Title: Mayesville Vacation Packages 2026 from $273 | Expedia.com

[Mayesville Travel Guide](https://expedia.com/Mayesville.dx3000456025)[Hotels in Mayesville](https://expedia.com/Mayesville-Hotels.d3000456025.Travel-Guide-Hotels)[Vacation Rentals in Mayesville](https://expedia.com/Mayesville-Vacation-Rentals.d3000456025.Travel-Guide-VacationRentals)[Flights to Mayesville](https://expedia.com/Cheap-Flights-To-Mayesville.d3000456025.Travel-Guide-Flights)[Car Rentals in Mayesville](https://expedia.com/Car-Rentals-In-Mayesville.d3000456025.Car-Rental-Guide)

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# Mayesville Vacations from $273

## Book a Hotel + Flight or Car together to unlock savings

- ##  
Plan, book, travel with confidence
- ###  
Better together  
Save up to $1,045 when you book a flight and hotel together\*
- ###  
Find the right fit  
With over 300,000 hotels worldwide, it's easy to create a perfect package
- ###  
Rest easy  
Plan, book, and manage your trip all in one place

## The Latest Mayesville vacation packages

Price found within the past 48 hours. Click for updated prices.

![Econo Lodge Cheraw Market Street](https://images.trvl-media.com/lodging/1000000/30000/23900/23844/8652d233_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Econo Lodge Cheraw Market Street

$273

per person

Apr 10 - Apr 12

found 18 hours ago

Roundtrip non-stop flight included

Houston (IAH) to Florence (FLO)

6.8/10 (70 reviews)

Was close to my event. Staff was kind and friendly. Great hot breakfast.

Reviewed on May 6, 2025

![Springhill Suites by Marriott Cheraw](https://images.trvl-media.com/lodging/90000000/89930000/89925000/89924960/3922a50b_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Springhill Suites by Marriott Cheraw

$368

per person

Apr 10 - Apr 12

found 18 hours ago

Roundtrip non-stop flight included

Houston (IAH) to Florence (FLO)

9.4/10 Exceptional! (267 reviews)

The room was fined but unfortunately the TV did not work and after several attempts from the maintenance man, Mr. Gary Cash, who was went above and beyond to get the TV to work it did not. The front desk did offer to change our room but we just said we were tired and just wanted to rest. So we were charged for a full night without the convenience of entertainment.

Reviewed on Jan 27, 2026

![Fairfield Inn by Marriott Hartsville](https://images.trvl-media.com/lodging/1000000/210000/202900/202854/c0813d21_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Fairfield Inn by Marriott Hartsville

$592

per person

Apr 1 - Apr 5

found 1 day ago

Roundtrip non-stop flight included

San Juan (SJU) to Florence (FLO)

8.6/10 Excellent! (668 reviews)

Room was large such a nice space, it includes microwave and refrigerator, but unfortunately it didn’t keep my food cold. I did report this when checking out. Staff is very helpful and great customer service. Offer discount but using Expedia or 3rs party was unable to process. Overall I would definitely stay again.

Reviewed on Feb 22, 2026

![Affordable Suites Florence](https://images.trvl-media.com/lodging/58000000/57720000/57719800/57719723/7895bf64_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Affordable Suites Florence

$535

per person

Apr 1 - Apr 5

found 1 day ago

Roundtrip non-stop flight included

San Juan (SJU) to Florence (FLO)

9.2/10 Wonderful! (120 reviews)

Super friendly manager, clean room and ample space. I highly recommend it for a good night sleep in Florence.

Reviewed on Feb 22, 2026

![Quality Inn Bennettsville](https://images.trvl-media.com/lodging/1000000/10000/3800/3732/9e9da60f_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

### Quality Inn Bennettsville

$290

per person

Apr 10 - Apr 12

found 18 hours ago

Roundtrip non-stop flight included

Houston (IAH) to Florence (FLO)

7.4/10 Good! (326 reviews)

The room was okay and the ceilings were neatly designed according to my wife.

Reviewed on Jan 18, 2026

Don't see what you're looking for?

See all available trips from Columbus to Mayesville

[View all trips](https://expedia.com/go/package/search/FlightHotel/2026-03-24/2026-03-31/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=FLO&NumRoom=1&NumAdult=2&NumChild=0&paandie=true)

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## 

The Annual Vacation Sale

Members save up to 40% on hotels and homes. Plan this year’s big trip and save.

[Book now](https://expedia.com/deals?rfrr=PKG_SPRING_PROMO_3000456025)

## Mayesville Hotel Deals

![Woodspring Suites Sumter Near Shaw Afb](https://images.trvl-media.com/lodging/114000000/113640000/113638700/113638614/ffe51947_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Woodspring Suites Sumter Near Shaw Afb

2715 Broad Street Sumter SC

8.2/10 Very Good! (170 reviews)

Very good experience staff is excellent

Reviewed on Feb 20, 2026

[Get rates](https://expedia.com/Hotel-Search?startDate=3%2F10%2F2026&endDate=3%2F11%2F2026&selected=113638614&PinnedHotelID=113638614&HadPinnedHotel=true&regionId=3000456025)

[](https://expedia.com/Hotel-Search?startDate=3%2F10%2F2026&endDate=3%2F11%2F2026&selected=113638614&PinnedHotelID=113638614&HadPinnedHotel=true&regionId=3000456025)

![SureStay Hotel by Best Western Manning](https://images.trvl-media.com/lodging/1000000/570000/569400/569301/e6b95688_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

SureStay Hotel by Best Western Manning

2816 Paxville Highway Manning SC

Fully refundableReserve now, pay when you stay

$89 nightly

$99 total

Feb 26 - Feb 27

Total with taxes and fees

8.6/10 Excellent! (1,006 reviews)

Nice

Reviewed on Feb 23, 2026

[](https://expedia.com/Hotel-Search?startDate=2%2F26%2F2026&endDate=2%2F27%2F2026&selected=569301&PinnedHotelID=569301&HadPinnedHotel=true&regionId=3000456025)

![Hyatt Place Sumter / Downtown](https://images.trvl-media.com/lodging/23000000/22520000/22514800/22514748/dfc7158d_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Hyatt Place Sumter / Downtown

18 N Main St Sumter SC

Fully refundableReserve now, pay when you stay

$184 nightly

$206 total

Feb 27 - Feb 28

Total with taxes and fees

9.2/10 Wonderful! (905 reviews)

The room was very clean and spacious

Reviewed on Feb 14, 2026

[](https://expedia.com/Hotel-Search?startDate=2%2F27%2F2026&endDate=2%2F28%2F2026&selected=22514748&PinnedHotelID=22514748&HadPinnedHotel=true&regionId=3000456025)

[See all 77 properties in Mayesville](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=2%2F25%2F2026&endDate=2%2F26%2F2026&regionId=3000456025)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

## Find the Best Mayesville Vacation Packages

## Mayesville Essential Information

| Language        | English                         |
| --------------- | ------------------------------- |
| Currency        | U.S dollars                     |
| Closest Airport | Florence Regional Airport (FLO) |
| Population      | 730                             |

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## Frequently asked questions

### How much does a Mayesville vacation package cost?

### What are the cheapest months to go to Mayesville?

### How many days is enough for Mayesville?

### How to find the best Mayesville package deals?

### Is it cheaper to book a Mayesville vacation as a package?

### When to book a vacation package to Mayesville?

### Does Expedia offer Book Now, Pay Later Mayesville vacation packages?

\* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.

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