom Lower-Level Duplex 5 Minutes to Mayo Clinic!

Rochester
9.6 out of 10, Exceptional, (20)
"House was very nice and clean. Everything was well stocked and very useful. Would definitely stay here again"
United States
Chandra A.
$167 nightly
The price is $192
Nov 16 - Nov 17
Total with taxes and fees
Discounted Oasis, 2 Bedroom Lower-Level Duplex 5 Minutes to Mayo Clinic!
Exterior detail
The Hen House Retreat - A Comfortable Place to Roost

The Hen House Retreat - A Comfortable Place to Roost

Highland
9.8 out of 10, Exceptional, (87)
"Our stay was fantastic, it was very clean with fun decor. We had a great time using the firepit."
United States
Trevor B.
$186 nightly
The price is $200
Nov 16 - Nov 17
Total with taxes and fees
The Hen House Retreat - A Comfortable Place to Roost
Terrace/patio
The Berkman

The Berkman

3.0 star property
Folwell
9.6 out of 10, Exceptional, (363)
"Perfect location for visit to hospital. "
United States
Sharon
$126 nightly
The price is $145
Nov 23 - Nov 24
Total with taxes and fees
The Berkman
Exterior
King Suite Close to Mayo Clinic! Free Breakfast. Pool & Hot Tub.

King Suite Close to Mayo Clinic! Free Breakfast. Pool & Hot Tub.

Rochester
10.0 out of 10, Exceptional, (1)
"Good hotel with plenty of space to spread out. Great location with coffee and dining across the street. Easy to find and easy access to highways. Will stay here again!"
United States
Michael F.
$144 nightly
The price is $166
Nov 28 - Nov 29
Total with taxes and fees
King Suite Close to Mayo Clinic! Free Breakfast. Pool & Hot Tub.
Interior
Charming 2-bedroom apartment in delightful Rochester with WiFi, AC

Charming 2-bedroom apartment in delightful Rochester with WiFi, AC

Rochester
10.0 out of 10, Exceptional, (1)
"Quiet, clean and in a friendly neighborhood. Staying there took some of the stress out of my Mayo Clinic visits. I always worry about my follow-up visits, but a good quiet place to stay helps me let that go."
United States
Maria L E.
$140 nightly
The price is $201
Nov 16 - Nov 17
Total with taxes and fees
Charming 2-bedroom apartment in delightful Rochester with WiFi, AC
Interior
Discounted Oasis! 5 Star-3 Bedroom Showstopping Duplex 4 Minutes to Mayo Clinic!

Discounted Oasis! 5 Star-3 Bedroom Showstopping Duplex 4 Minutes to Mayo Clinic!

East Side Pioneers
9.0 out of 10, Wonderful, (18)
"Nice quiet working class neighborhood. Walked my dog several times a day without concern. Downstairs renters very friendly. Comfortable beds. Toys for children. Spacious. Not far from Mayo. Wooded area behind house. Deer walk around. You’re in town but also feels like you’re in country."
United States
Roxanne B.
$188 nightly
The price is $216
Dec 14 - Dec 15
Total with taxes and fees
Discounted Oasis! 5 Star-3 Bedroom Showstopping Duplex 4 Minutes to Mayo Clinic!
Dining
Discounted 5-Star 3 Bedroom Duplex 5 Minutes to Mayo Clinic!

Discounted 5-Star 3 Bedroom Duplex 5 Minutes to Mayo Clinic!

Rochester
10.0 out of 10, Exceptional, (7)
"It was a very nice home away from home. It was clean and was very spacious. Nice neighborhood and the walking path was excellent, also close to Mayo Clinic. Quiet neighborhood, restful and peaceful. The Host responded to inquires very promptly. Would recommend. "
United States
Alysa M.
$195 nightly
The price is $225
Nov 16 - Nov 17
Total with taxes and fees
Discounted 5-Star 3 Bedroom Duplex 5 Minutes to Mayo Clinic!
Exterior
Cozy 3BR near Mayo and downtown. Charming, spotless, and designed for comfort with restful bedrooms, a stocked kitchen, and two welcoming living spaces. Perfect for Mayo visits, business trips, or family stays. Dogs allowed, too.

Cozy 3BR near Mayo and downtown. Charming, spotless, and designed for comfort with restful bedrooms, a stocked kitchen, and two welcoming living spaces. Perfect for Mayo visits, business trips, or family stays. Dogs allowed, too.

Rochester
9.8 out of 10, Exceptional, (6)
"Very cute and well maintained. We would definitely stay again. "
United States
Jen E.
$384 nightly
The price is $440
Nov 16 - Nov 17
Total with taxes and fees
Cozy 3BR near Mayo and downtown. Charming, spotless, and designed for comfort with restful bedrooms, a stocked kitchen, and two welcoming living spaces. Perfect for Mayo visits, business trips, or family stays. Dogs allowed, too.
Fridge, microwave, oven, stovetop
The Cozy Hideaway - 5-Minute Drive to Mayo Clinic

The Cozy Hideaway - 5-Minute Drive to Mayo Clinic

Northrup
10.0 out of 10, Exceptional, (3)
"The house was very clean and organized. There were extra blankets and a large washer/dryer set up in the basement. We loved the lunch buffet at the nearby Indian restaurant. The host responded readily with responses. "
United States
Linda K.
$206 nightly
The price is $237
Dec 2 - Dec 3
Total with taxes and fees
The Cozy Hideaway - 5-Minute Drive to Mayo Clinic
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top St. Charles Hotel Reviews

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

10/10 Excellent
"Courteous staff and clean room"
William C 2-night trip
Posted 3 days ago
SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

Find out more about St. Charles

Everything you need to know about St. Charles vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the St. Charles vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect St. Charles vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

St. Charles vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in St. Charles. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit St. Charles in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $117 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on St. Charles rentals

At Expedia, we put the best St. Charles vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top St. Charles rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream St. Charles vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around St. Charles. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Explore a world of travel with Expedia

Frequently asked questions

Can I find vacation rentals in St. Charles?

Yes, we offer vacation rentals close to the most popular attractions in St. Charles, or you can go with a more remote option if you want a relaxing place to stay. St. Charles is known for its parks.

What are some of the best vacation rentals that St. Charles has to offer?

Clean, fun, comfy ranch home near parks, 2.5 mi to Mayo w Pingpong and Playroom: Visitors like this St. Charles vacation home rental. It offers a patio, a garden, and a barbecue grill to help you feel perfectly comfortable in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. Make the most of the selection of games in this rental home to help you unwind.

What can I see and do in St. Charles?

While you're exploring the area, Whitewater River and Root River are a couple of picturesque spots to get outside and enjoy nature. Whitewater State Park and St. Mary's University of Minnesota are a couple of places you'll find in the larger area.

What are vacation rentals like in St. Charles?

Vacation rentals are privately owned properties you can book for short or long periods in St. Charles. Vacation rentals feature amenities such as patios, hot tubs, and fire pits so your stay will be comfortable. If you're concerned about a clean environment, a vacation rental can offer a sense of seclusion away from public hotel elevators and lobbies bustling with people while still allowing you to travel. You'll also find more space in a vacation rental than in a traditional hotel, which is another reason why a vacation rental is an attractive choice for families.