Wayne County Vacations & Trips from $611

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Your Wayne County Vacation

Set off on your next thrilling adventure with a Wayne County vacation package, and leave relaxed knowing the finer details are taken care of. Plus with the ability to tailor your escape, it'll be one to remember. A trip to Wayne County wouldn't be complete without spending a few nights in Piedmont. This city is among the best places to visit here. Whether you plan to travel on a shoestring or want to splurge, Expedia are here to help you tailor-make your next Wayne County vacation.

Top destinations in Wayne County

A gravel path leading to a stone structure with a triangular roof, surrounded by trees and a road.

Patterson

Patterson

The Latest Wayne County Vacation Packages

Price found within the past 48 hours. Click for updated prices.
University Inn of Carbondale by Hotel O

University Inn of Carbondale by Hotel O

$611
per person
Sep 9 - Sep 11
found 10 hours ago
Roundtrip non-stop flight included
Columbus (CMH) to Cape Girardeau (CGI)
5.8/10 (401 reviews)
To start there is only a kiosk for check in. After a very annoying check in I asked the lady on the screen if there was ever anyone at the desk. She said yes and that she was only filling in while the front desk was “out”. Apparently they were out for 2 days as I never saw one employee at the desk the 2 days I was there. I walked into the room and immediately noticed there was no tv remote. Upon further inspection there were also no cables hooked up to it. I went back to the kiosk and the lady said she would send someone to look at it. No one came to fix it. I left my room the next morning and when I returned my key would not work. Went back to the kiosk where I received 3 keys to try. None worked. Back to the kiosk and received 6 keys. None worked. Back to the kiosk where the kiosk lady had to call someone. I sat and waited. A lady in regular clothes appeared, went behind the desk, handed me a key and said nothing to me. From reading other reviews it sounds like this was the owner who lives on the 2nd floor. I would definitely not stay here again as I feel this is absolutely a safety concern with no employees in the building. You definitely get what you pay for.

Reviewed on Aug 4, 2026

Makanda Inn

Makanda Inn

$749
per person
Sep 9 - Sep 11
found 10 hours ago
Roundtrip non-stop flight included
Columbus (CMH) to Cape Girardeau (CGI)
10/10 Exceptional! (39 reviews)
I travel to So. Illinois annually to visit but this is my first stay at the Makanda Inn. It will not be my last. I had a very peaceful stay- after long days of family visit and running around with the grands, it was so nice to stay here where it was quiet and relaxing. Breakfast every morning was top notch and just the right portions.

Reviewed on Jul 22, 2026

Comfort Inn & Suites Carbondale University Area

Comfort Inn & Suites Carbondale University Area

$651
per person
Sep 9 - Sep 11
found 10 hours ago
Roundtrip non-stop flight included
Columbus (CMH) to Cape Girardeau (CGI)
7.6/10 Good! (573 reviews)
Hampton Inn Carbondale

Hampton Inn Carbondale

$674
per person
Sep 9 - Sep 11
found 10 hours ago
Roundtrip non-stop flight included
Columbus (CMH) to Cape Girardeau (CGI)
8.4/10 Very Good! (664 reviews)
Friendly and helpful desk staff. Clean room. The sink however was awkwardly made. The faucet was off to the side and the counter was not flush against the wall causing water to spill onto the floor each time the sink was used. Had to keep a towel on the floor.

Reviewed on Aug 6, 2026

Holiday Inn Express & Suites Carbondale - University Area by IHG

Holiday Inn Express & Suites Carbondale - University Area by IHG

$696
per person
Sep 9 - Sep 11
found 10 hours ago
Roundtrip non-stop flight included
Columbus (CMH) to Cape Girardeau (CGI)
8.8/10 Excellent! (721 reviews)

Find the Best Wayne County Vacation Packages

Wayne County Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Lambert-St. Louis Intl. Airport (STL)
Top Sights
Lake Wappapello, Clearwater Lake and Lake Wappapello State Park

Wayne County Hotel Deals

Camp Minnow Beach House

Camp Minnow Beach House

Wappapello MO
9.4/10 Exceptional! (18 reviews)
"Thank you for a great place to call home for a couple of days! The Penfields were awesome. Would book again if we are back that way again."

Reviewed on Jul 20, 2026

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Camp Minnow Beach House
Secluded Private Beautiful Cabin in Mill Spring MO

Secluded Private Beautiful Cabin in Mill Spring MO

Mill Spring MO
$148 nightly
$155 total
Aug 11 - Aug 12
Total with taxes and fees
10/10 Exceptional! (2 reviews)
"This was the perfect little place! The host was amazing and left us muffins and a welcome note. It was a super cute little place!"

Reviewed on Aug 2, 2026

Secluded Private Beautiful Cabin in Mill Spring MO
Cozy hobby farm cabin under the stars!

Cozy hobby farm cabin under the stars!

Greenville MO
$116 nightly
$122 total
Sep 8 - Sep 9
Total with taxes and fees
10/10 Exceptional! (7 reviews)
"Our second visit"

Reviewed on Aug 2, 2026

Cozy hobby farm cabin under the stars!
See all 204 properties in Wayne County
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Wayne County attractions

A sunset over a lake with boats and ducks.
Photo by JG Morris

Lake Wappapello

8.8/10 (54 reviews)
Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.
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A river with people swimming and standing in the water, surrounded by a forested hillside.
Photo by Isaac Richardson

Sam A. Baker State Park

You can take time to visit Sam A. Baker State Park during your travels to Patterson.
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A rocky shoreline with a calm lake and distant islands.
Photo by Kimberly Falk

Lake Wappapello State Park

10.0/10 (3 reviews)
You can take time to visit Lake Wappapello State Park during your travels to Wappapello.
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Eagle Point Recreation Area

Explore the great outdoors at Eagle Point Recreation Area, a lovely green space in Wappapello.
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Spillway Recreation Area

Explore the great outdoors at Spillway Recreation Area, a lovely green space in Wappapello.
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