Find Vacation Homes in Des Moines County, IA from $163

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Top Cities in Des Moines County

Vacation Homes in Des Moines County

Experience Beautiful Pioneer Home In Nauvoo!

Nauvoo
9.8 out of 10, Exceptional, (76)
"Authentic feel with modern day convenient items. Fun house with rich history. Would definitely stay again "
United States
Jared T.
$345 nightly
The price is $366
Dec 7 - Dec 8
Total with taxes and fees
Experience Beautiful Pioneer Home In Nauvoo!

50' from the Mississippi River, see the winter eagle migration, fish from there

Montrose
50' from the Mississippi River, see the winter eagle migration, fish from there

Historic Gem 1840's newly furnished brick house.

Nauvoo
10.0 out of 10, Exceptional, (80)
"Very convenient and unique stay. "
United States
Cindy P.
Historic Gem 1840's newly furnished brick house.

Grand Victorian on the Mississippi

Fort Madison
9.8 out of 10, Exceptional, (22)
"The Grand Victorian is AMAZING!! The house is gorgeous and beautifully decorated. Everything was there that we needed, the area was peaceful and easy to access. Highly recommend staying here! "
United States
Andrea S.
$383 nightly
The price is $429
Dec 8 - Dec 9
Total with taxes and fees
Grand Victorian on the Mississippi

Riverside Waterfront on the Mississippi River

Pontoosuc
9.8 out of 10, Exceptional, (21)
"The property is cute and very clean right on the river!! Would definitely stay again!!"
United States
Amy M.
$272 nightly
The price is $288
Dec 13 - Dec 14
Total with taxes and fees
Riverside Waterfront on the Mississippi River

Charming Nauvoo Farmhouse - 1 mile from Nauvoo Temple

Nauvoo
10.0 out of 10, Exceptional, (34)
"We had an amazing stay here in Nauvoo. It was great to be able to stay together as a family. The house was beautiful and had everything we needed. Contact with the owners was excellent. It was our favorite place to stay on our road trip. "
United States
Amanda M.
Charming Nauvoo Farmhouse - 1 mile from Nauvoo Temple

Oquawka Cottage With River View

Oquawka
9.6 out of 10, Exceptional, (8)
"Cute little cottage, very clean. Wonderful beds. Very peaceful visit. Will come again"
United States
sally
Oquawka Cottage With River View

Nauvoo Windmill Farmhouse 10-12 people

Niota
10.0 out of 10, Exceptional, (10)
"The check-in was pretty easy and the kitchen had everything we needed to make quick meals. "
United States
Tony H.
$155 nightly
The price is $164
Jan 4 - Jan 5, 2026
Total with taxes and fees
Nauvoo Windmill Farmhouse 10-12 people

Mayor's Manor - with everything you need in a homebase get away. Pet friendly.

Montrose
10.0 out of 10, Exceptional, (13)
"Very comfortable and convenient for our stay. Highly recommend."
United States
bob f.
Mayor's Manor - with everything you need in a homebase get away. Pet friendly.

Charming Cottage, close to all the sights.

Nauvoo
10.0 out of 10, Exceptional, (24)
"Really great home! "
United States
Julie Broc G.
Charming Cottage, close to all the sights.

PAGEANT -Eagles Nest home with view of the Mississippi and Gorgeous Sunsets

Nauvoo
9.0 out of 10, Wonderful, (2)
"beautiful view of the river, lovely high end finishes throughout home"
United States
anita s.
$332 nightly
The price is $352
Dec 11 - Dec 12
Total with taxes and fees
PAGEANT -Eagles Nest home with view of the Mississippi and Gorgeous Sunsets

Downtown Columbus 2 bedroom unit with great views!

Columbus Junction
8.0 out of 10, Very Good, (2)
"Clean and comfortable. Host communicated well. Nothing to complain about. Would stay here again."
United States
Geoff G.
Downtown Columbus 2 bedroom unit with great views!

Golf and Stay house is next to Twin Oaks Golf Course. Lovely 9 hole golf course.

Blandinsville
9.4 out of 10, Exceptional, (16)
"Stayed here while our daughter was at a volleyball camp at Western. Great little place. Will definitely pass on to friends whose kids go to Western and will stay again when we are back down."
United States
Jen A.
$154 nightly
The price is $163
Dec 8 - Dec 9
Total with taxes and fees
Golf and Stay house is next to Twin Oaks Golf Course. Lovely 9 hole golf course.

