Title: Patterson Vacation Packages 2026 from $451 | Expedia.com [Hotels in Patterson](https://expedia.com/Patterson-Hotels.d553248635975853657.Travel-Guide-Hotels)[Vacation Rentals in Patterson](https://expedia.com/Patterson-Vacation-Rentals.d553248635975853657.Travel-Guide-VacationRentals)[Car Rentals in Patterson](https://expedia.com/Car-Rentals-In-Patterson.d553248635975853657.Car-Rental-Guide) ![](https://images.trvl-media.com/place/227/7893459b-130a-4697-8b6f-5b03e0729355.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Patterson Vacations from $451 ## Book a Hotel + Flight or Car together to unlock savings Photo by Jonathan Khourie - ## Plan, book, travel with confidence - ### Better together Save up to $1,045 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Plan, book, and manage your trip all in one place ## Your Patterson Vacation With a vacation package to Patterson, say goodbye to endless planning and hello to an effortless adventure. Every detail of your journey has been taken care of before you go, so you can make the most of your time discovering this interesting city. Your trip to Patterson wouldn't be complete without checking out a few popular attractions, such as [Sam A. Baker State Park](https://www.expedia.com/Sam-A-Baker-State-Park-Missouri.d635033035420852224.Vacation-Attraction). Whoever you're going away with and whatever the size of your budget, your dream Patterson vacation is just a few clicks away with Expedia. ## The Latest Patterson vacation packages Price found within the past 48 hours. Click for updated prices. ![University Inn of Carbondale](https://images.trvl-media.com/lodging/60000000/59970000/59964600/59964501/e36c2c4c_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### University Inn of Carbondale $451 per person Jun 12 - Jun 19 found 1 day ago Roundtrip flight included Chicago (CHI) to Cape Girardeau (CGI) 6/10 (349 reviews) The room was alright, it needed cleaned a litter better..... The staff on the kiosk, was nice, however, the woman was not very kind at all Reviewed on Jan 22, 2026 ![Drury Plaza Hotel Cape Girardeau Conference Center](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/5929e46c_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Drury Plaza Hotel Cape Girardeau Conference Center $754 per person Jun 12 - Jun 19 found 1 day ago Roundtrip flight included Chicago (CHI) to Cape Girardeau (CGI) 9.6/10 Exceptional! (1,001 reviews) Beds were clean and well made however carpet in room was stained. There was a chicken nugget on the floor in the elevator upon arrival and was still there the next morning. Breakfast was good except for preparer wiping her nose with her plastic serving gloves on. Good coffee and easy check in. Reviewed on Mar 20, 2026 ![La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/47fa1edf_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau $613 per person Jun 12 - Jun 19 found 1 day ago Roundtrip flight included Chicago (CHI) to Cape Girardeau (CGI) 9/10 Wonderful! (720 reviews) Hotel staff were friendly and helpful. Store and restaurants were a short drive away. Reviewed on Mar 17, 2026 ![Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/fe49057f_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG $735 per person Jun 12 - Jun 19 found 1 day ago Roundtrip flight included Chicago (CHI) to Cape Girardeau (CGI) 9.4/10 Exceptional! (1,007 reviews) This was probably the cleanest hotel we have ever stayed in. The beds were also very comfortable. Staff was also friendly and helpful. Reviewed on Mar 23, 2026 ![Holiday Inn Carbondale-Conference Center by IHG](https://images.trvl-media.com/lodging/2000000/1490000/1489300/1489254/189476cd_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Holiday Inn Carbondale-Conference Center by IHG $689 per person Jun 12 - Jun 19 found 1 day ago Roundtrip flight included Chicago (CHI) to Cape Girardeau (CGI) 8.8/10 Excellent! (660 reviews) Clean and well taken care of. Breakfast was amazing. Staff was on top of everything! Reviewed on Mar 9, 2026 Don't see what you're looking for? See all available trips from Columbus to Patterson [View all trips](https://expedia.com/go/package/search/FlightHotel/2026-04-24/2026-05-01/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=POF&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ## Patterson Hotel Deals ![Sam A Baker State Park](https://images.trvl-media.com/lodging/115000000/114280000/114277700/114277672/0053b39a_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Sam A Baker State Park 5732 State Hwy Missouri 143 Patterson MO $135 nightly $143 total Mar 25 - Mar 26 Total with taxes and fees 9/10 Wonderful! (6 reviews) Janie and her staff were great and very flexible. We had all the hep we needed for everything. Will comeback asap! Reviewed on Dec 29, 2025 [](https://expedia.com/Hotel-Search?startDate=3%2F25%2F2026&endDate=3%2F26%2F2026&selected=114277672&PinnedHotelID=114277672&HadPinnedHotel=true®ionId=553248635975853657) ![Cozy hobby farm cabin under the stars!](https://images.trvl-media.com/lodging/121000000/120280000/120275000/120274982/94f1853a_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Cozy hobby farm cabin under the stars! Greenville MO 10/10 Exceptional! (2 reviews) Easy check in, very quiet, very calming and relaxing. Overall great stay and great property manager. Reviewed on Mar 21, 2026 [Get rates](https://expedia.com/Hotel-Search?startDate=4%2F7%2F2026&endDate=4%2F8%2F2026&selected=120274982&PinnedHotelID=120274982&HadPinnedHotel=true®ionId=553248635975853657) [](https://expedia.com/Hotel-Search?startDate=4%2F7%2F2026&endDate=4%2F8%2F2026&selected=120274982&PinnedHotelID=120274982&HadPinnedHotel=true®ionId=553248635975853657) ![Rustic River Cabin Getaway](https://images.trvl-media.com/lodging/69000000/68030000/68028800/68028738/214bb74d_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Rustic River Cabin Getaway Annapolis MO 9.8/10 Exceptional! (80 reviews) Wonderful location! This is the third October me and my friends come down to relax, unwind, and reconnect. We look forward to 2026 being pir 4th trip to the cabin! Reviewed on Oct 26, 2025 [Get rates](https://expedia.com/Hotel-Search?startDate=4%2F7%2F2026&endDate=4%2F8%2F2026&selected=68028738&PinnedHotelID=68028738&HadPinnedHotel=true®ionId=553248635975853657) [](https://expedia.com/Hotel-Search?startDate=4%2F7%2F2026&endDate=4%2F8%2F2026&selected=68028738&PinnedHotelID=68028738&HadPinnedHotel=true®ionId=553248635975853657) [See all 66 properties in Patterson](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=3%2F25%2F2026&endDate=3%2F26%2F2026®ionId=553248635975853657) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Find the Best Patterson Vacation Packages ## Patterson Essential Information | Language | English | | -------- | ----------- | | Currency | U.S dollars | ## More vacations you might like ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Vacations [](https://expedia.com/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Vacations [](https://expedia.com/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Kid Friendly Vacations 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