$232 Cheap Flights from San Francisco (SFO) to Panama City (PTY)

View $232 flight on Thu, Sep 11, 2025Opens in a new window

Popular airlines from San Francisco Intl. Airport (SFO) to Tocumen Intl. Airport (PTY)

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Cheap Flights from San Francisco to Panama City (SFO-PTY)

Prices were available within the past 7 days and start at $232 for one-way flights and $504 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Copa
Thu, Oct 9 - Thu, Oct 16
SFO
San Francisco
PTY
Panama City
$504 Roundtrip, found 8 hours ago
$504
Roundtrip
found 8 hours ago
Select Copa flight, departing Thu, Oct 9 from San Francisco to Panama City, returning Thu, Oct 16, priced at $504 found 8 hours ago
United
Thu, Oct 9 - Thu, Oct 16
SFO
San Francisco
PTY
Panama City
$504 Roundtrip, found 8 hours ago
$504
Roundtrip
found 8 hours ago
Select United flight, departing Thu, Oct 9 from San Francisco to Panama City, returning Thu, Oct 16, priced at $504 found 8 hours ago
United
Thu, Oct 2 - Mon, Oct 13
SFO
San Francisco
PTY
Panama City
$508 Roundtrip, found 3 hours ago
$508
Roundtrip
found 3 hours ago
Select United flight, departing Thu, Oct 2 from San Francisco to Panama City, returning Mon, Oct 13, priced at $508 found 3 hours ago
United
Thu, Oct 2 - Mon, Oct 13
SFO
San Francisco
PTY
Panama City
$514 Roundtrip, found 3 hours ago
$514
Roundtrip
found 3 hours ago
Select United flight, departing Thu, Oct 2 from San Francisco to Panama City, returning Mon, Oct 13, priced at $514 found 3 hours ago
Delta
Thu, Oct 23 - Thu, Oct 30
SFO
San Francisco
PTY
Panama City
$518 Roundtrip, found 7 hours ago
$518
Roundtrip
found 7 hours ago
Select Delta flight, departing Thu, Oct 23 from San Francisco to Panama City, returning Thu, Oct 30, priced at $518 found 7 hours ago
American Airlines
Wed, Sep 24 - Wed, Oct 1
SFO
San Francisco
PTY
Panama City
$518 Roundtrip, found 1 day ago
$518
Roundtrip
found 1 day ago
Select American Airlines flight, departing Wed, Sep 24 from San Francisco to Panama City, returning Wed, Oct 1, priced at $518 found 1 day ago
American Airlines
Thu, Oct 2 - Mon, Oct 13
SFO
San Francisco
PTY
Panama City
$523 Roundtrip, found 3 hours ago
$523
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Thu, Oct 2 from San Francisco to Panama City, returning Mon, Oct 13, priced at $523 found 3 hours ago
United
Tue, Sep 16 - Wed, Sep 24
SFO
San Francisco
PTY
Panama City
$523 Roundtrip, found 4 hours ago
$523
Roundtrip
found 4 hours ago
Select United flight, departing Tue, Sep 16 from San Francisco to Panama City, returning Wed, Sep 24, priced at $523 found 4 hours ago
avianca
Wed, Aug 27 - Wed, Sep 3
SFO
San Francisco
PTY
Panama City
$524 Roundtrip, just found
$524
Roundtrip
just found
Select avianca flight, departing Wed, Aug 27 from San Francisco to Panama City, returning Wed, Sep 3, priced at $524 just found
United
Thu, Oct 2 - Mon, Oct 13
SFO
San Francisco
PTY
Panama City
$526 Roundtrip, found 3 hours ago
$526
Roundtrip
found 3 hours ago
Select United flight, departing Thu, Oct 2 from San Francisco to Panama City, returning Mon, Oct 13, priced at $526 found 3 hours ago

Find the cheapest month to fly from San Francisco (SFO) to Panama City (PTY)

September is typically the cheapest month to fly

From $435 - $728 per traveler.

Graph displaying average flight prices per month

Alternative airports near Panama City

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Tocumen Intl. PTY. Cheapest option available. Average driving time to city center is 16 minutes. Flights from $524
PTY
Tocumen Intl.
Cheapest
Average driving time to city center16 min
Flights from $524
Flights from San Francisco (SFO) to Panama City (PTY)
Origin airport
San Francisco Intl.
Destination airport
Tocumen Intl.
Airlines serving
American Airlines, Copa, Delta, United, avianca
Roundtrip price
$503
Distance
3320 mi
Average flight time
9 hours 15 mins

San Francisco to Panama City Flights

The cheapest times to fly from San Francisco to Panama City

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from San Francisco to Panama City are during the month of October. You can find some of the cheapest flights from San Francisco to Panama City with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from San Francisco to Panama City

