$222 Cheap Flights from Des Moines (DSM) to Kirksville (IRK)

View $222 flight on Tue, Dec 30, 2025Opens in a new window

Popular airlines from Des Moines International Airport (DSM) to Kirksville, MO (IRK-Kirksville Municipal)

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Cheap Flights from Des Moines to Kirksville (DSM-IRK)

Prices were available within the past 7 days and start at $222 for one-way flights and for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Frequently asked questions

How much does a flight from Des Moines Intl. Airport (DSM) to Kirksville Municipal Airport (IRK) cost?
Grab a cheap one-way flight from $222 or cheap return flight from Des Moines Intl. Airport (DSM) to Kirksville Municipal Airport (IRK) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from Des Moines Intl. Airport (DSM) to Kirksville Municipal Airport (IRK)?
Flying in is a great way to save, as it's the cheapest month for flights between DSM and IRK. You'll typically find the lowest prices during off-peak months.
What is the cheapest airline that flies from Des Moines Intl. Airport (DSM) to Kirksville Municipal Airport (IRK)?
To find the cheapest airline that'll fly you from DSM to IRK, use Expedia's filter tool. Tailor your search based on your travel needs, such as preferred carriers and seat class. You can then sort your results by "Price (lowest to highest)" to discover the cheapest flight right away.
How many flights per day from Des Moines Intl. Airport (DSM) to Kirksville Municipal Airport (IRK)?
There aren't any daily direct flights departing from Des Moines Intl. Airport (DSM) to Kirksville Municipal Airport (IRK). But you can choose flights with layovers. Filter your search on Expedia to include one or more stops, and you'll be cruising above the clouds in no time.
What day of the week has the most flights from DSM to IRK?
Friday is typically the busiest day for flights, while Tuesday is often the quietest.* Just remember that flight schedules can change depending on various factors, such as the carrier and season.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Des Moines Intl. Airport (DSM) to Kirksville Municipal Airport (IRK)?
To avoid possible delays on the Des Moines Intl. Airport (DSM) to Kirksville Municipal Airport (IRK) route, aim to fly before 3 PM. Departures after this time have a 22% higher chance of cancellation.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Des Moines Intl. Airport (DSM) to Kirksville Municipal Airport (IRK) last-minute?
Last-minute fares from DSM to IRK are usually more expensive. For the best rates, start searching for flights as early as possible. That being said, if your travel plans are flexible, you may find a cheap fare right before you leave.
Is it cheaper to book a DSM to IRK flight and hotel package?
Compared with arranging flights and hotels separately, booking a DSM to IRK flight and hotel package with Expedia could result in significant savings. What's more, having everything in one place takes the hassle out of travel planning. Just pick your flights and choose from our extensive range of stays, then tailor your trip with extras like tours, car rentals and activities.
Can I cancel or change the date of my flight from Des Moines Intl. Airport (DSM) to Kirksville Municipal Airport (IRK)?
If you booked your DSM to IRK flight within the last 24 hours, you may be able to modify or cancel it at no cost. Depending on the airline and the fare type you purchased, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal for more details.

Travel information

Travel information

Origin airport
Des Moines Intl.
Destination airport
Kirksville Municipal
Distance
115 mi

Book with confidence

Book with confidence

Des Moines to Kirksville Flights

The cheapest times to fly from Des Moines to Kirksville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Des Moines to Kirksville are during the month of . You can find some of the cheapest flights from Des Moines to Kirksville with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Des Moines to Kirksville

Sunday is one of the best days to book for cheap flights from Des Moines to Kirksville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Des Moines to Kirksville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Des Moines to Kirksville in 2025. You can also book with separate airlines for your outbound and return journeys, from $222 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Des Moines to Kirksville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Des Moines to Kirksville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Des Moines to Kirksville Flights

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