$285 Cheap Flights from Cusco (CUZ) to Panama City (PTY)

View $285 flight on Sun, Nov 8, 2026Opens in a new window

Popular airlines from Alejandro Velasco Astete Intl. Airport (CUZ) to Tocumen Intl. Airport (PTY)

  • Be in the know

    Get alerts if flight prices drop or rise*

  • Book smarter

    Save up to 30% on select hotels after you book a flight*

  • Earn twice

    Earn your airline miles on top of our OneKeyCash
    Learn about One Key

Cheap Flights from Cusco to Panama City (CUZ-PTY)

Prices were available within the past 7 days and start at $285 for one-way flights and $776 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

avianca
Tue, May 5 - Sat, May 9
CUZ
Cusco
PTY
Panama City
$776 Roundtrip, found 5 days ago
$776
Roundtrip
found 5 days ago
Select avianca flight, departing Tue, May 5 from Cusco to Panama City, returning Sat, May 9, priced at $776 found 5 days ago
avianca
Tue, May 5 - Sat, May 9
CUZ
Cusco
PTY
Panama City
$789 Roundtrip, found 5 days ago
$789
Roundtrip
found 5 days ago
Select avianca flight, departing Tue, May 5 from Cusco to Panama City, returning Sat, May 9, priced at $789 found 5 days ago
avianca
Tue, May 26 - Tue, Jun 2
CUZ
Cusco
PTY
Panama City
$806 Roundtrip, just found
$806
Roundtrip
just found
Select avianca flight, departing Tue, May 26 from Cusco to Panama City, returning Tue, Jun 2, priced at $806 just found
avianca
Tue, May 26 - Tue, Jun 2
CUZ
Cusco
PTY
Panama City
$815 Roundtrip, just found
$815
Roundtrip
just found
Select avianca flight, departing Tue, May 26 from Cusco to Panama City, returning Tue, Jun 2, priced at $815 just found
avianca
Tue, May 26 - Tue, Jun 2
CUZ
Cusco
PTY
Panama City
$863 Roundtrip, just found
$863
Roundtrip
just found
Select avianca flight, departing Tue, May 26 from Cusco to Panama City, returning Tue, Jun 2, priced at $863 just found
avianca
Tue, May 5 - Sat, May 9
CUZ
Cusco
PTY
Panama City
$873 Roundtrip, found 5 days ago
$873
Roundtrip
found 5 days ago
Select avianca flight, departing Tue, May 5 from Cusco to Panama City, returning Sat, May 9, priced at $873 found 5 days ago
avianca
Tue, May 26 - Tue, Jun 2
CUZ
Cusco
PTY
Panama City
$891 Roundtrip, just found
$891
Roundtrip
just found
Select avianca flight, departing Tue, May 26 from Cusco to Panama City, returning Tue, Jun 2, priced at $891 just found
avianca
Tue, May 26 - Tue, Jun 2
CUZ
Cusco
PTY
Panama City
$900 Roundtrip, just found
$900
Roundtrip
just found
Select avianca flight, departing Tue, May 26 from Cusco to Panama City, returning Tue, Jun 2, priced at $900 just found
avianca
Wed, Apr 15 - Wed, Apr 22
CUZ
Cusco
PTY
Panama City
$941 Roundtrip, found 14 hours ago
$941
Roundtrip
found 14 hours ago
Select avianca flight, departing Wed, Apr 15 from Cusco to Panama City, returning Wed, Apr 22, priced at $941 found 14 hours ago
avianca
Tue, May 26 - Tue, Jun 2
CUZ
Cusco
PTY
Panama City
$945 Roundtrip, just found
$945
Roundtrip
just found
Select avianca flight, departing Tue, May 26 from Cusco to Panama City, returning Tue, Jun 2, priced at $945 just found

Alternative airports near Panama City

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Tocumen Intl. PTY. Cheapest option available. Average driving time to city center is 16 minutes. Flights from $806
PTY
Tocumen Intl.
Cheapest
Average driving time to city center16 min
Flights from $806

