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Find All Upstate South Carolina Hotels
We have found 2753 Upstate South Carolina Hotels
- Comfort Suites Simpsonville - Greenville
- Holiday Inn Express & Suites Greenville SE - Simpsonville by IHG
- Fairfield Inn by Marriott Greenville-Spartanburg Airport
- Days Inn by Wyndham Easley/Greenville/Clemson Area
- WoodSpring Suites Spartanburg - Duncan
- Holiday Inn Express & Suites Greenville-Spartanburg (Duncan) by IHG
- Staybridge Suites Greenville I-85 Woodruff Road by IHG
- Hampton Inn Anderson/ Alliance Business Park
- Fairfield Inn & Suites by Marriott Greenville Simpsonville
- Comfort Suites Anderson-Clemson
- Days Inn by Wyndham Clinton / Laurens I-26
- Hilton Garden Inn Spartanburg
- Hilton Garden Inn Anderson
- Hampton Inn Gaffney
- Swamp Rabbit Inn
- Hampton Inn Spartanburg-North I-85
- Best Western Seneca-Clemson
- Quality Inn Clemson near University
- Hampton Inn Simpsonville
- Hampton Inn Greenville I-385 - Woodruff Rd.
- Quality Inn Seneca Clemson Area US-123
- Hampton Inn Greenville/Travelers Rest
- Hometowne Studios Greenville
- Extended Stay America Premier Suites - Greenville - Spartanburg - I-85
- Holiday Inn Anderson by IHG
- Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG
- Hampton Inn & Suites Spartanburg-I-26-Westgate Mall
- Days Inn by Wyndham Simpsonville
- Rodeway Inn Expo Center
- Home2 Suites by Hilton Anderson Downtown
- Residence Inn by Marriott Greenville Downtown
- Comfort Suites Clinton near Presbyterian College
- Days Inn by Wyndham Seneca / Clemson Area
- Quality Inn
- Hampton Inn Easley
- Motel 6 Spartanburg, Sc – Northwest / Business 85
- Home2 Suites by Hilton Greenville Airport
- AC Hotel by Marriott Spartanburg
- Holiday Inn Spartanburg Northwest by IHG
- Residence Inn by Marriott Spartanburg
- Candlewood Suites Greenville by IHG
- Extended Stay America Select Suites Greenville Haywood Mall
- Super 8 by Wyndham Anderson/Clemson Area
- Country Inn & Suites by Radisson, Anderson, SC
- Home2 Suites by Hilton Duncan
- BEAUTIFUL Newly Built Retreat w/Private Marina Boat Slip at Upper Lake Keowee!!!
- Baymont by Wyndham Duncan/Spartanburg
- Hampton Inn & Suites Clinton - I-26
- Courtyard Marriott Clemson
- Red Roof Inn Spartanburg – I-26
- Baymont by Wyndham Anderson Clemson
- USA Economy Lodge
- Fairfield Inn & Suites by Marriott Anderson Clemson
- Motel 6 Simpsonville, SC - Greenville
- HomeTowne Studios by Red Roof Spartanburg - Asheville Highway
- Swamp Rabbit Inn Travelers Rest
- Days Inn by Wyndham Spartanburg
- Motel 6 Greenville, SC - I-85 Near Downtown
- Quality Inn & Suites Easley - Greenville
- Baymont by Wyndham Gaffney
- Residence Inn by Marriott Spartanburg Westgate
- Homewood Suites by Hilton Greenville
- Hampton Inn Greenville/I-385 Haywood Mall
- Red Roof Inn Gaffney
- Quality Inn Duncan - Spartanburg West
- Rodeway Inn
- Red Roof Inn Spartanburg - I-85
- Super 8 by Wyndham Gaffney
- Red Roof Inn & Suites Duncan
- Hampton Inn Anderson
- Quality Inn Clinton - Laurens I-26
- Super 8 by Wyndham Piedmont Greenville Area
- Sleep Inn Gaffney at I-85
- Holiday Inn Express Anderson by IHG
- Quality Inn
- Budget Inn Express
- Residence Inn by Marriott Anderson Clemson
- Studio 6 Greenville, SC - I-85 Near Downtown
- Red Roof Inn Greenville
- Americas Best Value Inn Anderson, SC
- Rodeway Inn
- Hotel Domestique
- Quality Inn Union US Hwy 176
- Quality Inn Gaffney I-85
- Fairfield Inn & Suites by Marriott Greenville Spartanburg/Duncan
- Econo Lodge
- Tanglewood Inn
- Suburban Studios Spartanburg - I-26
- The Bleckley Inn
- Whole Hearts Bed and Breakfast
- Pettigru Place Bed & Breakfast
- Rodeway Inn & Suites
- ✨ Steps from the Swamp Rabbit Trail, Tandem Coffee, Topsoil and more.
- Rodeway Inn
- stayAPT Suites Greenville Greer BMW
- Liberty Hall Bed and Breakfast
- The Night Inn
Let Expedia take you to the best Hotels in Upstate South Carolina. You'll find the largest selection of hotel deals, discount prices, and cheap hotel rates on reservations anywhere in the world. Expedia, the leader in world travel, gives you customer reviews, maps, and the best selection of hotels near landmarks and attractions.