Situated in Jacksonville Coast, this health care institution is worth a visit. But you'll find loads more to explore in the area. St. Johns Town Center, University of North Florida, and TPC Sawgrass aren't too far from Mayo Clinic Florida.
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Delta Hotels by Marriott Jacksonville Deerwood
Southside
Save 100% on your flight
Price was $539, price is now $359 per person
$359
per person
Nov 15 - Nov 20
found 1 day ago
Roundtrip flight included
Boston (BOS) to Jacksonville (JAX)
8.6/10 Excellent! (387 reviews)
Clean room. Very friendly staff.
Reviewed on Oct 9, 2025
DoubleTree by Hilton Hotel Jacksonville Riverfront
Downtown Jacksonville
Save 100% on your flight
Price was $609, price is now $410 per person
$410
per person
Nov 15 - Nov 20
found 1 day ago
Roundtrip flight included
Boston (BOS) to Jacksonville (JAX)
6.6/10 (1,383 reviews)
Beautiful hotel, comfortable beds, clean. A+ there.
Feedback on the hotel otherwise: Unable to find coffee in the lobby (was referred by the bar to get it in our room), AC unit in our room was SUPER loud all night long. (I did not tell the front desk because we were only staying one night)
Front desk check in and check out, both employees that helped us were amazing.
Would stay again, but wanted to give the feedback about the Coffee and AC in our room.
Reviewed on Oct 14, 2025
Popular places to visit
Adventure Landing
4/5(64 reviews)
This amusement park east of Jacksonville is a fun daytrip for the whole family with thrilling rides, exciting attractions for kids and a shipwreck-themed waterpark.
Windsor Parke Golf Club
4/5(1 review)
Enjoy a round of golf in Jacksonville at Windsor Parke Golf Club. Amble around the area's beautiful beaches or attend a sporting event.
Windsor Commons Shopping Center
4.5/5(17 reviews)
You can enjoy retail therapy at Windsor Commons Shopping Center during your trip to Jacksonville. Experience the area's entertainment choices and acclaimed theater scene.
Harbor City Municipal Golf Course
Enjoy a round of golf in Jacksonville at Harbor City Municipal Golf Course. Amble around the area's beautiful beaches or attend a sporting event.
Cradle Creek Preserve
Explore the great outdoors at Cradle Creek Preserve, a lovely green space in Jacksonville Beach. Amble around this family-friendly area's beautiful beaches and enjoy its top-notch restaurants.
Marsh Landing Country Club
Enjoy a round of golf in Ponte Vedra Beach at Marsh Landing Country Club. Stroll along the seaside or experience the entertainment choices in this family-friendly area.
Best Lodging Options Near Mayo Clinic Florida
Check availability on hotels close to Mayo Clinic Florida
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
14390 Mayo Boulevard, Jacksonville, FL
Hilton Jacksonville At Mayo Clinic
4745 Transformation Way, Jacksonville, FL
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
4905 SAN PABLO ROAD SOUTH, Jacksonville, FL
New 2 miles 2Mayo Clinic Intracoastal water views Mins to JaxBeach
Jacksonville
Fancy private pool home in Jax beach
Jacksonville
Big Wheelchair Accessible Home Close to Beach/Mayo with Zen Den and Fenced Yard
Jacksonville
Tranquility by Mayo w/ Heated Pool Mins to Beach
Jacksonville Beach
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
4791 Windsor Commons Ct, Jacksonville, FL
Margaritaville Jacksonville Beach
715 1st St N, Jacksonville Beach, FL
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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