$205 Cheap Flights from Key West (EYW) to Panama City (PTY)

View $205 flight on Tue, Aug 5, 2025Opens in a new window

Popular airlines from Key West Intl. Airport (EYW) to Tocumen Intl. Airport (PTY)

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Cheap Flights from Key West to Panama City (EYW-PTY)

Prices were available within the past 7 days and start at $205 for one-way flights and $452 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Wed, Nov 12 - Mon, Nov 17
EYW
Key West
PTY
Panama City
$452 Roundtrip, found 1 day ago
$452
Roundtrip
found 1 day ago
Select Delta flight, departing Wed, Nov 12 from Key West to Panama City, returning Mon, Nov 17, priced at $452 found 1 day ago
Delta
Thu, Nov 13 - Sat, Nov 15
EYW
Key West
PTY
Panama City
$455 Roundtrip, found 1 day ago
$455
Roundtrip
found 1 day ago
Select Delta flight, departing Thu, Nov 13 from Key West to Panama City, returning Sat, Nov 15, priced at $455 found 1 day ago
Delta
Wed, Nov 12 - Thu, Nov 13
EYW
Key West
PTY
Panama City
$464 Roundtrip, found 1 day ago
$464
Roundtrip
found 1 day ago
Select Delta flight, departing Wed, Nov 12 from Key West to Panama City, returning Thu, Nov 13, priced at $464 found 1 day ago
Delta
Thu, Nov 13 - Tue, Nov 18
EYW
Key West
PTY
Panama City
$464 Roundtrip, found 1 day ago
$464
Roundtrip
found 1 day ago
Select Delta flight, departing Thu, Nov 13 from Key West to Panama City, returning Tue, Nov 18, priced at $464 found 1 day ago
Delta
Wed, Nov 12 - Tue, Nov 18
EYW
Key West
PTY
Panama City
$472 Roundtrip, found 1 day ago
$472
Roundtrip
found 1 day ago
Select Delta flight, departing Wed, Nov 12 from Key West to Panama City, returning Tue, Nov 18, priced at $472 found 1 day ago
Delta
Fri, Nov 7 - Sat, Nov 15
EYW
Key West
PTY
Panama City
$475 Roundtrip, found 1 day ago
$475
Roundtrip
found 1 day ago
Select Delta flight, departing Fri, Nov 7 from Key West to Panama City, returning Sat, Nov 15, priced at $475 found 1 day ago
Delta
Sat, Nov 8 - Thu, Nov 13
EYW
Key West
PTY
Panama City
$484 Roundtrip, found 1 day ago
$484
Roundtrip
found 1 day ago
Select Delta flight, departing Sat, Nov 8 from Key West to Panama City, returning Thu, Nov 13, priced at $484 found 1 day ago
Delta
Fri, Aug 29 - Fri, Sep 5
EYW
Key West
PTY
Panama City
$484 Roundtrip, found 6 days ago
$484
Roundtrip
found 6 days ago
Select Delta flight, departing Fri, Aug 29 from Key West to Panama City, returning Fri, Sep 5, priced at $484 found 6 days ago
American Airlines
Tue, Nov 11 - Sun, Nov 16
EYW
Key West
PTY
Panama City
$500 Roundtrip, found 1 day ago
$500
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Nov 11 from Key West to Panama City, returning Sun, Nov 16, priced at $500 found 1 day ago
United
Tue, Nov 11 - Wed, Nov 12
EYW
Key West
PTY
Panama City
$7,523 Roundtrip, found 1 day ago
$7,523
Roundtrip
found 1 day ago
Select United flight, departing Tue, Nov 11 from Key West to Panama City, returning Wed, Nov 12, priced at $7,523 found 1 day ago
Flights from Key West (EYW) to Panama City (PTY)
Origin airport
Key West Intl.
Destination airport
Tocumen Intl.
Roundtrip price
$451
Distance
1081 mi

Key West to Panama City Flights

The cheapest times to fly from Key West to Panama City

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Key West to Panama City are during the month of November. You can find some of the cheapest flights from Key West to Panama City with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Key West to Panama City

Sunday is one of the best days to book for cheap flights from Key West to Panama City: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Key West to Panama City

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Key West to Panama City in 2025. You can also book with separate airlines for your outbound and return journeys, from $205 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Key West to Panama City flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Key West to Panama City airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Key West Intl. Airport (EYW) to Tocumen Intl. Airport (PTY) cost?
Discover the latest flight deals from EYW to PTY by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from EYW to PTY?
The cheapest flights from EYW to PTY are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from EYW to PTY?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that'll take you from EYW to PTY. Sort your results by "Price (lowest to highest)" to snap up a great deal.
How many flights per day from Key West Intl. Airport (EYW) to Tocumen Intl. Airport (PTY)?
There aren't any daily direct flights available from Key West Intl. Airport (EYW) to Tocumen Intl. Airport (PTY). But you can choose flights with layovers. Filter your search on Expedia to include one or more stops, and you'll be soaring above the clouds in no time at all.
What day of the week has the most flights from EYW to PTY?
Generally you'll find the greatest selection of flight options on a Friday. Tuesdays tend to be the quietest.* But this can vary depending on the airline, time of year and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Key West Intl. Airport (EYW) to Tocumen Intl. Airport (PTY)?
Book a flight from Key West Intl. Airport (EYW) to Tocumen Intl. Airport (PTY) that leaves before 3 PM to reduce the risk of delays and cancellations. Later departures are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Key West Intl. Airport (EYW) to Tocumen Intl. Airport (PTY) last-minute?
Booking your flight from EYW to PTY just before your trip is typically more expensive. But if there's some wiggle room with your itinerary, you could score a cheap last-minute fare.
Is it cheaper to book an EYW to PTY flight and hotel package?
Compared with arranging hotels and flights separately, booking an EYW to PTY flight and hotel package with Expedia could lead to significant savings. Better yet, managing everything in one place takes the hassle out of travel planning. Just secure your flights and select from our extensive range of hotels, then customize your trip with extras like activities, tours and car rentals.
Can I cancel or change the date of my flight from Key West Intl. Airport (EYW) to Tocumen Intl. Airport (PTY)?
If you booked your EYW to PTY flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal for more information.

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*Available to One Key members.