Santa Cruz Vacations from $1,288

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Your Santa Cruz Vacation

Booking a Santa Cruz vacation package is a good way to become acquainted with this unique neighborhood. From its must-visit places to its lesser-known treasures, there's a lot to delve into. Some leading nearby attractions to check out during your trip to Santa Cruz include Seville Cathedral, Alcázar and Plaza de España. Whatever your dream Santa Cruz vacation looks like, you can turn it into reality with Expedia.

The Latest Santa Cruz Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Eurostars Guadalquivir

Eurostars Guadalquivir

4 out of 5
Los Remedios
Price was $1,685, price is now $1,288 per person
$1,288
per person
Jun 10 - Jun 16
found 5 hours ago
Roundtrip non-stop flight included
New York (JFK) to Seville (SVQ)
9.4/10 Exceptional! (582 reviews)
The breakfast it was excellent and the staff also. We need to call several times regarding the room ice bucket , glasses.

Reviewed on Apr 25, 2026

Hotel Gravina 51

Hotel Gravina 51

4 out of 5
Historical Center
Price was $2,221, price is now $1,783 per person
$1,783
per person
Jun 29 - Jul 5
found 1 day ago
Roundtrip non-stop flight included
New York (NYC) to Seville (SVQ)
10/10 Exceptional! (930 reviews)
Absolutely beautiful hotel. Room large and very comfortable. Bedding and bed delightful. Bathroom good but so small. Lighting in room, as in most hotels, did not have a bright option so hard to see detail in mirrors etc. Bar small - never used the restaurant. Courtyard they promote is very small. Staff very accommodating. Would recommend but overall atmosphere felt a little pretentious and not relaxing in the public areas.

Reviewed on Apr 24, 2026

Hotel Boutique Casa del Poeta Sevilla

Hotel Boutique Casa del Poeta Sevilla

4 out of 5
Historical Center
Price was $3,082, price is now $2,484 per person
$2,484
per person
Jun 1 - Jun 5
found 1 day ago
Roundtrip non-stop flight included
Chicago (ORD) to Seville (SVQ)
9.8/10 Exceptional! (906 reviews)
We very much enjoyed our stay. The property is lovely and the staff were very friendly and attentive. The hotel is conveniently located to explore the city on foot. Would stay again.

Reviewed on Apr 25, 2026

Cavalta Boutique Hotel – Small Luxury Hotel

Cavalta Boutique Hotel – Small Luxury Hotel

5 out of 5
Triana
Price was $2,116, price is now $1,719 per person
$1,719
per person
Jun 30 - Jul 5
found 1 day ago
Roundtrip non-stop flight included
New York (JFK) to Seville (SVQ)
9.8/10 Exceptional! (107 reviews)
Very helpful staff and a beautiful building in a quiet part of the neighborhood. Can't wait to go back!

Reviewed on Apr 19, 2026

Joya del Casco Boutique Hotel

Joya del Casco Boutique Hotel

3.5 out of 5
Historical Center
Price was $2,200, price is now $1,810 per person
$1,810
per person
Jun 29 - Jul 5
found 1 day ago
Roundtrip non-stop flight included
New York (NYC) to Seville (SVQ)
9.6/10 Exceptional! (213 reviews)
What a wonderful little boutique hotel. Rooms are quiet, breakfast is lovely with unusual Portuguese items to try. Awesome views from the roof and only 3 mins walk to the Cathedral. We have stayed in several hotels in Seville and this is our favorite!

Reviewed on Apr 24, 2026

Where to stay in Santa Cruz

Find the best Santa Cruz areas and neighborhoods for the activities you enjoy most. Learn more about Santa Cruz
Historical Center

Historical Center

7 out of top 10 points of interest in this area
4.5/5(606 area reviews)

Go on an adventure through the ages when you visit the historical churches, palaces, plazas and mansions of Seville’s ancient heart.

Find hotels in Historical Center

Santa Cruz Hotel Deals

Hotel Alfonso XIII, a Luxury Collection Hotel, Seville

Hotel Alfonso XIII, a Luxury Collection Hotel, Seville

5 out of 5
San Fernando 2 Seville Seville
$741 nightly
The price is $815 total per night from May 27 to May 28
$815 total
May 27 - May 28
Total with taxes and fees
9.4/10 Exceptional! (1,001 reviews)
Stylish premises with lovely staff. Good breakfast and bar.

Reviewed on Apr 17, 2026

Hotel Alfonso XIII, a Luxury Collection Hotel, Seville
Hotel Murillo

Hotel Murillo

2 out of 5
Calle Lope de Rueda, 7-9 Seville Seville
Fully refundableReserve now, pay when you stay
$124 nightly
The price is $136 total per night from May 17 to May 18
$136 total
May 17 - May 18
Total with taxes and fees
8.8/10 Excellent! (1,009 reviews)
Great hotel! I landed late in Seville and needed a hotel last minute. Staff was very friendly and helpful. Great location and so beautiful!

Reviewed on Apr 26, 2026

Hotel Murillo
Las Casas de la Judería, Sevilla Historic City Center

Las Casas de la Judería, Sevilla Historic City Center

4 out of 5
Calle Santa Maria La Blanca 5 Seville Seville
$200 nightly
The price is $220 total per night from May 17 to May 18
$220 total
May 17 - May 18
Total with taxes and fees
9.4/10 Exceptional! (1,002 reviews)
This hotel is quite remarkable, featuring a historic estate composed of several buildings linked by a complex network of tunnels, each exuding its own unique charm. There are numerous quaint gardens nestled between the structures, along with a delightful rooftop swimming pool that offers stunning ...

Reviewed on Apr 26, 2026

Las Casas de la Judería, Sevilla Historic City Center
See all 434 properties in Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Discover the most popular places to visit in Santa Cruz

Royal Alcázar of Seville

Royal Alcázar of Seville

5/5(747 reviews)

Discover a millennium’s worth of royal treasures in this architectural masterpiece in the heart of Seville.

Royal Alcázar of Seville
Giralda Tower

Giralda Tower

4.5/5(500 reviews)

Once among the tallest religious monuments in the world, this former minaret is now the eye-catching bell tower to Seville Cathedral.

Giralda Tower
San Telmo Palace

San Telmo Palace

Tour the striking interior and exterior of a palatial building that serves as the headquarters of the president of the autonomous region of Andalusia.

San Telmo Palace

Things to do

Skip the line combo tour to Alcazar & Cathedral of Seville

Cathedral & Alcázar of Seville Guided Tour Combo

$39
per adult
92% of travellers recommend
Cathedral & Alcázar of Seville Guided Tour Combo
a narrow dirt road leading to a town in Spain

White Villages & Ronda Day Trip from Seville

$93
per adult
92% of travellers recommend
White Villages & Ronda Day Trip from Seville
Boat Trip "Los Rincones del Guadalquivir"

Boat Trip "Los Rincones del Guadalquivir"

$30
per adult
88% of travellers recommend
Boat Trip "Los Rincones del Guadalquivir"
See all activities in Seville

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.