South Main Vacations from $253
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Your South Main Vacation
Take the stress out of planning your next escape by booking a South Main vacation package. Take in the sights and sounds of this wonderful neighborhood and enjoy what it has to offer. Hoping to sightsee during your trip to South Main? Don't miss nearby attractions such as NRG Stadium, NRG Park and Rice Stadium. Expedia will help you turn your ideal South Main vacation into reality, whatever your budget or travel plans.
The Latest South Main Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Experience a First Class Stay - 2 BDRM
Save 100% on your flight
Price was $911, price is now $627 per person
$627
per person
Aug 28 - Sep 1
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to Houston (IAH)
8/10 Very Good! (5 reviews)
This people have water that smells like poop. Sewage water is what they use for water. Remnants of trash, sticky nastiness in drawers, air vents falling off ceilings. Random kids belts found? Candy stuck to floor? Trash wasn’t even taken out. Mind you I have kids that found these things as well.
Oh and don’t even try and ask for them to refund you for their disgusting rental. They will give you the run around and then IGNORE YOU. Awful establishment and these people NEED TO BE SHUTDOWN.
Reviewed on Mar 11, 2022
Galveston Beach Hotel
Near West End
Save 100% on your flight
Price was $1,383, price is now $986 per person
$986
per person
Sep 12 - Sep 16
found 1 day ago
Roundtrip flight included
Baltimore (BWI) to Houston (IAH)
8/10 Very Good! (3,106 reviews)
This hotel was honestly great for the price. It’s got everything you need for a quick stay, especially if just there for a cruise. The rooms were clean, A/C worked great and it was right by the beach. Can’t beat it for the price!
Reviewed on Jul 6, 2026
Where to stay in South Main
Find the best South Main areas and neighborhoods for the activities you enjoy most. Learn more about South Main
Downtown Houston
3 out of top 10 points of interest in this area
4.5/5(2,329 area reviews)
Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.
South Main Hotel Deals
Wyndham Houston near NRG Park/Medical Center
8686 Kirby Drive Houston TX
Fully refundableReserve now, pay when you stay
$89 nightly
The price is $104 total per night from Aug 3 to Aug 4
$104 total
Aug 3 - Aug 4
Total with taxes and fees
7/10 Good! (1,329 reviews)
"Awesome place!"
Reviewed on Jul 6, 2026
Hotel Zaza Houston Museum District
5701 Main Street Houston TX
Fully refundableReserve now, pay when you stay
$239 nightly
The price is $279 total per night from Jul 17 to Jul 18
$279 total
Jul 17 - Jul 18
Total with taxes and fees
9.2/10 Wonderful! (1,007 reviews)
"Love this property and its proximity to the Museum of Fine Art Houston and the Museum District. Restaurant is fair — kind of hit-or-miss on food and service. Nice to have the semi-outdoor patio for a buffer zone when the bar is hopping. Front desk and bell team are terrific."
Reviewed on Jul 6, 2026
Grand Tuscany Hotel
12801 Northwest Fwy Houston TX
Fully refundableReserve now, pay when you stay
$98 nightly
The price is $115 total per night from Jul 7 to Jul 8
$115 total
Jul 7 - Jul 8
Total with taxes and fees
8/10 Very Good! (152 reviews)
"Cheap owners-No waste basket (only in the bathroom), microwave, or fridge in the room. Long wait for elevator. Definitely not worth $178/night."
Reviewed on Jul 6, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Things to do
Houston: Space Center Houston Admission Ticket
$30
per adult
92% of travellers recommend
Houston's Official City & Mural Tour!
$45
per adult
88% of travellers recommend
NASA's Space Center & Official Houston City Tour with tickets
$109
per adult
92% of travellers recommend
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.