St. Charles Vacations from $482

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $1,045 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Your St. Charles Vacation

When you book a St. Charles vacation package, it's easy to enjoy your getaway to the fullest. Uncover the highlights of this vibrant city knowing that all the travel planning has been organized in advance. Any trip to St. Charles has to include a little sightseeing. Whitewater State Park is a good place to start your exploring. Whoever you're escaping with and whatever you want to spend, your dream St. Charles vacation is just a few clicks away with Expedia.

The Latest St. Charles vacation packages

Price found within the past 48 hours. Click for updated prices.
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

3 out of 5
Price was $542, price is now $482 per person
$482
per person
Jun 26 - Jun 28
found 8 hours ago
Roundtrip non-stop flight included
Portland (PDX) to Rochester (RST)
7.2/10 Good! (1,032 reviews)
Decent pretty standard breakfast

Reviewed on Apr 14, 2026

The Towers At Kahler Grand Hotel

The Towers At Kahler Grand Hotel

4 out of 5
Downtown Rochester
Price was $868, price is now $698 per person
$698
per person
Jun 26 - Jun 28
found 8 hours ago
Roundtrip non-stop flight included
Portland (PDX) to Rochester (RST)
9.4/10 Exceptional! (99 reviews)
Excellent accommodations, amazing staff

Reviewed on Dec 24, 2025

Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG

3.5 out of 5
Downtown Rochester
Price was $624, price is now $529 per person
$529
per person
Jun 26 - Jun 28
found 8 hours ago
Roundtrip non-stop flight included
Portland (PDX) to Rochester (RST)
8.8/10 Excellent! (971 reviews)
We had stayed at the hotel on a Saturday night for an event. The room was fine and the hotel was quiet. We got in late and before 8am the staff was cleaning the room next to us. We had a knock at our door at 805am with housekeeping opening the door while we were still trying to sleep.

Reviewed on Apr 12, 2026

The Berkman

The Berkman

3 out of 5
Folwell
Price was $625, price is now $544 per person
$544
per person
Jun 26 - Jun 28
found 8 hours ago
Roundtrip non-stop flight included
Portland (PDX) to Rochester (RST)
9.6/10 Exceptional! (400 reviews)
Check in was easy. The room was excellent! We loved the layout and location. Kitchen was fully equipped and parking was easy and safe. We will definitely book again.

Reviewed on Apr 11, 2026

Aspen Suites

Aspen Suites

3 out of 5
Price was $583, price is now $517 per person
$517
per person
Jun 26 - Jun 28
found 8 hours ago
Roundtrip non-stop flight included
Portland (PDX) to Rochester (RST)
9/10 Wonderful! (779 reviews)
The hotel was modern and clean, breakfast was lovely. My only complaint. I arrived 50 minutes before check in. Clerk said, “your room is ready.” To have early entry it costs $20. Typically if the room is ready you can go in for no charge. I resented that and found it to be tacky.

Reviewed on Apr 12, 2026

Don't see what you're looking for?
See all available trips from Columbus to St. Charles
View all trips

St. Charles Hotel Deals

Kahler Grand Hotel

Kahler Grand Hotel

3 out of 5
20 2nd Ave Sw Rochester MN
Fully refundableReserve now, pay when you stay
$127 nightly
The price is $146 total per night from Apr 19 to Apr 20
$146 total
Apr 19 - Apr 20
Total with taxes and fees
8.4/10 Very Good! (1,999 reviews)
Toilet plugged when we checked in. Took a long time to get it fixed. Room was hot. No air conditioning.

Reviewed on Apr 13, 2026

Kahler Grand Hotel
Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

3.5 out of 5
9 3rd Ave Nw Rochester MN
Fully refundableReserve now, pay when you stay
$132 nightly
The price is $152 total per night from Apr 15 to Apr 16
$152 total
Apr 15 - Apr 16
Total with taxes and fees
8/10 Very Good! (1,554 reviews)
Proximity to the Mayo Clinic was so convenient. You could connect the subway level from our hotel.

Reviewed on Apr 13, 2026

Kahler Inn and Suites - Mayo Clinic Area
Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG

3.5 out of 5
220 S Broadway Rochester MN
Fully refundable
$99 nightly
The price is $114 total per night from May 10 to May 11
$114 total
May 10 - May 11
Total with taxes and fees
8.8/10 Excellent! (988 reviews)
Bar

Reviewed on Apr 14, 2026

Hotel Indigo Rochester – Mayo Clinic Area by IHG
See all 507 properties in St. Charles
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best St. Charles Vacation Packages

St. Charles Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Rochester Intl. Airport (RST)
Population
3,700
Max Temp Winter
25ºF
Max Temp Summer
75ºF

More vacations you might like

All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Frequently asked questions

How much does a St. Charles vacation package cost?
You can grab a vacation package to this destination from $482 on Expedia. But how much your vacation to St. Charles costs will depend on factors like the season, length of stay and hotel choice.
What are the cheapest months to go to St. Charles?
January, February and November are great times to search for cheap St. Charles vacation packages. Traveling in less busy months means you can usually find reduced prices on hotels and flights.
How many days is enough for St. Charles?
Generally, a handful of days is enough to check out the main attractions during your St. Charles vacation. However, if you want to have more time to relax or go on day tours, consider extending your itinerary.
How to find the best St. Charles package deals?
Use Expedia's filter tool to find some terrific St. Charles package deals. When you start your search, just set your maximum budget and then sort the results by "Price: low to high." If you're looking to save, plan your trip for midweek, or browse for St. Charles package deals in the low season. Switch up your travel dates and you may score even better discounts. As a rule of thumb, it's typically best to book your vacation package as soon as possible.
Is it cheaper to book a St. Charles vacation as a package?
An Expedia vacation package could land you considerable savings when compared to booking hotels and flights separately. Better still, you can customize your St. Charles escape to match your exact needs. Pick your preferred flight time, select the hotel type and add a rental car. Explore our bundles to see how much you can save.
When to book a vacation package to St. Charles?
If you've got your St. Charles travel dates finalized, book early to grab some outstanding deals. With Expedia, you can generally reserve some flights up to one year ahead of time. Prefer spontaneous adventures? Our last-minute deals are ideal for setting off on a whim.
Does Expedia offer Book Now, Pay Later St. Charles vacation packages?
Your St. Charles getaway should be a relaxing escape from your busy life, not a reason for money-related stress. So to allow you a little more flexibility, we've partnered with online lender Affirm to bring you our Book Now, Pay Later vacations. Pick one of our vacation packages with payment plans and break down the cost over 3, 6 or 12 months. Plus, there aren't any hidden costs or late payment fees to worry about.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.