St. Charles Vacations from $503

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Your St. Charles Vacation

When you book a St. Charles vacation package, it's easy to enjoy your getaway to the fullest. Uncover the highlights of this vibrant city knowing that all the travel planning has been organized in advance. Any trip to St. Charles has to include a little sightseeing. Whitewater State Park is a good place to start your exploring. Whoever you're escaping with and whatever you want to spend, your dream St. Charles vacation is just a few clicks away with Expedia.

The Latest St. Charles vacation packages

Price found within the past 48 hours. Click for updated prices.
Comfort Inn & Suites Rochester South Mayo Clinic

Comfort Inn & Suites Rochester South Mayo Clinic

2 out of 5
Price was $534, price is now $503 per person
$503
per person
Jun 25 - Jun 28
found 15 hours ago
Roundtrip non-stop flight included
Denver (DEN) to Rochester (RST)
8.8/10 Excellent! (1,002 reviews)
staff was very, very helpful and accommodating

Reviewed on Apr 23, 2026

Aspen Select

Aspen Select

3.5 out of 5
Kutzky Park
Price was $594, price is now $513 per person
$513
per person
Jun 25 - Jun 28
found 15 hours ago
Roundtrip non-stop flight included
Denver (DEN) to Rochester (RST)
8.4/10 Very Good! (1,000 reviews)
We were in Rochester for an appointment at the Mayo clinic. Was a great location with free parking!

Reviewed on Apr 29, 2026

The Towers At Kahler Grand Hotel

The Towers At Kahler Grand Hotel

4 out of 5
Downtown Rochester
Price was $1,096, price is now $967 per person
$967
per person
Jun 25 - Jun 28
found 15 hours ago
Roundtrip non-stop flight included
Denver (DEN) to Rochester (RST)
9.4/10 Exceptional! (99 reviews)
Excellent accommodations, amazing staff

Reviewed on Dec 24, 2025

The Berkman

The Berkman

3 out of 5
Folwell
Price was $745, price is now $676 per person
$676
per person
Jun 25 - Jun 28
found 15 hours ago
Roundtrip non-stop flight included
Denver (DEN) to Rochester (RST)
9.6/10 Exceptional! (408 reviews)
Really the best place I've stayed in Rochester and being across the street from St Mary's was very helpful in getting in and out of the hospital. The staff and accommodations were perfect.

Reviewed on Apr 27, 2026

Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

3 out of 5
Kutzky Park
Price was $690, price is now $632 per person
$632
per person
Jun 25 - Jun 28
found 15 hours ago
Roundtrip non-stop flight included
Denver (DEN) to Rochester (RST)
9.4/10 Exceptional! (506 reviews)
Friendly staff, convenient parking, large ckean suite, good breakfast and great location.

Reviewed on Apr 14, 2026

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St. Charles Hotel Deals

Kahler Grand Hotel

Kahler Grand Hotel

3 out of 5
20 2nd Ave Sw Rochester MN
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $146 total per night from May 15 to May 16
$146 total
May 15 - May 16
Total with taxes and fees
8.4/10 Very Good! (2,027 reviews)
Was put in a room that is used for Expedia customers. Only 2 smaller windows, one foged up. Not a good mattress. 2 outside doors, on both side of our room. Slammed night and day. Rattled our room. Plan on better room next time.

Reviewed on Apr 27, 2026

Kahler Grand Hotel
Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

3.5 out of 5
9 3rd Ave Nw Rochester MN
Fully refundableReserve now, pay when you stay
$132 nightly
The price is $152 total per night from May 2 to May 3
$152 total
May 2 - May 3
Total with taxes and fees
8/10 Very Good! (1,558 reviews)
I was nice to have breakfast included. Parking was good and in the hotel.

Reviewed on Apr 28, 2026

Kahler Inn and Suites - Mayo Clinic Area
Med City Inn & Suites - Mayo Clinic Area

Med City Inn & Suites - Mayo Clinic Area

2.5 out of 5
435 16th Ave Nw Rochester MN
Fully refundableReserve now, pay when you stay
$81 nightly
The price is $93 total per night from May 20 to May 21
$93 total
May 20 - May 21
Total with taxes and fees
7.8/10 Good! (1,004 reviews)
Pool is wonderful with play stuff for kids and a great hot tub. The breakfast area is the cleanest ever! There is no meat for breakfast but otherwise anything you'd need. Great job there! The property is attached to Famous Dave's BBQ and it is GREAT! The property is old but clean. If you had to, ...

Reviewed on Apr 27, 2026

Med City Inn & Suites - Mayo Clinic Area
See all 511 properties in St. Charles
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best St. Charles Vacation Packages

St. Charles Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Rochester Intl. Airport (RST)
Population
3,700
Max Temp Winter
25ºF
Max Temp Summer
75ºF

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Frequently asked questions

How much does a St. Charles vacation package cost?
You can grab a vacation package to this destination from $503 on Expedia. But how much your vacation to St. Charles costs will depend on factors like the season, length of stay and hotel choice.
What are the cheapest months to go to St. Charles?
January, February and November are great times to search for cheap St. Charles vacation packages. Traveling in less busy months means you can usually find reduced prices on hotels and flights.
How many days is enough for St. Charles?
Generally, a handful of days is enough to check out the main attractions during your St. Charles vacation. However, if you want to have more time to relax or go on day tours, consider extending your itinerary.
How to find the best St. Charles package deals?
Use Expedia's filter tool to find some terrific St. Charles package deals. When you start your search, just set your maximum budget and then sort the results by "Price: low to high." If you're looking to save, plan your trip for midweek, or browse for St. Charles package deals in the low season. Switch up your travel dates and you may score even better discounts. As a rule of thumb, it's typically best to book your vacation package as soon as possible.
Is it cheaper to book a St. Charles vacation as a package?
An Expedia vacation package could land you considerable savings when compared to booking hotels and flights separately. Better still, you can customize your St. Charles escape to match your exact needs. Pick your preferred flight time, select the hotel type and add a rental car. Explore our bundles to see how much you can save.
When to book a vacation package to St. Charles?
If you've got your St. Charles travel dates finalized, book early to grab some outstanding deals. With Expedia, you can generally reserve some flights up to one year ahead of time. Prefer spontaneous adventures? Our last-minute deals are ideal for setting off on a whim.
Does Expedia offer Book Now, Pay Later St. Charles vacation packages?
Your St. Charles getaway should be a relaxing escape from your busy life, not a reason for money-related stress. So to allow you a little more flexibility, we've partnered with online lender Affirm to bring you our Book Now, Pay Later vacations. Pick one of our vacation packages with payment plans and break down the cost over 3, 6 or 12 months. Plus, there aren't any hidden costs or late payment fees to worry about.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.