Santa Fe Vacations from $626

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Your Santa Fe Vacation

Our vacation packages to Santa Fe let you customize your own adventure. Tailor your getaway to suit your interests and needs and make the most of your time in this interesting city. Want to explore your surroundings? Alto de Piedra Waterfall, Town Square and Cerro Tute are some of the most popular places to visit during your trip to Santa Fe. Stop daydreaming and start traveling. Browse the wide range of options on Expedia today and finally put your Santa Fe vacation plans into motion!

The Latest Santa Fe vacation packages

Price found within the past 48 hours. Click for updated prices.
Mahogany Suites

Mahogany Suites

2 out of 5
Price was $1,190, price is now $626 per person
$626
per person
Jan 11 - Jan 17
found 1 day ago
Roundtrip non-stop flight included
Atlanta (ATL) to Panama City (PTY)
20/10 Exceptional! (1 review)
Central Hotel Bocas del Toro

Central Hotel Bocas del Toro

3 out of 5
Price was $1,895, price is now $1,213 per person
$1,213
per person
Feb 13 - Feb 16
found 13 hours ago
Roundtrip non-stop flight included
New York (NYC) to Panama City (PTY)
No reviews
Casa Lefevre By Wynwood House

Casa Lefevre By Wynwood House

3.5 out of 5
Save 100% on your flight
Price was $1,339, price is now $870 per person
$870
per person
Feb 4 - Feb 10
found 1 day ago
Roundtrip flight included
Miami (MIA) to Panama City (PTY)
17.6/10 Exceptional! (3 reviews)
Reseña sugerida: La propiedad está muy bonita y completamente remodelada, lo cual se agradece mucho. Sin embargo, hubo varios detalles que no permitieron que mi estadía fuera 100% cómoda. • En los baños salía un olor desagradable de las cañerías, lo que impregnaba el ambiente. • Las baterías del control de aire acondicionado de un cuarto estaban agotadas y tuve que usar el control de otro. • La pared de piedra junto a la cama desprende un polvo fino que cae sobre la cama. • Para una estadía de 9 días, la cantidad de toallas (2), papel higiénico y bolsas de basura proporcionadas fue muy limitada. • La secadora no funcionaba, por lo que tuve que secar la ropa en otra parte de la casa. • Debido a la ubicación, se escucha bastante ruido en el apartamento. En general, la propiedad tiene mucho potencial y está bien ubicada, pero considero importante que se atiendan estos detalles para que la experiencia sea más placentera.

Reviewed on Sep 8, 2025

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Price was $1,363, price is now $900 per person
$900
per person
Jan 29 - Feb 1
found 1 day ago
Roundtrip non-stop flight included
Atlanta (ATL) to Panama City (PTY)
18/10 Exceptional! (1,002 reviews)
Hotel was beautiful, staff was very helpful and accommodating. We had the pool two separate days to ourselves. Breakfadt was very good. Staff was very helpful getting us drivers wherever we wanted to go in the city.

Reviewed on Nov 16, 2025

Gamboa Rainforest Reserve

Gamboa Rainforest Reserve

3.5 out of 5
Price was $1,129, price is now $760 per person
$760
per person
Feb 2 - Feb 7
found 1 day ago
Roundtrip non-stop flight included
New York (NYC) to Panama City (PTY)
15.6/10 Exceptional! (654 reviews)
So good ! Excellent activities for the kids. Amazing the tour guide ! The pool are the best !

Reviewed on Nov 4, 2025

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Discover the most popular places to visit in Santa Fe

Alto de Piedra Waterfall

Commune with nature and explore the great outdoors at Alto de Piedra Waterfall during your travels in Santa Fe. While you're in the area, wander around the natural setting.

Alto de Piedra Waterfall

Catholic Church of Santa Fe

After visiting Catholic Church of Santa Fe, make a plan to see the other sights and activities in Santa Fe. Stroll along the riverfront or visit the churches while you're in the area.

Catholic Church of Santa Fe

Town Square

You can find out about the history of Santa Fe with a stop at Town Square. Amble around the area's riverfront or visit its churches.

