$292 Cheap Flights from Des Moines (DSM) to Hermosillo (HMO)

View $292 flight on Mon, Dec 8, 2025Opens in a new window

Popular airlines from Des Moines International Airport (DSM) to Hermosillo, Sonora (HMO-General Ignacio Pesqueira Garcia Intl.)

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Cheap Flights from Des Moines to Hermosillo (DSM-HMO)

Prices were available within the past 7 days and start at $292 for one-way flights and $548 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Wed, Apr 1 - Wed, Apr 8
DSM
Des Moines
HMO
Hermosillo
$548 Roundtrip, found 18 hours ago
$548
Roundtrip
found 18 hours ago
Select American Airlines flight, departing Wed, Apr 1 from Des Moines to Hermosillo, returning Wed, Apr 8, priced at $548 found 18 hours ago
American Airlines
Wed, Apr 1 - Wed, Apr 8
DSM
Des Moines
HMO
Hermosillo
$559 Roundtrip, found 18 hours ago
$559
Roundtrip
found 18 hours ago
Select American Airlines flight, departing Wed, Apr 1 from Des Moines to Hermosillo, returning Wed, Apr 8, priced at $559 found 18 hours ago
American Airlines
Wed, Apr 1 - Wed, Apr 8
DSM
Des Moines
HMO
Hermosillo
$612 Roundtrip, found 18 hours ago
$612
Roundtrip
found 18 hours ago
Select American Airlines flight, departing Wed, Apr 1 from Des Moines to Hermosillo, returning Wed, Apr 8, priced at $612 found 18 hours ago
American Airlines
Wed, Apr 1 - Wed, Apr 8
DSM
Des Moines
HMO
Hermosillo
$624 Roundtrip, found 18 hours ago
$624
Roundtrip
found 18 hours ago
Select American Airlines flight, departing Wed, Apr 1 from Des Moines to Hermosillo, returning Wed, Apr 8, priced at $624 found 18 hours ago
Delta
Wed, Apr 1 - Wed, Apr 8
DSM
Des Moines
HMO
Hermosillo
$641 Roundtrip, found 18 hours ago
$641
Roundtrip
found 18 hours ago
Select Delta flight, departing Wed, Apr 1 from Des Moines to Hermosillo, returning Wed, Apr 8, priced at $641 found 18 hours ago
American Airlines
Mon, Mar 30 - Tue, Apr 7
DSM
Des Moines
HMO
Hermosillo
$656 Roundtrip, found 18 hours ago
$656
Roundtrip
found 18 hours ago
Select American Airlines flight, departing Mon, Mar 30 from Des Moines to Hermosillo, returning Tue, Apr 7, priced at $656 found 18 hours ago
American Airlines
Wed, Apr 1 - Tue, Apr 7
DSM
Des Moines
HMO
Hermosillo
$666 Roundtrip, found 18 hours ago
$666
Roundtrip
found 18 hours ago
Select American Airlines flight, departing Wed, Apr 1 from Des Moines to Hermosillo, returning Tue, Apr 7, priced at $666 found 18 hours ago
American Airlines
Wed, Apr 1 - Fri, Apr 10
DSM
Des Moines
HMO
Hermosillo
$671 Roundtrip, found 18 hours ago
$671
Roundtrip
found 18 hours ago
Select American Airlines flight, departing Wed, Apr 1 from Des Moines to Hermosillo, returning Fri, Apr 10, priced at $671 found 18 hours ago
Aeromexico
Wed, Apr 1 - Wed, Apr 8
DSM
Des Moines
HMO
Hermosillo
$671 Roundtrip, found 18 hours ago
$671
Roundtrip
found 18 hours ago
Select Aeromexico flight, departing Wed, Apr 1 from Des Moines to Hermosillo, returning Wed, Apr 8, priced at $671 found 18 hours ago
American Airlines
Wed, Apr 1 - Wed, Apr 8
DSM
Des Moines
HMO
Hermosillo
$678 Roundtrip, found 18 hours ago
$678
Roundtrip
found 18 hours ago
Select American Airlines flight, departing Wed, Apr 1 from Des Moines to Hermosillo, returning Wed, Apr 8, priced at $678 found 18 hours ago

