Title: Mayesville Vacation Packages 2026 from $665 | Expedia.com

[Mayesville Travel Guide](https://expedia.com/Mayesville.dx3000456025)[Hotels in Mayesville](https://expedia.com/Mayesville-Hotels.d3000456025.Travel-Guide-Hotels)[Vacation Rentals in Mayesville](https://expedia.com/Mayesville-Vacation-Rentals.d3000456025.Travel-Guide-VacationRentals)[Flights to Mayesville](https://expedia.com/Cheap-Flights-To-Mayesville.d3000456025.Travel-Guide-Flights)[Car Rentals in Mayesville](https://expedia.com/Car-Rentals-In-Mayesville.d3000456025.Car-Rental-Guide)

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# Mayesville Vacations from $665

## Book a Hotel + Flight or Car together to unlock savings

- ##  
Plan, book, travel with confidence
- ###  
Better together  
Save up to $1,045 when you book a flight and hotel together\*
- ###  
Find the right fit  
With over 300,000 hotels worldwide, it's easy to create a perfect package
- ###  
Rest easy  
Plan, book, and manage your trip all in one place

## The Latest Mayesville vacation packages

Price found within the past 48 hours. Click for updated prices.

![Tru by Hilton Florence I-95](https://images.trvl-media.com/lodging/28000000/27050000/27041900/27041849/a8854f5d_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Tru by Hilton Florence I-95

$665

per person

Mar 28 - Apr 1

found 20 hours ago

Roundtrip non-stop flight included

Philadelphia (PHL) to Florence (FLO)

8.4/10 Very Good! (1,003 reviews)

Great place for pups, good rates, nice rooms and services. Decent breakfast! Public areas are outstanding w/pool table.

Reviewed on Feb 15, 2026

Don't see what you're looking for?

See all available trips from Columbus to Mayesville

[View all trips](https://expedia.com/go/package/search/FlightHotel/2026-03-21/2026-03-28/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=FLO&NumRoom=1&NumAdult=2&NumChild=0&paandie=true)

![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh)

## 

The Annual Vacation Sale

Members save up to 40% on hotels and homes. Plan this year’s big trip and save.

[Book now](https://expedia.com/deals?rfrr=PKG_SPRING_PROMO_3000456025)

## Mayesville Hotel Deals

![Woodspring Suites Sumter Near Shaw Afb](https://images.trvl-media.com/lodging/114000000/113640000/113638700/113638614/ffe51947_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Woodspring Suites Sumter Near Shaw Afb

2715 Broad Street Sumter SC

$109 nightly

$122 total

Mar 9 - Mar 10

Total with taxes and fees

8.2/10 Very Good! (169 reviews)

Very good experience staff is excellent

Reviewed on Feb 20, 2026

[](https://expedia.com/Hotel-Search?startDate=3%2F9%2F2026&endDate=3%2F10%2F2026&selected=113638614&PinnedHotelID=113638614&HadPinnedHotel=true&regionId=3000456025)

![SureStay Hotel by Best Western Manning](https://images.trvl-media.com/lodging/1000000/570000/569400/569301/e6b95688_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

SureStay Hotel by Best Western Manning

2816 Paxville Highway Manning SC

Fully refundableReserve now, pay when you stay

$89 nightly

$99 total

Feb 22 - Feb 23

Total with taxes and fees

8.6/10 Excellent! (1,004 reviews)

Updated and comfortable room, pleasant employees, good breakfast

Reviewed on Feb 21, 2026

[](https://expedia.com/Hotel-Search?startDate=2%2F22%2F2026&endDate=2%2F23%2F2026&selected=569301&PinnedHotelID=569301&HadPinnedHotel=true&regionId=3000456025)

![Hampton Inn Manning](https://images.trvl-media.com/lodging/2000000/1420000/1418700/1418684/54902f8f_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Hampton Inn Manning

2822 Paxville Hwy Manning SC

Fully refundableReserve now, pay when you stay

$119 nightly

$132 total

Mar 1 - Mar 2

Total with taxes and fees

8.4/10 Very Good! (1,002 reviews)

Everything perfect

Reviewed on Feb 18, 2026

[](https://expedia.com/Hotel-Search?startDate=3%2F1%2F2026&endDate=3%2F2%2F2026&selected=1418684&PinnedHotelID=1418684&HadPinnedHotel=true&regionId=3000456025)

[See all 77 properties in Mayesville](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=2%2F22%2F2026&endDate=2%2F23%2F2026&regionId=3000456025)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

## Find the Best Mayesville Vacation Packages

## Mayesville Essential Information

| Language        | English                         |
| --------------- | ------------------------------- |
| Currency        | U.S dollars                     |
| Closest Airport | Florence Regional Airport (FLO) |
| Population      | 730                             |

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## Frequently asked questions

### How much does a Mayesville vacation package cost?

### What are the cheapest months to go to Mayesville?

### How many days is enough for Mayesville?

### How to find the best Mayesville package deals?

### Is it cheaper to book a Mayesville vacation as a package?

### When to book a vacation package to Mayesville?

### Does Expedia offer Book Now, Pay Later Mayesville vacation packages?

\* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.

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## Go further with the Expedia app

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