South Main Vacations from $239

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Your South Main Vacation

Take the stress out of planning your next escape by booking a South Main vacation package. Take in the sights and sounds of this wonderful neighborhood and enjoy what it has to offer. Hoping to sightsee during your trip to South Main? Don't miss nearby attractions such as NRG Stadium, NRG Park and Rice Stadium. Expedia will help you turn your ideal South Main vacation into reality, whatever your budget or travel plans.

The Latest South Main Vacation Packages

Price found within the past 48 hours. Click for updated prices.
DoubleTree by Hilton Hotel & Suites Houston by the Galleria

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

4 out of 5
Greater Uptown
Save 100% on your flight
Price was $389, price is now $239 per person
$239
per person
Nov 16 - Nov 19
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Houston (IAH)
8.2/10 Very Good! (2,530 reviews)
Balcony room was the excellent choice to go! Amazing view, and the room was nice and clean. Great area for walking around various stores, shops, and restaurants

Reviewed on Oct 13, 2025

Moody Gardens Hotel, Spa and Convention Center

Moody Gardens Hotel, Spa and Convention Center

4 out of 5
Near West End
Save 100% on your flight
Price was $773, price is now $469 per person
$469
per person
Nov 13 - Nov 16
found 1 day ago
Roundtrip non-stop flight included
New York (JFK) to Houston (IAH)
8.8/10 Excellent! (1,894 reviews)
The attractions and shows end a big too early. We arrived at the hotel in the afternoon but all attractions and shows ended and we have nothing to do. The staff at the rope course was pretty rude which made us decide not to take it.

Reviewed on Oct 13, 2025

Palace Inn Blue Edgebrook

Palace Inn Blue Edgebrook

3 out of 5
Southeast Houston
Price was $406, price is now $265 per person
$265
per person
Dec 19 - Dec 22
found 12 hours ago
Roundtrip flight included
Atlanta (ATL) to Houston (IAH)
9.4/10 Exceptional! (137 reviews)
Such a great place to stay! Absolutely amazing!

Reviewed on Oct 13, 2025

Hotel Granduca Houston

Hotel Granduca Houston

4 out of 5
The Galleria
Save 100% on your flight
Price was $760, price is now $506 per person
$506
per person
Nov 22 - Nov 25
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Houston (IAH)
9.2/10 Wonderful! (1,007 reviews)
Restaurant is excellent.

Reviewed on Oct 2, 2025

Hilton Houston North

Hilton Houston North

3.5 out of 5
Northside
Save 100% on your flight
Price was $361, price is now $242 per person
$242
per person
Nov 16 - Nov 19
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Houston (IAH)
8.2/10 Very Good! (1,010 reviews)
I enjoyed my stay, the housekeeping are very nice

Reviewed on Oct 13, 2025

Where to stay in South Main

Find the best South Main areas and neighborhoods for the activities you enjoy most. Learn more about South Main
Discovery Green which includes a city, central business district and a high rise building

Downtown Houston

3 out of top 10 points of interest in this area
4.5/5(2,300 area reviews)

Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

Find hotels in Downtown Houston

South Main Hotel Deals

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

4 out of 5
5353 Westheimer Rd, Houston, TX
Fully refundableReserve now, pay when you stay
$123 nightly
The price is $144 total per night from Oct 30 to Oct 31
$144 total
Oct 30 - Oct 31
Total with taxes and fees
8.2/10 Very Good! (2,656 reviews)
"Parking"

Reviewed on Oct 7, 2025

DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston

4 out of 5
1085 Rusk Street, Houston, TX
Fully refundableReserve now, pay when you stay
$117 nightly
The price is $137 total per night from Oct 16 to Oct 17
$137 total
Oct 16 - Oct 17
Total with taxes and fees
8.4/10 Very Good! (3,763 reviews)
"decent"

Reviewed on Oct 8, 2025

Club Quarters Hotel Downtown, Houston
Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District

4.5 out of 5
5701 Main Street, Houston, TX
Fully refundableReserve now, pay when you stay
$284 nightly
The price is $333 total per night from Nov 2 to Nov 3
$333 total
Nov 2 - Nov 3
Total with taxes and fees
8.8/10 Excellent! (1,790 reviews)
"I was having some significant mental health issues…This was cheaper and more therapeutic. The staff was just reflexively nice and accommodating. Sometimes all you need is nice and well intentioned people around you, in any companies, to relax, to restores Thanks y’all ❤️"

Reviewed on Oct 8, 2025

Hotel Zaza Houston Museum District
See all 6,562 properties in South Main
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Discover the most popular places to visit in South Main

Close to the entrance of convention center.

George R. Brown Convention Center

4/5(961 reviews)

During your trip, find out what's happening at George R. Brown Convention Center, a top convention center in Houston. Experience the acclaimed theater scene and entertainment choices in this vibrant area.

George R. Brown Convention Center
NASA Johnson Space Center

NASA Johnson Space Center

4.5/5(1,214 reviews)

After visiting NASA Johnson Space Center, make a plan to see the other sights and activities in Houston. Amble around the area's lakeside or attend a sporting event.

NASA Johnson Space Center
Friday night fireworks.

Daikin Park

4.5/5(907 reviews)

Catch an event at Daikin Park during your trip to Houston. Experience the entertainment choices and great live music in this vibrant area.

Daikin Park

Things to do

Houston Space Center

Space Center Houston Admission Ticket

$33
per adult
88% of travellers recommend
Space Center Houston Admission Ticket
Houston: Houston Botanic Garden Entry Ticket

Houston: Houston Botanic Garden Entry Ticket

$12
per adult
80% of travellers recommend
Houston: Houston Botanic Garden Entry Ticket
Houston: Children's Museum Houston Entry Ticket

Houston: Children's Museum Houston Entry Ticket

$20
per adult
100% of travellers recommend
Houston: Children's Museum Houston Entry Ticket
See all activities in Houston
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.