Find 5 Star Hotels in Florida Keys from $282
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Compare Florida Keys 5 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.
Cheeca Lodge & Spa
Isla Bella Beach Resort & Spa
Explore similar 4-star hotels
Hawks Cay Resort
Learn more about Florida Keys
Snorkel crystal-clear waters teeming with colorful fish, then feast on fresh-caught lobster at a laid-back waterfront shack. Drive the scenic Overseas Highway, stopping at Key West's Ernest Hemingway Home and Dry Tortugas National Park for island adventures.
Top Florida Keys Hotel Reviews
Cheeca Lodge & Spa
Isla Bella Beach Resort & Spa
Find out more about Florida Keys
Ready for an incredible adventure? Add an extra layer of luxury on your next trip to Florida Keys by treating yourself to the best of the best when it comes to lodging. It's an ideal combination. After all, you love the finer things in life, both at home and when you book a getaway. You'll join the multitudes of vacationers who have made Florida Keys so popular in the last year. There's no reason to delay a getaway to Florida Keys any longer. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. Book one of Expedia's luxurious 5-star hotels in Florida Keys and get ready to be pampered like never before. Don't wait any longer!
Get a Great Deal on 5-Star Hotels in Florida Keys
You'll have a fantastic time at one of these 5-star hotels. Exceptional service, delicious meals, and personalized service are all waiting for you. Our numerous hotels in the area will ensure you find the perfect space to kick back after a long day. You can also look forward to an outstanding experience and fantastic customer care, so get ready to kick back and indulge. What creature comforts do you want in your lodging? 24-hour room service, so you can order that filet mignon in the wee hours of the morning? A reflexology treatment that will leave you feeling refreshed and alive? Butler services? Whatever it is your heart desires, you're bound to find it here.
Ready for experiences outside your hotel room? We've got you covered. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what you end up doing, the 5-star hotels in Florida Keys are waiting for you to relax after a busy day. Ready to learn more? Then check out our listings and pick the perfect accommodation for your needs.
Your Getaway Starts Today
Numerous visitors make Florida Keys the place to vacation. Why not join their ranks? If you've been dreaming about a vacation set here, then go ahead and book it. A surge in interest means these great hotel rooms will go quickly. Your great getaway is just a mouse-click away. Choose one of Expedia's Florida Keys 5-star hotels today and soothe yourself in luxe surroundings tomorrow.