$226 Cheap Flights from Medellín (MDE) to Arequipa (AQP)

View $226 flight on Thu, Dec 11, 2025Opens in a new window

Popular airlines from Jose Maria Cordova Intl. Airport (MDE) to Arequipa (AQP-Rodriguez Ballon Intl.)

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Cheap Flights from Medellín to Arequipa (MDE-AQP)

Prices were available within the past 7 days and start at $226 for one-way flights and $424 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

LATAM Airlines Group
Mon, Dec 1 - Wed, Dec 10
MDE
Medellin
AQP
Arequipa
$424 Roundtrip, found 4 days ago
$424
Roundtrip
found 4 days ago
Select LATAM Airlines Group flight, departing Mon, Dec 1 from Medellin to Arequipa, returning Wed, Dec 10, priced at $424 found 4 days ago
LATAM Airlines Group
Tue, Dec 2 - Thu, Dec 11
MDE
Medellin
AQP
Arequipa
$424 Roundtrip, found 6 days ago
$424
Roundtrip
found 6 days ago
Select LATAM Airlines Group flight, departing Tue, Dec 2 from Medellin to Arequipa, returning Thu, Dec 11, priced at $424 found 6 days ago
LATAM Airlines Group
Mon, Dec 1 - Wed, Dec 10
MDE
Medellin
AQP
Arequipa
$434 Roundtrip, found 4 days ago
$434
Roundtrip
found 4 days ago
Select LATAM Airlines Group flight, departing Mon, Dec 1 from Medellin to Arequipa, returning Wed, Dec 10, priced at $434 found 4 days ago
LATAM Airlines Group
Sun, Nov 30 - Wed, Dec 10
MDE
Medellin
AQP
Arequipa
$442 Roundtrip, found 4 days ago
$442
Roundtrip
found 4 days ago
Select LATAM Airlines Group flight, departing Sun, Nov 30 from Medellin to Arequipa, returning Wed, Dec 10, priced at $442 found 4 days ago
LATAM Airlines Group
Mon, Dec 1 - Wed, Dec 10
MDE
Medellin
AQP
Arequipa
$447 Roundtrip, found 4 days ago
$447
Roundtrip
found 4 days ago
Select LATAM Airlines Group flight, departing Mon, Dec 1 from Medellin to Arequipa, returning Wed, Dec 10, priced at $447 found 4 days ago
LATAM Airlines Group
Mon, Dec 1 - Wed, Dec 10
MDE
Medellin
AQP
Arequipa
$452 Roundtrip, found 4 days ago
$452
Roundtrip
found 4 days ago
Select LATAM Airlines Group flight, departing Mon, Dec 1 from Medellin to Arequipa, returning Wed, Dec 10, priced at $452 found 4 days ago
LATAM Airlines Group
Sun, Nov 30 - Sat, Dec 13
MDE
Medellin
AQP
Arequipa
$455 Roundtrip, found 4 days ago
$455
Roundtrip
found 4 days ago
Select LATAM Airlines Group flight, departing Sun, Nov 30 from Medellin to Arequipa, returning Sat, Dec 13, priced at $455 found 4 days ago
LATAM Airlines Group
Tue, Dec 2 - Thu, Dec 11
MDE
Medellin
AQP
Arequipa
$461 Roundtrip, found 6 days ago
$461
Roundtrip
found 6 days ago
Select LATAM Airlines Group flight, departing Tue, Dec 2 from Medellin to Arequipa, returning Thu, Dec 11, priced at $461 found 6 days ago
LATAM Airlines Group
Tue, Dec 2 - Thu, Dec 11
MDE
Medellin
AQP
Arequipa
$464 Roundtrip, found 6 days ago
$464
Roundtrip
found 6 days ago
Select LATAM Airlines Group flight, departing Tue, Dec 2 from Medellin to Arequipa, returning Thu, Dec 11, priced at $464 found 6 days ago
LATAM Airlines Group
Mon, Dec 1 - Wed, Dec 10
MDE
Medellin
AQP
Arequipa
$465 Roundtrip, found 4 days ago
$465
Roundtrip
found 4 days ago
Select LATAM Airlines Group flight, departing Mon, Dec 1 from Medellin to Arequipa, returning Wed, Dec 10, priced at $465 found 4 days ago
Flights from Medellín (MDE) to Arequipa (AQP)
Origin airport
José María Córdova Intl.
Destination airport
Rodriguez Ballon Intl.
Airlines serving
LATAM Airlines Group
Roundtrip price
$423
Distance
1577 mi

Medellín to Arequipa Flights

The cheapest times to fly from Medellín to Arequipa

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Medellín to Arequipa are during the month of December. You can find some of the cheapest flights from Medellín to Arequipa with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Medellín to Arequipa

Sunday is one of the best days to book for cheap flights from Medellín to Arequipa: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Medellín to Arequipa

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Medellín to Arequipa in 2025. You can also book with separate airlines for your outbound and return journeys, from $226 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Medellín to Arequipa flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Medellín to Arequipa airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Jose Maria Cordova Intl. Airport (MDE) to Rodriguez Ballon Intl. Airport (AQP) cost?
Get a cheap one-way flight from $226 or cheap return flight from $424 from Jose Maria Cordova Intl. Airport (MDE) to Rodriguez Ballon Intl. Airport (AQP) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Jose Maria Cordova Intl. Airport (MDE) to Rodriguez Ballon Intl. Airport (AQP)?
The cheapest month to fly from MDE to AQP is December, when demand is low. Off-peak season is usually when better flight deals are available between these airports.
What is the cheapest airline that flies from Jose Maria Cordova Intl. Airport (MDE) to Rodriguez Ballon Intl. Airport (AQP)?
To find the cheapest airline flying from MDE to AQP, use Expedia's filter tool. Customize your search based on your travel needs, such as preferred carriers and flight duration. You can then sort your results by "Price (lowest to highest)" to list the most affordable options first.
How many flights per day from Jose Maria Cordova Intl. Airport (MDE) to Rodriguez Ballon Intl. Airport (AQP)?
You'll have to catch a flight with a layover if you're traveling from Jose Maria Cordova Intl. Airport (MDE) to Rodriguez Ballon Intl. Airport (AQP). There are no daily direct flights on this route. However, just filter your search to include one or two stops to find the best option for your trip.
What day of the week has the most flights from MDE to AQP?
Generally you'll find the greatest selection of flight options on a Friday. Tuesdays are often the quietest.* However, this can vary based on the season, carrier and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Jose Maria Cordova Intl. Airport (MDE) to Rodriguez Ballon Intl. Airport (AQP)?
To touch down at Rodriguez Ballon Intl. Airport (AQP) without delays, select a flight that leaves from Jose Maria Cordova Intl. Airport (MDE) before 3 PM. The likelihood of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Jose Maria Cordova Intl. Airport (MDE) to Rodriguez Ballon Intl. Airport (AQP) last-minute?
Waiting until just before your departure to book your flight from MDE to AQP often results in higher prices. Although you may find some last-minute deals, they're not always guaranteed. Be flexible with your travel plans for the best chance of scoring a bargain.
Is it cheaper to book a MDE to AQP flight and hotel package?
Booking a MDE to AQP flight and hotel package tends to be cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your trip all in one place. Pick from our wide range of stays and then add activities, car rentals and flights to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Jose Maria Cordova Intl. Airport (MDE) to Rodriguez Ballon Intl. Airport (AQP)?
If you booked your MDE to AQP flight within the last 24 hours, you may be able to modify or cancel it without fees. Depending on the airline and the type of ticket you purchased, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal for more details.

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*Available to One Key members.