Zona 21 Vacations from $887
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Your Zona 21 Vacation
Planning your next adventure just got easier with a vacation package to Zona 21. Embrace the best this neighborhood has to offer while creating fond memories that will last forever. When the time comes to go see the sights, your trip to Zona 21 should include a visit to Mundo Petapa and Universidad del San Carlos de Guatemala. Stop daydreaming and start doing. When it's time to book your vacation to Zona 21, Expedia will help get you there.
The Latest Zona 21 Vacation Packages
Price found within the past 48 hours. Click for updated prices.
- Hotel Casa Ki'iil San Juan La Laguna
Jan 16 - Jan 22Hotel Casa Ki'iil San Juan La Laguna + Flight
San Juan La Laguna6 nights2.0 star property9.2/10 - Wonderful (46 reviews)"Rosario and the groundskeeper Pancho were Amazingly helpful and the Location was perfect to visit San Marcos and San Pedro!!! The room was cute and the View was Beautiful :)"Reviewed September 24, 2026Roundtrip • New York (EWR) - Guatemala City (GUA)JFK - GUA • 1 stop GUA - JFK • 1 stop$1,223$887found 1 day agoper traveler - Villas La Mar
Jan 16 - Jan 22Villas La Mar + Flight
Taxisco6 nights4.0 star property8.2/10 - Very good (152 reviews)"Excellent"Reviewed November 2, 2026Roundtrip • New York (EWR) - Guatemala City (GUA)EWR - SAL • Nonstop SAL - EWR • Nonstop$2,625$1,607found 1 day agoper traveler - El Carmen Hotel
Jan 27 - Jan 31El Carmen Hotel + Flight
Historic Center4 nights3.0 star property9.0/10 - Wonderful (962 reviews)"centrally located with a beautiful terrace view restaurant cant ask for more.."Reviewed November 8, 2026Roundtrip • New York (JFK) - Guatemala City (GUA)JFK - GUA • 1 stop GUA - JFK • 1 stop$1,433$998found 1 day agoper traveler - Kula Maya Boutique Hotel & Spa
Jan 16 - Jan 22Kula Maya Boutique Hotel & Spa + Flight
San Marcos La Laguna6 nights5.0 star property9.4/10 - Exceptional (183 reviews)"Beautiful hotel right on the Lake Atitlan, amazing views, staff were great, and the food at their restaurant was fantastic! My girlfriend also did a four-hour spa treatment that she described as "life changing." Highly recommend this place."Reviewed November 1, 2026Roundtrip • New York (EWR) - Guatemala City (GUA)JFK - GUA • 1 stop GUA - JFK • 1 stop$2,011$1,405found 1 day agoper traveler - Casa Faustina Boutique Hotel
Jan 16 - Jan 22Casa Faustina Boutique Hotel + Flight
Antigua Guatemala6 nights4.0 star property8.8/10 - Excellent (131 reviews)"Very clean and quiet place close to everything"Reviewed October 30, 2026Roundtrip • New York (EWR) - Guatemala City (GUA)EWR - SAL • Nonstop SAL - EWR • Nonstop$1,542$1,086found 1 day agoper traveler
Where to stay in Zona 21
Find the best Zona 21 areas and neighborhoods for the activities you enjoy most.
Zona 10
Zona 10 is known for its ample dining options, and you can make a stop by Oakland Mall and Plaza Fontabella Shopping Center while in the area.
Zona 13
Zona 13 is noteworthy for its gardens, and you can make a stop at top attractions like Avenida Las Américas and La Aurora Zoo.
Zona 9
Zona 9 is known for its abundant dining options, and you can plan a trip to Avenida La Reforma and Torre del Reformador while you're in town.
Photo by Garrett Britton
Open Photo by Garrett Britton
Photo by Iv' Larios
Open Photo by Iv' Larios
Photo by Isa
Open Photo by Isa
Zona 1
Zona 1 is noteworthy for its historic sites, and you can make a stop at top attractions like Catedral Metropolitana and Palacio Nacional de la Cultura.
Zona 4
Visitors to Zona 4 enjoy its restaurants, and if you want to do some exploring, Avenida La Reforma is worth a stop.
What to do near Zona 21
UNESCO JEWEL Antigua Guatemala & Jade Factory Full Day Tour
$60
per adult
100% of travelers recommend
Antigua Guatemala Full-Day Shared City Tour
$355
per adult
80% of travelers recommend
Zona 21 Hotel Deals
Casa hermosa a 20 minutos del aeropuerto
Casa hermosa a 20 minutos del aeropuerto3.0 star property
Zona 21
9.0 out of 10, Wonderful, (2 reviews)
9.0/10
Wonderful
(2 reviews)
"Awesome"
$221 nightly
The price is $265
$265 total
Nov 9 - Nov 10
Total with taxes and fees
9.2 out of 10, Wonderful, (242 reviews)
9.2/10
Wonderful
(242 reviews)
"A wonderful boutique hotel that is modern, clean with great beds and a delicious breakfast. Highly recommend."
$76 nightly
The price is $93
$93 total
Dec 1 - Dec 2
Total with taxes and fees
9.6 out of 10, Exceptional, (1,011 reviews)
9.6/10
Exceptional
(1,011 reviews)
"Quiet central location. Kitchen is nice but doesn’t have any plates, glasses etc. Pool and jacuzzi area is nice. Restaurant is adequate and breakfast was good."
$112 nightly
The price is $136
$136 total
Dec 5 - Dec 6
Total with taxes and fees
9.0 out of 10, Wonderful, (264 reviews)
9.0/10
Wonderful
(264 reviews)
$49 nightly
The price is $60
$60 total
Nov 16 - Nov 17
Total with taxes and fees
9.0 out of 10, Wonderful, (717 reviews)
9.0/10
Wonderful
(717 reviews)
"Es una buena opción para pasar una noche antes de volar temprano por la cercanía al aeropuerto"
$46 nightly
The price is $58
$58 total
Dec 9 - Dec 10
Total with taxes and fees
9.0 out of 10, Wonderful, (122 reviews)
9.0/10
Wonderful
(122 reviews)
"Muy céntrico y cerca del aeropuerto"
$49 nightly
The price is $60
$60 total
Nov 15 - Nov 16
Total with taxes and fees
9.0 out of 10, Wonderful, (413 reviews)
9.0/10
Wonderful
(413 reviews)
$39 nightly
The price is $47
$47 total
Nov 24 - Nov 25
Total with taxes and fees
8.6 out of 10, Excellent, (932 reviews)
8.6/10
Excellent
(932 reviews)
"Good room and service. Poor Wi-Fi in the room downstairs. had to stay upstairs for Wi-Fi connection."
$68 nightly
The price is $84
$84 total
Nov 26 - Nov 27
Total with taxes and fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.