$216 Cheap Flights from Des Moines (DSM) to Missoula (MSO)

View $216 flight on Tue, Jun 23, 2026Opens in a new window

Popular airlines from Des Moines International Airport (DSM) to Missoula Intl. Airport (MSO)

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Cheap Flights from Des Moines to Missoula (DSM-MSO)

Prices were available within the past 7 days and start at $216 for one-way flights and $259 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Sat, Dec 6 - Wed, Dec 10
DSM
Des Moines
MSO
Missoula
$259 Roundtrip, just found
$259
Roundtrip
just found
Select Delta flight, departing Sat, Dec 6 from Des Moines to Missoula, returning Wed, Dec 10, priced at $259 just found
United
Sat, Dec 6 - Wed, Dec 10
DSM
Des Moines
MSO
Missoula
$259 Roundtrip, just found
$259
Roundtrip
just found
Select United flight, departing Sat, Dec 6 from Des Moines to Missoula, returning Wed, Dec 10, priced at $259 just found
United
Sat, Dec 6 - Wed, Dec 10
DSM
Des Moines
MSO
Missoula
$264 Roundtrip, just found
$264
Roundtrip
just found
Select United flight, departing Sat, Dec 6 from Des Moines to Missoula, returning Wed, Dec 10, priced at $264 just found
Delta
Mon, Nov 10 - Sun, Nov 16
DSM
Des Moines
MSO
Missoula
$274 Roundtrip, found 18 hours ago
$274
Roundtrip
found 18 hours ago
Select Delta flight, departing Mon, Nov 10 from Des Moines to Missoula, returning Sun, Nov 16, priced at $274 found 18 hours ago
United
Sat, Dec 6 - Wed, Dec 10
DSM
Des Moines
MSO
Missoula
$288 Roundtrip, just found
$288
Roundtrip
just found
Select United flight, departing Sat, Dec 6 from Des Moines to Missoula, returning Wed, Dec 10, priced at $288 just found
United
Sat, Dec 6 - Wed, Dec 10
DSM
Des Moines
MSO
Missoula
$304 Roundtrip, just found
$304
Roundtrip
just found
Select United flight, departing Sat, Dec 6 from Des Moines to Missoula, returning Wed, Dec 10, priced at $304 just found
Delta
Wed, Jan 7 - Wed, Jan 14
DSM
Des Moines
MSO
Missoula
$309 Roundtrip, found 7 hours ago
$309
Roundtrip
found 7 hours ago
Select Delta flight, departing Wed, Jan 7 from Des Moines to Missoula, returning Wed, Jan 14, priced at $309 found 7 hours ago
United
Thu, Dec 4 - Mon, Dec 8
DSM
Des Moines
MSO
Missoula
$317 Roundtrip, found 3 days ago
$317
Roundtrip
found 3 days ago
Select United flight, departing Thu, Dec 4 from Des Moines to Missoula, returning Mon, Dec 8, priced at $317 found 3 days ago
Delta
Mon, Oct 27 - Sat, Nov 8
DSM
Des Moines
MSO
Missoula
$319 Roundtrip, found 5 days ago
$319
Roundtrip
found 5 days ago
Select Delta flight, departing Mon, Oct 27 from Des Moines to Missoula, returning Sat, Nov 8, priced at $319 found 5 days ago
United
Tue, Nov 11 - Sat, Nov 15
DSM
Des Moines
MSO
Missoula
$322 Roundtrip, found 4 days ago
$322
Roundtrip
found 4 days ago
Select United flight, departing Tue, Nov 11 from Des Moines to Missoula, returning Sat, Nov 15, priced at $322 found 4 days ago

Find the cheapest month to fly from Des Moines (DSM) to Missoula (MSO)

April is typically the cheapest month to fly

From $258 - $539 per traveler.

Alternative airports near Missoula

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Missoula Intl. MSO. Cheapest and Closest option available. Average driving time to city center is 8 minutes. Flights from $274
MSO
Missoula Intl.
CheapestClosest
Average driving time to city center8 min
Flights from $274

Frequently asked questions

How much does a flight from Des Moines Intl. Airport (DSM) to Missoula Intl. Airport (MSO) cost?
Snag a cheap one-way flight from $216 or cheap return flight from $259 from Des Moines Intl. Airport (DSM) to Missoula Intl. Airport (MSO) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from Des Moines Intl. Airport (DSM) to Missoula Intl. Airport (MSO)?
Traveling in December may help you find better deals, as it's the cheapest month for flights between DSM and MSO. You'll often find the lowest prices during the off-season.
What is the cheapest airline that flies from Des Moines Intl. Airport (DSM) to Missoula Intl. Airport (MSO)?
Expedia's filter tool lets you easily compare airlines, flight times and fares all in one place. Select your preferences, then sort by "Price (lowest to highest)" to find the carrier with the cheapest DSM to MSO flight.
How many flights per day from Des Moines Intl. Airport (DSM) to Missoula Intl. Airport (MSO)?
Direct flights from Des Moines Intl. Airport (DSM) to Missoula Intl. Airport (MSO) aren't available daily, so you'll need to take a flight with a layover. Explore your options with our filter tool. Enter your dates and select either "1 Stop" or "2+ Stops."
What day of the week has the most flights from DSM to MSO?
Friday is generally the busiest day for flights, while Tuesday tends to be the quietest.* Remember that flight schedules can change depending on a range of factors, including the airline and season.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Des Moines Intl. Airport (DSM) to Missoula Intl. Airport (MSO)?
To avoid potential delays on the Des Moines Intl. Airport (DSM) to Missoula Intl. Airport (MSO) route, aim to fly before 3 PM. Departures after this time have a 22% higher chance of being canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Des Moines Intl. Airport (DSM) to Missoula Intl. Airport (MSO) last-minute?
Last-minute fares from DSM to MSO are typically more expensive. To secure the cheapest rates, start looking for flights as early as possible. That said, if you're flexible with your travel plans, it's possible to score a cheap ticket right before your journey.
Is it cheaper to book a DSM to MSO flight and hotel package?
You can save money by securing a DSM to MSO flight and hotel package compared to booking separately. In fact, travelers could save hundreds of dollars by bundling with Expedia. And it's simple to manage it all in one place. Once you've selected your preferred flights and accommodations, consider other add-ons like activities, car rentals and tours.
Can I cancel or change the date of my flight from Des Moines Intl. Airport (DSM) to Missoula Intl. Airport (MSO)?
In most cases, you can modify or cancel your DSM to MSO flight. However, there may be additional fees, especially if you booked over 24 hours ago. Double-check your itinerary for the airline's fees and rules on flight changes, or if you'd like more details, head to our Customer Service portal.

Travel information

Origin airport
Des Moines Intl.
Destination airport
Missoula Intl.
Airlines serving
American Airlines, Delta, United
Roundtrip price
$258
Distance
1074 mi

Book with confidence

Des Moines to Missoula Flights

The cheapest times to fly from Des Moines to Missoula

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Des Moines to Missoula are during the month of December. You can find some of the cheapest flights from Des Moines to Missoula with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Des Moines to Missoula

Sunday is one of the best days to book for cheap flights from Des Moines to Missoula: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Des Moines to Missoula

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Des Moines to Missoula in 2025. You can also book with separate airlines for your outbound and return journeys, from $216 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Des Moines to Missoula flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Des Moines to Missoula airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Des Moines to Missoula Flights

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*Available to One Key members.