St. Charles Vacations from $609

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $2,000 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Your St. Charles Vacation

When you book a St. Charles vacation package, it's easy to enjoy your getaway to the fullest. Uncover the highlights of this vibrant city knowing that all the travel planning has been organized in advance. Any trip to St. Charles has to include a little sightseeing. Whitewater State Park is a good place to start your exploring. Whoever you're escaping with and whatever you want to spend, your dream St. Charles vacation is just a few clicks away with Expedia.

The Latest St. Charles vacation packages

Price found within the past 48 hours. Click for updated prices.
Holiday Inn Express Rochester South - Mayo Area by IHG

Holiday Inn Express Rochester South - Mayo Area by IHG

2.5 out of 5
Price was $646, price is now $609 per person
$609
per person
Dec 14 - Dec 17
found 24 hours ago
Roundtrip flight included
Houston (IAH) to Rochester (RST)
8.8/10 Excellent! (1,001 reviews)
This hotel is conveniently located , very well maintained. It also features a very nice breakfast bar with hot items ,lots of fresh fruit , yogurts etc.. With future visits this hotel will probably be our first choice for accommodations..

Reviewed on Nov 14, 2026

The Berkman

The Berkman

3 out of 5
Folwell
Price was $820, price is now $742 per person
$742
per person
Dec 14 - Dec 17
found 24 hours ago
Roundtrip flight included
Houston (IAH) to Rochester (RST)
9.6/10 Exceptional! (449 reviews)

Hyatt House Rochester/Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area

3 out of 5
Downtown Rochester
Price was $770, price is now $708 per person
$708
per person
Dec 14 - Dec 17
found 24 hours ago
Roundtrip flight included
Houston (IAH) to Rochester (RST)
9/10 Wonderful! (1,004 reviews)
Friendly staff. Very helpful with accommodating my husband’s needs.

Reviewed on Nov 14, 2026

Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

3 out of 5
Kutzky Park
Price was $722, price is now $665 per person
$665
per person
Dec 14 - Dec 17
found 24 hours ago
Roundtrip flight included
Houston (IAH) to Rochester (RST)
9.2/10 Wonderful! (539 reviews)
Clean, spacious and very modern. Would definitely stay here again.

Reviewed on Nov 6, 2026

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

3 out of 5
Historic Southwest
Price was $669, price is now $624 per person
$624
per person
Dec 14 - Dec 17
found 24 hours ago
Roundtrip flight included
Houston (IAH) to Rochester (RST)
8.6/10 Excellent! (1,014 reviews)

Don't see what you're looking for?
See all available trips from Columbus to St. Charles
View all trips

St. Charles Hotel Deals

Kahler Grand Hotel

Kahler Grand Hotel

3 out of 5
20 2nd Ave Sw Rochester MN
Fully refundableReserve now, pay when you stay
$155 nightly
The price is $178 total per night from Nov 26 to Nov 27
$178 total
Nov 26 - Nov 27
Total with taxes and fees
8.4/10 Very Good! (2,414 reviews)
"Staff was very good did not use Hot Tub or Pool rooms were clean, but not enough towels had issues for maintenance with the AC other than that and they came and fixed it other than that the stay was fine and I would go back again"

Reviewed on Nov 13, 2026

Kahler Grand Hotel
Med City Inn & Suites - Mayo Clinic Area

Med City Inn & Suites - Mayo Clinic Area

2.5 out of 5
435 16th Ave Nw Rochester MN
Fully refundableReserve now, pay when you stay
$75 nightly
The price is $86 total per night from Dec 15 to Dec 16
$86 total
Dec 15 - Dec 16
Total with taxes and fees
Med City Inn & Suites - Mayo Clinic Area
AmericInn by Wyndham Rochester Near Mayo Clinic

AmericInn by Wyndham Rochester Near Mayo Clinic

3 out of 5
1625 Broadway Ave S Rochester MN
Fully refundableReserve now, pay when you stay
$73 nightly
The price is $84 total per night from Dec 6 to Dec 7
$84 total
Dec 6 - Dec 7
Total with taxes and fees
AmericInn by Wyndham Rochester Near Mayo Clinic
See all 496 properties in St. Charles
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best St. Charles Vacation Packages

St. Charles Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Rochester Intl. Airport (RST)
Population
3,700
Max Temp Winter
25ºF
Max Temp Summer
75ºF

More vacations you might like

All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Kid Friendly Vacations
Kid Friendly Vacations

Frequently asked questions

How much does a St. Charles vacation package cost?
You can grab a vacation package to this destination from $609 on Expedia. But how much your vacation to St. Charles costs will depend on factors like the season, length of stay and hotel choice.
What are the cheapest months to go to St. Charles?
January, February and November are great times to search for cheap St. Charles vacation packages. Traveling in less busy months means you can usually find reduced prices on hotels and flights.
How many days is enough for St. Charles?
Generally, a handful of days is enough to check out the main attractions during your St. Charles vacation. However, if you want to have more time to relax or go on day tours, consider extending your itinerary.
How to find the best St. Charles package deals?
Use Expedia's filter tool to find some terrific St. Charles package deals. When you start your search, just set your maximum budget and then sort the results by "Price: low to high." If you're looking to save, plan your trip for midweek, or browse for St. Charles package deals in the low season. Switch up your travel dates and you may score even better discounts. As a rule of thumb, it's typically best to book your vacation package as soon as possible.
Is it cheaper to book a St. Charles vacation as a package?
An Expedia vacation package could land you considerable savings when compared to booking hotels and flights separately. Better still, you can customize your St. Charles escape to match your exact needs. Pick your preferred flight time, select the hotel type and add a rental car. Explore our bundles to see how much you can save.
When to book a vacation package to St. Charles?
If you've got your St. Charles travel dates finalized, book early to grab some outstanding deals. With Expedia, you can generally reserve some flights up to one year ahead of time. Prefer spontaneous adventures? Our last-minute deals are ideal for setting off on a whim.
Does Expedia offer Book Now, Pay Later St. Charles vacation packages?
Your St. Charles getaway should be a relaxing escape from your busy life, not a reason for money-related stress. So to allow you a little more flexibility, we've partnered with online lender Affirm to bring you our Book Now, Pay Later vacations. Pick one of our vacation packages with payment plans and break down the cost over 3, 6 or 12 months. Plus, there aren't any hidden costs or late payment fees to worry about.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.