St. Charles Vacations from $690

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Your St. Charles Vacation

When you book a St. Charles vacation package, it's easy to enjoy your getaway to the fullest. Uncover the highlights of this vibrant city knowing that all the travel planning has been organized in advance. Any trip to St. Charles has to include a little sightseeing. Whitewater State Park is a good place to start your exploring. Whoever you're escaping with and whatever you want to spend, your dream St. Charles vacation is just a few clicks away with Expedia.

The Latest St. Charles vacation packages

Price found within the past 48 hours. Click for updated prices.
Holiday Inn Express Rochester South - Mayo Area by IHG

Holiday Inn Express Rochester South - Mayo Area by IHG

2.5 out of 5
Price was $779, price is now $690 per person
$690
per person
Jan 4 - Jan 9
found 16 hours ago
Roundtrip non-stop flight included
Las Vegas (LAS) to Rochester (RST)
8.8/10 Excellent! (1,001 reviews)
The hot tub was out of service, something we really were looking forward to after a long drive. Otherwise, clean and modern. The "lake" is a fill pond from highway construction, so not very exciting. We could hear trucks on the highway from our room, but it was not too bad.

Reviewed on Nov 9, 2026

The Berkman

The Berkman

3 out of 5
Folwell
Price was $1,061, price is now $906 per person
$906
per person
Jan 4 - Jan 9
found 16 hours ago
Roundtrip non-stop flight included
Las Vegas (LAS) to Rochester (RST)
9.6/10 Exceptional! (449 reviews)

Hyatt House Rochester/Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area

3 out of 5
Downtown Rochester
Price was $939, price is now $825 per person
$825
per person
Jan 4 - Jan 9
found 16 hours ago
Roundtrip non-stop flight included
Las Vegas (LAS) to Rochester (RST)
9/10 Wonderful! (1,004 reviews)
Great stay.

Reviewed on Nov 8, 2026

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

3 out of 5
Historic Southwest
Price was $835, price is now $745 per person
$745
per person
Jan 4 - Jan 9
found 16 hours ago
Roundtrip non-stop flight included
Las Vegas (LAS) to Rochester (RST)
8.6/10 Excellent! (1,014 reviews)
Close to Mayo.

Reviewed on Nov 9, 2026

Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

3 out of 5
Kutzky Park
Price was $854, price is now $772 per person
$772
per person
Jan 4 - Jan 9
found 16 hours ago
Roundtrip non-stop flight included
Las Vegas (LAS) to Rochester (RST)
9.6/10 Exceptional! (748 reviews)
Wonderful breakfast, very clean and quiet, next to a nice jogging path for a morning run. Very well maintained property.

Reviewed on Nov 9, 2026

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St. Charles Hotel Deals

Kahler Grand Hotel

Kahler Grand Hotel

3 out of 5
20 2nd Ave Sw Rochester MN
Fully refundableReserve now, pay when you stay
$155 nightly
The price is $178 total per night from Nov 26 to Nov 27
$178 total
Nov 26 - Nov 27
Total with taxes and fees
8.4/10 Very Good! (2,407 reviews)
"Always enjoy my stay at the Kahler Grand! You can’t get a better location for Mayo Clinic appointments, shopping, terrific restaurants and friendly staff."

Reviewed on Nov 9, 2026

Kahler Grand Hotel
Med City Inn & Suites - Mayo Clinic Area

Med City Inn & Suites - Mayo Clinic Area

2.5 out of 5
435 16th Ave Nw Rochester MN
Fully refundableReserve now, pay when you stay
$75 nightly
The price is $86 total per night from Dec 10 to Dec 11
$86 total
Dec 10 - Dec 11
Total with taxes and fees
Med City Inn & Suites - Mayo Clinic Area
AmericInn by Wyndham Rochester Near Mayo Clinic

AmericInn by Wyndham Rochester Near Mayo Clinic

3 out of 5
1625 Broadway Ave S Rochester MN
Fully refundableReserve now, pay when you stay
$73 nightly
The price is $84 total per night from Dec 6 to Dec 7
$84 total
Dec 6 - Dec 7
Total with taxes and fees
AmericInn by Wyndham Rochester Near Mayo Clinic
See all 496 properties in St. Charles
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best St. Charles Vacation Packages

St. Charles Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Rochester Intl. Airport (RST)
Population
3,700
Max Temp Winter
25ºF
Max Temp Summer
75ºF

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Frequently asked questions

How much does a St. Charles vacation package cost?
You can grab a vacation package to this destination from $690 on Expedia. But how much your vacation to St. Charles costs will depend on factors like the season, length of stay and hotel choice.
What are the cheapest months to go to St. Charles?
January, February and November are great times to search for cheap St. Charles vacation packages. Traveling in less busy months means you can usually find reduced prices on hotels and flights.
How many days is enough for St. Charles?
Generally, a handful of days is enough to check out the main attractions during your St. Charles vacation. However, if you want to have more time to relax or go on day tours, consider extending your itinerary.
How to find the best St. Charles package deals?
Use Expedia's filter tool to find some terrific St. Charles package deals. When you start your search, just set your maximum budget and then sort the results by "Price: low to high." If you're looking to save, plan your trip for midweek, or browse for St. Charles package deals in the low season. Switch up your travel dates and you may score even better discounts. As a rule of thumb, it's typically best to book your vacation package as soon as possible.
Is it cheaper to book a St. Charles vacation as a package?
An Expedia vacation package could land you considerable savings when compared to booking hotels and flights separately. Better still, you can customize your St. Charles escape to match your exact needs. Pick your preferred flight time, select the hotel type and add a rental car. Explore our bundles to see how much you can save.
When to book a vacation package to St. Charles?
If you've got your St. Charles travel dates finalized, book early to grab some outstanding deals. With Expedia, you can generally reserve some flights up to one year ahead of time. Prefer spontaneous adventures? Our last-minute deals are ideal for setting off on a whim.
Does Expedia offer Book Now, Pay Later St. Charles vacation packages?
Your St. Charles getaway should be a relaxing escape from your busy life, not a reason for money-related stress. So to allow you a little more flexibility, we've partnered with online lender Affirm to bring you our Book Now, Pay Later vacations. Pick one of our vacation packages with payment plans and break down the cost over 3, 6 or 12 months. Plus, there aren't any hidden costs or late payment fees to worry about.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.