Find hotels near Colleton Medical Center, Walterboro from $52

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Compare 248 hotels close to Colleton Medical Center with room rates, reviews, and availability. Most hotels are fully refundable.

Free daily on-the-go breakfast
Sleep Inn Walterboro I-95

Sleep Inn Walterboro I-95

2.5 star property
1.2 mi from Colleton Medical Center
7.6 out of 10, Good, (572)
"Quiet and very accesible place."
United States
Lisa
$84 nightly
The price is $94
Jan 4 - Jan 5, 2026
Total with taxes and fees
Sleep Inn Walterboro I-95
Standard Room, 1 King Bed | Desk, free WiFi
Southern Inn By OYO Walterboro I-95

Southern Inn By OYO Walterboro I-95

2.5 star property
1.1 mi from Colleton Medical Center
7.0 out of 10, Good, (79)
"Room is badly overrated. Sink was clogged. Interior badly needs remodeled."
United States
Ronnie
$47 nightly
The price is $52
Dec 14 - Dec 15
Total with taxes and fees
Southern Inn By OYO Walterboro I-95
Front of property - evening/night
Travelodge by Wyndham Walterboro

Travelodge by Wyndham Walterboro

2.0 star property
1.1 mi from Colleton Medical Center
6.2 out of 10, (526)
"Everything is ok "
United States
Fonda
$54 nightly
The price is $60
Jan 3 - Jan 4, 2026
Total with taxes and fees
Travelodge by Wyndham Walterboro
Exterior
Super 8 by Wyndham Walterboro

Super 8 by Wyndham Walterboro

2.0 star property
1.5 mi from Colleton Medical Center
6.2 out of 10, (211)
"Stay was good. "
United States
Cindy
$59 nightly
The price is $66
Dec 15 - Dec 16
Total with taxes and fees
Super 8 by Wyndham Walterboro
Free daily buffet breakfast
Hampton Inn & Suites Walterboro

Hampton Inn & Suites Walterboro

2.5 star property
4.3 mi from Colleton Medical Center
9.2 out of 10, Wonderful, (1002)
"Wonderful stay!"
United States
Efrain
$154 nightly
The price is $172
Dec 14 - Dec 15
Total with taxes and fees
Hampton Inn & Suites Walterboro
Free daily buffet breakfast
Holiday Inn Exp Walterboro by IHG

Holiday Inn Exp Walterboro by IHG

2.5 star property
4.2 mi from Colleton Medical Center
8.6 out of 10, Excellent, (1000)
"Clean stay, helpful service"
United States
Imani
$148 nightly
The price is $166
Dec 14 - Dec 15
Total with taxes and fees
Holiday Inn Exp Walterboro by IHG
Desk, iron/ironing board, free WiFi, bed sheets
Comfort Inn & Suites Walterboro I-95

Comfort Inn & Suites Walterboro I-95

2.5 star property
4.1 mi from Colleton Medical Center
8.4 out of 10, Very Good, (1002)
"Room is clean and staff was very courteous and check in was a breeze. Would stay here again"
United States
Teddy
$101 nightly
The price is $114
Dec 14 - Dec 15
Total with taxes and fees
Comfort Inn & Suites Walterboro I-95
Free WiFi, bed sheets
Motel 6 Walterboro, SC

Motel 6 Walterboro, SC

2.0 star property
4.1 mi from Colleton Medical Center
8.2 out of 10, Very Good, (1416)
"Room was spotless and the staff was excellent. Would love to stay here again. "
United States
Tina
$56 nightly
The price is $63
Dec 7 - Dec 8
Total with taxes and fees
Motel 6 Walterboro, SC
Breakfast area
Econo Lodge

Econo Lodge

2.0 star property
3.7 mi from Colleton Medical Center
7.8 out of 10, Good, (1000)
"Great motel and great prices "
United States
Kent
$52 nightly
The price is $58
Dec 14 - Dec 15
Total with taxes and fees
Econo Lodge
Exterior
Microtel Inn & Suites by Wyndham Walterboro

Microtel Inn & Suites by Wyndham Walterboro

2.0 star property
4.3 mi from Colleton Medical Center
8.0 out of 10, Very Good, (1003)
"Room was clean and friendly staff"
United States
Katina
$94 nightly
The price is $106
Jan 5 - Jan 6, 2026
Total with taxes and fees
Microtel Inn & Suites by Wyndham Walterboro
Lobby
Best Western Of Walterboro

