Name: Hotel Museo Spa Casa Santo Domingo
Price range: $265 total
Rating: 9.2

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Your Central Highlands Vacation

Leave all the planning up to us with a Central Highlands vacation package. With everything organized before you depart, all you need to do is sit back, chill out and enjoy this destination's culture and charm. Your trip to Central Highlands wouldn't be complete without spending some time in its most renowned cities, starting with Guatemala City. A couple of the top attractions here include Paseo Cayala and La Aurora Zoo. Chiquimula is another favorite city with Central Highlands travelers. Visitors to this destination enjoy Ismael Cerna Park and Nuestra Senora del Transito Church. Expedia is your one-stop shop when it comes to planning your Central Highlands vacation. From hotels and flights, to activities and more, we know how to curate a travel experience like no other.

The Latest Central Highlands vacation packages

Price found within the past 48 hours. Click for updated prices.

Atitlan Oasis Eco Hotel and Spa Kaalpul

Save 100% on your flight

$613

per person

Dec 28 - Jan 4

found 6 hours ago

Roundtrip non-stop flight included

Newark Liberty Intl. Airport (EWR) to Guatemala City (GUA)

8.8/10 Excellent! (72 reviews)

A magical spot! Totally secluded with stunning views of Lake Atitlan. Alexis is extraordinarily kind.

Reviewed on Mar 18, 2025

Kula Maya Boutique Hotel & Spa

Save 100% on your flight

$1,355

per person

Dec 28 - Jan 4

found 6 hours ago

Roundtrip non-stop flight included

Newark Liberty Intl. Airport (EWR) to Guatemala City (GUA)

9.6/10 Exceptional! (96 reviews)

I have never been to a hotel with staff this wonderful. The views are idealic. The restaurant on site was excellent and a good value. We felt at home very quickly. The hotel only has 10 total rooms. We were able to chop it up and meet other guests. A+. Staff always cheerful and helpful! I only have one complaint that is the same at every other hotel I have stayed at around Lake Atitlan. That complaint is the dogs! They are barking all night and here is a disco which can get rather loud. The hotel actually has ear plugs laid out for guests when they checkin.

Reviewed on Sep 24, 2025

Aviva Hotel

Save 100% on your flight

$1,344

per person

Dec 22 - Dec 27

found 19 hours ago

Roundtrip non-stop flight included

Newark Liberty Intl. Airport (EWR) to Guatemala City (GUA)

9.8/10 Exceptional! (13 reviews)

Todo perfecto limpio cómodo cilenciosa para descansar vista impresionante a el Lago pero el camino para llegar no está my bonito

Reviewed on Oct 2, 2025

Villas La Mar

Save 100% on your flight

$1,511

per person

Nov 22 - Nov 27

found 1 day ago

Roundtrip flight included

Miami (MIA) to Guatemala City (GUA)

8.2/10 Very Good! (138 reviews)

El lugar es muy bonito, ahora la propiedad está algo descuidada, se observa poco mantenimiento en el mobiliario cercano a la piscina o la terraza y la refrigeradora. Y en cuanto apoyo por medio del chat del app de expedía es nulo, el personal del lugar no atiende por el app, sino solicita que se llame a recepción en horario donde está disponible la recepción, en mi estadía tuve un inconveniente que me costó contactar alguien que me apoyara, finalmente se solventó y fue esperando al personal de la recepción. Ahora el lugar cuenta con una cocina, si en caso no se desea cocinar hay un restaurante que lo sugiero si se bebe alcohol es rápido ahora si es por comida tener paciencia para esperar.

Reviewed on Sep 16, 2025

Hotel Soleil Pacifico

Save 100% on your flight

$782

per person

Nov 22 - Nov 27

found 1 day ago

Roundtrip flight included

Miami (MIA) to Guatemala City (GUA)

7/10 Good! (353 reviews)

Great customer service!

Reviewed on Sep 24, 2025

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Where to stay in Central Highlands

Find the best Central Highlands areas and neighborhoods for the activities you enjoy most. Learn more about Central Highlands

Zona 10

2 out of top 10 points of interest in this area

4.5/5(505 area reviews)

Zona 10 is known for its ample dining options, and you can make a stop by Oakland Mall and Plaza Fontabella Shopping Center while in the area.

Discover the most popular places to visit in Central Highlands

Ruins of Old Mayan Monastery destroyed during earthquake in 15th century !

Casa Santo Domingo Museum

4.5/5(223 reviews)

You can browse the exhibits at Casa Santo Domingo Museum, a museum with a story of its own, during your travels to Antigua Guatemala. Discover the volcano viewpoints and shops in this romantic area.

Central Park

4.5/5(493 reviews)

Enjoy the volcano viewpoints and explore Central Park, a lovely green space in Antigua Guatemala. Discover the area's shops, or seek out its local tours.

Antigua Guatemala Cathedral

4.5/5(423 reviews)

After visiting Antigua Guatemala Cathedral, make a plan to see the other sights and activities in Antigua Guatemala. Discover the area's volcano viewpoints, or seek out its local tours.

Central Highlands Hotel Deals

Barceló Guatemala City

7 Avenida 15-45, Zona 9, Guatemala City, Guatemala

Fully refundableReserve now, pay when you stay

$90 nightly

$110 total

Nov 9 - Nov 10

Total with taxes and fees

9/10 Wonderful! (3,069 reviews)

"Very nice clean and profesional staff"

Reviewed on Oct 14, 2025

Tikal Futura Hotel & Convention Center

Calzada Roosevelt 22-43, Zona 11, Guatemala City, Guatemala

Fully refundableReserve now, pay when you stay

$111 nightly

$136 total

Nov 9 - Nov 10

Total with taxes and fees

8.8/10 Excellent! (1,018 reviews)

"Ok"

Reviewed on Oct 11, 2025

Hotel Museo Spa Casa Santo Domingo

3a Calle Oriente No 28 A, Antigua Guatemala, Sacatepequez

Fully refundableReserve now, pay when you stay

$218 nightly

$265 total

Nov 11 - Nov 12

Total with taxes and fees

9.2/10 Wonderful! (1,019 reviews)

"Excellent"

Reviewed on Oct 6, 2025

See all 1,275 properties in Central Highlands

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.