Town Square

Santa Fe Hotel Deals

La Qhia Eco Retreat

La Qhia Eco Retreat

2.5 out of 5
Barriada el Cerro A 100 Mts De Santa Fe Veraguas
Fully refundableReserve now, pay when you stay
$55 nightly
The price is $60 total per night from Nov 22 to Nov 23
$60 total
Nov 22 - Nov 23
Total with taxes and fees
7.8/10 Good! (18 reviews)
Nice stay in Santa Fe
Our room had some drawbacks, like many gaps between the roof and walls that enable insects to go inside, but we used our own mosquito net and we were safe to sleep quietly. The second night ants invaded our room, we were offered to be moved to another room, but we were ok with the solution to spray ...

Reviewed on Mar 17, 2025

La Qhia Eco Retreat
Hotel Anachoreo

Hotel Anachoreo

3 out of 5
Calle Chinita Santa Fe Veraguas Province
Fully refundableReserve now, pay when you stay
9.4/10 Exceptional! (35 reviews)
Wonderful location with absolutely breathing taking views! Room was quite large with a seating area. Beds comfortable but could use slightly better pillows.

Reviewed on Nov 14, 2025

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Hotel Anachoreo
Cabana Vergara Santa Fe

Cabana Vergara Santa Fe

2 out of 5
Provincia de Veraguas, Panama Panama
$160 nightly
The price is $160 total per night from Nov 22 to Nov 23
$160 total
Nov 22 - Nov 23
Total with taxes and fees
Cabana Vergara Santa Fe
See all 16 properties in Santa Fe
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Santa Fe Vacation Packages

Santa Fe Essential Information

Language
Spanish
Currency
Panamanian balboas
Local Welcome
¡Hola!
Local Goodbye
Adiós
Population
970
Max Temp Winter
90ºF
Max Temp Summer
85ºF
Top Sights
Alto de Piedra Waterfall, Cascada de Bermejo and Town Square

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Frequently asked questions

How much does a Santa Fe vacation package cost?
You'll find cheap prices from $626 on Expedia for your Santa Fe break. However, factors like the season, length of stay and your choice of hotel will determine how much your vacation to Santa Fe costs.
What are the cheapest months to go to Santa Fe?
If you're looking to score a cheap Santa Fe vacation package, consider traveling in April, July and August. You'll generally find lower prices on airfares and hotels during these quieter months — perfect for a budget-friendly break.
How many days is enough for Santa Fe?
Typically, a handful of days is enough to check out the main attractions during your Santa Fe vacation. But if you'd like to have some time to rest or go on day trips, think about extending your itinerary.
Is it worth booking a vacation package to Santa Fe?
Well known for its nature, hiking and a host of other highlights, you can be certain Santa Fe is a good vacation destination. Some of the top attractions to put on your to-do list? Don't miss Alto de Piedra Waterfall and Town Square during your Santa Fe vacation.
How to find the best Santa Fe package deals?
Start your search for a Santa Fe package deal by entering your preferred travel dates and destination under our "Packages" tab. Then add some filters, like "Property type" and "Amenities," to tailor the results to your exact needs. You can also sort by "Package discount" and browse offers that come with big savings. If you don't find the perfect Santa Fe package deal straight away, just play around with your dates and search again. Remember that deals are only available for a limited time, so book early and get your Santa Fe getaway off to a flying start.
Is it cheaper to book a Santa Fe vacation as a package?
Expedia vacation packages are designed to help you keep more money in your pocket. Bundle your flight, car rental and hotel into one great-value price and you could save hundreds of dollars. You'll generally land a better deal than booking each component individually. And you'll still get the flexibility to create a personalized Santa Fe vacation by choosing your favorite accommodation type, airline and car class.
When to book a vacation package to Santa Fe?
Enjoy incredible discounts by reserving your flights early with Expedia. If being spontaneous is more your thing, grab one of our last-minute deals for an impromptu Santa Fe trip.
Does Expedia offer Book Now, Pay Later Santa Fe vacation packages?
Secure your ideal getaway to Santa Fe with Expedia's Book Now, Pay Later vacations. There's no need to scrimp and save or wait for your next paycheck — we've partnered with online lender Affirm to give you more flexibility and choice. Our vacation packages with payment plans let you spread the total cost over 3, 6 or 12 months. With no hidden or late payment fees, it's a breeze to stick to your budget and snap up bargains before they disappear.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.