$1,026 Cheap Flights from Charlotte (CLT) to São Tomé Island (TMS)

View $1,026 flight on Mon, Oct 13, 2025Opens in a new window

Popular airlines from Charlotte-Douglas Intl. Airport (CLT) to São Tomé Island (TMS-São Tomé Intl.)

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Cheap Flights from Charlotte to São Tomé Island (CLT-TMS)

Prices were available within the past 7 days and start at $1,026 for one-way flights and $1,501 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Lufthansa
Mon, Oct 13 - Sun, Oct 19
CLT
Charlotte
TMS
São Tomé Island
$1,501 Roundtrip, found 1 day ago
$1,501
Roundtrip
found 1 day ago
Select Lufthansa flight, departing Mon, Oct 13 from Charlotte to São Tomé Island, returning Sun, Oct 19, priced at $1,501 found 1 day ago
Air Canada
Mon, Oct 13 - Sun, Oct 19
CLT
Charlotte
TMS
São Tomé Island
$1,503 Roundtrip, found 1 day ago
$1,503
Roundtrip
found 1 day ago
Select Air Canada flight, departing Mon, Oct 13 from Charlotte to São Tomé Island, returning Sun, Oct 19, priced at $1,503 found 1 day ago
United
Mon, Oct 13 - Sun, Oct 19
CLT
Charlotte
TMS
São Tomé Island
$1,507 Roundtrip, found 1 day ago
$1,507
Roundtrip
found 1 day ago
Select United flight, departing Mon, Oct 13 from Charlotte to São Tomé Island, returning Sun, Oct 19, priced at $1,507 found 1 day ago
United
Mon, Oct 13 - Sun, Oct 19
CLT
Charlotte
TMS
São Tomé Island
$1,507 Roundtrip, found 1 day ago
$1,507
Roundtrip
found 1 day ago
Select United flight, departing Mon, Oct 13 from Charlotte to São Tomé Island, returning Sun, Oct 19, priced at $1,507 found 1 day ago
Air Canada
Mon, Oct 13 - Sun, Oct 19
CLT
Charlotte
TMS
São Tomé Island
$1,509 Roundtrip, found 1 day ago
$1,509
Roundtrip
found 1 day ago
Select Air Canada flight, departing Mon, Oct 13 from Charlotte to São Tomé Island, returning Sun, Oct 19, priced at $1,509 found 1 day ago
Lufthansa
Mon, Oct 13 - Sun, Oct 19
CLT
Charlotte
TMS
São Tomé Island
$1,511 Roundtrip, found 1 day ago
$1,511
Roundtrip
found 1 day ago
Select Lufthansa flight, departing Mon, Oct 13 from Charlotte to São Tomé Island, returning Sun, Oct 19, priced at $1,511 found 1 day ago
United
Mon, Oct 13 - Sun, Oct 19
CLT
Charlotte
TMS
São Tomé Island
$1,513 Roundtrip, found 1 day ago
$1,513
Roundtrip
found 1 day ago
Select United flight, departing Mon, Oct 13 from Charlotte to São Tomé Island, returning Sun, Oct 19, priced at $1,513 found 1 day ago
Lufthansa
Mon, Oct 13 - Sun, Oct 19
CLT
Charlotte
TMS
São Tomé Island
$1,518 Roundtrip, found 1 day ago
$1,518
Roundtrip
found 1 day ago
Select Lufthansa flight, departing Mon, Oct 13 from Charlotte to São Tomé Island, returning Sun, Oct 19, priced at $1,518 found 1 day ago
Lufthansa
Mon, Oct 13 - Sun, Oct 19
CLT
Charlotte
TMS
São Tomé Island
$1,518 Roundtrip, found 1 day ago
$1,518
Roundtrip
found 1 day ago
Select Lufthansa flight, departing Mon, Oct 13 from Charlotte to São Tomé Island, returning Sun, Oct 19, priced at $1,518 found 1 day ago
Lufthansa
Mon, Oct 13 - Sun, Oct 19
CLT
Charlotte
TMS
São Tomé Island
$1,525 Roundtrip, found 1 day ago
$1,525
Roundtrip
found 1 day ago
Select Lufthansa flight, departing Mon, Oct 13 from Charlotte to São Tomé Island, returning Sun, Oct 19, priced at $1,525 found 1 day ago
Flights from Charlotte (CLT) to São Tomé Island (TMS)
Origin airport
Charlotte-Douglas Intl.
Destination airport
São Tomé Intl.
Roundtrip price
$1,500
Distance
6070 mi

Charlotte to São Tomé Island Flights

The cheapest times to fly from Charlotte to São Tomé Island

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Charlotte to São Tomé Island are during the month of October. You can find some of the cheapest flights from Charlotte to São Tomé Island with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Charlotte to São Tomé Island

Sunday is one of the best days to book for cheap flights from Charlotte to São Tomé Island: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Charlotte to São Tomé Island

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Charlotte to São Tomé Island in 2025. You can also book with separate airlines for your outbound and return journeys, from $1,026 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Charlotte to São Tomé Island flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Charlotte to São Tomé Island airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Charlotte-Douglas Intl. Airport (CLT) to Sao Tome Intl. Airport (TMS) cost?
Discover the latest flight deals from CLT to TMS by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from CLT to TMS?
The cheapest flights from CLT to TMS are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from CLT to TMS?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that'll take you from CLT to TMS. Sort your results by "Price (lowest to highest)" to snap up a great deal.
How many flights per day from Charlotte-Douglas Intl. Airport (CLT) to Sao Tome Intl. Airport (TMS)?
You'll need to hop on a flight with a layover when traveling from Charlotte-Douglas Intl. Airport (CLT) to Sao Tome Intl. Airport (TMS). Direct flights don't operate daily on this route. However, just filter your search to include one or more stops to find the best option for your trip.
What day of the week has the most flights from CLT to TMS?
Friday is typically the busiest day for flights, while Tuesday is often the quietest.* Keep in mind that flight schedules can change depending on a range of factors, such as the season and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Charlotte-Douglas Intl. Airport (CLT) to Sao Tome Intl. Airport (TMS)?
To avoid possible delays on the Charlotte-Douglas Intl. Airport (CLT) to Sao Tome Intl. Airport (TMS) route, aim to travel before 3 PM. Flights after this time have a 22% higher chance of cancellation.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Charlotte-Douglas Intl. Airport (CLT) to Sao Tome Intl. Airport (TMS) last-minute?
Booking your ticket from CLT to TMS right before your journey is generally more expensive. But if there's some wiggle room with your departure dates and times, you could grab a cheap last-minute fare.
Is it cheaper to book a CLT to TMS flight and hotel package?
Booking a CLT to TMS flight and hotel package is generally cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your trip in one place. Pick from our wide range of accommodations and then add car rentals, flights and activities to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Charlotte-Douglas Intl. Airport (CLT) to Sao Tome Intl. Airport (TMS)?
It's generally possible to cancel or reschedule your CLT to TMS flight. However, if the booking was made more than 24 hours ago, additional fees may apply. Check your airline's policies in your itinerary to see what changes are allowed and whether any costs are involved. You'll also find more details on our Customer Service portal.

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*Available to One Key members.