$521 Cheap Flights from Santiago (SCL) to Greenville (GSP)

View $521 flight on Mon, Oct 20, 2025Opens in a new window

Popular airlines from Santiago Intl. Airport (SCL) to Greenville-Spartanburg Intl. Airport (GSP)

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Cheap Flights from Santiago to Greenville (SCL-GSP)

Prices were available within the past 7 days and start at $521 for one-way flights and $714 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Thu, Oct 23 - Wed, Oct 29
SCL
Santiago
GSP
Greenville
$714 Roundtrip, found 13 hours ago
$714
Roundtrip
found 13 hours ago
Select Delta flight, departing Thu, Oct 23 from Santiago to Greenville, returning Wed, Oct 29, priced at $714 found 13 hours ago
United
Mon, Oct 27 - Tue, Nov 4
SCL
Santiago
GSP
Greenville
$714 Roundtrip, found 13 hours ago
$714
Roundtrip
found 13 hours ago
Select United flight, departing Mon, Oct 27 from Santiago to Greenville, returning Tue, Nov 4, priced at $714 found 13 hours ago
United
Mon, Oct 27 - Mon, Nov 3
SCL
Santiago
GSP
Greenville
$719 Roundtrip, found 13 hours ago
$719
Roundtrip
found 13 hours ago
Select United flight, departing Mon, Oct 27 from Santiago to Greenville, returning Mon, Nov 3, priced at $719 found 13 hours ago
American Airlines
Mon, Oct 20 - Mon, Nov 3
SCL
Santiago
GSP
Greenville
$722 Roundtrip, found 6 days ago
$722
Roundtrip
found 6 days ago
Select American Airlines flight, departing Mon, Oct 20 from Santiago to Greenville, returning Mon, Nov 3, priced at $722 found 6 days ago
Delta
Wed, Oct 22 - Wed, Nov 5
SCL
Santiago
GSP
Greenville
$726 Roundtrip, found 1 day ago
$726
Roundtrip
found 1 day ago
Select Delta flight, departing Wed, Oct 22 from Santiago to Greenville, returning Wed, Nov 5, priced at $726 found 1 day ago
LATAM Airlines Group
Wed, Dec 24 - Thu, Jan 15
SCL
Santiago
GSP
Greenville
$734 Roundtrip, found 3 days ago
$734
Roundtrip
found 3 days ago
Select LATAM Airlines Group flight, departing Wed, Dec 24 from Santiago to Greenville, returning Thu, Jan 15, priced at $734 found 3 days ago
LATAM Airlines Group
Wed, Oct 22 - Mon, Nov 3
SCL
Santiago
GSP
Greenville
$739 Roundtrip, found 1 day ago
$739
Roundtrip
found 1 day ago
Select LATAM Airlines Group flight, departing Wed, Oct 22 from Santiago to Greenville, returning Mon, Nov 3, priced at $739 found 1 day ago
LATAM Airlines Group
Wed, Dec 24 - Thu, Jan 15
SCL
Santiago
GSP
Greenville
$744 Roundtrip, found 3 days ago
$744
Roundtrip
found 3 days ago
Select LATAM Airlines Group flight, departing Wed, Dec 24 from Santiago to Greenville, returning Thu, Jan 15, priced at $744 found 3 days ago
LATAM Airlines Group
Wed, Dec 24 - Thu, Jan 15
SCL
Santiago
GSP
Greenville
$745 Roundtrip, found 3 days ago
$745
Roundtrip
found 3 days ago
Select LATAM Airlines Group flight, departing Wed, Dec 24 from Santiago to Greenville, returning Thu, Jan 15, priced at $745 found 3 days ago
Air Canada
Tue, Mar 10 - Sun, Mar 15
SCL
Santiago
GSP
Greenville
$1,962 Roundtrip, found 4 hours ago
$1,962
Roundtrip
found 4 hours ago
Select Air Canada flight, departing Tue, Mar 10 from Santiago to Greenville, returning Sun, Mar 15, priced at $1,962 found 4 hours ago
Flights from Santiago (SCL) to Greenville (GSP)
Origin airport
Arturo Merino Benitez
Destination airport
Greenville-Spartanburg Intl.
Airlines serving
American Airlines, Copa, Delta, LATAM Airlines Group, United
Roundtrip price
$714
Distance
4775 mi

Santiago to Greenville Flights

The cheapest times to fly from Santiago to Greenville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Santiago to Greenville are during the month of October. You can find some of the cheapest flights from Santiago to Greenville with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Santiago to Greenville

Sunday is one of the best days to book for cheap flights from Santiago to Greenville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Santiago to Greenville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Santiago to Greenville in 2025. You can also book with separate airlines for your outbound and return journeys, from $521 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Santiago to Greenville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Santiago to Greenville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Arturo Merino Benitez Airport (SCL) to Greenville-Spartanburg Intl. Airport (GSP) cost?
Snag a cheap one-way flight from $521 or cheap return flight from $714 from Arturo Merino Benitez Airport (SCL) to Greenville-Spartanburg Intl. Airport (GSP) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Arturo Merino Benitez Airport (SCL) to Greenville-Spartanburg Intl. Airport (GSP)?
The cheapest month to fly from SCL to GSP is October, when demand is low. Off-peak months are often when better flight deals are available between these airports.
What is the cheapest airline that flies from Arturo Merino Benitez Airport (SCL) to Greenville-Spartanburg Intl. Airport (GSP)?
Use the filters on Expedia to compare airlines and find the most affordable carrier that'll fly you from SCL to GSP. Then, sort your results by "Price (lowest to highest)" to pick up the best deal available.
How many flights per day from Arturo Merino Benitez Airport (SCL) to Greenville-Spartanburg Intl. Airport (GSP)?
You'll have to hop on a flight with a layover if you're traveling from Arturo Merino Benitez Airport (SCL) to Greenville-Spartanburg Intl. Airport (GSP). Direct flights don't operate daily on this route. However, simply filter your search to include one or two stops to find an option that works for you.
What day of the week has the most flights from SCL to GSP?
You'll generally find Tuesday the quietest day for flights, while Fridays are often the busiest.* However this can change from season to season and during peak travel times or public holidays.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Arturo Merino Benitez Airport (SCL) to Greenville-Spartanburg Intl. Airport (GSP)?
To land at Greenville-Spartanburg Intl. Airport (GSP) on time, opt for a flight that takes off from Arturo Merino Benitez Airport (SCL) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Arturo Merino Benitez Airport (SCL) to Greenville-Spartanburg Intl. Airport (GSP) last-minute?
Last-minute bookings from SCL to GSP are usually more expensive. To lock in the best rates, start looking for flights well ahead of time. That said, if your travel plans are flexible, it's possible to find a cheap fare right before your journey.
Is it cheaper to book a SCL to GSP flight and hotel package?
You'll generally save money by booking a SCL to GSP flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's easy to manage everything in one place. Once you've selected your preferred accommodations and flights, you can add extras such as car rentals, activities and tours.
Can I cancel or change the date of my flight from Arturo Merino Benitez Airport (SCL) to Greenville-Spartanburg Intl. Airport (GSP)?
In most instances, you can reschedule or cancel your SCL to GSP flight. However, additional fees may apply, especially if your booking was made over 24 hours ago. Check your itinerary for the airline's rules and fees on flight changes, or if you'd like further information, go to our Customer Service portal.

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*Available to One Key members.