$174 Cheap Flights from Columbus (CMH) to Panama City (PTY)

View $174 flight on Wed, Apr 8, 2026Opens in a new window

Popular airlines from John Glenn Columbus Intl. Airport (CMH) to Tocumen Intl. Airport (PTY)

Cheap Flights from Columbus to Panama City (CMH-PTY)

Prices were available within the past 7 days and start at $174 for one-way flights and $413 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Wed, Apr 8 - Wed, Apr 15
CMH
Columbus
PTY
Panama City
$413 Roundtrip, just found
$413
Roundtrip
just found
Select American Airlines flight, departing Wed, Apr 8 from Columbus to Panama City, returning Wed, Apr 15, priced at $413 just found
United
Wed, Apr 8 - Wed, Apr 15
CMH
Columbus
PTY
Panama City
$413 Roundtrip, just found
$413
Roundtrip
just found
Select United flight, departing Wed, Apr 8 from Columbus to Panama City, returning Wed, Apr 15, priced at $413 just found
American Airlines
Fri, Dec 5 - Fri, Dec 12
CMH
Columbus
PTY
Panama City
$418 Roundtrip, found 1 hour ago
$418
Roundtrip
found 1 hour ago
Select American Airlines flight, departing Fri, Dec 5 from Columbus to Panama City, returning Fri, Dec 12, priced at $418 found 1 hour ago
United
Tue, Mar 10 - Wed, Mar 18
CMH
Columbus
PTY
Panama City
$420 Roundtrip, found 6 days ago
$420
Roundtrip
found 6 days ago
Select United flight, departing Tue, Mar 10 from Columbus to Panama City, returning Wed, Mar 18, priced at $420 found 6 days ago
United
Wed, May 13 - Wed, May 20
CMH
Columbus
PTY
Panama City
$423 Roundtrip, found 21 hours ago
$423
Roundtrip
found 21 hours ago
Select United flight, departing Wed, May 13 from Columbus to Panama City, returning Wed, May 20, priced at $423 found 21 hours ago
American Airlines
Wed, Apr 8 - Wed, Apr 15
CMH
Columbus
PTY
Panama City
$426 Roundtrip, just found
$426
Roundtrip
just found
Select American Airlines flight, departing Wed, Apr 8 from Columbus to Panama City, returning Wed, Apr 15, priced at $426 just found
American Airlines
Mon, Feb 2 - Thu, Feb 5
CMH
Columbus
PTY
Panama City
$428 Roundtrip, found 9 hours ago
$428
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Mon, Feb 2 from Columbus to Panama City, returning Thu, Feb 5, priced at $428 found 9 hours ago
Delta
Wed, Apr 8 - Wed, Apr 15
CMH
Columbus
PTY
Panama City
$438 Roundtrip, just found
$438
Roundtrip
just found
Select Delta flight, departing Wed, Apr 8 from Columbus to Panama City, returning Wed, Apr 15, priced at $438 just found
avianca
Mon, Oct 20 - Fri, Oct 24
CMH
Columbus
PTY
Panama City
$971 Roundtrip, found 20 hours ago
$971
Roundtrip
found 20 hours ago
Select avianca flight, departing Mon, Oct 20 from Columbus to Panama City, returning Fri, Oct 24, priced at $971 found 20 hours ago
Copa
Wed, Apr 8 - Wed, Apr 15
CMH
Columbus
PTY
Panama City
$1,165 Roundtrip, just found
$1,165
Roundtrip
just found
Select Copa flight, departing Wed, Apr 8 from Columbus to Panama City, returning Wed, Apr 15, priced at $1,165 just found

Find the cheapest month to fly from Columbus (CMH) to Panama City (PTY)

October is typically the cheapest month to fly

From $359 - $1,255 per traveler.

Alternative airports near Panama City

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Tocumen Intl. PTY. Cheapest option available. Average driving time to city center is 16 minutes. Flights from $569
PTY
Tocumen Intl.
Cheapest
Average driving time to city center16 min
Flights from $569
Flights from Columbus (CMH) to Panama City (PTY)
Origin airport
John Glenn Columbus Intl.
Destination airport
Tocumen Intl.
Airlines serving
American Airlines, Copa, Delta, United, avianca
Roundtrip price
$413
Distance
2147 mi

Columbus to Panama City Flights

The cheapest times to fly from Columbus to Panama City

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Columbus to Panama City are during the month of April. You can find some of the cheapest flights from Columbus to Panama City with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Columbus to Panama City

Sunday is one of the best days to book for cheap flights from Columbus to Panama City: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Columbus to Panama City

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Columbus to Panama City in 2025. You can also book with separate airlines for your outbound and return journeys, from $174 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Columbus to Panama City flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Columbus to Panama City airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from John Glenn Columbus Intl. Airport (CMH) to Tocumen Intl. Airport (PTY) cost?
Lock in a cheap one-way flight from $174 or cheap return flight from $413 from John Glenn Columbus Intl. Airport (CMH) to Tocumen Intl. Airport (PTY) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from John Glenn Columbus Intl. Airport (CMH) to Tocumen Intl. Airport (PTY)?
The cheapest month to fly from CMH to PTY is April, when demand is low. Off-peak months are generally when you'll find lower airfares between these airports.
What is the cheapest airline that flies from John Glenn Columbus Intl. Airport (CMH) to Tocumen Intl. Airport (PTY)?
Expedia's filter tool lets you easily compare different airlines, departure times and fares all in one place. Select your preferences, then sort by "Price (lowest to highest)" to see which carrier offers the cheapest CMH to PTY flight.
How many flights per day from John Glenn Columbus Intl. Airport (CMH) to Tocumen Intl. Airport (PTY)?
There aren't any daily nonstop flights departing from John Glenn Columbus Intl. Airport (CMH) to Tocumen Intl. Airport (PTY). But you can opt for flights with layovers. Filter your search results on Expedia to include one or more stops, and you'll be cruising above the clouds before you know it.
What day of the week has the most flights from CMH to PTY?
Friday is usually the busiest day for flights, while Tuesday is often the quietest.* Just remember that flight schedules can vary based on a range of factors, including the season and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from John Glenn Columbus Intl. Airport (CMH) to Tocumen Intl. Airport (PTY)?
To avoid potential delays on the John Glenn Columbus Intl. Airport (CMH) to Tocumen Intl. Airport (PTY) route, aim to fly before 3 PM. Later flights have a 22% higher chance of being canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from John Glenn Columbus Intl. Airport (CMH) to Tocumen Intl. Airport (PTY) last-minute?
Last-minute bookings from CMH to PTY are generally more expensive. For the lowest prices, start looking for flights ahead of time. That said, if you're flexible with your travel dates, it's possible to find a cheap ticket right before your trip.
Is it cheaper to book a CMH to PTY flight and hotel package?
Booking a CMH to PTY flight and hotel package is generally cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels in one place. Pick from our impressive range of accommodations and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from John Glenn Columbus Intl. Airport (CMH) to Tocumen Intl. Airport (PTY)?
It's usually possible to cancel or reschedule your CMH to PTY flight. However, if it's been more than 24 hours since booking, additional fees may apply. Check your airline's policies in your itinerary to see what changes are possible and if any costs are involved. You'll also find more information on our Customer Service portal.

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*Available to One Key members.