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Check availability on Cairo Luxury Hotels

Check prices for these dates

Tonight
Jul 13 - Jul 14
Tomorrow
Jul 14 - Jul 15
Next weekend
Jul 18 - Jul 20
In two weeks
Jul 25 - Jul 27

Top Cairo Luxury Hotels

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Recommended hotels in Cairo

Quality Inn Cairo I-57
Relax in the stylish lobby, featuring a reception desk, comfortable seating areas, and beautiful artwork.

Quality Inn Cairo I-57

2.5 star property
6.6 out of 10, (260)
"Outdated, but clean could have made up for that. The bed was comfortable. The tub was stained with what appeared to be grout and filth. There were also whitish drips all over the brown doorframes. The mirror was definitely cleaned with the previous tenant’s dirty towels. The coffee condiments were incomplete and hadn’t been replaced. And if all the above wasn’t enough, the place is in a true ghost town!"
Anita L
$75 nightly
The price is $83
Jul 28 - Jul 29
Total includes taxes and fees
Quality Inn Cairo I-57
Charming Home just minutes from Interstate and Mall
Guests can sit on the porch in a single Adirondack chair.

Charming Home just minutes from Interstate and Mall

10.0 out of 10, Exceptional, (18)
"Everything was perfect. Cozy, comfortable beds and the home was comfy!! Would stay again!!!"
mike a.
$165 nightly
The price is $187
Jul 14 - Jul 15
Total includes taxes and fees
Charming Home just minutes from Interstate and Mall
La Center Motel
Relax in this inviting room with two single beds, a desk, and a bathroom featuring a sink and mirror.

La Center Motel

2.0 star property
7.8 out of 10, Good, (14)
"Nice economy stay on the way to Paducah. Had a microwave, refrigerator and satellite TV. Could use a little paint. Bed was comfortable. "
Wendi
$59 nightly
The price is $63
Jul 14 - Jul 15
Total includes taxes and fees
La Center Motel
Charming cottage overlooking Lake Acre
Situated on a well-maintained lawn, this charming house features a front porch with a swing and a flagpole.

Charming cottage overlooking Lake Acre

10.0 out of 10, Exceptional, (95)
"The cabin is so comfy and homey. We loved the setting and could watch birds as we ate on the deck. Centrally located for birding. Only 30 minutes from several hot birding/hiking spots. We thoroughly enjoyed the stay and hope to be back soon."
Barbara S.
$237 nightly
The price is $237
Jul 14 - Jul 15
Total includes taxes and fees
Charming cottage overlooking Lake Acre
Beautiful Cabin Retreat
Interior

Beautiful Cabin Retreat

8.2 out of 10, Very Good, (41)
"Host had the cabin very clean. New leather couch & recliner. Mattress was extremely comfortable. Washer & Dryer were excellent. Another Rental house near, long-term renters were very quiet. Internet not very good in the Illinois woods. Closed cabin has a musty smell from humidity in the woods. Host had an automatic air freshener going to help with air quality."
Bob & Patricia B.
$194 nightly
The price is $194
Jul 14 - Jul 15
Total includes taxes and fees
Beautiful Cabin Retreat
Eagle Inn Charleston
Two single beds with white linens and dark headboards, a green accent wall, and a window with a brown curtain.

Eagle Inn Charleston

2.0 star property
6.8 out of 10, (100)
"Comfortable bed, easy access to room"
Kathy
$66 nightly
The price is $73
Jul 14 - Jul 15
Total includes taxes and fees
Eagle Inn Charleston
Peaceful secluded cabin located near Horseshoe Lake
Situated in a wooded area, this cabin features a steeply pitched roof and a front door with a small porch and bench.

Peaceful secluded cabin located near Horseshoe Lake

9.8 out of 10, Exceptional, (12)
"This stay was comfortable and quiet an amazing weekend stay!!"
Chyaria B.
$190 nightly
The price is $190
Jul 14 - Jul 15
Total includes taxes and fees
Peaceful secluded cabin located near Horseshoe Lake
Super 8 by Wyndham Charleston/Sikeston East MO
Welcome to Simmons Hotel, where guests can enjoy a convenient covered entrance and parking.

Super 8 by Wyndham Charleston/Sikeston East MO

2.0 star property
6.6 out of 10, (572)
"I was passing by and decided to take a break here. The bed was clean, had hot water and the heat was working. Took a quick 5 hour sleep and was back on the road. "
Krastyu
$65 nightly
The price is $72
Jul 28 - Jul 29
Total includes taxes and fees
Super 8 by Wyndham Charleston/Sikeston East MO
Quality Inn Charleston - Sikeston
Two single beds with matching headboards, a wooden dresser, and a desk with a chair.

Quality Inn Charleston - Sikeston

2.5 star property
6.8 out of 10, (389)
"This place is horrible with the worst customer service. The guy told me I booked smoking rooms (when I in fact did not) and wouldn’t change them unless I paid for new rooms entirely. When questioned about it he kept talking in circles and never would help us. The super 8 down the road was very helpful and friendly and the beds were comfortable…stay at Super 8 if you’re in Charleston! "
Lauren
$69 nightly
The price is $77
Jul 28 - Jul 29
Total includes taxes and fees
Quality Inn Charleston - Sikeston
Cozy cabins on beautiful Horseshoe Lake
Cozy dining area with a wooden table for four, potted plant, and a view of the surrounding grassy area.

Cozy cabins on beautiful Horseshoe Lake

9.8 out of 10, Exceptional, (32)
"Pretty, secluded location. The pictures may be deceiving to some, but we stayed with 4 people and there was plenty of room. Communication was super easy with host, very responsive. Cabin was supplied with many amenities for cooking and just basic stay needs. Host pretty thought of everything. "
Gerald
$124 nightly
The price is $124
Jul 14 - Jul 15
Total includes taxes and fees
Cozy cabins on beautiful Horseshoe Lake
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

Are you searching for the perfect hotel for your luxury trip to Cairo?
Let Expedia help you arrange your flight to Cairo, IL (CIR-Cairo Regional) airport or Paducah, KY (PAH-Barkley Regional) airport, and then choose from some places to stay that will deliver the luxury you seek. Amenities are important when you plan a trip, so we make it easy to find what you need to make your stay special. If you want an upscale hotel with a spa, an indoor pool, or luxury bedding, Expedia can assist you in finding the best luxury hotel experience that Cairo has to offer. Cairo has some interesting things to see and do including Mississippi River and Fort Defiance State Park, so you might want to take in the local sights during your visit.
When can I expect good weather in Cairo?
Planning for the weather is an important factor for making your trip to Cairo a success, especially when you're splurging. The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for Cairo is 61 inches.
What's there to see and do in Cairo?
Enjoy all that Cairo has to offer and visit Mississippi River, Fort Defiance State Park, and Columbus-Belmont State Park. If you have spare time during your trip, you might want to make a stop at Ullin City Hall and Ballard Wildlife Management Area.