Title: The Best 5 Star Hotels in Clemson, SC from $161 | Expedia.com [Clemson Travel Guide](https://expedia.com/Clemson.dx6594)[Hotels in Clemson](https://expedia.com/Clemson-Hotels.d6594.Travel-Guide-Hotels)[Vacation Rentals in Clemson](https://expedia.com/Clemson-Vacation-Rentals.d6594.Travel-Guide-VacationRentals)[Flights to Clemson](https://expedia.com/Cheap-Flights-To-Clemson.d6594.Travel-Guide-Flights)[Car Rentals in Clemson](https://expedia.com/Car-Rentals-In-Clemson.d6594.Car-Rental-Guide)[Clemson Vacation Packages](https://expedia.com/Clemson.d6594.Destination-Travel-Guides) ![Sunset on the Docks in Clemson, South Carolina; Shutterstock ID 1068665087; purchase_order: SP-1269 HA 2018 Batch 1; Order: ; client: ; other:](https://images.trvl-media.com/place/6594/3559af33-8fc4-4b07-8fe6-f8db466d3d41.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6594/3559af33-8fc4-4b07-8fe6-f8db466d3d41.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Upfront pricing Our total price for your stay includes taxes and fees - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save 10% or more on over 100,000 hotels worldwide with Member Prices [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Clemson 5 Star Hotels Tonight [Mar 16 - Mar 17](https://www.expedia.com/Hotel-Search?regionId=6594&startDate=2026-03-16&endDate=2026-03-17&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Mar 17 - Mar 18](https://www.expedia.com/Hotel-Search?regionId=6594&startDate=2026-03-17&endDate=2026-03-18&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Mar 20 - Mar 22](https://www.expedia.com/Hotel-Search?regionId=6594&startDate=2026-03-20&endDate=2026-03-22&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Mar 27 - Mar 29](https://www.expedia.com/Hotel-Search?regionId=6594&startDate=2026-03-27&endDate=2026-03-29&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Clemson-Hotels.s50-0-d6594.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Clemson-Hotels.s50-0-d6594.Travel-Guide-Filter-Hotels) ## Explore similar 4-star hotels Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Clemson. ![The Shepherd Hotel Downtown Clemson](https://images.trvl-media.com/lodging/88000000/87690000/87688200/87688155/bd45b45c_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### The Shepherd Hotel Downtown Clemson 110 Sloan St Clemson SC $229 nightly $254 total Apr 6 - Apr 7 Total with taxes and fees 9.8/10 Exceptional! (769 reviews) [](https://expedia.com/Clemson-Hotels-The-Shepherd-Hotel-Downtown-Clemson.h87688155.Hotel-Information) ![The Abernathy of Clemson](https://images.trvl-media.com/lodging/18000000/17230000/17229400/17229377/ead974b7_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### The Abernathy of Clemson 157 Old Greenville Hwy Clemson SC $170 nightly $189 total Apr 15 - Apr 16 Total with taxes and fees 9.6/10 Exceptional! (574 reviews) [](https://expedia.com/Anderson-Hotels-The-Abernathy-Of-Clemson.h17229377.Hotel-Information) ![Liberty Hall Bed and Breakfast](https://images.trvl-media.com/lodging/84000000/83030000/83025300/83025265/7ccc39b2_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Liberty Hall Bed and Breakfast 621 S Mechanic St Pendleton SC $145 nightly $161 total Mar 23 - Mar 24 Total with taxes and fees 10/10 Exceptional! (84 reviews) [](https://expedia.com/Pendleton-Hotels-Liberty-Hall-Bed-And-Breakfast.h83025265.Hotel-Information) Still don't see what you're looking for? [See all properties in