Sunday is one of the best days to book for cheap flights from San Francisco to Panama City: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from San Francisco to Panama City

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from San Francisco to Panama City in 2025. You can also book with separate airlines for your outbound and return journeys, from $232 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap San Francisco to Panama City flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your San Francisco to Panama City airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from San Francisco Intl. Airport (SFO) to Tocumen Intl. Airport (PTY) cost?
Cheap round-trip fares from San Francisco Intl. Airport (SFO) to Tocumen Intl. Airport (PTY) start from $504. This information is based on the cheapest price found on Expedia for this return journey departing within the next three months. This airfare is for a Copa flight leaving SFO on August 17 2025 and touching down at PTY. The price was last updated on July 23 2025 and has not changed since.
What is the cheapest month to fly from SFO to PTY?
The cheapest flights from SFO to PTY are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
Which airlines fly direct from San Francisco Intl. Airport (SFO) to Tocumen Intl. Airport (PTY)?
Fly nonstop from San Francisco Intl. Airport (SFO) to Tocumen Intl. Airport (PTY) on a Copa Airlines flight.
What is the cheapest airline that flies from SFO to PTY?
With prices as low as $400 for a one-way flight from SFO to PTY, United is currently the cheapest airline for this route. This fare is based on the lowest price found on Expedia departing within the next three months. The flight takes off from SFO on October 3 2025. Prices were last updated on July 23 2025 and have not changed since.
How many flights per day from San Francisco Intl. Airport (SFO) to Tocumen Intl. Airport (PTY)?
On average, just 1 direct flight departs daily from San Francisco Intl. Airport (SFO) to Tocumen Intl. Airport (PTY). Need more options? Use Expedia's filters to find flights with layovers and add an extra destination to your journey.
What are the most popular departure times for flights from San Francisco Intl. Airport (SFO) to Tocumen Intl. Airport (PTY)?
More people fly between SFO and PTY at 12 AM than at any other time. Looking for a quieter experience? Travel outside of rush hours and it's possible you'll save on your ticket as well.
What day of the week has the most flights from SFO to PTY?
Depart on a Friday if you're looking for the best selection of flights from San Francisco Intl. Airport (SFO) to Tocumen Intl. Airport (PTY).
What is the earliest flight from San Francisco Intl. Airport (SFO) to Tocumen Intl. Airport (PTY)?
Take the earliest flight at around 12:44AM UTC-8, leaving from San Francisco Intl. Airport (SFO). You'll be traveling for roughly 7h 2m, landing at Tocumen Intl. Airport (PTY) at approximately 10:46AM UTC-5.
How long does it take to fly from San Francisco Intl. Airport (SFO) to Tocumen Intl. Airport (PTY)?
Flights from SFO to PTY have an average travel time of 7 hours and 1 minute. The total distance between the two airports is 3,300 mi.
What airline has the least delays from SFO to PTY?
With 85% of journeys usually arriving on schedule, Copa Airlines has the best on-time performance for nonstop flights from San Francisco Intl. Airport (SFO) to Tocumen Intl. Airport (PTY). To keep track of your flight status and get notified if anything changes, head to the Expedia App.
What is the best time to fly from San Francisco Intl. Airport (SFO) to Tocumen Intl. Airport (PTY)?
To reach Tocumen Intl. Airport (PTY) on schedule, pick a flight that takes off from San Francisco Intl. Airport (SFO) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this time.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
What airports do you fly into for Panama City from San Francisco Intl. Airport (SFO)?
Tocumen Intl. Airport (PTY) is the only airport in Panama City with direct flights from San Francisco Intl. Airport (SFO). Explore the options and discover cheap fares on Expedia.
Is it cheaper to buy a plane ticket from San Francisco Intl. Airport (SFO) to Tocumen Intl. Airport (PTY) last-minute?
Booking your flight from SFO to PTY shortly before your trip is usually more expensive. However, if you're flexible with your departure times and dates, you could snag a cheap last-minute fare.
Is it cheaper to book a SFO to PTY flight and hotel package?
Compared with arranging flights and hotels separately, booking a SFO to PTY flight and hotel package with Expedia could result in significant savings. Better yet, having everything in one convenient place will take the hassle out of planning your trip. Just pick your flights and select from our wide range of stays, then customize your trip with extras like tours and car rentals.
Can I cancel or change the date of my flight from San Francisco Intl. Airport (SFO) to Tocumen Intl. Airport (PTY)?
In most instances, you can reschedule or cancel your SFO to PTY flight. However, there may be additional fees, especially if you booked more than 24 hours ago. Double-check your itinerary for the airline's fees and policies on flight changes, or if you need further information, go to our Customer Service portal.

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