Historic 1840s Lamoreaux House / Modern Addition

Nauvoo
9.8 out of 10, Exceptional, (18)
"We had a great time. It was fun to stay in a historic home. "
United States
David A.
$372 nightly
The price is $394
Dec 7 - Dec 8
Total with taxes and fees
Historic 1840s Lamoreaux House / Modern Addition

Charming Modern 1950s Mid-Century Ranch.

Mount Pleasant
9.8 out of 10, Exceptional, (13)
"Great house, location but the host was amazing. Will stay here again "
United States
Annette M.
Charming Modern 1950s Mid-Century Ranch.

Home Away From Home

Biggsville
10.0 out of 10, Exceptional, (2)
"Our experience all around was good. Communication with host was easy and they worked with us great. House was clean, in a quite neighborhood and definitely better than a hotel."
United States
Thomas A.
$189 nightly
The price is $200
Dec 8 - Dec 9
Total with taxes and fees
Home Away From Home

Cozy House

Biggsville
10.0 out of 10, Exceptional, (4)
"Used the house to stay in while hunting in area."
United States
Jared S.
$167 nightly
The price is $176
Dec 7 - Dec 8
Total with taxes and fees
Cozy House

Historic St Joseph Catholic Church 2.5 blocks from Mississippi River

Fort Madison
Historic St Joseph Catholic Church 2.5 blocks from Mississippi River

The Fleetwood Inn with Dreamy Porch

Burlington
The Fleetwood Inn with Dreamy Porch

1 Mi to Dtwn Burlington: Modern Home w/ Yard!

2.0 star property
Burlington
1 Mi to Dtwn Burlington: Modern Home w/ Yard!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Des Moines County Hotel Reviews

Find out more about Des Moines County

Booking Tips to Find the Best Des Moines County Vacation Homes


How much does it cost to rent a vacation home in Des Moines County?

You can find incredible Des Moines County vacation homes for all types of budgets: between $163 and $429 per night. The more amenities the rental has, and its proximity to popular places, the higher the price.


What is the best time to stay in a vacation home in Des Moines County?

If you are looking for a great deal on your vacation home in Des Moines County, consider visiting in , when prices are usually cheaper.


How many vacation homes are available for rent in Des Moines County?

There are 26 rental houses to choose from for your trip. You’ll find holiday homes located throughout the city, near sightseeing spots, and close to local nature areas.


How do I find the best deal for a vacation home in Des Moines County?

Begin by entering your trip dates to see what type of Des Moines County rental houses are available. Use the map to zoom closer into the areas or zoom out to include more locations. Use the filters on the left side of your search results to narrow down by star rating, price, number of bedrooms, amenities, and more—Expedia makes it easy to score the best deal for your budget.


Why should I rent a vacation home in Des Moines County?

Booking Des Moines County vacation home rentals is the perfect way to spend a vacation because of the privacy, variety of amenities, and comfort you’ll have in your own space.


What amenities are available in a private vacation home?

When thinking about what you want in your Des Moines County rental house, dream big! Depending on your budget and the area, you’ll find amenities like a private pool, hot tub, free parking, fully-equipped kitchen, in-home washer and dryer, Wi-Fi, and a beautiful view or easy access to local sightseeing spots. You can even filter your search results by accessibility to ensure that everyone in your party will be comfortable.


Why should I book a vacation home with Expedia?

Expedia has some of the best selection and deals on available vacation homes in the area—and all in one place. We reward you with members points back on every booking and ensure you get the right accommodation for the best price. And you’ll save big when you bundle your travel together, like booking a car rental in Des Moines County along with your vacation property, into a Des Moines County vacation package.


Can I cancel my vacation home with Expedia?

Some accommodations are free to cancel and refundable if done so by a specific date, while others may be non-refundable. To make sure that you can get your money back on cancellations, use the “free cancellation” filter during your search. Contact our customer service portal if you need help.

Des Moines County Vacation Homes information

Number of reviews
336
Accommodation
26 Vacation Homes
Lowest Price
$163
Highest Price
$429

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