
South Main Vacations from $253
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Your South Main Vacation
Take the stress out of planning your next escape by booking a South Main vacation package. Take in the sights and sounds of this wonderful neighborhood and enjoy what it has to offer. Hoping to sightsee during your trip to South Main? Don't miss nearby attractions such as NRG Stadium, NRG Park and Rice Stadium. Expedia will help you turn your ideal South Main vacation into reality, whatever your budget or travel plans.
The Latest South Main Vacation Packages



Experience a First Class Stay - 2 BDRM
Reviewed on Mar 11, 2022

Galveston Beach Hotel
Reviewed on Jul 6, 2026
Where to stay in South Main

Downtown Houston
Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.
South Main Hotel Deals

Wyndham Houston near NRG Park/Medical Center
"Awesome place!"
Reviewed on Jul 6, 2026

Hotel Zaza Houston Museum District
"Love this property and its proximity to the Museum of Fine Art Houston and the Museum District. Restaurant is fair — kind of hit-or-miss on food and service. Nice to have the semi-outdoor patio for a buffer zone when the bar is hopping. Front desk and bell team are terrific."
Reviewed on Jul 6, 2026

Grand Tuscany Hotel
"Cheap owners-No waste basket (only in the bathroom), microwave, or fridge in the room. Long wait for elevator. Definitely not worth $178/night."
Reviewed on Jul 6, 2026
Things to do

Houston: Space Center Houston Admission Ticket

Houston's Official City & Mural Tour!
























