$269 Cheap Flights from Cusco (CUZ) to Panama City (PTY)

View $269 flight on Tue, Nov 18, 2025Opens in a new window

Popular airlines from Alejandro Velasco Astete Intl. Airport (CUZ) to Tocumen Intl. Airport (PTY)

Cheap Flights from Cusco to Panama City (CUZ-PTY)

Prices were available within the past 7 days and start at $269 for one-way flights and $606 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

avianca
Wed, Oct 15 - Sun, Oct 19
CUZ
Cusco
PTY
Panama City
$606 Roundtrip, found 5 hours ago
$606
Roundtrip
found 5 hours ago
Select avianca flight, departing Wed, Oct 15 from Cusco to Panama City, returning Sun, Oct 19, priced at $606 found 5 hours ago
avianca
Tue, Oct 14 - Sat, Oct 18
CUZ
Cusco
PTY
Panama City
$875 Roundtrip, found 1 day ago
$875
Roundtrip
found 1 day ago
Select avianca flight, departing Tue, Oct 14 from Cusco to Panama City, returning Sat, Oct 18, priced at $875 found 1 day ago

Alternative airports near Panama City

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Tocumen Intl. PTY. Cheapest option available. Average driving time to city center is 16 minutes. Flights from $875
PTY
Tocumen Intl.
Cheapest
Average driving time to city center16 min
Flights from $875

Frequently asked questions

How much does a flight from Alejandro Velasco Astete Intl. Airport (CUZ) to Tocumen Intl. Airport (PTY) cost?
Snag a cheap one-way flight from $269 or cheap return flight from $606 from Alejandro Velasco Astete Intl. Airport (CUZ) to Tocumen Intl. Airport (PTY) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Alejandro Velasco Astete Intl. Airport (CUZ) to Tocumen Intl. Airport (PTY)?
October is the most affordable month to fly from CUZ to PTY. Traveling during quieter months is often the key to scoring lower fares.
What is the cheapest airline that flies from Alejandro Velasco Astete Intl. Airport (CUZ) to Tocumen Intl. Airport (PTY)?
Use the filters on Expedia to compare airlines and find the most affordable carrier that'll fly you from CUZ to PTY. Then, sort your results by "Price (lowest to highest)" to snag a great deal.
How many flights per day from Alejandro Velasco Astete Intl. Airport (CUZ) to Tocumen Intl. Airport (PTY)?
You'll need to take a flight with a layover if you're traveling from Alejandro Velasco Astete Intl. Airport (CUZ) to Tocumen Intl. Airport (PTY). Direct flights don't operate daily on this route. However, just filter your search to include one or more stops to find an option that works for you.
What day of the week has the most flights from CUZ to PTY?
Usually you'll find the greatest selection of flight options on a Friday. Tuesdays are often the quietest.* But this can vary depending on the season, airline and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Alejandro Velasco Astete Intl. Airport (CUZ) to Tocumen Intl. Airport (PTY)?
To avoid possible delays on the Alejandro Velasco Astete Intl. Airport (CUZ) to Tocumen Intl. Airport (PTY) route, aim to fly before 3 PM. Later departures are 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Alejandro Velasco Astete Intl. Airport (CUZ) to Tocumen Intl. Airport (PTY) last-minute?
Booking your plane ticket from CUZ to PTY just before your trip is typically more expensive. But if you're flexible with your travel dates and times, you could snag a cheap last-minute fare.
Is it cheaper to book a CUZ to PTY flight and hotel package?
You'll generally save money by booking a CUZ to PTY flight and hotel package compared to booking separately. In fact, travelers could save hundreds of dollars by bundling with Expedia. And it's easy to manage it all in one place. Once you've selected your ideal accommodations and flights, you can add extras like activities, tours and car rentals.
Can I cancel or change the date of my flight from Alejandro Velasco Astete Intl. Airport (CUZ) to Tocumen Intl. Airport (PTY)?
In most instances, you can cancel or reschedule your CUZ to PTY flight. However, there may be additional fees, especially if your booking was made more than 24 hours ago. Check your itinerary for the airline's rules and fees on flight changes, or if you'd like further information, go to our Customer Service portal.

Travel information

Travel information

Origin airport
Alejandro Velasco Astete Intl.
Destination airport
Tocumen Intl.
Airlines serving
avianca
Roundtrip price
$606
Distance
1643 mi

Book with confidence

Book with confidence

Cusco to Panama City Flights

The cheapest times to fly from Cusco to Panama City

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Cusco to Panama City are during the month of October. You can find some of the cheapest flights from Cusco to Panama City with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Cusco to Panama City

Sunday is one of the best days to book for cheap flights from Cusco to Panama City: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Cusco to Panama City

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Cusco to Panama City in 2025. You can also book with separate airlines for your outbound and return journeys, from $269 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Cusco to Panama City flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Cusco to Panama City airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Cusco to Panama City Flights

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Explore a world of travel with Expedia

*Available to One Key members.