South Main, TX
Houston
Visit South Main
Things to do
Houston: Space Center Houston Admission Ticket
Houston's Official City & Mural Tour!
NASA's Space Center & Official Houston City Tour with tickets
Astroville Tunnel Tour of Downtown Houston (Air-Conditioned)
Houston: Houston Botanic Garden Entry Ticket
South Main Hotel Deals
Wyndham Houston near NRG Park/Medical Center
"Awesome place!"
Reviewed on Jul 6, 2026
Hotel Zaza Houston Museum District
"Love this property and its proximity to the Museum of Fine Art Houston and the Museum District. Restaurant is fair — kind of hit-or-miss on food and service. Nice to have the semi-outdoor patio for a buffer zone when the bar is hopping. Front desk and bell team are terrific."
Reviewed on Jul 6, 2026
Grand Tuscany Hotel
"Cheap owners-No waste basket (only in the bathroom), microwave, or fridge in the room. Long wait for elevator. Definitely not worth $178/night."
Reviewed on Jul 6, 2026
Club Quarters Hotel Downtown, Houston
"I didn’t like the hotel, it’s outdated."
Reviewed on Jul 6, 2026
Marriott Marquis Houston
"Everyone at the hotel was so nice!"
Reviewed on Jul 6, 2026
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
"The room where very clean and staff were very nice and helpful"
Reviewed on Jul 5, 2026
Where to stay in South Main
Downtown Houston
Known for its abundant dining options and live music, there's plenty to explore in Downtown Houston. Top attractions like Daikin Park and Toyota Center are major draws, and you can catch the metro at Central Station Main or Main Street Square Station to see more of the city.
The Galleria
Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.
Texas Medical Center
Well-liked for its restaurants, museums, and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo is a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.
Montrose
Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.