Frequently asked questions

How much does a flight from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Panama City (PTY-Tocumen Intl.) cost?
You can find cheap one-way flights from $285 and cheap return flights from $776 Cusco (CUZ-Alejandro Velasco Astete Intl.) to Panama City (PTY-Tocumen Intl.) with Expedia. One-way flights typically cost between $276 and $890. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Cusco (CUZ-Alejandro Velasco Astete Intl.) to Panama City (PTY-Tocumen Intl.) ticket fares go up or down.*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
What is the cheapest month to fly from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Panama City (PTY-Tocumen Intl.)?
The cheapest month to fly from CUZ to PTY is May when demand is low. Traveling in off-peak or shoulder months is usually a good way to secure cheap tickets, just remember to avoid flying during holidays if you're able to. Use the calendar view in your search to see which months have low fares on this route.
Which airlines fly direct from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Panama City (PTY-Tocumen Intl.)?
Enter CUZ to PTY and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
What is the cheapest airline that flies from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Panama City (PTY-Tocumen Intl.)?
Avianca, LATAM Airlines Group and LAN Airlines are just some of the carriers that fly from Cusco (CUZ) to Panama City (PTY). Use Expedia's flight search tool to compare airlines on this route and find our cheapest option for your trip. Use Expedia's search tool to compare the prices and schedules of airlines that fly this route to find the best option for your plans and budget.*Prices based on flights available on Expedia in the last year.
How do I find cheap flights from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Panama City (PTY-Tocumen Intl.)?
To find a cheap flight from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Panama City (PTY-Tocumen Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Panama City (PTY-Tocumen Intl.)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
What is the earliest flight from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Panama City (PTY-Tocumen Intl.)?
The earliest flight from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Panama City (PTY-Tocumen Intl.) typically departs at around 12:15 PM, operated by Avianca. This seasonal service allows you to enjoy a relaxed morning before your journey. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What are the most popular departure times for flights from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Panama City (PTY-Tocumen Intl.)?
The most popular departure times for flights from Cusco (CUZ) to Panama City (PTY) are in the afternoon, from 3pm to 6pm. About 54% of passengers prefer this time window. Avianca is a major carrier that offers flights during this time. Many travelers choose this timing as it allows for a leisurely morning in Cusco before heading to the airport.
How long does it take to fly from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Panama City (PTY-Tocumen Intl.)?
Flying from CUZ to PTY with a connection usually takes about 23 hours 50 minutes, traveling roughly 1,643 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Panama City (PTY-Tocumen Intl.)?
Business class seats are offered on the CUZ to PTY route with Avianca.
How do I earn miles on a Cusco (CUZ-Alejandro Velasco Astete Intl.) to Panama City (PTY-Tocumen Intl.) flight with Expedia?
It's easy to earn miles on a Cusco (CUZ-Alejandro Velasco Astete Intl.) to Panama City (PTY-Tocumen Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Panama City from Alejandro Velasco Astete Intl. (CUZ)?
From Alejandro Velasco Astete Intl. (CUZ), you can fly into Tocumen Intl. (PTY) to reach Panama City. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Panama City (PTY-Tocumen Intl.) at the last minute?
Typically, booking a last minute flight from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Panama City (PTY-Tocumen Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Cusco (CUZ-Alejandro Velasco Astete Intl.) to Panama City (PTY-Tocumen Intl.) flight and hotel package?
Securing a Cusco (CUZ-Alejandro Velasco Astete Intl.) to Panama City (PTY-Tocumen Intl.) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Cusco (CUZ-Alejandro Velasco Astete Intl.) to Panama City (PTY-Tocumen Intl.)?
If you booked your Cusco (CUZ-Alejandro Velasco Astete Intl.) to Panama City (PTY-Tocumen Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Alejandro Velasco Astete Intl.
Destination airport
Tocumen Intl.
Airlines serving
avianca
Roundtrip price
$776
Distance
1643 mi

Book with confidence

Cusco to Panama City Flights

The cheapest times to fly from Cusco to Panama City

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Cusco to Panama City are during the month of May. You can find some of the cheapest flights from Cusco to Panama City with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Cusco to Panama City

Sunday is one of the best days to book for cheap flights from Cusco to Panama City: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Cusco to Panama City

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Cusco to Panama City in 2026. You can also book with separate airlines for your outbound and return journeys, from $285 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Cusco to Panama City flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Cusco to Panama City airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Cusco to Panama City Flights

*Flight schedules are subject to change.

*Available to One Key members.

 

Explore a world of travel with Expedia