Find hotels in Santa Maria from $90

The best area to stay in Santa Maria, Piedmont, is the historic town center, particularly around Piazza della Repubblica.This central area is the heart of Santa Maria, characterized by its well-preserved medieval architecture and narrow, winding streets. You'll find many local shops, traditional trattorias, and charming cafes clustered around the main square and along Via Roma. It's a very walkable district, allowing you to easily explore the town's heritage.Couples often find this area ideal for a romantic and authentic Italian experience. The historic center provides a picturesque backdrop for strolls, and its numerous restaurants offer intimate dining options featuring local Piedmontese cuisine. It's also a convenient base for exploring the surrounding wine country.For solo travelers seeking a relaxed and culturally rich experience, the historic center offers easy access to local museums, art galleries, and the weekly market.

The best time to go to Santa Maria is during the spring (late April to early June) and fall (September to October) months, when the weather is pleasant and the region's culinary and wine experiences are at their peak.Spring offers mild temperatures and blooming landscapes, making it ideal for exploring the rolling hills and vineyards. Many local festivals celebrating spring produce begin around this time. This period is particularly good for couples who enjoy scenic drives and outdoor dining without the summer crowds.Fall is harvest season in Piedmont, making it an excellent time for those interested in wine and food. The weather remains comfortable, and the vineyards are vibrant with autumn colors. This is when truffle hunting excursions begin, and many wineries offer special tasting events.

With Expedia, you earn OneKeyCash™* on eligible Santa Maria hotel bookings for every dollar you spend – just join our One Key™ travel rewards program to get started. It's free to join, and you'll unlock our lowest Member Prices as soon as you're signed in. On top of this, you could also save significantly by bundling your hotel and flights together on Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.