Frequently asked questions

How much does a flight from Des Moines Intl. Airport (DSM) to General Ignacio Pesqueira Garcia Intl. Airport (HMO) cost?
Lock in a cheap one-way flight from $292 or cheap return flight from $548 from Des Moines Intl. Airport (DSM) to General Ignacio Pesqueira Garcia Intl. Airport (HMO) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Des Moines Intl. Airport (DSM) to General Ignacio Pesqueira Garcia Intl. Airport (HMO)?
Traveling in April is a great way to save, as it's the cheapest month for flights between DSM and HMO. You'll often find the lowest fares during the off-season.
What is the cheapest airline that flies from Des Moines Intl. Airport (DSM) to General Ignacio Pesqueira Garcia Intl. Airport (HMO)?
Expedia's filter tool lets you easily compare airlines, flight times and fares all in one place. Tailor the search to your trip, then sort by "Price (lowest to highest)" to find out which carrier offers the cheapest DSM to HMO flight.
How many flights per day from Des Moines Intl. Airport (DSM) to General Ignacio Pesqueira Garcia Intl. Airport (HMO)?
You'll need to catch a flight with a layover when traveling from Des Moines Intl. Airport (DSM) to General Ignacio Pesqueira Garcia Intl. Airport (HMO). There are no daily direct flights on this route. However, just filter your search to include one or more stops to discover an option that works for you.
What day of the week has the most flights from DSM to HMO?
Friday is generally the busiest day for flights, while Tuesday tends to be the quietest.* Just remember that flight schedules can vary based on a range of factors, such as the airline and season.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Des Moines Intl. Airport (DSM) to General Ignacio Pesqueira Garcia Intl. Airport (HMO)?
To avoid possible delays on the Des Moines Intl. Airport (DSM) to General Ignacio Pesqueira Garcia Intl. Airport (HMO) route, aim to travel before 3 PM. Later departures have a 22% higher chance of cancellation.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Des Moines Intl. Airport (DSM) to General Ignacio Pesqueira Garcia Intl. Airport (HMO) last-minute?
Booking your flight from DSM to HMO shortly before your journey is usually more expensive. But if you're flexible with your departure times and dates, you could snag a cheap last-minute fare.
Is it cheaper to book a DSM to HMO flight and hotel package?
Compared with arranging flights and hotels separately, booking a DSM to HMO flight and hotel package with Expedia could lead to significant savings. What's more, managing everything in one place takes the hassle out of planning your trip. Simply secure your flights and choose from our wide range of hotels, then personalize your trip with extras like car rentals and activities.
Can I cancel or change the date of my flight from Des Moines Intl. Airport (DSM) to General Ignacio Pesqueira Garcia Intl. Airport (HMO)?
In most instances, you can cancel or modify your DSM to HMO flight. However, additional fees may apply, especially if you booked over 24 hours ago. Double-check your itinerary for the airline's fees and policies on flight changes, or if you need more details, go to our Customer Service portal.

Travel information

Travel information

Origin airport
Des Moines Intl.
Destination airport
General Ignacio Pesqueira Garcia Intl.
Airlines serving
Aeromexico, American Airlines, Delta
Roundtrip price
$547
Distance
1299 mi

Book with confidence

Book with confidence

Des Moines to Hermosillo Flights

The cheapest times to fly from Des Moines to Hermosillo

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Des Moines to Hermosillo are during the month of April. You can find some of the cheapest flights from Des Moines to Hermosillo with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Des Moines to Hermosillo

Sunday is one of the best days to book for cheap flights from Des Moines to Hermosillo: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Des Moines to Hermosillo

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Des Moines to Hermosillo in 2025. You can also book with separate airlines for your outbound and return journeys, from $292 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Des Moines to Hermosillo flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Des Moines to Hermosillo airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Des Moines to Hermosillo Flights

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*Available to One Key members.