Santa Maria Vacations from $347

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Your Santa Maria Vacation

Make planning your travels easy by reserving a vacation package to Santa Maria. Let us take care of all the details, so you can focus on appreciating everything this neighborhood has to offer. Can't wait to head out and see the sights during your trip to Santa Maria? Make sure you stop by nearby attractions like Banco Pichincha Monumental Stadium, Mall del Sol Commercial Center and San Marino Mall. Expedia will help you turn your ideal Santa Maria vacation into reality, no matter your travel plans or budget.

The Latest Santa Maria Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Mansión Alcázar Boutique Hotel

Mansión Alcázar Boutique Hotel

4 out of 5
Downtown Cuenca
Save 100% on your flight
per person
Sep 29 - Oct 4
found 1 day ago
Roundtrip flight included
Quito (UIO) to Guayaquil (GYE)
9.6/10 Exceptional! (290 reviews)
The best part of my stay eas the staff - they were incrredibly helpful.

Reviewed on Jul 16, 2025

Hotel Rio Guayas

Hotel Rio Guayas

2.5 out of 5
Las Peñas
per person
Sep 19 - Sep 26
found 1 day ago
Roundtrip non-stop flight included
New York (JFK) to Guayaquil (GYE)
No reviews
Hotel Cruz del Vado

Hotel Cruz del Vado

4.5 out of 5
Save 100% on your flight
per person
Aug 19 - Aug 26
found 1 day ago
Roundtrip flight included
New York (JFK) to Guayaquil (GYE)
9.4/10 Exceptional! (36 reviews)
Muy bonito, súper limpio, el cuarto hermoso pero pequeño, al rededor del hotel, el área no es tan buena q se diga.

Reviewed on May 29, 2025

Luxury Suites Riverfront GYE

Luxury Suites Riverfront GYE

3.5 out of 5
Puerto Santa Ana
per person
Sep 19 - Sep 26
found 1 day ago
Roundtrip non-stop flight included
New York (JFK) to Guayaquil (GYE)
9.4/10 Exceptional! (91 reviews)
The property is close to the Malecon and airport. The shades and windows were dirty. It looked a bit drab inside.

Reviewed on May 15, 2025

Hotel Marcelius

Hotel Marcelius

3.5 out of 5
Kennedy
per person
Sep 19 - Sep 26
found 1 day ago
Roundtrip non-stop flight included
New York (JFK) to Guayaquil (GYE)
8.2/10 Very Good! (202 reviews)
Love this property… the pool needs maintenance and cleaning

Reviewed on Jan 24, 2025

Where to stay in Santa Maria

Find the best Santa Maria areas and neighborhoods for the activities you enjoy most. Learn more about Santa Maria
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Ecuador

Though Ecuador might not have many top sights, you can venture to the surrounding area to see attractions like C.C. Riocentro Sur and Mall del Sur.

Find hotels in Ecuador

Santa Maria Hotel Deals

Oro Verde Guayaquil

Oro Verde Guayaquil

5 out of 5
9 De Octubre Y Garcia Moreno, Guayaquil, Guayas
Fully refundableReserve now, pay when you stay
$90 nightly
The price is $102 total per night from Aug 18 to Aug 19
$102 total
Aug 18 - Aug 19
9.4/10 Exceptional! (1,002 reviews)
"Retired airline with lots of experience in South America. Very nice hotel great restaurant good location."

Reviewed on Jul 16, 2025

Oro Verde Guayaquil
Wyndham Guayaquil Puerto Santa Ana

Wyndham Guayaquil Puerto Santa Ana

4.5 out of 5
Calle Numa Pompilio Llona S N, Ciudad del Rio - Puerto Santa Ana, Guayaquil, Guayas
Fully refundableReserve now, pay when you stay
$122 nightly
The price is $137 total per night from Jul 20 to Jul 21
$137 total
Jul 20 - Jul 21
9.2/10 Wonderful! (1,003 reviews)
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Reviewed on Jul 18, 2025

Wyndham Guayaquil Puerto Santa Ana
Holiday Inn Guayaquil Airport by IHG

Holiday Inn Guayaquil Airport by IHG

3.5 out of 5
Av. de Las Américas,junto al Aeropuerto, Intl. Jose Joaquin de Olmedo, Guayaquil, Guayas
Fully refundable
$88 nightly
The price is $99 total per night from Aug 3 to Aug 4
$99 total
Aug 3 - Aug 4
9.2/10 Wonderful! (1,009 reviews)
"It's very close to the airport, shuttle service is reliable, room is comfortable, buffet breakfast is a sumptuous spread. Congratulations to me for making a good hotel choice 😀"

Reviewed on Jul 15, 2025

Holiday Inn Guayaquil Airport by IHG
See all 382 properties in Santa Maria
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

All Inclusive Vacations

All Inclusive Vacations

Beach Vacations

Beach Vacations

Kid Friendly Vacations

Kid Friendly Vacations

Discover the most popular places to visit in Santa Maria

By the riverside

Malecon 2000

4.5/5(180 reviews)

Malecon 2000 is just one of the places to see in Guayaquil, so why not enjoy the other things to explore during your travels? While you're in the area, find time to visit its shops.

Malecon 2000
Santa Ana Hill

Santa Ana Hill

4.5/5(14 reviews)

Explore the great outdoors at Santa Ana Hill, a lovely green space in Guayaquil. While you're in the area, find time to visit its shops.

Santa Ana Hill

U.S. Consulate General

4/5(22 reviews)

U.S. Consulate General is just one of the places to see in San Eduardo, so why not enjoy the other things to explore during your travels? While you're in the area, find time to visit its shops.

U.S. Consulate General

Things to do

Cocoa Farm

Small Group Guayaquil and Cocoa Farm Full-Day Tour

$180
per adult
Small Group Guayaquil and Cocoa Farm Full-Day Tour
Guayaquil: Cloud Forest, Hiking & Canyoning Full Day Tour

Guayaquil: Cloud Forest, Hiking & Canyoning Full Day Tour

$309
per adult
Guayaquil: Cloud Forest, Hiking & Canyoning Full Day Tour
Full-Day Cuenca and Traditional Craft Beer Tasting Tour

Full-Day Cuenca and Traditional Craft Beer Tasting Tour

$460
per adult
Full-Day Cuenca and Traditional Craft Beer Tasting Tour
See all activities in Guayaquil
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.