$1,225 Cheap Flights from Houston (HOU) to Sao Luis (SLZ)

View $1,225 flight on Wed, Dec 24, 2025Opens in a new window

Popular airlines from Houston William Hobby Airport (HOU) to Sao Luis (SLZ-Marechal Cunha Machado Intl.)

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Cheap Flights from Houston to Sao Luis (HOU-SLZ)

Prices were available within the past 7 days and start at $1,225 for one-way flights and $1,851 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

LATAM Airlines Group
Wed, Feb 4 - Tue, Feb 17
HOU
Houston
SLZ
São Luís
$1,851 Roundtrip, found 4 days ago
$1,851
Roundtrip
found 4 days ago
Select LATAM Airlines Group flight, departing Wed, Feb 4 from Houston to São Luís, returning Tue, Feb 17, priced at $1,851 found 4 days ago
Flights from Houston (HOU) to Sao Luis (SLZ)
Origin airport
William P. Hobby
Destination airport
Marechal Cunha Machado Intl.
Roundtrip price
$1,851
Distance
4036 mi

Houston to Sao Luis Flights

The cheapest times to fly from Houston to Sao Luis

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Houston to Sao Luis are during the month of February. You can find some of the cheapest flights from Houston to Sao Luis with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Houston to Sao Luis

Sunday is one of the best days to book for cheap flights from Houston to Sao Luis: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Houston to Sao Luis

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Houston to Sao Luis in 2025. You can also book with separate airlines for your outbound and return journeys, from $1,225 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Houston to Sao Luis flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Houston to Sao Luis airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from William P. Hobby Airport (HOU) to Marechal Cunha Machado Intl. Airport (SLZ) cost?
Secure a cheap one-way flight from $1,225 or cheap return flight from $1,851 from William P. Hobby Airport (HOU) to Marechal Cunha Machado Intl. Airport (SLZ) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from William P. Hobby Airport (HOU) to Marechal Cunha Machado Intl. Airport (SLZ)?
Planning your getaway for February is a good way to save, as it's the cheapest month for flights between HOU and SLZ. You'll usually find the lowest prices during off-peak months.
What is the cheapest airline that flies from William P. Hobby Airport (HOU) to Marechal Cunha Machado Intl. Airport (SLZ)?
Expedia's filter tool lets you easily compare different airlines, travel time and fares all in one place. Choose your preferences, then sort by "Price (lowest to highest)" to find the carrier with the cheapest HOU to SLZ flight.
How many flights per day from William P. Hobby Airport (HOU) to Marechal Cunha Machado Intl. Airport (SLZ)?
Nonstop flights from William P. Hobby Airport (HOU) to Marechal Cunha Machado Intl. Airport (SLZ) aren't available daily, so you'll have to take a flight with a layover. Explore your options with our filter tool. Enter your travel dates and choose either "1 Stop" or "2+ Stops."
What day of the week has the most flights from HOU to SLZ?
Usually you'll find the widest variety of flight choices on a Friday. Tuesdays tend to be the quietest.* However, this can vary based on the time of year, airline and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from William P. Hobby Airport (HOU) to Marechal Cunha Machado Intl. Airport (SLZ)?
Opt for a flight from William P. Hobby Airport (HOU) to Marechal Cunha Machado Intl. Airport (SLZ) that takes off before 3 PM to reduce the risk of cancellations and delays. Departures later than this have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from William P. Hobby Airport (HOU) to Marechal Cunha Machado Intl. Airport (SLZ) last-minute?
Last-minute fares from HOU to SLZ are usually more expensive. To lock in the cheapest rates, start searching for flights as soon as possible. That said, if you can play around with your travel dates, it's possible to land a cheap ticket right before you leave.
Is it cheaper to book a HOU to SLZ flight and hotel package?
Opting for a HOU to SLZ flight and hotel package is generally cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your trip all in one place. Choose from our wide range of stays and then add activities, flights and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from William P. Hobby Airport (HOU) to Marechal Cunha Machado Intl. Airport (SLZ)?
It's generally possible to reschedule or cancel your HOU to SLZ flight. However, for bookings made more than 24 hours ago, additional fees may apply. Check your airline's policies in your itinerary to see what changes are allowed and if any costs are involved. You'll also find further details on our Customer Service portal.

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*Available to One Key members.