Best Western Of Walterboro

2.5 star property
3.9 mi from Colleton Medical Center
7.6 out of 10, Good, (333)
"Room was very clean and quiet. Easy check in and check out. "
United States
Jessica
$81 nightly
The price is $91
Dec 8 - Dec 9
Total with taxes and fees
Best Western Of Walterboro
Free daily buffet breakfast
Quality Inn

Quality Inn

2.5 star property
4.3 mi from Colleton Medical Center
7.6 out of 10, Good, (851)
"Comfy beds and clean room with frig and microwave!"
United States
Cynthia
$55 nightly
The price is $61
Dec 22 - Dec 23
Total with taxes and fees
Quality Inn
Lobby
Days Inn by Wyndham Walterboro

Days Inn by Wyndham Walterboro

2.0 star property
4.2 mi from Colleton Medical Center
7.2 out of 10, Good, (762)
"Welcoming front desk and friendly staff"
United States
Mounika
$64 nightly
The price is $71
Dec 9 - Dec 10
Total with taxes and fees
Days Inn by Wyndham Walterboro
Standard Room, 2 Double Beds, Smoking | Room amenity
Rodeway Inn Walterboro I-95

Rodeway Inn Walterboro I-95

2.0 star property
4 mi from Colleton Medical Center
7.0 out of 10, Good, (259)
"The AC worked hgreat, .my room was clean and the staff was friendly. "
United States
Tammy
$47 nightly
The price is $52
Dec 21 - Dec 22
Total with taxes and fees
Rodeway Inn Walterboro I-95
Premium bedding, desk, soundproofing, iron/ironing board
Red Roof Inn Walterboro

Red Roof Inn Walterboro

2.0 star property
3.8 mi from Colleton Medical Center
6.6 out of 10, (859)
"Always stay here on our way to the mountains "
United States
Judy
$58 nightly
The price is $66
Jan 1 - Jan 2, 2026
Total with taxes and fees
Red Roof Inn Walterboro
Front of property - evening/night
Baymont by Wyndham Walterboro

Baymont by Wyndham Walterboro

2.5 star property
3.9 mi from Colleton Medical Center
6.2 out of 10, (1041)
"I like the quietness. "
United States
Joseph
$47 nightly
The price is $52
Dec 7 - Dec 8
Total with taxes and fees
Baymont by Wyndham Walterboro
Reception
Budgetel

Budgetel

2.0 star property
3.7 mi from Colleton Medical Center
3.6 out of 10, (5)
"There was bedbugs! Tim was very friendly though. "
United States
Abu
$70 nightly
The price is $78
Dec 7 - Dec 8
Total with taxes and fees
Budgetel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Colleton Medical Center Hotel Reviews

Motel 6 Walterboro, SC

Motel 6 Walterboro, SC

10/10 Excellent
"Hotel does not serve breakfast Heat worked great Room was clean Towels and sheets clean and white Sheets were crisp"
Ann 1-night trip
Posted 3 days ago
Motel 6 Walterboro, SC

Hotels near other Colleton Medical Center attractions

First Baptist Church

3.9/5 (30 reviews)
After visiting First Baptist Church, make a plan to see the other sights and activities in Walterboro. While you're here, you can savor the top-notch restaurants.
See properties

Forest Hills Tennis Center

Catch an event at Forest Hills Tennis Center during your trip to Walterboro. While you're here, you can savor the top-notch restaurants.
See properties

Frequently asked questions

What's the area like around Colleton Medical Center?
Colleton Medical Center is located in Walterboro. This welcoming area is known for its array of dining options. You'll find 35 hotels and other accommodations within a few miles for a convenient home base.
What's the best place to stay near Colleton Medical Center?
Comfort Inn & Suites Walterboro I-95 is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and free parking. It's located 4.1 mi (6.6 km) from Colleton Medical Center. Other good choices within a few miles include Motel 6 Walterboro, SC and Microtel Inn & Suites by Wyndham Walterboro.
How many hotels will I be able to find close to Colleton Medical Center?
Expedia has 35 hotels and other accommodations a few miles from Colleton Medical Center.
If I need to cancel the hotel reservation for my stay near Colleton Medical Center, will I receive a refund?
Yes, most hotel room reservations are refundable if you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of the scheduled arrival. If you have a reservation that's non-refundable, you may still be able to cancel and receive a refund within 24 hours of booking. Plug in your dates, click on "Search", then use the "fully refundable" filter to view the best deals available near Colleton Medical Center.
Where can I learn more about changing or cancelling my trip in the area near Colleton Medical Center?
To access more information about rescheduling or cancelling your stay near Colleton Medical Center, click here.