Wayne County Vacation Packages 2026 from $1,010

Photo by Isaac Richardson

Your Wayne County Vacation

Set off on your next thrilling adventure with a Wayne County vacation package, and leave relaxed knowing the finer details are taken care of. Plus with the ability to tailor your escape, it'll be one to remember. A trip to Wayne County wouldn't be complete without spending a few nights in Piedmont. This city is among the best places to visit here. Whether you plan to travel on a shoestring or want to splurge, Expedia are here to help you tailor-make your next Wayne County vacation.

Top destinations in Wayne County

A gravel path leading to a stone structure with a triangular roof, surrounded by trees and a road.

The Latest Wayne County Vacation Packages

Price found within the past 48 hours. Click for updated prices.

Candlewood Suites Cape Girardeau by IHG

$1,010

per person

Nov 27 - Nov 29

found 19 hours ago

Roundtrip non-stop flight included

Buffalo (BUF) to Cape Girardeau (CGI)

8/10 Very Good! (1,000 reviews)

For the price we paid it was an acceptable accommodation.

Reviewed on Sep 20, 2026

Makanda Inn

$1,150

per person

Nov 27 - Nov 29

found 19 hours ago

Roundtrip non-stop flight included

Buffalo (BUF) to Cape Girardeau (CGI)

10/10 Exceptional! (39 reviews)

This was a unique and very enjoyable visit. We enjoyed the site as it sits in the woods. The birds of the area were plentiful and great in the morning. The room was great with a marvelous bathroom. Comfortable bed. The breakfast we had there was excellent. A wonderful choice.

Reviewed on Sep 15, 2026

EC Reed's Mercantile and Hotel

$1,020

per person

Nov 27 - Nov 29

found 19 hours ago

Roundtrip non-stop flight included

Buffalo (BUF) to Cape Girardeau (CGI)

9.4/10 Exceptional! (109 reviews)

Quiet and comfy. Great price.

Reviewed on Sep 19, 2026

The Riverview

$1,030

per person

Nov 27 - Nov 29

found 19 hours ago

Roundtrip non-stop flight included

Buffalo (BUF) to Cape Girardeau (CGI)

9.4/10 Exceptional! (649 reviews)

Nice room and friendly staff. Everything was great except for the bathroom having a sliding door which provides less privacy. Also the mini refrigerator wasnt very cold even when on the coldest setting. Other than that zero complaints.

Reviewed on Sep 18, 2026

Drury Plaza Hotel Cape Girardeau Conference Center

$1,032

per person

Nov 27 - Nov 29

found 19 hours ago

Roundtrip non-stop flight included

Buffalo (BUF) to Cape Girardeau (CGI)

9.6/10 Exceptional! (1,014 reviews)

Find the Best Wayne County Vacation Packages

Wayne County Essential Information

Language	English
Currency	U.S dollars
Closest Airport	Lambert-St. Louis Intl. Airport (STL)
Top Sights	Lake Wappapello, Clearwater Lake and Lake Wappapello State Park

Wayne County Hotel Deals

Camp Minnow Beach House

Wappapello MO

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Sam A Baker State Park

5732 State Hwy Missouri 143 Patterson MO

$150 nightly

$159 total

Oct 11 - Oct 12

Total with taxes and fees

9/10 Wonderful! (6 reviews)

"Janie and her staff were great and very flexible. We had all the hep we needed for everything. Will comeback asap!"

Reviewed on Dec 29, 2025

Secluded Private Beautiful Cabin in the foothills of the Missouri Ozarks

Mill Spring MO

$164 nightly

$173 total

Oct 16 - Oct 17

Total with taxes and fees

10/10 Exceptional! (4 reviews)

"Beautiful area in the southern Missouri Ozarks. Cabin was clean and everything was well thought out. Also near Clearwater lake."

Reviewed on Sep 7, 2026

See all 209 properties in Wayne County

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Wayne County attractions

A sunset over a lake with boats and ducks.

Lake Wappapello

8.8/10 (54 reviews)

Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.

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