Clemson.](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F17%2F2026&endDate=3%2F18%2F2026®ionId=6594&star=50) You can also use these popular filters to refine your search. [Pool](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F17%2F2026&endDate=3%2F18%2F2026®ionId=6594&star=50&star=50&amenities=POOL)[Spa](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F17%2F2026&endDate=3%2F18%2F2026®ionId=6594&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F17%2F2026&endDate=3%2F18%2F2026®ionId=6594&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F17%2F2026&endDate=3%2F18%2F2026®ionId=6594&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=3%2F17%2F2026&endDate=3%2F18%2F2026®ionId=6594&star=50&star=50&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Learn more about Clemson Football Saturdays transform this college town into a sea of orange where tailgating is practically a competitive sport. Explore Lake Hartwell's peaceful shores during the day, then head downtown where local restaurants serve Southern classics with a modern twist. [See all hotels in Clemson](https://www.expedia.com/Hotel-Search?startDate=2026-03-30&endDate=2026-03-31&adults=2®ionId=6594) ![Sunset on the Docks in Clemson, South Carolina; Shutterstock ID 1068665087; purchase_order: SP-1269 HA 2018 Batch 1; Order: ; client: ; other:](https://images.trvl-media.com/place/6594/3559af33-8fc4-4b07-8fe6-f8db466d3d41.jpg?impolicy=fcrop&w=900&h=600&p=1&q=high) ## Top Clemson Hotel Reviews ## Find out more about Clemson Ready to experience the next standard in luxury? We know you're thinking about it. Why not request total luxury during your jaunt to Clemson? There's no reason to delay a getaway to Clemson any longer. You'll join the multitudes of vacationers who have made Clemson so fashionable in the last year. Additionally, the hotels in this area receive outstanding marks for guest services, so you know you'll want for nothing during your getaway. What are you waiting for? Our 5-star hotels in Clemson are the perfect places to relax in when you really need to escape. ### 5-Star Hotels in Clemson Don't be afraid to be pampered during your trip, along with pristine rooms. Michelin-starred restaurants, exceptional customer care, and fabulous spa offerings are all on offer. You're sure to find exactly the accommodation you need. Besides that, you'll find that these hotels are kept in fantastic condition and provide a fine place to lay your head at night. How do you want to relax? A concierge to help you pick out your next adventure? A Swedish massage to help your cares fall away? Comfortable beds, piping hot coffees, and even spectacular views...these hotels have it all. But you aren't going to spend your entire vacation in your room, of course. We've got you covered. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what you end up doing, the 5-star hotels in Clemson are waiting for you to rest up after a busy day. Ready to learn more? Then check out the many reviews left by previous guests -- you can take their word for it! ### Make Your Escape The results are in, and Clemson 5-star hotels are the place to be when you book your next vacation. Many visitors recommend a trip to this location, so don't wait any longer. Expedia can help you land a great deal on accommodation. Don't put off your dream vacation any longer. Opt for one of the 5-star hotels in Clemson today and soothe yourself in the lap of luxury tomorrow. ## Frequently asked questions ### How much does it cost to stay in a 5-star hotel in Clemson? > - Search for the lowest price per night from $161 ### What makes a hotel 5 stars in Clemson? ### Are there any 5-star all-inclusive resorts in Clemson? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - [Hotels near Clemson University ](https://www.expedia.com/Clemson-University-Hotels.0-l6127431-0.Travel-Guide-Filter-Hotels) - [Hotels near Memorial Stadium ](https://www.expedia.com/Memorial-Stadium-Hotels.0-l6193935-0.Travel-Guide-Filter-Hotels) - [Hotels near Fort Hill ](https://www.expedia.com/Fort-Hill-Hotels.0-l553248621532656693-0.Travel-Guide-Filter-Hotels) - [Hotels near Larry W. Abernathy Waterfront Park ](https://www.expedia.com/Larry-W-Abernathy-Waterfront-Park-Hotels.0-l553248621532656695-0.Travel-Guide-Filter-Hotels) - [Hotels near Littlejohn Coliseum ](https://www.expedia.com/Littlejohn-Coliseum-Hotels.0-l6228662-0.Travel-Guide-Filter-Hotels) - [Hotels near Clemson Station ](https://www.expedia.com/Clemson-Station-Hotels.d6194530.Travel-Guide-Hotels) - [Hotels near Brooks Center for the Performing Arts ](https://www.expedia.com/Brooks-Center-For-The-Performing-Arts-Hotels.0-l6228683-0.Travel-Guide-Filter-Hotels) - [Hotels near South Carolina Botanical Gardens ](https://www.expedia.com/South-Carolina-Botanical-Gardens-Hotels.0-l6228711-0.Travel-Guide-Filter-Hotels) - [Hotels near Walker Golf Course ](https://www.expedia.com/Walker-Golf-Course-Hotels.0-l6228657-0.Travel-Guide-Filter-Hotels) - [Gay friendly Hotels in Keowee ](https://www.expedia.com/Keowee-Hotels-LGBT-Welcoming-Hotel.0-0-d553248635975848347-tLGBTWelcomingHotel.Travel-Guide-Filter-Hotels) - [Hotels near Oconee County Regional ](https://www.expedia.com/Oconee-County-Regional-Airport-Hotels.0-aCEU-0.Travel-Guide-Filter-Hotels) - [Flights from Oconee County Regional ](https://www.expedia.com/lp/airports/ceu/flights-from-oconee-county-regional-airport) - [Flights from Atlanta (ATL) to Clemson (CEU) ](https://www.expedia.com/lp/flights/atl/ceu/atlanta-to-clemson) - [Flights from Charlotte (CLT) to Clemson (CEU) ](https://www.expedia.com/lp/flights/clt/ceu/charlotte-to-clemson) - [Flights from New York (JFK) to Clemson (CEU) ](https://www.expedia.com/lp/flights/jfk/ceu/new-york-to-clemson) - [Flights from Boston (BOS) to Clemson (CEU) ](https://www.expedia.com/lp/flights/bos/ceu/boston-to-clemson) - [Flights from Asheville (AVL) to Clemson (CEU) ](https://www.expedia.com/lp/flights/avl/ceu/asheville-to-clemson) - [Flights from Washington (DCA) to Clemson (CEU) ](https://www.expedia.com/lp/flights/dca/ceu/washington-to-clemson) - [Flights from Philadelphia (PHL) to Clemson (CEU) ](https://www.expedia.com/lp/flights/phl/ceu/philadelphia-to-clemson) - [Flights from Miami (MIA) to Clemson (CEU) ](https://www.expedia.com/lp/flights/mia/ceu/miami-to-clemson) - [Flights from Tampa (TPA) to Clemson (CEU) ](https://www.expedia.com/lp/flights/tpa/ceu/tampa-to-clemson) - [Flights from Chicago (ORD) to Clemson (CEU) ](https://www.expedia.com/lp/flights/ord/ceu/chicago-to-clemson) - [Flights from Nashville (BNA) to Clemson (CEU) ](https://www.expedia.com/lp/flights/bna/ceu/nashville-to-clemson) - [Flights from Pittsburgh (PIT) to Clemson (CEU) ](https://www.expedia.com/lp/flights/pit/ceu/pittsburgh-to-clemson) - [Flights from Dallas (DFW) to Clemson (CEU) ](https://www.expedia.com/lp/flights/dfw/ceu/dallas-to-clemson) - [Flights to Oconee County Regional ](https://www.expedia.com/Cheap-Flights-To-Oconee-County-Regional.d6026946.Travel-Guide-Flights) - [Flights