A coastal town with terracotta-roofed houses, a beach, and a castle on a hill.

Mytilene Vacation Rentals

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Check prices for these dates

In two weeks
Sep 4 - Sep 6
In two months
Oct 16 - Oct 18
In three months
Nov 13 - Nov 15
In four months
Dec 11 - Dec 13

Our top choices for Mytilene vacation rentals

In-room safe, desk, WiFi (free)

1. Akti Vigla Premium

Akti Vigla Premium
Lesvos
10.0 out of 10, Exceptional, (14 reviews)
"Very clean room with friendly staff.a lot of parking and wonderful breakfast. But there are many stairs to get into the building"
United States
Anat
$90 nightly
The price is $101
Sep 13 - Sep 14
Total with taxes and fees
Akti Vigla Premium
Garden

2. Loriet Hotel

Loriet Hotel
4.0 star property
Lesvos
8.4 out of 10, Very Good, (89 reviews)
"Lovely mansion house and a great breakfast."
United States
Malcolm
$121 nightly
The price is $144
Sep 16 - Sep 17
Total with taxes and fees
Loriet Hotel
1 bedroom, iron/ironing board, internet, bed sheets

3. Your refuge overlooking port

Your refuge overlooking port
Mytilene
$130 nightly
The price is $130
Aug 19 - Aug 20
Total with taxes and fees
Your refuge overlooking port
Exterior

4. Elies Residences

Elies Residences
Lesvos
9.8 out of 10, Exceptional, (36 reviews)
"Beautiful quiet nice little place.Very cosy !!"
Australia
Anonymous traveler
$181 nightly
The price is $200
Sep 11 - Sep 12
Total with taxes and fees
Elies Residences
1 bedroom, iron/ironing board, WiFi (free)

5. Experience Comfort in our Newly Remodeled 5A

Experience Comfort in our Newly Remodeled 5A
Mitilini
2.0 out of 10, (1 review)
$140 nightly
The price is $150
Sep 5 - Sep 6
Total with taxes and fees
Experience Comfort in our Newly Remodeled 5A
Outdoor pool

6. Villa PETRA

Villa PETRA
ΜΥΤΙΛΗΝΗ
10.0 out of 10, Exceptional, (1 review)
"Rena and Anna were very helpful and friendly. The property had very high standards. We stayed there for a week. Breakfast can be ordered to room with a fee. We ordered a chicken pancake for €7.2 which came in 4 pieces, it was large enough for 2 people. There is a place called Istoriko at seaside within 10min walk which serves food&coctails we liked it so much. Cab costs €8, local bus €2 if you want to go to the city centre. I highly recommend this villa."
United Kingdom
Yigit
$247 nightly
The price is $247
Sep 12 - Sep 13
Total with taxes and fees
Villa PETRA
Terrace/patio

7. The Heart of Mytilene

The Heart of Mytilene
Mitilini
$94 nightly
The price is $94
Sep 4 - Sep 5
Total with taxes and fees
The Heart of Mytilene
Outdoor pool

8. Villa ERESOS

Villa ERESOS
ΜΥΤΙΛΗΝΗ
$250 nightly
The price is $250
Sep 1 - Sep 2
Total with taxes and fees
Villa ERESOS
Outdoor pool

9. Villa SIGRI

Villa SIGRI
MYTILENE
$241 nightly
The price is $241
Sep 7 - Sep 8
Total with taxes and fees
Villa SIGRI
Outdoor pool

10. Villa SYKAMIA

Villa SYKAMIA
ΜΥΤΙΛΗΝΗ
$250 nightly
The price is $250
Sep 1 - Sep 2
Total with taxes and fees
Villa SYKAMIA
Living area

11. The house of ilias , next to the beach

The house of ilias , next to the beach
Ευρειακη
8.0 out of 10, Very Good, (1 review)
"Haus war für sechs Personen sehr gut und hatte sehr viel Platz. Gastgeber war immer nett und hat bei Fragen schnell geantwortet. Die Restaurant im Ort direkt kann ich nur empfehlen. Nur ein Fernsehen hat im Haus gefällt. "
Germany
Georgios R.
$199 nightly
The price is $199
Sep 6 - Sep 7
Total with taxes and fees
The house of ilias , next to the beach
Smart TV

12. Gianni's House

Gianni's House
Polichnitos
10.0 out of 10, Exceptional, (1 review)
"A nice, quiet, comfy and simple place. I felt welcomed. The village is the same. I really enjoyed it."
Canada
Jean-Philippe
$90 nightly
The price is $102
Aug 19 - Aug 20
Total with taxes and fees
Gianni's House
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Mytilene Hotel Reviews

Blue Sea

Blue Sea

8/10 Good
"Long delay to check in however the hotel delivers a very clean environment, comfortable rooms and views and located in ideal location."
Lance 1-night trip
Posted 18 hours ago
Blue Sea

Find out more about Mytilene

Everything you need to know about Mytilene vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Mytilene vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Mytilene vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Mytilene vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Mytilene. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Mytilene in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $101 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Mytilene rentals

At Expedia, we put the best Mytilene vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Mytilene rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Mytilene vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Mytilene. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Explore a world of travel with Expedia

Frequently asked questions

Are there vacation rentals in Mytilene?

Yes, we give you a choice of vacation rentals close to the most popular attractions in Mytilene, or you can select a more remote option if you want a relaxing place to stay. Nature enthusiasts will enjoy the seaside in Mytilene. Make sure you have time to check out the museums and monuments during your trip.

What's the top vacation rental that Mytilene has to offer?

V House Cozy & Quiet Escape: This highly rated vacation home rental in Mytilene offers a terrace, a garden, and air-conditioning to help you feel perfectly comfortable in your new surroundings. Kitchen amenities include a fridge, a stovetop, and kitchenware.

How many vacation rentals will I find in Mytilene?

Choose from 16 Expedia vacation rentals in Mytilene for a memorable vacation.

What’s there to see and do in Mytilene?

Enjoy the outdoors at Thermes Gera Hot Springs and Thermi Beach, or simply take in cultural attractions like Olive-press Museum of Archipelagos Society and Ecclesiastical Byzantine Museum. While here, Port of Mytilene and Mytilini Castle are other places worth a visit.

What’s a vacation rental in Mytilene like?

A vacation rental is a private property you can stay in for a couple of days or more in Mytilene. Vacation rentals provide amenities such as kitchens and laundry facilities so you'll have a home away from home. If you're concerned about a sanitized environment, a vacation rental can provide a sense of seclusion away from shared hotel elevators and busy lobbies while still allowing you the excitement and enjoyment of travel. You'll also get more space in a vacation rental than in a traditional hotel, which makes a vacation rental an attractive choice for family trips.