South Main Vacation Packages 2026 from $195

Your South Main Vacation

Take the stress out of planning your next escape by booking a South Main vacation package. Take in the sights and sounds of this wonderful neighborhood and enjoy what it has to offer. Hoping to sightsee during your trip to South Main? Don't miss nearby attractions such as NRG Stadium, NRG Park and Rice Stadium. Expedia will help you turn your ideal South Main vacation into reality, whatever your budget or travel plans.

The Latest South Main Vacation Packages

Price found within the past 48 hours. Click for updated prices.

Heritage Place Houston Brookhollow

Lazybrook/Timbergrove

$195

per person

Dec 11 - Dec 15

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Houston (IAH)

9/10 Wonderful! (218 reviews)

Tx Home Group- Houston

Northside

Save 100% on your flight

$266

per person

Dec 11 - Dec 15

found 2 days ago

Roundtrip flight included

Atlanta (ATL) to Houston (IAH)

No reviews

Blackout Haus HTX 15 Mins from DT

Northeast Houston

Save 100% on your flight

$499

per person

Nov 11 - Nov 16

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Houston (IAH)

10/10 Exceptional! (1 review)

Can we just put our card on file for this location EVERYTIME we visit Houston!! The host was very nice when I called her before check-in. Yes I was able to call her which means a lot because before finding this location I had a bad experience with no communication from the host which made me feel uncomfortable with my reservations. I will make sure to reserve this location everytime!!

Reviewed on Jul 7, 2026

Hotel Granduca Houston

The Galleria

Save 100% on your flight

$778

per person

Nov 12 - Nov 16

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Houston (IAH)

9.2/10 Wonderful! (1,001 reviews)

Staff and facilities were wonderful! Will definitely return! No issues at all.

Reviewed on Oct 6, 2026

Dejs' Modern Retreat

Southeast Houston

Save 100% on your flight

$230

per person

Dec 11 - Dec 13

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to Houston (IAH)

10/10 Exceptional! (1 review)

Where to stay in South Main

Find the best South Main areas and neighborhoods for the activities you enjoy most. Learn more about South Main

A city square with tall buildings, trees, and green lights.

Downtown Houston

3 out of top 10 points of interest in this area

Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

A person walking in front of a building with a brick facade and three arched windows.

The Galleria

Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.

A cityscape with a park, a river, and a large building with a red roof.

Texas Medical Center

1 out of top 10 points of interest in this area

Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.

A colorful mural on a building, a street with outdoor seating, and a van parked on the side.

Montrose

Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

A cityscape with modern skyscrapers and a parking lot filled with cars.

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.

South Main Hotel Deals

Wyndham Houston at Reliant Park & Medical Center

8686 Kirby Drive Houston TX

Fully refundableReserve now, pay when you stay

$98 nightly

$115 total

Oct 11 - Oct 12

Total with taxes and fees

7.2/10 Good! (1,435 reviews)

"na"

Reviewed on Oct 6, 2026

Club Quarters Hotel Downtown, Houston

1085 Rusk Street Houston TX

Fully refundableReserve now, pay when you stay

$98 nightly

$114 total

Oct 11 - Oct 12

Total with taxes and fees

8.6/10 Excellent! (4,510 reviews)

"Second time staying. Always a pleasure. Walking distance to the ballpark"

Reviewed on Oct 6, 2026

DoubleTree by Hilton Hotel & Suites Houston by the Galleria

5353 Westheimer Rd Houston TX

Fully refundableReserve now, pay when you stay

$136 nightly

$159 total

Oct 17 - Oct 18

Total with taxes and fees

See all 7,433 properties in South Main

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.