from Tallahassee (TLH) to Clemson (CEU) ](https://www.expedia.com/lp/flights/tlh/ceu/tallahassee-to-clemson) - [Flights from Baltimore (BWI) to Clemson (CEU) ](https://www.expedia.com/lp/flights/bwi/ceu/baltimore-to-clemson) - [Flights from Hartford (BDL) to Clemson (CEU) ](https://www.expedia.com/lp/flights/bdl/ceu/hartford-to-clemson) - [Flights from Austin (AUS) to Clemson (CEU) ](https://www.expedia.com/lp/flights/aus/ceu/austin-to-clemson) - [Flights from Augusta (AGS) to Clemson (CEU) ](https://www.expedia.com/lp/flights/ags/ceu/augusta-to-clemson) - [Flights from Richmond (RIC) to Clemson (CEU) ](https://www.expedia.com/lp/flights/ric/ceu/richmond-to-clemson) - [Flights from Syracuse (SYR) to Clemson (CEU) ](https://www.expedia.com/lp/flights/syr/ceu/syracuse-to-clemson) - [Flights from Indianapolis (IND) to Clemson (CEU) ](https://www.expedia.com/lp/flights/ind/ceu/indianapolis-to-clemson) - [Flights from Albany (ALB) to Clemson (CEU) ](https://www.expedia.com/lp/flights/alb/ceu/albany-to-clemson) - [Flights from Chattanooga (CHA) to Clemson (CEU) ](https://www.expedia.com/lp/flights/cha/ceu/chattanooga-to-clemson) - [Flights from Fort Lauderdale (FLL) to Clemson (CEU) ](https://www.expedia.com/lp/flights/fll/ceu/fort-lauderdale-to-clemson) - [Flights from Jacksonville (JAX) to Clemson (CEU) ](https://www.expedia.com/lp/flights/jax/ceu/jacksonville-to-clemson) - 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[Flights from Panama City (PTY) to Clemson (CEU) ](https://www.expedia.com/lp/flights/pty/ceu/panama-city-to-clemson) - [Flights from Colorado Springs (COS) to Clemson (CEU) ](https://www.expedia.com/lp/flights/cos/ceu/colorado-springs-to-clemson) - [Flights from Fresno (FAT) to Clemson (CEU) ](https://www.expedia.com/lp/flights/fat/ceu/fresno-to-clemson) - [Flights from Moline (MLI) to Clemson (CEU) ](https://www.expedia.com/lp/flights/mli/ceu/moline-to-clemson) - [Larry W. Abernathy Waterfront Park ](https://www.expedia.com/Larry-W-Abernathy-Waterfront-Park-Clemson.d553248621532656695.Vacation-Attraction) - [Fort Hill ](https://www.expedia.com/Fort-Hill-Clemson.d553248621532656693.Vacation-Attraction) - [Memorial Stadium ](https://www.expedia.com/Memorial-Stadium-Clemson.d6193935.Vacation-Attraction) - [Clemson University ](https://www.expedia.com/Clemson-University-Clemson.d6127431.Vacation-Attraction) - [Littlejohn Coliseum ](https://www.expedia.com/Littlejohn-Coliseum-Clemson.d6228662.Vacation-Attraction) - [Lee Gallery ](https://www.expedia.com/Lee-Gallery-Clemson.d553248621532656692.Vacation-Attraction) - [Brooks Center for the Performing Arts ](https://www.expedia.com/Brooks-Center-For-The-Performing-Arts-Clemson.d6228683.Vacation-Attraction) - [South Carolina Botanical Gardens ](https://www.expedia.com/South-Carolina-Botanical-Gardens-Clemson.d6228711.Vacation-Attraction) - [Van Car Rentals near Clemson University ](https://www.expedia.com/Van-Car-Rentals-In-Clemson-University.d6127431-tVan.Car-Rental-Guide-Class) - [Car rentals near Clemson University ](https://www.expedia.com/Car-Rentals-In-Clemson-University.d6127431.Car-Rental-Guide) - [Car rentals near Littlejohn Coliseum ](https://www.expedia.com/Car-Rentals-In-Littlejohn-Coliseum.d6228662.Car-Rental-Guide) - [Car rentals near Keowee ](https://www.expedia.com/Car-Rentals-In-Keowee.d553248635975848347.Car-Rental-Guide) - [Car rental Seneca Airport (CEU) ](https://www.expedia.com/Car-Rentals-In-Oconee-County-Regional.d6026946.Car-Rental-Guide)