Find luxury hotels in Keowee, SC

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Our top choices for Keowee luxury hotels

The Abernathy of Clemson

The Abernathy of Clemson
4.0 star property
Clemson
9.6 out of 10, Exceptional, (557)
"location is amazing! "
United States
colleen
$145 nightly
The price is $161
Dec 29 - Dec 30
Total with taxes and fees
The Abernathy of Clemson

The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
4.0 star property
Clemson
9.8 out of 10, Exceptional, (742)
"Staff was amazing and our room was clean and comfortable. "
United States
Amanda R
$166 nightly
The price is $185
Dec 14 - Dec 15
Total with taxes and fees
The Shepherd Hotel Downtown Clemson

Liberty Hall Bed and Breakfast

Liberty Hall Bed and Breakfast
4.0 star property
Pendleton
10.0 out of 10, Exceptional, (78)
"The owners are amazing. Comfy rooms, stellar breakfast and good people. "
United States
Renee
$224 nightly
The price is $249
Jan 4 - Jan 5, 2026
Total with taxes and fees
Liberty Hall Bed and Breakfast

Lake Hartwell Frank Howard Home Clemson

Lake Hartwell Frank Howard Home Clemson
4.0 star property
Anderson
$266 nightly
The price is $295
Dec 14 - Dec 15
Total with taxes and fees
Lake Hartwell Frank Howard Home Clemson
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Keowee Hotel Reviews

Frequently asked questions

Are you looking for a luxury hotel for your stay in Keowee?
Expedia can help you arrange a flight to Greenville-Spartanburg Intl. Airport (GSP) airport, and then you can select from various places to stay that will deliver the luxury you'd like to find. Amenities are an important consideration when you plan a trip, so we make it easy to find what you need to make your stay special. If you want a posh hotel with a spa, an indoor pool, or luxury bedding, Expedia can assist you in finding the best luxury hotel experience that Keowee has to offer.
When can I expect good weather in Keowee?
Planning for the weather is a good way to make your trip to Keowee relaxing and enjoyable, especially when you're splurging. The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 46°F. Average annual precipitation for Keowee is 61 inches.
What's there to see and do in Keowee?
Experience all that Keowee has to offer when you visit Littlejohn Coliseum, Memorial Stadium, and Fort Hill. If you have some spare time during your trip, you might want to check out Walker Golf Course and The Walker Course at Clemson University.

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