Grand Isle, FL
Port St. Joe
Visit Grand Isle
Grand Isle Hotel Deals
Comfort Suites
264 N Tyndall Pkwy Panama City FL
$86 nightly
The price is $92 total per night from Aug 16 to Aug 17
$92 total
Aug 16 - Aug 17
Total with taxes and fees
Book a stay at this business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.4/10 Very Good! (802 reviews)
"Had a great time clean the only problem I had was a great indoor pool to cold to swim in and was told by staff that it's not heated was very unsatisfied with it since this is why I picked this motel"
Reviewed on Aug 10, 2026
Holiday Inn Express Hotel & Suites Panama City-Tyndall by IHG
5627 E Highway 22 State Route Panama City FL
$102 nightly
The price is $109 total per night from Aug 27 to Aug 28
$109 total
Aug 27 - Aug 28
Total with taxes and fees
Book a stay at this business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
8.6/10 Excellent! (513 reviews)
"Staff was great! Couldn’t figure out the television and someone came up to help me even after explaining on the phone. Great service & went the extra mile!"
Reviewed on Aug 9, 2026
Days Inn by Wyndham Panama City/Callaway
435 North Tyndall Parkway Panama City FL
$58 nightly
The price is $62 total per night from Aug 23 to Aug 24
$62 total
Aug 23 - Aug 24
Total with taxes and fees
Stay at this hotel in Panama City. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the helpful staff in our reviews. Popular attractions ...
6.8/10 (550 reviews)
"I stayed at this hotel during a long work weekend. While the room ultimately served its purpose and I was able to sleep well—the bed was comfortable—there were several issues that made the overall experience disappointing. For a non-smoking hotel, the hallways reeked of cigarette smoke, which was ..."
Reviewed on Aug 10, 2026
Driftwood Inn
2105 U.S. 98 Mexico Beach FL
$227 nightly
The price is $254 total per night from Aug 12 to Aug 13
$254 total
Aug 12 - Aug 13
Total with taxes and fees
Book a stay at this beach hotel in Port St. Joe. Enjoy free WiFi, free parking, and a beach locale. Popular attractions Mexico Beach and Mexico Beach Park are ...
9.6/10 Exceptional! (97 reviews)
"This was a great find on Mexico beach! Beautiful hotel! Would stay again. I was terrified when we arrived late after a 6 hour drive, I didn’t see the sign to call because our code wasn’t working. I opened a hallway door and went down to the lobby and was able to easily get ahold of someone and get ..."
Reviewed on Aug 8, 2026
MainStay Suites Port Saint Joe South
3951 E Highway 98 Port St. Joe FL
$135 nightly
The price is $151 total per night from Sep 10 to Sep 11
$151 total
Sep 10 - Sep 11
Total with taxes and fees
Book a stay at this business-friendly hotel in Port St. Joe. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
The Port Inn - Port St Joe, an Ascend Collection Hotel
501 Monument Ave. Port St. Joe FL
$189 nightly
The price is $212 total per night from Aug 23 to Aug 24
$212 total
Aug 23 - Aug 24
Total with taxes and fees
Stay at this hotel in Port St. Joe. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
9/10 Wonderful! (467 reviews)
"We really enjoyed our stay! We have a dog and they gave us a first floor room which made it easy to take her in and out. Very friendly and helpful front desk staff too! Walkable to the many restaurants and shops in Port St. Joe. We never had to drive to dinner:) the hotel was clean and comfortable, ..."
Reviewed on Aug 10, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Grand Isle
Find the best Grand Isle areas and neighborhoods for the activities you enjoy most.
Photo by Matt Russell
Open Photo by Matt Russell
Downtown Port St. Joe
While visiting Downtown Port St. Joe, you might make a stop by sights like Port Saint Joe City Hall and Port St. Joe Marina.
Cape Breezes
While Cape Breezes isn't home to many top sights, T.H. Stone Memorial St. Joseph Peninsula State Park and St. Joseph Peninsula State Park are some notable places to visit nearby.
Gulf Aire
While Gulf Aire isn't home to many top sights, Saint Joe Beach and Mexico Beach are some notable places to visit nearby.
Waterside Village
Though Waterside Village might not have many top sights, you can venture to the surrounding area to see attractions like Mexico Beach Marina and Mexico Beach.
Palms
While there might not be top attractions in Palms, you can explore the larger area and discover places like Mexico Beach and Mexico Beach Marina.
